Review
Biotechnology & Applied Microbiology
Riccardo Marconcini, Gaetano Pezzicoli, Luigia Stefania Stucci, Maria Chiara Sergi, Lucia Lospalluti, Camillo Porta, Marco Tucci
Summary: Cutaneous Melanoma is an aggressive cancer with increasing incidence worldwide. The development of new drugs targeting biology and genes driving cell growth, such as BRAF targeting agents and immune checkpoint inhibitors, has improved patient outcomes. However, drug resistance remains a challenge, leading to the need for new strategies, such as combination therapies and clinical trials investigating novel ICIs.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Article
Oncology
Lauren Jones, Rebekah Rittberg, Bonnie Leung, Aria Shokoohi, Alexandra Pender, Selina Wong, Zamzam Al-Hashami, Ying Wang, Cheryl Ho
Summary: There was no significant difference in overall survival between the Q3W and Q6W dosing schedules of pembrolizumab in patients with stage IV non-small cell lung cancer. This study supports the use of Q6W dosing, allowing for less frequent interactions with the medical system.
Review
Biochemistry & Molecular Biology
Cang Li, Le Kuai, Rutao Cui, Xiao Miao
Summary: Understanding the mechanism of melanogenesis is crucial for identifying new preventive and therapeutic strategies in treating melanoma. Key factors include UVR-induced signaling pathways, the role of MC1R, and transcriptional regulation by MITF. Targeting BRAF, NRAS, and MC1R, along with combination therapies of immunotherapy and targeted kinase inhibitors, are promising treatment options for advanced melanoma.
Review
Pharmacology & Pharmacy
Signe Caksa, Usman Baqai, Andrew E. Aplin
Summary: Melanoma, a growing cancer, is currently treated with targeted inhibitors in the MAPK pathway, but drug resistance limits its effectiveness. However, new applications and combinations with other therapies may provide hope for melanoma treatment.
PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Biology
Michael H. Storandt, Peter C. Kurniali, Amit Mahipal, Zhaohui Jin
Summary: Primary tumor resection and liver transplantation are the main treatment options for cholangiocarcinoma (CCA), but for advanced or metastatic cases, palliative systemic therapy is the only option. Targeted therapies, such as mutated isocitrate dehydrogenase-1, HER2 overexpression/amplification, and FGFR2 fusion, have shown promise in CCA treatment. Multiple novel therapies have been developed to target these genetic alterations, with some receiving FDA approval for second-line use.
Article
Nanoscience & Nanotechnology
Jinlu Liu, Ling Yang, Xin Yuan, Meimei Xiong, Jiao Zhu, Wenbi Wu, Min Ren, Jianlin Long, Xuewen Xu, Maling Gou
Summary: LACTB gene is downregulated in melanoma tissues, and the iDPP/LACTB nanocomplexes can induce melanoma cell apoptosis and inhibit tumor growth effectively without obvious side effects, providing a new option for melanoma gene therapy research.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Review
Immunology
Jiajia Du, Xing Lv, Zunyi Zhang, Zhiyong Huang, Erlei Zhang
Summary: Cholangiocarcinoma (CCA) is a rare and aggressive type of cancer with increasing incidence in recent years. Surgery is the most effective treatment, but not suitable for all patients. Targeted therapy focusing on FGFR, IDH, and EGFR2, as well as immunotherapy with PD-1 inhibitors, CAR-T cells, and TILs, have shown promising results in CCA treatment. Combining targeted therapy, immunotherapy, and conventional chemotherapy can greatly improve the prognosis of advanced CCA patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Pier Francesco Ferrucci, Marko Lens, Emilia Cocorocchio
Summary: Combining BRAF-targeted therapy with immune checkpoint inhibitors may show promising anti-tumor activity in patients with BRAF-mutated advanced melanoma, but the frequent occurrence of autoimmunity-induced toxicities needs to be carefully considered. Further clinical investigation is needed to understand the effects of these novel treatment modalities on the immune system and cancer cell modulation.
CURRENT ONCOLOGY REPORTS
(2021)
Article
Medicine, General & Internal
Hussein A. Tawbi, Dirk Schadendorf, Evan J. Lipson, Paolo A. Ascierto, Luis Matamala, Erika Castillo Gutierrez, Piotr Rutkowski, Helen J. Gogas, Christopher D. Lao, Juliana Janoski De Menezes, Stephane Dalle, Ana Arance, Jean-Jacques Grob, Shivani Srivastava, Mena Abaskharoun, Melissa Hamilton, Sarah Keidel, Katy L. Simonsen, Anne Marie Sobiesk, Bin Li, F. Stephen Hodi, Georgina Long
Summary: LAG-3 and PD-1 are two distinct inhibitory immune checkpoints that contribute to T-cell exhaustion. The combination of relatlimab and nivolumab has been shown to be safe and effective in previously treated melanoma patients, and this study aimed to evaluate its safety and activity in previously untreated melanoma patients. The results demonstrated that the combination therapy provided a greater benefit in terms of progression-free survival compared to nivolumab alone, without any new safety signals.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Xiaohui Wei, Shabnam Naseer, Edward A. Weinstein, Dmitri Iarikov, Sumathi Nambiar, Kellie S. Reynolds, Seong H. Jang
Summary: In this report, we describe our scientific approach for including effluent flow rate (Q(E))-based dosing recommendations of cefiderocol for patients receiving continuous renal replacement therapy (CRRT) in the product labeling. The total clearance (CL) of cefiderocol in CRRT patients was estimated by considering both nonrenal and extracorporeal clearance. The dosing regimens for CRRT patients were determined to achieve similar pharmacokinetic profiles as patients not receiving CRRT.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Engineering, Biomedical
Tanveer A. Tabish, Roger J. Narayan
Summary: There have been significant efforts in developing targeted therapies for treating cancer, with mitochondria-targeted therapy emerging as an alternative strategy. Research on nanotechnology-driven strategies and graphene targeting cancer mitochondria show promising potential for future cancer treatments. This review highlights the importance of cross-disciplinary research and the design of mitochondria-targeted graphene for selectively targeting cancer mitochondria.
ACTA BIOMATERIALIA
(2021)
Review
Oncology
Manuel Felipe Fernandez, Jacob Choi, Jeffrey Sosman
Summary: Immune checkpoint inhibitors and BRAF/MEK inhibitors are the main treatments for melanoma, but resistance to these therapies emphasizes the need for new treatment options. Monoclonal antibodies and small molecules allow targeted therapy by focusing on specific mediators of cancer. Melanoma has several driver mutations, and targeting them could lead to novel therapies.
Article
Pediatrics
Autumn M. Mcknite, Danielle J. Green, Raoul Nelson, Simon C. Brewer, Kevin M. Watt
Summary: There are notable differences in medication patterns and dosing guidance between iHD and CKRT patients, with antibiotics, diuretics, and sedatives being more common in CKRT patients. Only 34% and 28% of the 50 most commonly administered medications in the two modalities had dosing guidance for iHD and CKRT, respectively.
PEDIATRIC NEPHROLOGY
(2023)
Article
Oncology
Veronique Roche, Victor Sandoval, Zachary Senders, Joshua Lyons, Claire Wolford, Mei Zhang
Summary: The study suggests that targeting myeloid components using BG34-200 can create systemic antitumor immune responses in advanced melanoma, improving the treatment outcome for patients who do not respond to current therapies.
Article
Oncology
Saira Sanjida, Brigid Betz-Stablein, Victoria Atkinson, Monika Janda, Ramez Barsoum, Harrison Aljian Edwards, Frank Chiu, My Co Tran, H. Peter Soyer, Helmut Schaider
Summary: This study describes the characteristics and outcomes of patients with advanced melanoma receiving immunotherapies and/or targeted therapies in a real-world setting. Despite having multiple comorbidities, the survival of these patients was similar or better compared to those in clinical trials.
Article
Pathology
Benedicte Oules, Samia Mourah, Barouyr Baroudjian, Fanelie Jouenne, Julie Delyon, Baptiste Louveau, Aurelia Gruber, Celeste Lebbe, Maxime Battistella
Summary: The study suggests that CTNNB1 mutations in melanomas are associated with increased proliferative characteristics and progression to metastatic stage, regardless of the concurrent presence of MAPK mutations. Additionally, the co-occurrence of CTNNB1 and MAPK mutations does not necessarily result in a deep penetrating nevi phenotype.
Article
Health Care Sciences & Services
Noemie Trystram, Pauline Laly, Philippe Bertheau, Barouyr Baroudjian, Thomas Aparicio, Jean-Marc Gornet
Summary: We present a unique case of haemorrhagic shock in a patient with resistant diffuse ulcerative enteritis treated with immunotherapy. Treatment with infliximab resulted in a dramatic improvement, with complete cessation of bleeding and mucosal healing.
ANNALS OF PALLIATIVE MEDICINE
(2022)
Article
Oncology
Andrey A. Yurchenko, Oltin T. Pop, Meriem Ighilahriz, Ismael Padioleau, Fatemeh Rajabi, Hayley J. Sharpe, Nicolas Poulalhon, Brigitte Dreno, Amir Khammari, Marc Delord, Antonio Alberti, Nadem Soufir, Maxime Battistella, Samia Mourah, Fanny Bouquet, Ariel Savina, Andrej Besse, Max Mendez-Lopez, Florent Grange, Sandrine Monestier, Laurent Mortier, Nicolas Meyer, Caroline Dutriaux, Caroline Robert, Philippe Saiag, Florian Herms, Jerome Lambert, Frederic J. de Sauvage, Nicolas Dumaz, Lukas Flatz, Nicole Basset-Seguin, Sergey Nikolaev
Summary: This study found that intrinsic resistance (IR) to vismodegib in locally advanced basal cell carcinoma (laBCC) is rare. IR-BCC patients often have resistance mutations in the Hh pathway, but also exhibit hyperactivation of the HIPPO-YAP and WNT pathways.
CLINICAL CANCER RESEARCH
(2022)
Article
Dermatology
Florian Herms, Barouyr Baroudjian, Julie Delyon, Pauline Laly, Pauline Tetu, Celeste Lebbe, Nicole Basset-Seguin
Summary: A real-world study was conducted to evaluate the efficacy and safety of Sonidegib for the treatment of locally advanced basal cell carcinoma. The results showed consistent efficacy and tolerability, supporting its use as a first-line treatment.
ACTA DERMATO-VENEREOLOGICA
(2022)
Article
Cardiac & Cardiovascular Systems
John R. Power, Joachim Alexandre, Arrush Choudhary, Benay Ozbay, Salim S. Hayeke, Aarti Asnani, Yuichi Tamura, Mandar Aras, Jennifer Cautela, Franck Thuny, Lauren Gilstrap, Dimitri Arangalage, Steven Ewer, Shi Huang, Anita Deswal, Nicolas L. Palaskas, Daniel Finke, Lorenz H. Lehmann, Stephane Ederhy, Javid Moslehi, Joe-Elie Salem
Summary: This study evaluated the association between electrocardiogram findings in ICI-myocarditis and myocarditis-related mortality and life-threatening arrhythmia. The study found that patients with ICI-myocarditis who developed complete heart block or life-threatening cardiac arrhythmias had a higher risk of myocarditis-related mortality. Pathological Q waves, low QRS voltage, and Sokolow-Lyon index on admission electrocardiogram were also associated with increased risk of myocarditis-related mortality.
ARCHIVES OF CARDIOVASCULAR DISEASES
(2022)
Article
Oncology
Marie-Lea Gauci, Jerome Giustiniani, Clemence Lepelletier, Christian Garbar, Nicolas Thonnart, Nicolas Dumaz, Arnaud Foussat, Celeste Lebbe, Armand Bensussan, Anne Marie-Cardine
Summary: Research has found that CD160 is highly expressed in the tumor tissues of melanoma patients. Melanoma cells express CD160-GPI isoform and release soluble form (sCD160), which inhibits the cytotoxic activity of NK cells. In addition, sCD160 is found in the serum of melanoma patients and is associated with increased tumor dissemination.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Letter
Dermatology
Marion Marcaillou, Jeremie Dion, Barouyr Baroudjian, Emilien Ezrine, Cristina Carrera, Alisa Anderle, Zoe Apalla, Azael Freites-Martinez, Cecile Pages, Celeste Lebbe, Nicolas Meyer, Vincent Sibaud, Thibault Comont
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Alexandra Landras, Coralie Reger de Moura, Bruno O. Villoutreix, Maxime Battistella, Aurelie Sadoux, Nicolas Dumaz, Suzanne Menashi, Juan Fernandez-Recio, Celeste Lebbe, Samia Mourah
Summary: CD147i, a specific inhibitor of CD147/VEGFR-2 interaction, shows potential therapeutic effects for NRAS(mut) melanoma cells. It significantly inhibits malignant properties of melanoma and exhibits synergy with MEKi.
Article
Oncology
Louise Pesque, Julie Delyon, Coralie Lheure, Barouyr Baroudjian, Maxime Battistella, Pascal Merlet, Celeste Lebbe, Laetitia Vercellino
Summary: FDG PET/CT demonstrates good sensitivity and specificity for staging Kaposi sarcoma, except for digestive involvement, and can be utilized for patients with active Kaposi sarcoma.
Review
Medicine, General & Internal
Laetitia Vercellino, Dorine de Jong, Laurent Dercle, Benoit Hosten, Brian Braumuller, Jeeban Paul Das, Aileen Deng, Antoine Moya-Plana, Camry A'Keen, Randy Yeh, Pascal Merlet, Barouyr Baroudjian, Mary M. Salvatore, Kathleen M. Capaccione
Summary: Advances in immunotherapy and targeted therapy have improved patient survival for melanoma. Molecular targeted PET imaging can identify pathways promoting disease progression and provide physiological information for assessing prognosis and monitoring treatment response.
Article
Oncology
Alexia Rivas, Julie Delyon, Antoine Martineau, Estelle Blanc, Clara Allayous, Laetitia Da Meda, Pascal Merlet, Celeste Lebbe, Barouyr Baroudjian, Laetitia Vercellino
Summary: This study investigated the value of metabolic criteria in assessing the therapeutic response to immune checkpoint inhibitors in patients with advanced or metastatic melanoma. The results showed that evaluating the response using metabolic imaging was significantly associated with overall survival. Combined approaches may improve confidence in evaluating the response to immunotherapy.
Letter
Dermatology
Parna Moghadam, Florian Herms, Barouyr Baroudjian, Pauline Tetu, Julie Delyon, Fanelie Jouenne, Marie Boisson, Baptiste Louveau, Samia Mourah, Florence Brunet-Possenti, Lucie Duverger, Valerie Gounant, Celeste Lebbe, Nicole Basset-Seguin
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Oncology
Caroline Robert, Celeste Lebbe, Thierry Lesimple, Eija Lundstrom, Valerie Nicolas, Bruno Gavillet, Philippa Crompton, Barouyr Baroudjian, Emilie Routier, Ferdy J. Lejeune
Summary: This study evaluated the safety and efficacy of combined treatment with GnRH agonist triptorelin and nivolumab in male melanoma patients resistant to anti-PD-1. The results showed that this combination therapy effectively controlled the disease, with a disease control rate of 42.8% according to RECIST criteria. However, evidence for thymus rejuvenation was limited.
CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
Julie Delyon, Anais Vallet, Melanie Bernard-Cacciarella, Isabelle Kuzniak, Coralie Reger de Moura, Baptiste Louveau, Fanelie Jouenne, Samia Mourah, Celeste Lebbe, Nicolas Dumaz
Summary: TERT promoter mutations are frequently found in melanoma and are associated with a poorer prognosis. Our data suggest that TERT mRNA level is a reliable marker for prognosis and is associated with resistance to targeted therapy in melanoma. We showed that TERT overexpression drives resistance to BRAF and MEK inhibitors, and inhibition of TERT can be a therapeutic option for melanoma with acquired resistance to BRAF inhibition.