期刊
CURRENT OPINION IN NEUROBIOLOGY
卷 65, 期 -, 页码 38-48出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2020.08.003
关键词
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资金
- Swiss National Science Foundation [31003A_182010]
- Marie Sklodowska-Curie Actions [665667, 798617]
- Brain Science Foundation
- Ichiro Kanehara Foundation
- Research Foundation for Opto-Science and Technology
- Swiss National Science Foundation (SNF) [31003A_182010] Funding Source: Swiss National Science Foundation (SNF)
- Marie Curie Actions (MSCA) [798617] Funding Source: Marie Curie Actions (MSCA)
Animals can learn to use sensory stimuli to generate motor actions in order to obtain rewards. However, the precise neuronal circuits driving learning and execution of a specific goal-directed sensory-to-motor transformation remain to be elucidated. Here, we review progress in understanding the contribution of cortical neuronal circuits to a task in which head-restrained water-restricted mice learn to lick a reward spout in response to whisker deflection. We first examine 'innate' pathways for whisker sensory processing and licking motor control, and then discuss how these might become linked through reward-based learning, perhaps enabled by cholinergic-gated and dopaminergic-gated plasticity. The aim is to uncover the synaptically connected neuronal pathways that mediate reward-based learning and execution of a well-defined sensory-to-motor transformation.
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