期刊
CURRENT OPINION IN GENETICS & DEVELOPMENT
卷 65, 期 -, 页码 8-13出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2020.04.005
关键词
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资金
- Howard Hughes Medical Institute Funding Source: Medline
It has long been appreciated that activity sculpts the formation of neuronal circuits in the mammalian brain. By contrast, in Drosophila it was generally thought that genetically hardwired mechanisms of development, mediated by cell recognition molecules, are sufficient to specify the connectome-the complex and stereotyped pattern of connections between neurons. Here, we consider recent findings that activity during development also contributes to circuit assembly in the fly. These observations suggest that activity is a fundamental aspect of brain development in general. They also highlight the opportunities to learn about the role of this phenomenon through the extensive Drosophila toolkit for examining circuit development, structure, and function.
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