Article
Critical Care Medicine
Alexis Tabah, Niccolo Buetti, Quentin Staiquly, Stephane Ruckly, Murat Akova, Abdullah Tarik Aslan, Marc Leone, Andrew Conway Morris, Matteo Bassetti, Kostoula Arvaniti, Jeffrey Lipman, Ricard Ferrer, Haibo Qiu, Jose-Artur Paiva, Pedro Povoa, Liesbet De Bus, Jan De Waele, Farid Zand, Mohan Gurjar, Adel Alsisi, Khalid Abidi, Hendrik Bracht, Yoshiro Hayashi, Kyeongman Jeon, Muhammed Elhadi, Francois Barbier, Jean-Francois Timsit
Summary: This study investigated hospital-acquired bloodstream infections (HA-BSI) in 2600 adult patients from 333 ICUs in 52 countries. HA-BSI were frequently caused by Gram-negative, carbapenem-resistant, and difficult-to-treat pathogens. Antimicrobial resistance led to delays in adequate antimicrobial therapy, resulting in high mortality rates.
INTENSIVE CARE MEDICINE
(2023)
Article
Medicine, General & Internal
He-Ning Wu, Er-Yan Yuan, Wen-Bin Li, Min Peng, Qing-Yu Zhang, Ke-liang Xie
Summary: This study retrospectively analyzed the microbiological and clinical data of bloodstream infection (BSI) patients in an ICU in Tianjin, China. The results showed that Gram-negative bacteria had the highest drug resistance rate and resulted in more severe brain damage, renal function damage, and thrombocytopenia. The test index of procalcitonin (PCT) could be used to distinguish Gram-negative bacteremia from Gram-positive and differentiate bacteremia from fungemia, but further research is needed.
FRONTIERS IN MEDICINE
(2022)
Article
Infectious Diseases
Mandira Chakraborty, Sayani Sardar, Rituparna De, Malabika Biswas, Maria Teresa Mascellino, Maria Claudia Miele, Silpak Biswas, Anita Nandi Mitra
Summary: Nosocomial infections caused by multidrug-resistant bacteria are a major concern in ICUs, and the resistance patterns of these pathogens were examined in a tertiary care hospital in Kolkata, India. The study found that multidrug-resistant bacteria were prevalent in both adult and pediatric ICUs and showed high resistance against multiple antibiotics.
Article
Public, Environmental & Occupational Health
Dharm Raj Bhatta, Supram Hosuru Subramanya, Deependra Hamal, Rajani Shrestha, Eva Gauchan, Sahisnuta Basnet, Niranjan Nayak, Shishir Gokhale
Summary: This study found a high level of bacterial contamination of objects/instruments in the NICU. Common potential pathogens isolated were Escherichia coli, Klebsiella species, and Staphylococcus aureus. Most bacterial isolates were susceptible to gentamicin and amikacin.
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
(2021)
Article
Infectious Diseases
Cecilia Herbozo, Irene Julca, Fiorella Flores, Roger Hernandez, Jaime Zegarra
Summary: This study aimed to determine the incidence of late onset sepsis and the most frequent causative microorganisms in the neonatal unit at Hospital Cayetano Heredia in Lima, Peru. The results showed that late onset sepsis was more prevalent in low birth weight infants, with gram-negative bacteria being the main causative microorganism in very low birth weight infants.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Medicine, General & Internal
Mohammad Nizam Mokhtar, Izzuddin Azaharuddin, Farah Hanim Abdullah, Azarinah Izaham, Raha Abdul Rahman
Summary: Pseudomonas putida is a rare pathogen that can cause nosocomial and central nervous system infections. This article reports on a gardener with extensive subarachnoid hemorrhage who developed P. putida infection during intensive care unit treatment. It emphasizes the importance of early detection and appropriate antibiotic treatment, as well as strict hygiene precautions, to prevent the development of multidrug-resistant strains.
FRONTIERS IN MEDICINE
(2022)
Article
Cell Biology
Drew J. Schwartz, Nitan Shalon, Kate Wardenburg, Anna DeVeaux, Meghan A. Wallace, Carla Hall-Moore, I. Malick Ndao, Janice E. Sullivan, Paula Radmacher, Marilyn Escobedo, Carey-Ann D. Burnham, Barbara B. Warner, Phillip I. Tarr, Gautam Dantas
Summary: BSI in preterm infants is commonly transmitted through the gut microbiome and is associated with antibiotic exposure. Ampicillin, gentamicin, or vancomycin can increase the abundance of Enterobacteriaceae and Enterococcaceae in the gut of preterm infants. This study suggests that the microbial composition of the gut can be utilized to predict the risk of BSI in hospitalized preterm infants.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
D. Strelkova, S. Rachina, L. Fedina, A. Vlasenko, M. Tetevina, D. Drogashevskaya, M. Chesnokova, V. Kuleshov, E. Burmistrova, I. Sychev, N. Ananicheva
Summary: This study aimed to identify the risk factors for nosocomial bloodstream infections (BSIs) in intensive care unit (ICU) patients with COVID-19 and develop a predictive model for BSIs. The study found that certain medications, abnormal physiological indicators, and treatment methods for patients transferred to the ICU were associated with the occurrence of BSIs. These findings are important for clinicians in promptly identifying high-risk patients.
JOURNAL OF HOSPITAL INFECTION
(2023)
Article
Multidisciplinary Sciences
Mera A. Ababneh, Mohammad Al Domi, Abeer M. Rababa'h
Summary: This study investigated the types of antimicrobial agents used in the ICU and factors associated with mortality in bloodstream infections (BSIs) patients. The study found that a combination of three or more antimicrobial agents was commonly used, and the mortality rate was high among BSI patients. Factors such as age, comorbidities, hospital infections, and length of ICU stay were associated with mortality. The study suggests the evaluation of antimicrobial stewardship protocols in the ICU and implementation of infection control measures and comorbidity management to reduce mortality rates.
Article
Infectious Diseases
Tommaso Bardi, Vicente Pintado, Maria Gomez-Rojo, Rosa Escudero-Sanchez, Amal Azzam Lopez, Yolanda Diez-Remesal, Nilda Martinez Castro, Patricia Ruiz-Garbajosa, David Pestana
Summary: Co-infection of bacteria and fungi is common in ICU-admitted COVID-19 patients and usually presents as a severe form of infection, associated with a high mortality rate and longer ICU stay.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2021)
Article
Immunology
Steven M. Smoke, Alison Brophy, Samuel Reveron, Alina Iovleva, Ellen G. Kline, Michael Marano, Lincoln P. Miller, Ryan K. Shields
Summary: This study reports on the treatment outcomes of 11 critically ill burn patients using cefiderocol for carbapenem-resistant Acinetobacter baumannii infections. The clinical success rate was 36%, but was complicated by the emergence of treatment-resistant A. baumannii and its transmission among patients. The resistant strains harbored disrupted pirA and piuA genes, which were not disrupted in susceptible strains.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Lise Cremet, Anne-Gaelle Leroy, Damien Muller, Sandie Delanou, Alexandra Burghelea, Alexis Broquet, Antoine Roquilly, Nathalie Caroff
Summary: This study revealed the within-host heterogeneity of Pseudomonas aeruginosa populations from pneumonia by examining colonies from bronchoalveolar lavage (BAL), showing differences in antibiotic susceptibility and quorum-sensing (QS) phenotypes. It also highlighted a significant association between QS deficiency and ceftazidime resistance, emphasizing the importance of examining diverse colonies when analyzing BAL cultures.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2021)
Article
Multidisciplinary Sciences
Ines Lakbar, Sophie Medam, Romain Ronfle, Nadim Cassir, Louis Delamarre, Emmanuelle Hammad, Alexandre Lopez, Alain Lepape, Anais Machut, Mohamed Boucekine, Laurent Zieleskiewicz, Karine Baumstarck, Anne Savey, Marc Leone
Summary: This study found that ICU-acquired pneumonia caused by highly antimicrobial-resistant (HAMR) bacteria is associated with a significantly increased ICU mortality rate. The research also showed that patients with pneumonia caused by HAMR bacteria had longer ICU length of stay and mechanical ventilation duration.
SCIENTIFIC REPORTS
(2021)
Article
Infectious Diseases
Jordana Almeida Santana, Amanda Oliveira Paraguassu, Ranielle Stephanie Toledo Santana, Rafael Gariglio Clark Xavier, Patricia Maria Colleto Freitas, Flavia Figueira Aburjaile, Vasco Ariston de Carvalho Azevedo, Bertram Brenig, Anders Miki Bojesen, Rodrigo Otavio Silveira Silva
Summary: This study evaluated the risk factors associated with MRSP colonization in dogs admitted to an ICU, and reported antimicrobial resistance profiles and genetic relatedness of MRSP isolates. The results found that female sex, age (>7 years), and previous antimicrobial treatment were associated with MRSP acquisition. Whole-genome sequencing revealed the presence of the same MRSP clone causing infections in dogs outside the ICU. Therefore, improved infection prevention and control practices are necessary in veterinary hospitals, especially in ICUs.
Article
Pediatrics
Halima Dabaja-Younis, Maha Alaiyan, Ranaa Damouni Shalabi, Josef Ben-Ari, Tamar Alon, Amir Hadash, Yael Shachor-Meyouhas, Imad Kassis, Khetam Hussein
Summary: This study aimed to investigate the profile of bloodstream infections (BSI) in the pediatric intensive care unit (PICU) and identify predictors of mortality. Data from hospital records for children younger than 18-years who developed BSI during their PICU stay between 2014 and 2019 were collected. The results showed that the incidence of BSI was relatively high, with Gram-negative rods being the most common isolates. BSI was associated with increased mortality, and hemodynamic instability, higher blood urea nitrogen (BUN), and lower albumin levels were identified as risk factors for ICU mortality.
