Safety and Efficacy of Sovateltide (IRL-1620) in a Multicenter Randomized Controlled Clinical Trial in Patients with Acute Cerebral Ischemic Stroke

Sovateltide (IRL-1620) affects neuronal progenitors and prevents cerebral tissue damage after ischemic stroke

(2020) Amaresh K Ranjan et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Human Placental Trophoblast Progenitor Cells (hTPCs) Promote Angiogenesis and Neurogenesis After Focal Cerebral Ischemia in Rats

(2020) Muge Molbay et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Vascular Endothelial Growth Factor 165-Binding Heparan Sulfate Promotes Functional Recovery From Cerebral Ischemia

(2020) Su Jing Chan et al.   STROKE

Sovateltide (IRL-1620) activates neuronal differentiation and prevents mitochondrial dysfunction in adult mammalian brains following stroke

(2020) Amaresh K. Ranjan et al.   Scientific Reports

Atrasentan and renal events in patients with type 2 diabetes and chronic kidney disease (SONAR): a double-blind, randomised, placebo-controlled trial

(2019) Hiddo J L Heerspink et al.   LANCET

Anti-apoptotic activity of ETB receptor agonist, IRL-1620, protects neural cells in rats with cerebral ischemia

(2019) Seema Briyal et al.   Scientific Reports

Endovascular Thrombectomy for Acute Ischemic Stroke

(2019) Tasneem F. Hasan et al.   Current Cardiology Reports

Phase I/II Study of Safety and Preliminary Efficacy of Intravenous Allogeneic Mesenchymal Stem Cells in Chronic Stroke

(2019) Michael L. Levy et al.   STROKE

Nestin-expressing progenitor cells: function, identity and therapeutic implications

(2018) Aurora Bernal et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Direct mechanical thrombectomy in tPA-ineligible and -eligible patients versus the bridging approach: a meta-analysis

(2018) Johannes Kaesmacher et al.   Journal of NeuroInterventional Surgery

A new era for stroke therapy: Integrating neurovascular protection with optimal reperfusion

(2018) Ligen Shi et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Global, Regional, and Country-Specific Lifetime Risks of Stroke, 1990 and 2016

(2018)   NEW ENGLAND JOURNAL OF MEDICINE

Neuroprotective Effect of IRL-1620, an Endothelin B Receptor Agonist, on a Pediatric Rat Model of Middle Cerebral Artery Occlusion

(2018) Enrique G. Cifuentes et al.   Frontiers in Pediatrics

Endothelin ET A Receptor Blockade, by Activating ET B Receptors, Increases Vascular Permeability and Induces Exaggerated Fluid Retention

(2017) Magali Vercauteren et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Safety Outcomes After Thrombolysis for Acute Ischemic Stroke in Patients With Recent Stroke

(2017) Alexander E. Merkler et al.   STROKE

Strategies to Extend Thrombolytic Time Window for Ischemic Stroke Treatment: An Unmet Clinical Need

(2017) Ike dela Peña et al.   Journal of Stroke

Endothelin Receptors, Mitochondria and Neurogenesis in Cerebral Ischemia

(2016) Anil Gulati   Current Neuropharmacology

Ontogeny of endothelin receptors in the brain, heart, and kidneys of neonatal rats

(2015) Bhagya Puppala et al.   BRAIN & DEVELOPMENT

Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials

(2014) Jonathan Emberson et al.   LANCET

Intra-Arterial Immunoselected CD34+ Stem Cells for Acute Ischemic Stroke

(2014) Soma Banerjee et al.   Stem Cells Translational Medicine

Endothelin B receptor agonist, IRL-1620, enhances angiogenesis and neurogenesis following cerebral ischemia in rats

(2013) Mary G. Leonard et al.   BRAIN RESEARCH

Repeated Administration of Centhaquin to Pregnant Rats did not Affect Postnatal Development and Expression of Endothelin Receptors in the Brain, Heart or Kidney of Pups

(2012) S. Briyal et al.   ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH

Endothelin B receptor agonist, IRL-1620, provides long-term neuroprotection in cerebral ischemia in rats

(2012) Mary G. Leonard et al.   BRAIN RESEARCH

Adult Neural Stem Cells: Response to Stroke Injury and Potential for Therapeutic Applications

(2012) Basam Z. Barkho et al.   Current Stem Cell Research & Therapy

Endothelin B receptor agonist, IRL-1620, reduces neurological damage following permanent middle cerebral artery occlusion in rats

(2011) Mary G. Leonard et al.   BRAIN RESEARCH

I.c.v administration of an endothelin ETB receptor agonist stimulates vascular endothelial growth factor-A production and activates vascular endothelial growth factor receptors in rat brain

(2011) Y. Koyama et al.   NEUROSCIENCE

Endothelin-A receptor antagonist BQ123 potentiates acetaminophen induced hypothermia and reduces infarction following focal cerebral ischemia in rats

(2010) Seema Briyal et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Neuron Protection as a Therapeutic Target in Acute Ischemic Stroke

(2009) Antonino Tuttolomondo et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Neurorestorative therapies for stroke: underlying mechanisms and translation to the clinic

(2009) Zheng Gang Zhang et al.   LANCET NEUROLOGY

Deficiency in Endothelin Receptor B Reduces Proliferation of Neuronal Progenitors and Increases Apoptosis in Postnatal Rat Cerebellum

(2008) Maria Vidovic et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

SB 234551 selective ETA receptor antagonism: Perfusion/Diffusion MRI used to define treatable stroke model, time to treatment and mechanism of protection

(2008) Jeffrey J. Legos et al.   EXPERIMENTAL NEUROLOGY

Targeting of endothelin receptor-B to the neural crest

(2008) Noah R. Druckenbrod et al.   GENESIS

Nestin expression defines both glial and neuronal progenitors in postnatal sympathetic ganglia

(2008) Huilin Shi et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Synergistic Effect of an Endothelin Type A Receptor Antagonist, S-0139, With rtPA on the Neuroprotection After Embolic Stroke

(2008) Rui Lan Zhang et al.   STROKE