Article
Nutrition & Dietetics
Arabella Fischer, Noemi Kiss, Valerie-Anna Rudas, Kristina Nieding, Cecilia Veraar, Isabel Timmermann, Konstantin Liebau, Maximilian Pesta, Timo Siebenrock, Martin Anwar, Ricarda Hahn, Anatol Hertwig, Jonas Brugger, Helmut Ringl, Dietmar Tamandl, Michael Hiesmayr
Summary: This study investigates the effect of choosing different cut-off points on the prevalence of low muscle mass in CT scans at the third lumbar vertebra. The results show that the choice of cut-off points significantly affects the prevalence of low muscle mass and its distribution across different age and BMI groups.
Article
Multidisciplinary Sciences
Shaohua Liu, Xia Han, Jianjun Li, Xia Xie, Yunkai Yang, Wangyan Jiang, Li Liu, Zhelong Liu
Summary: This study found that skeletal muscle mass can be assessed using images obtained from routine chest CT scans at the first lumbar vertebra (L1) level. There were strong correlations between measurements at the L1 and L3 levels, and factors such as age, body mass index, and body surface area were associated with skeletal muscle mass. The findings suggest that L1 measurements may serve as surrogate markers for assessing overall skeletal muscle mass.
Article
Medicine, General & Internal
Kazuki Ohashi, Toru Ishikawa, Asami Hoshii, Tamaki Hokari, Hirohito Noguchi, Mitsuyuki Suzuki, Hiroshi Hirosawa, Michitaka Imai, Yuta Mitobe, Toshiaki Yoshida
Summary: Using CT scans to measure total muscle area at the level of the third lumbar vertebra as the cut-off values for Skeletal Muscle Mass Index (SMI), with DXA as the reference method.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Ping-Huai Wang, Chien-Hung Gow, Yen-Ling Chiu, Tien-Chi Li
Summary: The study highlights the importance of cutoff values for L1MI derived from LDCT and its impact on muscle quantity in COPD patients, providing additional information on sarcopenia during health assessments.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Aisha A. Arayne, Richard Gartrell, Jing Qiao, Paul N. Baird, Justin M. C. Yeung
Summary: This study assessed the variation and reproducibility of skeletal muscle mass at vertebral levels T4, T12 and L3 in pre-operative rectal cancer patients, and found that measuring skeletal muscle mass at the T4 vertebral level is comparable to measures achieved at L3 in patients with rectal cancer.
Article
Nutrition & Dietetics
Ming Kong, Ning Lin, Lili Wang, Nan Geng, Manman Xu, Shanshan Li, Wenyan Song, Ying Zhou, Yuetong Piao, Zuoqing Han, Rong Guo, Chao Yang, Nan Luo, Zhong Wang, Quanxiao Xu, Daimeng Shi, Wanchun Qiu, Junfeng Li, Eddie C. Cheung, Lei Ma, Yu Chen, Zhongping Duan
Summary: The study aimed to establish reference values for low L3-PMI to define sarcopenia in the Northern Chinese population. The results showed a negative linear correlation between L3-PMI and age, and a strong correlation with the skeletal muscle index taken at the third lumbar vertebrae (L3-SMI).
FRONTIERS IN NUTRITION
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hugo C. van Heusden, Najiba Chargi, Jan Willem Dankbaar, Ernst J. Smid, Remco de Bree
Summary: Low skeletal muscle mass is common in patients with head and neck cancer. This study found a moderate to strong association between masseter muscle volume and C3 and L3 skeletal muscle cross sectional area (CSA), and masseter skeletal muscle index predicts overall survival.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2022)
Article
Geriatrics & Gerontology
D. De Marco, S. Mamane, W. Choo, L. Mullie, X. Xue, M. Afilalo, J. Afilalo
Summary: This study provides reference values and age-related decline trends for CT muscle parameters at L4 in a healthy population, using an accessible web-based software, which is valuable for interpreting and applying these imaging biomarkers of sarcopenia in clinical care.
JOURNAL OF NUTRITION HEALTH & AGING
(2022)
Article
Geriatrics & Gerontology
Sung Woo Moon, Sang Hoon Lee, Ala Woo, Ah Young Leem, Su Hwan Lee, Kyung Soo Chung, Eun Young Kim, Ji Ye Jung, Young Ae Kang, Moo Suk Park, Young Sam Kim, Chang Oh Kim, Song Yee Kim
Summary: This study aimed to establish reference values for sarcopenia of thoracic skeletal muscles acquired from chest CT scans and analyze variables related to sarcopenia. The findings provide sex-specific standardized methods for quantifying thoracic muscle mass and assessing sarcopenia.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Geriatrics & Gerontology
Takafumi Mizuno, Yasumoto Matsui, Makiko Tomida, Yasuo Suzuki, Yukiko Nishita, Chikako Tange, Hiroshi Shimokata, Shiro Imagama, Rei Otsuka, Hidenori Arai
Summary: The study found that both quadriceps muscle cross-sectional area and computed tomography values decreased with age, while intermuscular adipose tissue area did not show a clear trend. There were sex-related differences and differences in the muscles contributing to knee extension strength between men and women. Quadriceps cross-sectional area and computed tomography values are useful for objectively assessing age-related and sex-related muscle deterioration and knee extension strength.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Article
Cardiac & Cardiovascular Systems
Tsutomu Sunayama, Yudai Fujimoto, Yuya Matsuea, Taishi Dotare, Maeda Daichi, Shoichiro Yatsu, Sayaki Ishiwata, Yutaka Nakamura, Yuka Akama, Yuichiro Tsujimura, Shoko Suda, Takao Kato, Masaru Hiki, Takatoshi Kasai, Tohru Minamino
Summary: Heart failure with concomitant sarcopenia has a poor prognosis. This study compared the prognostic value of low ASMI measured using a biomarker model and an anthropometric model in patients with heart failure.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Article
Physiology
Masatoshi Naruse, William A. Fountain, Alex Claiborne, W. Holmes Finch, Scott Trappe, Todd A. Trappe
Summary: This study shows that older individuals experience muscle atrophy and hypertrophy in a muscle-specific manner, with the quadriceps, hamstrings, psoas, and rectus abdominis atrophying while the lateral abdominals and paraspinals hypertrophying. These findings contribute to a better understanding of skeletal muscle aging and highlight the importance of studying muscle-specific changes in older adults.
JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Geriatrics & Gerontology
Julian Alcazar, Luis M. Alegre, Evelien Van Roie, Joao P. Magalhaes, Barbara R. Nielsen, Marcela Gonzalez-Gross, Pedro B. Judice, Jose A. Casajus, Christophe Delecluse, Luis B. Sardinha, Charlotte Suetta, Ignacio Ara
Summary: Relative muscle power measured by the sit-to-stand (STS) test was found to decrease significantly after the age of 50 years, and was strongly associated with mobility limitations in older adults. The study provides normative data, relevant cut-off points, and MCID values for STS power, which can be used in daily clinical practice.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Article
Medicine, General & Internal
Aniek T. Zwart, Wolf Portzgen, Irene Van Rijn-Dekker, Grigory A. Sidorenkov, Rudi A. J. O. Dierckx, Roel J. H. M. Steenbakkers, Inge Wegner, Anouk van der Hoorn, Geertruida H. de Bock, Gyorgy B. Halmos
Summary: A low skeletal muscle index (SMI) is a promising predictor for adverse events in head and neck squamous cell cancer patients. Sex-specific SMI cut-off values were generated based on the occurrence of adverse events, and low SMI and tumor stage were independently related to (chemo-)radiotherapy toxicity in these patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Health Care Sciences & Services
Ji-Hoon Sim, Soo-Ho Lee, Ji-Wan Kim, Won-Uk Koh, Hyung-Tae Kim, Young-Jin Ro, Ha-Jung Kim
Summary: The study found that PLVI was significantly associated with mortality after hip fracture surgery, with low PLVI being linked to higher mortality rates. Therefore, PLVI might be an independent predictor of mortality in elderly patients undergoing hip fracture surgery.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Medicine, General & Internal
Gulistan Bahat, Nezahat Muge Catikkas, Mehmet Akif Karan, Mirko Petrovic
Summary: SGLT-2 inhibitors have shown positive effects on frailty, blood pressure, and glucose control in older adults with high cardiovascular risk, while cessation of metformin in patients with anorexia/weight loss can lead to improvements in frailty and reduced inappropriate medication use. The study highlights the potential benefits of SGLT-2 inhibitors and discontinuation of metformin in managing diabetes in older adults with different clinical conditions.
ACTA CLINICA BELGICA
(2022)
Article
Geriatrics & Gerontology
Serdar Ozkok, Caglar Ozer Aydin, Duygu Erbas Sacar, Nezahat Muge Catikkas, Tugba Erdogan, Cihan Kilic, Mehmet Akif Karan, Gulistan Bahat
Summary: Polypharmacy is associated with poor physical performance in older adults, particularly reflected in worse SPPB and longer CSST, with no significant association with usual gait speed. Further longitudinal studies are needed to clarify whether polypharmacy causes a deterioration in physical performance.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2022)
Article
Medicine, General & Internal
Gulistan Bahat, Birkan Ilhan, Nezahat Muge Catikkas, Asli Tufan, Savas Ozturk, Hafize Dogan, Mehmet Akif Karan
Summary: This study examines the associations of obesity alone, self-reported muscle weakness alone, and their combination with mortality in nursing home residents. The findings suggest that obesity is associated with lower mortality risk if weakness is not present, but obesity with concomitant weakness is associated with similar mortality risk as non-weak non-obese or weak alone participants.
ACTA CLINICA BELGICA
(2023)
Letter
Nutrition & Dietetics
Gulistan Bahat, Nezahat Muge Catikkas, Zumrut Bahat, Mehmet Akif Karan
CLINICAL NUTRITION
(2022)
Letter
Nutrition & Dietetics
Nezahat Muge Catikkas, Mehmet Akif Karan, Zumrut Bahat, Gulistan Bahat
CLINICAL NUTRITION
(2022)
Article
Nutrition & Dietetics
Serdar Ozkok, Caglar Ozer Aydin, Duygu Erbas Sacar, Nezahat Muge Catikkas, Tugba Erdogan, Meris Esra Bozkurt, Cihan Kilic, Mehmet Akif Karan, Gulistan Bahat
Summary: The study aimed to investigate the associations between sarcopenic obesity and frailty and poor physical performance. The results showed that both sarcopenic obesity and sarcopenia alone were independently associated with frailty and impaired physical performance, but the risk was lower in sarcopenic obesity. Longitudinal studies are needed to determine if an obesity paradox exists in frailty and physical performance in older adults.
CLINICAL NUTRITION
(2022)
Article
Geriatrics & Gerontology
Gulistan Bahat, Birkan Ilhan, Tugba Erdogan, Nezahat Muge Catikkas, Mehmet Akif Karan, Michael Drey, Jerzy Gasowski, Marina Kotsani, Karolina Piotrowicz, John Morley
Summary: Frailty is a common geriatric syndrome that indicates declining homeostasis and increased risk of disability and mortality. The Simplified Modified Fried Frailty Scale is a practical screening tool that can be adapted and validated in different European languages.
EXPERIMENTAL GERONTOLOGY
(2022)
Letter
Nutrition & Dietetics
Nezahat Muge Catikkas, Umut Safer
CLINICAL NUTRITION
(2023)
Article
Acoustics
Nezahat Muge Catikkas, Vildan Binay Safer
Summary: This study is the first to investigate factors associated with mortality, including ultrasonographic muscle measurements in both the lower and upper extremities, in a palliative care center. The study found that malignancy and biceps brachii CSA may have prognostic value in predicting mortality in palliative patients.
JOURNAL OF CLINICAL ULTRASOUND
(2023)
Article
Medicine, General & Internal
Meris Esra Bozkurt, Nezahat Muge Catikkas, Tugba Erdogan, Meryem Merve Oren, Cihan Kilic, Mehmet Akif Karan, Gulistan Bahat
Summary: This study investigated the prevalence of frailty and associated factors among community-dwelling older adults. The results showed that among the 204 participants, 30.4% were robust, 42.6% were pre-frail, and 27% were frail. Multivariate analysis identified the number of drugs, cognitive impairment, and falls as associated factors of frailty.
REVISTA DA ASSOCIACAO MEDICA BRASILEIRA
(2023)
Letter
Nutrition & Dietetics
Nezahat Muge Catikkas, Umut Safer
CLINICAL NUTRITION
(2023)
Letter
Oncology
Nezahat Muge Catikkas, Umut Safer
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Meeting Abstract
Geriatrics & Gerontology
N. Muge Catikkas, B. Ozulu Turkmen, M. Esra Bozkurt, M. Akif Karan, G. Bahat
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Review
Geriatrics & Gerontology
Nezahat Muge Catikkas, Zumrut Bahat, Meryem Merve Oren, Gulistan Bahat
Summary: This study aimed to investigate the prevalence of sarcopenia and its relationship with outcomes in older cancer patients who underwent radiotherapy without chemotherapy. A systematic review of 8 eligible studies found that sarcopenia was not associated with overall survival (OS) or OS at 3 years when defined as low muscle mass (LMM), but it was related when defined as the concomitant presence of LMM and muscle strength/function. Heterogeneity existed among the studies due to variations in inclusion criteria, definitions and assessment methods for sarcopenia, cutoffs for low muscle mass and strength, imaging techniques, and covariates.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Article
Geriatrics & Gerontology
Mustafa Kahraman, Banu Ozulu Turkmen, Gulistan Bahat-Ozturk, Nezahat Muge Catikkas, Meryem Merve Oren, Ayla Sahin, Aynur Daglar, Sukru Ozturk, Sukru Palanduz, Ali Sarper Diler, Mehmet Akif Karan
Summary: The study aimed to examine the relationship between ACTN3 gene polymorphism and sarcopenia, revealing a significant difference in genotype only in association with low muscle mass under specific conditions, with female gender being independently associated with low muscle mass. Further research is needed to understand how ethnicity affects the muscles of older adults with ACTN3 gene polymorphism.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)