Article
Chemistry, Applied
Baoshuai Wang, Taotao Qiang, Longfang Ren, Tianyu Liang, Fei Cheng, Mingli Li, Wei Hu
Summary: Autophagy serves as a protective mechanism in cells and plays a crucial role in maintaining normal physiological morphology and regulating diseases in living organisms. The changes in lysosomal polarity have been identified as an important indicator for assessing cellular autophagy. During scrap leather-induced neuroinflammation, the fluorescence signal of Lyso-Pola was significantly lower, indicating a correlation between neuroinflammation, reactive oxygen species release, and cellular autophagy.
Article
Biophysics
Baoshuai Wang, Longfang Ren, Tianyu Liang, Wei Hu, Taotao Qiang
Summary: Autophagy is an important process for eukaryotic cells to maintain homeostasis by degrading damaged biomolecules and organelles. Understanding the changes in lysosomal polarity during autophagy is crucial for studying membrane fluidity and enzymatic reactions.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Chemistry, Analytical
Xinru Wang, Qi Chen, Kun Dong, Chuan Sun, Yinliang Huang, Zeming Qiang, Baoqian Chen, Man Chen, Yan Feng, Xiangming Meng
Summary: Mitophagy is crucial in maintaining cellular functions, and in this research, a multifunctional two-photon fluorescent probe Mito-PV was developed for tracking changes in polarity, viscosity, and morphology of mitochondria. The probe successfully enabled real-time and accurate monitoring of mitophagy, showing potential as a tool for evaluating mitophagy-related processes and drug effects.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Xinru Wang, Qi Chen, Jiale Ou, Yinliang Huang, Congchun Wang, Yue-an Chen, Jilou Qin, Man Chen, Yan Feng, Guoyong Xu, Xiangming Meng
Summary: The designed multifunctional two-photon fluorescent probe Mito-PF can be used for real-time monitoring of mitochondria-related apoptosis, and successfully evaluated the effect of the drug bpV(phen).
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Multidisciplinary
Xiaoqin Wei, Yiming Zhu, Xiang Yu, Lei Cai, Nanan Ruan, Luling Wu, Nengqin Jia, Tony D. James, Chusen Huang
Summary: The presence of ER stress is a significant factor in various biological processes associated with numerous diseases. By creating a new ER-targeting fluorescent probe, researchers have been able to measure changes in intracellular ER viscosity caused by ER stress. Their findings indicate an increase in ER viscosity during autophagy.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Applied
Jialu Yang, Lizheng Duan, Yunhao Zhou, Tian Wu, Jiahui Shi, Yanmei Zhou
Summary: Autophagy is closely related to the inflammatory response and cancer cell migration, and changes in lysosomal polarity can serve as indicators of intracellular autophagy and inflammation. The development of a novel near-infrared lysosome polarity probe allows for clear imaging of intracellular autophagy and inflammation, and assessment of autophagy inhibition-induced inflammation-driven cancer cell migration.
Article
Chemistry, Analytical
Lixia Guo, Xueyun Zhang, Danning Wen, Lei Ding, Yan Niu, Lihong Li, Wen Liu, Haipeng Diao, Liheng Feng
Summary: Accurate measurement of pH is crucial in biological and medical research. This article introduces a ratiometric pH probe called PCHC, which can sensitively detect the pH changes of both cytoplasm and lysosome, with potential applications in the study of pH-related diseases.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Optics
Yonghe Tang, Juanjuan Peng, Rui Guo, Huixu Lu, Weiying Lin
Summary: In this study, a novel lysosome-targeted fluorescent probe Cys-J was synthesized using naphthalimide as fluorophore scaffolds. Cys-J exhibited excellent optical properties, quick response, simple synthesis, and good stability. It was able to detect cysteine and release H2S with therapeutic potential. Additionally, Cys-J was successfully used for two-photon fluorescence imaging to visualize cysteine levels in kidney diseases for the first time.
JOURNAL OF LUMINESCENCE
(2023)
Article
Spectroscopy
Yu-Xu Tu, Natarajan Vijay, Han-Xiang Ko, Yuan-Pin Lo, Sivan Velmathi, Shu-Pao Wu
Summary: The new fluorescent probe ANP can rapidly and efficiently detect cysteine, and it can evaluate the distribution of cysteine in living cells and tissues.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Spectroscopy
Yujing Zuo, Yanfu Chai, Xiaofei Liu, Zhiming Gao, Xiaofeng Jin, Feng Wang, Yongjie Bai, Zhijun Zheng
Summary: Autophagy is a process where dysfunctional or nonessential cellular components are broken down and recycled for normal cell activities. Developing a fluorescent probe to monitor lysosomal autophagy process is crucial. A fluorescent probe based on spiropyran with lysosomal targeting and pH response was designed to address this issue.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Biophysics
Rui Chen, Kangqiang Qiu, Daniel C. Y. Leong, Bidyut Kumar Kundu, Chengying Zhang, Prasenjit Srivastava, Katie E. White, Guodong Li, Guanqun Han, Ziyuan Guo, Christopher G. Elles, Jiajie Diao, Yujie Sun
Summary: This article introduces three new small-molecule probes with good fluorescence quantum yield and aqueous solubility, which exhibit excellent two-photon absorption in the near-infrared region. Lyso-2arm and Mito-3arm show good targeting abilities for lysosomes and mitochondria, respectively. In two-photon microscopy experiments, Mito-3arm outperforms a commercial two-photon dye, delivering enhanced resolution, broader NIR light excitation window, and higher signal-to-noise ratio. Moreover, the two-photon bioimaging of 3D human forebrain organoids confirms the successful deep tissue imaging capabilities of both Lyso-2arm and Mito-3arm. Overall, this work presents a rational design strategy for developing competent two-photon-absorbing probes by varying the number of conjugated arms for bioimaging applications.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Spectroscopy
Xinya Hao, Jingting Zhan, Chen Geng, Weiying Lin
Summary: A new fluorescent probe was developed to detect changes in intracellular viscosity. The probe showed high sensitivity for viscosity measurement and demonstrated excellent performance in both living cells and tissues, indicating its wide potential applications in biomedicine.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Chemistry, Analytical
Jiaxin Hong, Qianhua Li, Qingfeng Xia, Guoqiang Feng
Summary: DCIP, a dicyanoisophorone-based probe, shows great potential for high-fidelity imaging and tracking of lysosomes, with strong fluorescence, good cell permeability, and high photostability. It can achieve long-term and high spatiotemporal resolution imaging of lysosomes, as well as track lysosomal dynamics at extremely low concentrations.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Wen-Jing Shi, Jinrong Yang, Yong-Feng Wei, Xiao-Tong Li, Xu-Hui Yan, Yuxuan Wang, Huaxiang Leng, Liyao Zheng, Jin-wu Yan
Summary: Two novel meso-CF3 BODIPY-based fluorescent rotors were rationally prepared and found to sensitively respond to viscosity in living cells with a fluorescence turn-on effect, which can be attributed to the special restricted rotation of meso-CF3 group in viscous environments. Interestingly, a monostyryl probe with one cationic group exhibited good mitochondrial localization and aggregation-induced emission (AIE) property.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Shayeri Biswas, Mousumi Baruah, Anushree Shil, Sourav Sarkar, Mudassar Ali, Animesh Samanta, Sankarprasad Bhuniya
Summary: In this study, a dual organelle-targeted fluorescent probe was developed to visualize the interaction between mitochondrial dysfunction and lipid droplet fluctuation in live cells. The probe's two-photon ability allowed for deep tissue imaging. For the first time, the probe was shown to track the accumulation of lipid droplets in different mouse organs during pancreatic inflammation. This lipid droplet probe has great potential for studying lipid droplet-associated biology.
Article
Chemistry, Multidisciplinary
Qian Wu, Yubo Cui, Guifeng Xia, Jinlong Yang, Shuming Du, Xinhong Xiong, Li Yang, Dong Xu, Xu Deng, Jiaxi Cui
Summary: Passive daytime radiative cooling (PDRC) technology, while promising for global spacing cooling, faces limitations in practical application due to reduced cooling effectiveness caused by wear and dirt contamination. Researchers have developed a renewable armor structure using fluorinated hollow glass microspheres to enhance the anti-fouling and cooling properties of PDRC coatings. The coatings exhibit high solar reflectance and thermal emittance, leading to significant temperature reduction below ambient temperature.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Qiang Bei, Bei Zhang, Kaifeng Wang, Shiming Zhang, Guichuan Xing, Clement Cabanetos
Summary: The power conversion efficiency (PCE) of organic solar cells (OSCs) has reached 20% in recent years, thanks to the advantages of organic photoactive materials. Benzothiadiazole (BT) has attracted significant research attention as a building block of OSCs. OSCs based on BT structure have shown diversity, and the increasing PCE values indicate a promising future for OSCs. This review analyzes the progress made in the last decades, focusing on effective BT small-molecules and BT polymers for OSCs. The structure-property relationships, donor-acceptor matching criteria, and morphology control approaches are discussed. The remaining challenges and a personal perspective on the future advancement of OSCs are summarized.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Rong He, Dandan Tang, Ningge Xu, Heng Liu, Kun Dou, Xuejun Zhou, Fabiao Yu
Summary: Nasopharyngeal carcinoma (NPC) is a common malignant tumor of the head and neck, with a high incidence in China and Southeast Asian countries. In this study, a novel near-infrared fluorescent probe, SNAFL-GSH, was designed and synthesized for the detection of glutathione (GSH). The probe showed selective detection of GSH and the ability to distinguish normal and cancer cells. It has great potential for application in the diagnosis and evaluation of NPC.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Zhukang Guo, Baijiang Jin, Yile Fang, Lian Jin, Song Li, Yan Deng, Zhu Chen, Hui Chen, Yuanying Zhang, Rabia Usman, Nongyue He
Summary: This study isolated primary cells that can be stably passaged from spontaneous tumors of genetically engineered pancreatic ductal adenocarcinoma model mice and used an autonomously developed automated screening instrument for efficient nucleic acid aptamer screening. The obtained aptamers were affinity verified at the cellular level. The study also investigated the impact of cell growth environment difference on the recognition ability of aptamers and confirmed the targeting ability and drug loading ability of the aptamer.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Zhongshan Yang, Qiqi Zhang, Hui Song, Xin Chen, Jiwei Cui, Yanhui Sun, Lequan Liu, Jinhua Ye
Summary: Methane chemistry is a significant area of research in catalysis. Converting methane into value-added chemicals is desirable but challenging due to its high C-H bonding energy and lack of pi bonding or unpaired electrons. Photocatalytic partial oxidation of methane to liquid oxygenates is a promising technology for achieving high efficiency and selectivity under mild conditions. The choice and activation of oxidants are crucial for its performance.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Peng Shan, Jing Liao, Jiayi Li, Chengyan Wang, Jie Zhou, Linqiang Mei, Yunlu Dai, Qiang Wang, Wenyan Yin
Summary: This study reports an oral radioprotectant Gel@GYY that combines a gelatin-based hydrogel and a pH-responsive hydrogen sulfide donor. Gel@GYY has excellent adhesion and sustained release properties, allowing it to release H2S in the gastrointestinal tract and effectively scavenge free radicals induced by radiation. It also reduces inflammation and has biodegradable properties.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Lu Liu, Ziyi Liu, Jingnan Cui, Guiling Ning, Weitao Gong
Summary: The development of new metal-free heterogeneous catalysts has been the subject of extensive research. In this study, a new Troger's base (TB)-derived porous organic polymer (POPs) was designed and prepared by integrating multifunctional monomers. The resulting polymer, which combines the advantages of pillar[5]arene macrocycle and TB moiety, exhibited enhanced catalytic performance in Knoevenagel condensation and CO2 conversion, serving as an effective metal-free catalyst. This work provides a new strategy for fabricating metal-free heterogeneous catalysts based on macrocyclic POPs.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Leyong Zhou, Changyin Yang, Weitao Dou, Tongxia Jin, Haibo Yang, Lin Xu
Summary: This review summarizes the application of micro/nanofluidic techniques in constructing supramolecular assemblies of different scales, and highlights the advantages of these techniques over conventional synthesis methods. Furthermore, it emphasizes the potential of micro/nanofluidic systems in improving our understanding of supramolecular self-assembly processes.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Yanchao Jin, Suixiaochen Chen, Peiwen Huang, Xiongjian Chen, Chun-Yan Lin, Li-Ping Li, Xiao Chen, Rui Ding, Jianxi Liu, Riyao Chen
Summary: In this study, magnesium and coconut shell carbon were used to disinfect water by adsorbing copper(II) and converting dissolved oxygen to hydrogen peroxide through Mg corrosion. The copper was enriched on the carbon surface and efficiently catalyzed the hydrogen peroxide to inactivate E.coli. The process showed promising disinfection performance both in laboratory experiments and real wastewater treatment.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Haihong Lai, Zehong Chen, Hao Zhuo, Yijie Hu, Xuan Zhao, Jiwang Yi, Hongzhi Zheng, Ge Shi, Yifan Tong, Ling Meng, Xinwen Peng, Linxin Zhong
Summary: By altering the pyrolysis route of cellulose nanofiber, the structural defects of carbon aerogels can be reduced, leading to improved compressibility and stress retention, as well as higher stress sensor sensitivity and temperature coefficient.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Lina Guo, Jinsong Ding, Wenhu Zhou
Summary: Bacteria-based tumor therapy has resurfaced due to the revolution of tumor immunotherapy, offering unique solutions for traditional tumor treatments. Bacteria with active tropism can selectively colonize tumor sites and suppress tumor growth through various mechanisms, making them attractive tools for tumor treatment. This critical review introduces recent advances in bacteria-based tumor therapy, including bacterial properties, their benefits for tumor therapy, anti-tumor mechanisms, challenges, and future perspectives.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Lan Liang, Chuanbin Wang, Xukai Lu, Yunan Sun, Beibei Yan, Ning Li, Guanyi Chen, Li'an Hou
Summary: This study investigates the interactions between phenol and benzaldehyde in the ECH process through experiments and theoretical calculations. The results show that phenol can accelerate the conversion of benzaldehyde, while benzaldehyde inhibits the conversion of phenol. The research provides a theoretical basis for the application of ECH in practical bio-oil upgrading.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Pengcheng Fan, Yuhao He, Junan Pan, Ning Sun, Qiyu Zhang, Chen Gu, Kang Chen, Weinan Yin, Longlu Wang
Summary: This study focuses on the recent progress in hydrogen evolution reaction (HER) based on photothermal effect. It introduces the main pathways of photothermal conversions applied in H2 evolution, summarizes the functions of the photothermal effect, and presents a method to improve the catalytic system through thermal means. The study also discusses the challenges and outlook in this promising area.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Leiduo Lai, Hongyu Zhou, Yichen Hong, Mengfan Luo, Yang Shi, Heng Zhang, Zhaokun Xiong, Gang Yao, Bo Lai
Summary: In this study, a facile ammonia reduction strategy was proposed and a novel FeVO3-x catalyst was synthesized for the activation of peroxymonosulfate (PMS) to degrade the pharmaceutical carbamazepine (CBZ). The results showed that the system could rapidly degrade CBZ and generate various active species involved in the degradation process.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Tangxin Xiao, Xiuxiu Li, Liangliang Zhang, Kai Diao, Zheng-Yi Li, Xiao-Qiang Sun, Leyong Wang
Summary: This study presents the construction of a supramolecular light harvesting system based on sequential energy transfer. The system demonstrates tunable fluorescence emission through self-assembly of polymers into nanoparticles, achieving efficient two-step light harvesting.
CHINESE CHEMICAL LETTERS
(2024)