Article
Engineering, Environmental
Weiwei Wang, Jie Zhang, Ze Li, Jie Gu, Jingyu Qin, Jiali Li, Xiaona Zhang, Shaoguo Ru
Summary: BPS exposure accelerates the progression of ASCVD, inducing characteristic symptoms in zebrafish embryo-larvae model, such as inflammation, macrophage recruitment, and oxLDL accumulation in blood vessels.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Environmental Sciences
Yonghua Wang, Beibei Wang, Qianqian Wang, Yuxuan Liu, Xiaodan Liu, Bing Wu, Guanghua Lu
Summary: The intestine serves as an important bioaccumulation site for Bisphenol F (BPF) and Bisphenol S (BPS). Exposure to BPF and BPS in zebrafish has been found to induce morphological and functional abnormalities. However, the mechanisms behind this and the combined toxicities of BPS and BPF in the intestine have not been well-studied. The study showed that exposure to BPF, BPS, and the combination of BPF and BPS resulted in increased oxidative damage and inflammation in the zebrafish intestine, with changes in gene expression profiles and alterations in microbial community structure. Increased levels of potentially pathogenic bacteria in the intestine may indicate health hazards. These results provide important information for assessing the health risks of BPS and BPF in aquatic organisms.
Article
Environmental Sciences
Junjie Ao, Yongjie Liu, Weifeng Tang, Jun Zhang
Summary: This study investigates the potential effects and mechanisms of bisphenol S (BPS) exposure on human colon mucosal epithelial cells. The results show that BPS exposure increases the production of pro-inflammatory cytokines, destroys the tight junctions of the cells, and affects neurotransmitters. These findings suggest that BPS exposure may disrupt the balance of the gut-brain axis, leading to inflammatory cytokine production and tight junction destruction.
Article
Environmental Sciences
Sumiko Morimoto, Edgar Solis-Lemus, Jesica Jimenez-Vivanco, Dafne Castellanos-Ruiz, Eulises Diaz-Diaz, C. Adriana Mendoza-Rodriguez
Summary: A study found that low doses of BPS affected glucose metabolism in rats, causing them to exhibit more female-like responses during the perinatal period. However, these effects disappeared in adulthood.
ENVIRONMENTAL TOXICOLOGY
(2022)
Review
Environmental Sciences
Radia Bousoumah, Veruscka Leso, Ivo Iavicoli, Pasi Huuskonen, Susana Viegas, Simo P. Porras, Tiina Santonen, Nadine Frery, Alain Robert, Sophie Ndaw
Summary: This study found a lack of recent occupational HBM studies on bisphenols, especially on BPS and BPF. Different methodological designs make comparisons between studies difficult. Few studies have been conducted on the industrial applications of bisphenols outside of Asia.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Environmental Sciences
Eric Gyimah, Hai Xu, Xing Dong, Xuchun Qiu, Zhen Zhang, Yuanqing Bu, Osei Akoto
Summary: Exposure to low concentrations of BPA and BPS during embryonic development can have deleterious effects on the central nervous system development and induce behavioral abnormalities in zebrafish, potentially by interfering with the normal expression of development-related genes.
Article
Environmental Sciences
Cindy Peillex, Anthony Kerever, Asmaa Lachhab, Martin Pelletier
Summary: The study found that BPA, BPS, and their metabolites can affect the energy metabolism and antimicrobial responses of neutrophils. While these chemicals do not impact cell cytotoxicity, phagocytosis, or superoxide anion production, they significantly reduce CXCL8/IL-8 production. BPS and the glucuronidated metabolites of BPA and BPS were found to have higher endocrine-disrupting potential than BPA.
ENVIRONMENTAL RESEARCH
(2021)
Article
Environmental Sciences
Liguo Qiu, Shuhui Wei, Yunsheng Wang, Rui Zhang, Shaoguo Ru, Xiaona Zhang
Summary: This study found that BPS affects the visual function of zebrafish larvae and stimulates the metabolism of all-trans-retinoic acid. By modulating the expression of CYP26A1 and TRO, it was found that CYP26A1 plays a crucial role in the oxidative metabolism of atRA and regeneration of retinoids in the visual cycle, and TRO mediates cyp26a1 expression in zebrafish eyes.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Environmental Sciences
Jun Zeng, Junli Li, Sishangyu Liu, Zhiqiang Yang, Yue Zhong, Xiaomei Chen, Guiling Li, Jia Li
Summary: The lipidomic study revealed comprehensive lipidome disturbance induced by both BPA and BPS exposure, with a significant similarity between the two. Lipid remodeling in response to exposure involved cardiolipins, phosphatidylglycerols, and fatty acids metabolic pathways, providing novel clues on the potential mechanism linking BPA/BPS exposure to increased risk of insulin resistance. The substitution of BPA by BPS should be performed with caution, as BPA-free products are not necessarily safer.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Food Science & Technology
Wenjuan Zhang, Tao Huang, Zhangbei Sun, Haibin Kuang, Yangyang Yuan, Weiying Zou, Fangming Liu, Fan Zhang, Bei Yang, Lei Wu, Dalei Zhang
Summary: This study demonstrates that exposure to BPS can cause cytotoxicity to Leydig cells through inducing oxidative stress, mitochondrial impairment, autophagic disturbance, and apoptosis.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Environmental Sciences
Weili Mao, Lingling Mao, Nan Zhao, Yingying Zhang, Meirong Zhao, Hangbiao Jin
Summary: This study investigated the occurrence of free Bisphenol S (BPS) and its conjugated metabolites in rat internal tissues, blood, and excreta after continuous BPS dosage. The results showed that concentrations of free BPS and its metabolites reached steady state after 9 days of continuous dosage. The study also found that analyzing human blood and urine may not accurately reflect the contamination of BPS metabolites in human internal tissues.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Axelle Brulport, Ludovic Le Corre, Guillaume Maquart, Virginie Barbet, Aurelie Dastugue, Isabelle Severin, Daniel Vaiman, Marie-Christine Chagnon
Summary: This study found that perinatal exposure to BPS can lead to sex-dependent obesogen effects in multiple generations of mice. In the F1 generation, male mice showed overweight while female mice exhibited dyslipidemia. In the F2 generation, BPS exposure was associated with increased body weight, fat, and visceral adipose tissue in both males and females.
ENVIRONMENTAL POLLUTION
(2021)
Article
Chemistry, Medicinal
Lingling Mao, Shuhong Fang, Meirong Zhao, Weiping Liu, Hangbiao Jin
Summary: This study utilized metabolomics to examine the metabolic changes in rat plasma following exposure to BPA or BPS, revealing distinct alterations in metabolome and the up-regulation/down-regulation of specific metabolites in the different exposure groups. Pathway analysis also highlighted significant disruptions in metabolic pathways associated with BPA and BPS exposure.
CHEMICAL RESEARCH IN TOXICOLOGY
(2021)
Article
Environmental Sciences
Liguo Qiu, Shuhui Wei, Yixin Yang, Rui Zhang, Shaoguo Ru, Xiaona Zhang
Summary: In this study, transgenic zebrafish larvae were exposed to BPS during retinal development. The results showed that BPS induced DNA damage, structural damage, altered gene expression, abnormal development of key neurons, and inhibited light-electrical signal transduction, leading to color vision impairment.
ENVIRONMENTAL POLLUTION
(2023)
Article
Food Science & Technology
Pei Cao, Huai-ning Zhong, Kai Qiu, Dan Li, Gang Wu, Hai-xia Sui, Yan Song
Summary: The study estimated dietary exposures to BPA, BPF, and BPS from canned foods and beverages in China. The results showed that canned products significantly contributed to BPA and BPF exposure among children and adults in China.
Article
Environmental Sciences
Axelle Brulport, Ludovic Le Corre, Guillaume Maquart, Virginie Barbet, Aurelie Dastugue, Isabelle Severin, Daniel Vaiman, Marie-Christine Chagnon
Summary: This study found that perinatal exposure to BPS can lead to sex-dependent obesogen effects in multiple generations of mice. In the F1 generation, male mice showed overweight while female mice exhibited dyslipidemia. In the F2 generation, BPS exposure was associated with increased body weight, fat, and visceral adipose tissue in both males and females.
ENVIRONMENTAL POLLUTION
(2021)
Review
Biochemistry & Molecular Biology
Laurence Guzylack-Piriou, Sandrine Menard
Summary: The global prevalence of obesity and type 2 diabetes presents a major public health challenge, with factors beyond caloric intake and exercise, such as food contaminants and social stress, potentially playing a role. Early life adverse events may impact offspring weight gain and diabetes occurrence, paving the way for metabolic disorders in adulthood. The evidence suggests developmental origins of metabolic disorders with early life adverse events as independent risk factors.
Article
Nanoscience & Nanotechnology
Yann Pellequer, Gilbert Zanetta, Jean-Michel Rebibou, Isabelle Severin, Marie-Christine Chagnon, Gernot Zissel, Fabrice Neiers, Renaud Seigneuric
Summary: The current frontiers in Biology, Medicine, and Pharmacy are focused on the nanoscale, particularly in extracting, synthesizing, visualizing, and characterizing nanoparticles. Various instruments are being developed to quantify and compare nanoparticles sizes. This study introduces a statistical approach for comparing different groups of biological samples with potential applications in different fields such as determining the size differences in liposomes and extracellular vesicles.
APPLIED NANOSCIENCE
(2021)
Article
Toxicology
Laurence Dahbi, Amaury Farce, Nicolas Kambia, Isabelle Severin, Thierry Dine, Emmanuel Moreau, Valerie Sautou, Marie-Christine Chagnon
Summary: This study investigated the endocrine-disrupting effects of metabolites of the plasticizer TEHTM, commonly used in medical devices. The results showed that two of the metabolites (4-MEHTM and 2/1-MEHTM) had effects on hormone activity in vitro. However, the concentrations of these metabolites found in human urine were unlikely to have active effects on estrogen, androgen, thyroid receptors, and steroidogenesis-mediated effects.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ludovic Le Corre, Axelle Brulport, Daniel Vaiman, Marie-Christine Chagnon
Summary: Perinatal exposure to EPOX induces transgenerational effects on the liver, resulting in histological and transcriptomic changes that are dependent on the sex and generation of the animal.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Pharmacology & Pharmacy
Barbara Misme-Aucouturier, Marion De Carvalho, Erwan Delage, Eleonore Dijoux, Martin Klein, Carole Brosseau, Marie Bodinier, Laurence Guzylack-Piriou, Gregory Bouchaud
Summary: The prevalence of allergic diseases is increasing worldwide, and this can be attributed to the growing chemical pollution of the environment. This study investigates the effects of Bisphenol A (BPA) on food allergies, revealing its impact on the immune system, gut microbiota, and barrier functions. The findings indicate that BPA exposure leads to increased markers of food allergy and intestinal permeability, as well as dysbiosis and decreased microbial diversity.
Meeting Abstract
Toxicology
T. Lacour, R. Hayrapetyan, I. Severin, I. Mouche, F. Finot, M-C. Chagnon
TOXICOLOGY LETTERS
(2022)
Article
Biochemistry & Molecular Biology
Alix Pierron, Laurence Guzylack-Piriou, Didier Tardieu, Gilles Foucras, Philippe Guerre
Summary: This study investigated the changes in the sphingolipidome in various tissues and fluids of mice after intraperitoneal injection of zymosan. The concentrations of various sphingolipids were increased after zymosan administration, with the most significant changes observed in peritoneal cells and fluid. The observed changes suggest an increase in de novo synthesis of sphingolipids in response to zymosan.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Sarah Walachowski, Koen Breyne, Thomas Secher, Celine Cougoule, Laurence Guzylack-Piriou, Evelyne Meyer, Gilles Foucras, Guillaume Tabouret
Summary: The study demonstrates that oral administration of beta-glucans can improve the outcome of Escherichia coli infection and reduce tissue damage caused by excessive inflammatory response, and this protective mechanism is not necessarily linked to immune system hyperactivation or immune training.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Nutrition & Dietetics
Isabelle Severin, Laurence Dahbi, Sandra Domenek, Phuong-Mai Nguyen, Anne Platel, Olivier Vitrac, Marie Christine Chagnon
Summary: Risk assessment of Non-Intentionally Added Substances (NIAS) in food contact packaging is a challenge. This article presents a strategy involving analytical tools, in silico and in vitro studies, to identify hazards in packaging extract/migrate and avoid undesirable substances in food. This approach is particularly important in the context of circular economy with increased use of bio-based and recycled materials. Traceability of these materials remains difficult.
CAHIERS DE NUTRITION ET DE DIETETIQUE
(2023)
