From Carbohydrates to Complex Organofluorines: Synthesis, Conformation, and Lipophilicity of Multivicinal‐Fluorine‐Containing Hexitol Analogues

Polar organofluorine substituents: Multivicinal fluorines on alkyl chains and alicyclic rings

(2020) David O'Hagan   CHEMISTRY-A EUROPEAN JOURNAL

Systematic Investigation of Lipophilicity Modulation by Aliphatic Fluorination Motifs

(2020) Benjamin Jeffries et al.   JOURNAL OF MEDICINAL CHEMISTRY

Addressing the structural complexity of fluorinated glucose analogues: Insight into lipophilicities and solvation effects

(2020) Jacob St-Gelais et al.   CHEMISTRY-A EUROPEAN JOURNAL

Fluorine effect in nucleophilic fluorination at C4 of 1,6-anhydro-2,3-dideoxy-2,3-difluoro-β-D-hexopyranose

(2020) Danny Lainé et al.   Beilstein Journal of Organic Chemistry

Stereoselective Synthesis of Fluorinated Galactopyranosides as Potential Molecular Probes for Galactophilic Proteins: Assessment of Monofluorogalactoside–LecA Interactions

(2019) Vincent Denavit et al.   CHEMISTRY-A EUROPEAN JOURNAL

Exploring the chemistry of non‐sticky sugars: Synthesis of polyfluorinated carbohydrate analogs of D‐allopyranose

(2019) Vincent Denavit et al.   CHEMISTRY-A EUROPEAN JOURNAL

Inverting Small Molecule-Protein Recognition by the Fluorine Gauche Effect: Selectivity Regulated by Multiple H→F Bioisosterism

(2019) Patrick Bentler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis and Lipophilicity of Trifluorinated Analogues of Glucose

(2019) Jacob St-Gelais et al.   JOURNAL OF ORGANIC CHEMISTRY

Stereocontrolled Synthesis of Tetrafluoropentanols: Multivicinal Fluorinated Alkane Units for Drug Discovery

(2019) Patrick Bentler et al.   ORGANIC LETTERS

Informing Molecular Design by Stereoelectronic Theory: The Fluorine Gauche Effect in Catalysis

(2018) Marialuisa Aufiero et al.   ACCOUNTS OF CHEMICAL RESEARCH

A Chiron approach towards the stereoselective synthesis of polyfluorinated carbohydrates

(2018) Vincent Denavit et al.   Nature Communications

Emulating Natural Product Conformation by Cooperative, Non-Covalent Fluorine Interactions

(2016) Felix Scheidt et al.   CHEMISTRY-A EUROPEAN JOURNAL

Investigating the Influence of (Deoxy)fluorination on the Lipophilicity of Non-UV-Active Fluorinated Alkanols and Carbohydrates by a New log P Determination Method

(2015) Bruno Linclau et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Fluorination Patterning: A Study of Structural Motifs That Impact Physicochemical Properties of Relevance to Drug Discovery

(2015) Quentin A. Huchet et al.   JOURNAL OF MEDICINAL CHEMISTRY

Applications of Fluorine in Medicinal Chemistry

(2015) Eric P. Gillis et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural Basis of Ligand Binding to UDP-Galactopyranose Mutase from Mycobacterium tuberculosis Using Substrate and Tetrafluorinated Substrate Analogues

(2015) Karin E. van Straaten et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

All-cis 1,2,3,4,5,6-hexafluorocyclohexane is a facially polarized cyclohexane

(2015) Neil S. Keddie et al.   Nature Chemistry

Tetrafluorination of Sugars as Strategy for Enhancing Protein-Carbohydrate Affinity: Application to UDP-GalpMutase Inhibition

(2013) Inès N'Go et al.   CHEMISTRY-A EUROPEAN JOURNAL

Organofluorine Chemistry: Synthesis and Conformation of Vicinal Fluoromethylene Motifs

(2012) David O’Hagan   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of a MUC1-glycopeptide–BSA conjugate vaccine bearing the 3′-deoxy-3′-fluoro-Thomsen–Friedenreich antigen

(2011) Anja Hoffmann-Röder et al.   CHEMICAL COMMUNICATIONS

Antibody recognition of fluorinated MUC1 glycopeptide antigens

(2011) Thomas Oberbillig et al.   CHEMICAL COMMUNICATIONS

Synthesis and Conformational Analysis of α,β-Difluoro-γ-amino Acid Derivatives

(2011) Luke Hunter et al.   CHEMISTRY-A EUROPEAN JOURNAL

The C–F bond as a conformational tool in organic and biological chemistry

(2010) Luke Hunter   Beilstein Journal of Organic Chemistry

Diastereoselective Synthesis of 2,3,4,5,6-Pentafluoroheptanes

(2009) Daniel Farran et al.   JOURNAL OF ORGANIC CHEMISTRY

Asymmetric de novo synthesis of fluorinated d-glucitol and d-mannitol analogues

(2009) Guy T. Giuffredi et al.   TETRAHEDRON-ASYMMETRY

Fragmentation of Carbohydrate Anomeric Alkoxyl Radicals: New Synthesis of Chiral 1-Fluoro-1-halo-1-iodoalditols

(2008) Cosme G. Francisco et al.   CHEMISTRY-A EUROPEAN JOURNAL

The multi-vicinal fluoroalkane motif: an examination of 2,3,4,5-tetrafluorohexane stereoisomers

(2008) Luke Hunter et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Multi-vicinal fluoroalkanes: a new class of organofluorine compounds

(2008) Luke Hunter et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Understanding organofluorine chemistry. An introduction to the C–F bond

(2007) David O'Hagan   CHEMICAL SOCIETY REVIEWS

Fluorine in medicinal chemistry

(2007) Sophie Purser et al.   CHEMICAL SOCIETY REVIEWS