Microfluidics for extracellular vesicle separation and mimetic synthesis: Recent advances and future perspectives

The biology, function, and biomedical applications of exosomes

(2020) Raghu Kalluri et al.   SCIENCE

High Throughput Nanoliposome Formation Using 3D Printed Microfluidic Flow Focusing Chips

(2019) Zhu Chen et al.   Advanced Materials Technologies

Asymmetric-flow field-flow fractionation technology for exomere and small extracellular vesicle separation and characterization

(2019) Haiying Zhang et al.   Nature Protocols

λ-DNA- and Aptamer-Mediated Sorting and Analysis of Extracellular Vesicles

(2019) Chao Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ultrasensitive detection of circulating exosomes with a 3D-nanopatterned microfluidic chip

(2019) Peng Zhang et al.   Nature Biomedical Engineering

DEP-on-a-Chip: Dielectrophoresis Applied to Microfluidic Platforms

(2019) Haoqing Zhang et al.   Micromachines

Acoustic Tweezers for Particle and Fluid Micromanipulation

(2019) M. Baudoin et al.   Annual Review of Fluid Mechanics

Acoustofluidic Synthesis of Particulate Nanomaterials

(2019) Po‐Hsun Huang et al.   Advanced Science

Extracellular miRNAs: From Biomarkers to Mediators of Physiology and Disease

(2019) Marcelo A. Mori et al.   Cell Metabolism

Oscillatory Viscoelastic Microfluidics for Efficient Focusing and Separation of Nanoscale Species

(2019) Mohammad Asghari et al.   ACS Nano

Integrated Analysis of Exosomal Protein Biomarkers on Alternating Current Electrokinetic Chips Enables Rapid Detection of Pancreatic Cancer in Patient Blood

(2018) Jean M. Lewis et al.   ACS Nano

Highly Sensitive Electrochemical Detection of Tumor Exosomes Based on Aptamer Recognition-Induced Multi-DNA Release and Cyclic Enzymatic Amplification

(2018) Huilei Dong et al.   ANALYTICAL CHEMISTRY

Detailed analysis of the plasma extracellular vesicle proteome after separation from lipoproteins

(2018) Nasibeh Karimi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Extracellular vesicles in cancer — implications for future improvements in cancer care

(2018) Rong Xu et al.   Nature Reviews Clinical Oncology

Shedding light on the cell biology of extracellular vesicles

(2018) Guillaume van Niel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Isolation of Extracellular Vesicles: General Methodologies and Latest Trends

(2018) Maria Yu. Konoshenko et al.   Biomed Research International

A Magnetic-Based Microfluidic Device for On-Chip Isolation and Detection of Tumor-Derived Exosomes

(2018) Huiying Xu et al.   ANALYTICAL CHEMISTRY

Particle manipulations in non-Newtonian microfluidics: A review

(2017) Xinyu Lu et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

A nano flow cytometer for single lipid vesicle analysis

(2017) Remo Friedrich et al.   LAB ON A CHIP

Microfluidics for exosome isolation and analysis: enabling liquid biopsy for personalized medicine

(2017) Jose C. Contreras-Naranjo et al.   LAB ON A CHIP

Human Pericardial Fluid Contains Exosomes Enriched with Cardiovascular-Expressed MicroRNAs and Promotes Therapeutic Angiogenesis

(2017) Cristina Beltrami et al.   MOLECULAR THERAPY

High-purity capture and release of circulating exosomes using an exosome-specific dual-patterned immunofiltration (ExoDIF) device

(2017) Yoon-Tae Kang et al.   Nanoscale

Isolation of exosomes from whole blood by integrating acoustics and microfluidics

(2017) Mengxi Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circulating microRNAs as Potential Biomarkers of Infectious Disease

(2017) Carolina N. Correia et al.   Frontiers in Immunology

An integrated double-filtration microfluidic device for isolation, enrichment and quantification of urinary extracellular vesicles for detection of bladder cancer

(2017) Li-Guo Liang et al.   Scientific Reports

Ultrasensitive microfluidic analysis of circulating exosomes using a nanostructured graphene oxide/polydopamine coating

(2016) Peng Zhang et al.   LAB ON A CHIP

Separation of nanoparticles by a nano-orifice based DC-dielectrophoresis method in a pressure-driven flow

(2016) Kai Zhao et al.   Nanoscale

Nanoscale lateral displacement arrays for the separation of exosomes and colloids down to 20 nm

(2016) Benjamin H. Wunsch et al.   Nature Nanotechnology

Isolation of extracellular vesicle from blood plasma using electrophoretic migration through porous membrane

(2016) Siwoo Cho et al.   SENSORS AND ACTUATORS B-CHEMICAL

Acoustic Purification of Extracellular Microvesicles

(2015) Kyungheon Lee et al.   ACS Nano

Generation of nanovesicles with sliced cellular membrane fragments for exogenous material delivery

(2015) Jaewoong Yoon et al.   BIOMATERIALS

In Vivo Imaging Reveals Extracellular Vesicle-Mediated Phenocopying of Metastatic Behavior

(2015) Anoek Zomer et al.   CELL

Cell-derived vesicles for drug therapy and diagnostics: Opportunities and challenges

(2015) Gregor Fuhrmann et al.   Nano Today

Chip-based analysis of exosomal mRNA mediating drug resistance in glioblastoma

(2015) Huilin Shao et al.   Nature Communications

Microfluidic isolation of cancer-cell-derived microvesicles from hetergeneous extracellular shed vesicle populations

(2014) Steven M. Santana et al.   BIOMEDICAL MICRODEVICES

Microfluidic fabrication of cell-derived nanovesicles as endogenous RNA carriers

(2014) Wonju Jo et al.   LAB ON A CHIP

Integrated immunoisolation and protein analysis of circulating exosomes using microfluidic technology

(2014) Mei He et al.   LAB ON A CHIP

Microfluidic device (ExoChip) for on-chip isolation, quantification and characterization of circulating exosomes

(2014) Shailender Singh Kanwar et al.   LAB ON A CHIP

Label-free detection and molecular profiling of exosomes with a nano-plasmonic sensor

(2014) Hyungsoon Im et al.   NATURE BIOTECHNOLOGY

Decreased miR-26a Expression Correlates with the Progression of Podocyte Injury in Autoimmune Glomerulonephritis

(2014) Osamu Ichii et al.   PLoS One

Single Step Reconstitution of Multifunctional High-Density Lipoprotein-Derived Nanomaterials Using Microfluidics

(2013) YongTae Kim et al.   ACS Nano

On-Chip Fabrication of Paclitaxel-Loaded Chitosan Nanoparticles for Cancer Therapeutics

(2013) Fatemeh Sadat Majedi et al.   ADVANCED FUNCTIONAL MATERIALS

Synthesis of Polymer–Lipid Nanoparticles for Image-Guided Delivery of Dual Modality Therapy

(2013) Aneta J. Mieszawska et al.   BIOCONJUGATE CHEMISTRY

Altered microRNA profiles in bronchoalveolar lavage fluid exosomes in asthmatic patients

(2013) Bettina Levänen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Biodegradable Core–Shell Carriers for Simultaneous Encapsulation of Synergistic Actives

(2013) Maike Windbergs et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ciliated micropillars for the microfluidic-based isolation of nanoscale lipid vesicles

(2013) Zongxing Wang et al.   LAB ON A CHIP

Rapid Discovery of Potent siRNA-Containing Lipid Nanoparticles Enabled by Controlled Microfluidic Formulation

(2012) Delai Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nanoporous micro-element arrays for particle interception in microfluidic cell separation

(2012) Grace D. Chen et al.   LAB ON A CHIP

Microfluidic filtration system to isolate extracellular vesicles from blood

(2012) Ryan T. Davies et al.   LAB ON A CHIP

Bottom-Up Design and Synthesis of Limit Size Lipid Nanoparticle Systems with Aqueous and Triglyceride Cores Using Millisecond Microfluidic Mixing

(2012) Igor V. Zhigaltsev et al.   LANGMUIR

Mass Production and Size Control of Lipid–Polymer Hybrid Nanoparticles through Controlled Microvortices

(2012) YongTae Kim et al.   NANO LETTERS

A ‘microfluidic pinball’ for on-chip generation of Layer-by-Layer polyelectrolyte microcapsules

(2011) Chaitanya Kantak et al.   LAB ON A CHIP

Microfluidic isolation and transcriptome analysis of serum microvesicles

(2009) Chihchen Chen et al.   LAB ON A CHIP

Electrophoretic separations on microfluidic chips

(2007) Dapeng Wu et al.   JOURNAL OF CHROMATOGRAPHY A