期刊
CHEMCATCHEM
卷 13, 期 2, 页码 543-547出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cctc.202001589
关键词
photoredox catalysis; multicomponent cyclization; dihydrobenzofurans; sulfur ylides; N-alkoxypyridiniums
资金
- NNSFC [91856119, 21971081, 21820102003, 91956201, 21772053]
- Science and Technology Department of Hubei Province [2017AHB047]
- Excellent Doctoral Dissertation Cultivation Grant from CCNU [2019YBZZ017, 2019YBZZ014]
- Program of Introducing Talents of Discipline to Universities of China (111 Program) [B17019]
The synthesis of 2,3-dihydrobenzofuran ring systems remains a topic of significant interest, with a visible-light-driven photoredox-catalyzed radical multicomponent cyclization described in this study. The reaction success relies on the use of both N-alkoxypyridinium salts and sulfur ylides as radical precursors, allowing for the modular synthesis of various 2,3-disubstituted dihydrobenzofurans with good functional group tolerance, easily available starting materials, simple operation, and mild reaction conditions. Mechanistic studies have shed light on some aspects associated with the key radical intermediates.
The 2,3-dihydrobenzofuran ring systems are a privileged class of oxygen heterocycles, and their synthesis continues to attract considerable effort. Herein, a visible-light-driven photoredox-catalyzed radical multicomponent cyclization of 2-vinyl phenols, N-alkoxypyridinium salts, and sulfur ylides is described. The key to the reaction success involves the use of both N-alkoxypyridinium salts and sulfur ylides as radical precursors. This redox-neutral protocol features good functional group tolerance, easily available starting materials, simple operation, and mild reaction conditions, enabling the modular synthesis of various 2,3-disubstituted dihydrobenzofurans. Mechanistic studies have also elucidated some of the aspects associated with the key radical intermediates.
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