Retromer dysfunction at the nexus of tauopathies

A pharmacological chaperone improves memory by reducing Aβ and tau neuropathology in a mouse model with plaques and tangles

(2020) Jian-Guo Li et al.   Molecular Neurodegeneration

Novel tau filament fold in corticobasal degeneration

(2020) Wenjuan Zhang et al.   NATURE

DNA and RNA sequencing identified a novel oncogene VPS35 in liver hepatocellular carcinoma

(2020) Guiji Zhang et al.   ONCOGENE

LRP1 is a master regulator of tau uptake and spread

(2020) Jennifer N. Rauch et al.   NATURE

Mechanism of cargo recognition by retromer-linked SNX-BAR proteins

(2020) Xin Yong et al.   PLOS BIOLOGY

Tau molecular diversity contributes to clinical heterogeneity in Alzheimer’s disease

(2020) Simon Dujardin et al.   NATURE MEDICINE

Retromer stabilization results in neuroprotection in a model of Amyotrophic Lateral Sclerosis

(2020) Luca Muzio et al.   Nature Communications

Retromer regulates the lysosomal clearance of MAPT/tau

(2020) Julian M. Carosi et al.   Autophagy

Parkinson’s disease-linkedD620N VPS35knockin mice manifest tau neuropathology and dopaminergic neurodegeneration

(2019) Xi Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Full recovery of the Alzheimer’s disease phenotype by gain of function of vacuolar protein sorting 35

(2019) Jian-Guo Li et al.   MOLECULAR PSYCHIATRY

Retromer facilitates the localization of Bcl-xL to the mitochondrial outer membrane

(2019) Trey Farmer et al.   MOLECULAR BIOLOGY OF THE CELL

Rapamycin and Alzheimer disease: a double-edged sword?

(2019) Julian M Carosi et al.   Autophagy

VPS35 regulates tau phosphorylation and neuropathology in tauopathy

(2019) Alana N. Vagnozzi et al.   MOLECULAR PSYCHIATRY

Factors other than hTau overexpression that contribute to tauopathy-like phenotype in rTg4510 mice

(2019) Julia Gamache et al.   Nature Communications

Retromer and TBC1D5 maintain late endosomal RAB7 domains to enable amino acid–induced mTORC1 signaling

(2019) Arunas Kvainickas et al.   JOURNAL OF CELL BIOLOGY

Author Correction: Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

(2019) Brian W. Kunkle et al.   NATURE GENETICS

Galectin-3 Coordinates a Cellular System for Lysosomal Repair and Removal

(2019) Jingyue Jia et al.   DEVELOPMENTAL CELL

OUP accepted manuscript

(2018)   BRAIN

Tau reduction in the presence of amyloid-β prevents tau pathology and neuronal death in vivo

(2018) Sarah L DeVos et al.   BRAIN

Sorting nexin 27 (SNX27) regulates the trafficking and activity of the glutamine transporter ASCT2

(2018) Zhe Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of TBC1D5 activates Rab7a and can enhance the function of the retromer cargo-selective complex

(2018) Matthew N. J. Seaman et al.   JOURNAL OF CELL SCIENCE

Unconventional Secretion Mediates the Trans-cellular Spreading of Tau

(2018) Taxiarchis Katsinelos et al.   Cell Reports

Extracellular Monomeric and Aggregated Tau Efficiently Enter Human Neurons through Overlapping but Distinct Pathways

(2018) Lewis D. Evans et al.   Cell Reports

Stabilizing the Retromer Complex in a Human Stem Cell Model of Alzheimer’s Disease Reduces TAU Phosphorylation Independently of Amyloid Precursor Protein

(2018) Jessica E. Young et al.   Stem Cell Reports

Reduced retromer function results in the accumulation of amyloid-beta oligomers

(2018) Anna Ansell-Schultz et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Cargo induces retromer-mediated membrane remodeling on membranes

(2018) Latha Kallur Purushothaman et al.   MOLECULAR BIOLOGY OF THE CELL

Structures of filaments from Pick’s disease reveal a novel tau protein fold

(2018) Benjamin Falcon et al.   NATURE

Soluble tau aggregates, not large fibrils, are the toxic species that display seeding and cross-seeding behavior

(2018) Gaurav Ghag et al.   PROTEIN SCIENCE

Living Neurons with Tau Filaments Aberrantly Expose Phosphatidylserine and Are Phagocytosed by Microglia

(2018) Jack Brelstaff et al.   Cell Reports

Retromer has a selective function in cargo sorting via endosome transport carriers

(2018) Yi Cui et al.   JOURNAL OF CELL BIOLOGY

Impaired axonal retrograde trafficking of the retromer complex augments lysosomal deficits in Alzheimer’s disease neurons

(2017) Prasad Tammineni et al.   HUMAN MOLECULAR GENETICS

Galectin-8–mediated selective autophagy protects against seeded tau aggregation

(2017) Benjamin Falcon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cryo-EM structures of tau filaments from Alzheimer’s disease

(2017) Anthony W. P. Fitzpatrick et al.   NATURE

The retromer complex system in a transgenic mouse model of AD: influence of age

(2017) Jin Chu et al.   NEUROBIOLOGY OF AGING

The Retromer Supports AMPA Receptor Trafficking During LTP

(2017) Paul Temkin et al.   NEURON

SNX-1 and RME-8 oppose the assembly of HGRS-1/ESCRT-0 degradative microdomains on endosomes

(2017) Anne Norris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy

(2017) Sarah L. DeVos et al.   Science Translational Medicine

Multivalent cross-linking of actin filaments and microtubules through the microtubule-associated protein Tau

(2017) Yunior Cabrales Fontela et al.   Nature Communications

Association of Longitudinal Cognitive Decline With Amyloid Burden in Middle-aged and Older Adults

(2017) Michelle E. Farrell et al.   JAMA Neurology

The ordered assembly of tau is the gain-of-toxic function that causes human tauopathies

(2016) Michel Goedert   Alzheimers & Dementia

Structural Mechanism for Cargo Recognition by the Retromer Complex

(2016) María Lucas et al.   CELL

VCP/p97 cooperates with YOD1, UBXD1 and PLAA to drive clearance of ruptured lysosomes by autophagy

(2016) Chrisovalantis Papadopoulos et al.   EMBO JOURNAL

Parkinson Disease-linked Vps35 R524W Mutation Impairs the Endosomal Association of Retromer and Induces α-Synuclein Aggregation

(2016) Jordan Follett et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tau Prion Strains Dictate Patterns of Cell Pathology, Progression Rate, and Regional Vulnerability In Vivo

(2016) Sarah K. Kaufman et al.   NEURON

Tauopathies as clinicopathological entities

(2016) David J. Irwin   PARKINSONISM & RELATED DISORDERS

Alzheimer’s disease due to loss of function: A new synthesis of the available data

(2016) Kasper P. Kepp   PROGRESS IN NEUROBIOLOGY

Site-specific phosphorylation of tau inhibits amyloid-β toxicity in Alzheimer’s mice

(2016) Arne Ittner et al.   SCIENCE

Tau and Aβ imaging, CSF measures, and cognition in Alzheimer’s disease

(2016) Matthew R. Brier et al.   Science Translational Medicine

Vps35-dependent recycling of Trem2 regulates microglial function

(2016) Jie Yin et al.   TRAFFIC

The neuritic plaque facilitates pathological conversion of tau in an Alzheimer’s disease mouse model

(2016) Tong Li et al.   Nature Communications

Deletion of endogenous Tau proteins is not detrimental in Drosophila

(2016) Sylvie Burnouf et al.   Scientific Reports

RNA Binds to Tau Fibrils and Sustains Template-Assisted Growth

(2015) Paul D. Dinkel et al.   BIOCHEMISTRY

Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain

(2015) Nicole Maphis et al.   BRAIN

No full admission for tau to the exclusive prion club yet

(2015) J. C. Polanco et al.   EMBO JOURNAL

Removing endogenous tau does not prevent tau propagation yet reduces its neurotoxicity

(2015) S. Wegmann et al.   EMBO JOURNAL

Tau Trimers Are the Minimal Propagation Unit Spontaneously Internalized to Seed Intracellular Aggregation

(2015) Hilda Mirbaha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for  -Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease

(2015) F.-L. Tang et al.   JOURNAL OF NEUROSCIENCE

The Role of Retromer in Alzheimer’s Disease

(2015) Qiu-Yue Zhang et al.   MOLECULAR NEUROBIOLOGY

De novo deleterious genetic variations target a biological network centered on Aβ peptide in early-onset Alzheimer disease

(2015) A Rovelet-Lecrux et al.   MOLECULAR PSYCHIATRY

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

(2015) Hirohide Asai et al.   NATURE NEUROSCIENCE

Tau in physiology and pathology

(2015) Yipeng Wang et al.   NATURE REVIEWS NEUROSCIENCE

Intracerebral injection of preformed synthetic tau fibrils initiates widespread tauopathy and neuronal loss in the brains of tau transgenic mice

(2015) Eve Peeraer et al.   NEUROBIOLOGY OF DISEASE

Tau stabilizes microtubules by binding at the interface between tubulin heterodimers

(2015) Harindranath Kadavath et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A mechanistic model of tau amyloid aggregation based on direct observation of oligomers

(2015) Sarah L. Shammas et al.   Nature Communications

VPS35 Deficiency or Mutation Causes Dopaminergic Neuronal Loss by Impairing Mitochondrial Fusion and Function

(2015) Fu-Lei Tang et al.   Cell Reports

Primary age-related tauopathy (PART): a common pathology associated with human aging

(2014) John F. Crary et al.   ACTA NEUROPATHOLOGICA

Loss of tau results in defects in photoreceptor development and progressive neuronal degeneration inDrosophila

(2014) Bonnie J. Bolkan et al.   Developmental Neurobiology

RME-8 coordinates the activity of the WASH complex with the function of the retromer SNX dimer to control endosomal tubulation

(2014) C. L. Freeman et al.   JOURNAL OF CELL SCIENCE

Pharmacological chaperones stabilize retromer to limit APP processing

(2014) Vincent J Mecozzi et al.   Nature Chemical Biology

VPS35 dysfunction impairs lysosomal degradation of α-synuclein and exacerbates neurotoxicity in a Drosophila model of Parkinson's disease

(2014) Emiko Miura et al.   NEUROBIOLOGY OF DISEASE

Distinct Tau Prion Strains Propagate in Cells and Mice and Define Different Tauopathies

(2014) David W. Sanders et al.   NEURON

Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease

(2014) Valentina Escott-Price et al.   PLoS One

Proteopathic tau seeding predicts tauopathy in vivo

(2014) B. B. Holmes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tau mutants bind tubulin heterodimers with enhanced affinity

(2014) S. Elbaum-Garfinkle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutation in VPS35 associated with Parkinson’s disease impairs WASH complex association and inhibits autophagy

(2014) Eszter Zavodszky et al.   Nature Communications

Peripheral administration of tau aggregates triggers intracerebral tauopathy in transgenic mice

(2013) Florence Clavaguera et al.   ACTA NEUROPATHOLOGICA

Novel mutation in MAPT exon 13 (p.N410H) causes corticobasal degeneration

(2013) Naomi Kouri et al.   ACTA NEUROPATHOLOGICA

Mammalian Target of Rapamycin (mTor) Mediates Tau Protein Dyshomeostasis

(2013) Zhi Tang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tau Loss Attenuates Neuronal Network Hyperexcitability in Mouse and Drosophila Genetic Models of Epilepsy

(2013) J. K. Holth et al.   JOURNAL OF NEUROSCIENCE

Antisense Reduction of Tau in Adult Mice Protects against Seizures

(2013) S. L. DeVos et al.   JOURNAL OF NEUROSCIENCE

A global analysis of SNX27–retromer assembly and cargo specificity reveals a function in glucose and metal ion transport

(2013) Florian Steinberg et al.   NATURE CELL BIOLOGY

Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome

(2013) Xin Wang et al.   NATURE MEDICINE

Microglial Beclin 1 Regulates Retromer Trafficking and Phagocytosis and Is Impaired in Alzheimer’s Disease

(2013) Kurt M. Lucin et al.   NEURON

Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds

(2013) B. B. Holmes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Charcot-Marie-Tooth 2B mutations in rab7 cause dosage-dependent neurodegeneration due to partial loss of function

(2013) Smita Cherry et al.   eLife

Are Tau Aggregates Toxic or Protective in Tauopathies?

(2013) Catherine M. Cowan et al.   Frontiers in Neurology

Cognitive defects are reversible in inducible mice expressing pro-aggregant full-length human Tau

(2012) Ann Van der Jeugd et al.   ACTA NEUROPATHOLOGICA

Identification of oligomers at early stages of tau aggregation in Alzheimer's disease

(2012) Cristian A. Lasagna-Reeves et al.   FASEB JOURNAL

Retromer Binds the FANSHY Sorting Motif in SorLA to Regulate Amyloid Precursor Protein Sorting and Processing

(2012) A. W. Fjorback et al.   JOURNAL OF NEUROSCIENCE

Identification of Alzheimer disease-associated variants in genes that regulate retromer function

(2012) Badri N. Vardarajan et al.   NEUROBIOLOGY OF AGING

Subjective cognitive complaints and amyloid burden in cognitively normal older individuals

(2012) Rebecca E. Amariglio et al.   NEUROPSYCHOLOGIA

Trans-Synaptic Spread of Tau Pathology In Vivo

(2012) Li Liu et al.   PLoS One

Amyloid precursor protein (APP) traffics from the cell surface via endosomes for amyloid β (Aβ) production in thetrans-Golgi network

(2012) Regina Wai-Yan Choy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Mutation in VPS35, Encoding a Subunit of the Retromer Complex, Causes Late-Onset Parkinson Disease

(2011) Alexander Zimprich et al.   AMERICAN JOURNAL OF HUMAN GENETICS

VPS35 Mutations in Parkinson Disease

(2011) Carles Vilariño-Güell et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Novel diffusion barrier for axonal retention of Tau in neurons and its failure in neurodegeneration

(2011) Xiaoyu Li et al.   EMBO JOURNAL

Seeding of Normal Tau by Pathological Tau Conformers Drives Pathogenesis of Alzheimer-like Tangles

(2011) Jing L. Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice

(2011) Cristian A Lasagna-Reeves et al.   Molecular Neurodegeneration

A SNX3-dependent retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion

(2011) Martin Harterink et al.   NATURE CELL BIOLOGY

Sorting nexins provide diversity for retromer-dependent trafficking events

(2011) Peter J. Cullen et al.   NATURE CELL BIOLOGY

Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy

(2011) Günter U Höglinger et al.   NATURE GENETICS

Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci

(2011) Jaspal S Kooner et al.   NATURE GENETICS

Retromer disruption promotes amyloidogenic APP processing

(2011) Christopher P. Sullivan et al.   NEUROBIOLOGY OF DISEASE

P301S Mutant Human Tau Transgenic Mice Manifest Early Symptoms of Human Tauopathies with Dementia and Altered Sensorimotor Gating

(2011) Hiroki Takeuchi et al.   PLoS One

Inducing Autophagy by Rapamycin Before, but Not After, the Formation of Plaques and Tangles Ameliorates Cognitive Deficits

(2011) Smita Majumder et al.   PLoS One

Retrieval of the Alzheimer's amyloid precursor protein from the endosome to the TGN is S655 phosphorylation state-dependent and retromer-mediated

(2010) Sandra I Vieira et al.   Molecular Neurodegeneration

The Retromer Coat Complex Coordinates Endosomal Sorting and Dynein-Mediated Transport, with Carrier Recognition by the trans-Golgi Network

(2009) Thomas Wassmer et al.   DEVELOPMENTAL CELL

A FAM21-Containing WASH Complex Regulates Retromer-Dependent Sorting

(2009) Timothy S. Gomez et al.   DEVELOPMENTAL CELL

Genome-wide association studies in Alzheimer's disease

(2009) L. Bertram et al.   HUMAN MOLECULAR GENETICS

Developmental regulation of tau phosphorylation, tau kinases, and tau phosphatases

(2009) Yang Yu et al.   JOURNAL OF NEUROCHEMISTRY

Transmission and spreading of tauopathy in transgenic mouse brain

(2009) Florence Clavaguera et al.   NATURE CELL BIOLOGY

Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and A  accumulation

(2008) A. Muhammad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential Regulation of Dynein and Kinesin Motor Proteins by Tau

(2008) R. Dixit et al.   SCIENCE