Article
Gastroenterology & Hepatology
Chaochao Xu, Lina Fan, Yifeng Lin, Weiyi Shen, Yadong Qi, Ying Zhang, Zhehang Chen, Lan Wang, Yanqin Long, Tongyao Hou, Jianmin Si, Shujie Chen
Summary: In this study, it was found that F. nucleatum plays a crucial role in promoting CRC metastasis by activating CCL20 and inducing M2 macrophage polarization. Moreover, the regulatory micro-RNA miR-1322 was identified to be involved in this process by regulating CCL20.
Article
Oncology
Ming Xiao, Qi Bian, Yimin Lao, Jing Yi, Xueqing Sun, Xuxu Sun, Jie Yang
Summary: Deletion of SUMO-specific protease 3 in macrophages promotes polarization towards the M2 subtype and accelerates breast cancer malignancy. The deficiency of SENP3 leads to increased SUMOylation of Akt1, resulting in hyper-phosphorylation and activation of Akt1, thus facilitating M2 polarization and tumor progression.
MOLECULAR ONCOLOGY
(2022)
Article
Cell Biology
Xuefeng Yang, Shuang Cai, Yue Shu, Xun Deng, Yuanwei Zhang, Nian He, Lei Wan, Xu Chen, Yan Qu, Shouyang Yu
Summary: The study showed an increase in the proportion of M2 macrophages in gastric cancer tissues, where M2 macrophages promoted cell proliferation and tumorigenesis through exosomal miR-487a targeting TIA1. These findings may contribute to the development of novel diagnostic and therapeutic methods for gastric cancer.
Article
Immunology
Min Zhou, Bingshu Li, Cheng Liu, Ming Hu, Jianming Tang, Jie Min, Jianhong Cheng, Li Hong
Summary: The study reveals that M2 macrophages promote myoblast differentiation and muscle regeneration through exosomal miR-501, suggesting a potential therapeutic approach for muscle injuries, including SUI.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Engineering, Biomedical
Paul Taufalele, Wenjun Wang, Alan J. Simmons, Austin N. Southard-Smith, Bob Chen, Joshua D. Greenlee, Michael R. King, Ken S. Lau, Duane C. Hassane, Francois Bordeleau, Cynthia A. Reinhart-King
Summary: Intratumor heterogeneity plays a crucial role in cancer therapy, and the mechanisms of cell-cell interactions are still unclear. This study investigated the transcriptional differences between tumors with different stiffness using single-cell RNA sequencing. It was found that tumors with higher stiffness had a higher concentration of tumor-promoting macrophages. These findings highlight the importance of cell-cell interactions and macrophage recruitment in tumor development.
ACTA BIOMATERIALIA
(2023)
Article
Multidisciplinary Sciences
Chenghao Yi, Shilong Wu, Qianyu Duan, Lei Liu, Li Li, Yonghui Luo, Anan Wang
Summary: This study investigates the impact of ferroptosis-induced cancer cell-derived exosomes on macrophage polarization and breast cancer progression. The results demonstrate that these exosomes inhibit M2 polarization of macrophages and suppress the migration and invasion of breast cancer cells. This study provides novel therapeutic strategies for breast cancer patients.
Article
Oncology
Yujiao Zhang, Yizeng Fan, Xin Jing, Lin Zhao, Tianjie Liu, Lu Wang, Lifen Zhang, Shanzhi Gu, Xinhan Zhao, Yan Teng
Summary: Studies have shown that the activation of YAP increases macrophage recruitment, but its role in macrophage polarization, especially in TNBC progression, is still unclear. TNBC cells were found to increase YAP expression in macrophages via OTUD5-mediated deubiquitination and stabilization, leading to polarization towards the M2-like phenotype. Additionally, high expression of YAP in M2-like macrophages was associated with pro-metastatic potential of TNBC cells through the MCP-1/CCR2 pathway, and negatively related to survival. This suggests that targeting YAP(+) M2 macrophages could be a novel therapeutic strategy for TNBC treatment.
Article
Oncology
Hao Jiang, Wen Deng, Ke Zhu, Zhenhao Zeng, Bing Hu, Zhengtao Zhou, An Xie, Cheng Zhang, Bin Fu, Xiaochen Zhou, Gongxian Wang
Summary: The study revealed that LINC00467 was upregulated in prostate cancer, and its inhibition suppressed the growth, migration, and invasion of PC cells, leading to a suppression of tumor growth. Furthermore, LINC00467 was primarily localized in the cytoplasm, promoting prostate cancer progression through the miR-494-3p/STAT3 axis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Chengxin Ma, Dasa He, Pu Tian, Yuan Wang, Yunfei He, Qiuyao Wu, Zhenchang Jia, Xue Zhang, Peiyuan Zhang, Hao Ying, Zi-Bing Jin, Guohong Hu
Summary: This study reveals the crucial role of the TGF beta/miR-182/TLR4 axis in the polarization of tumor-associated macrophages (TAMs) and provides a theoretical basis for RNA-based therapeutics targeting TAMs in cancer.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biology
Ke Zhang, Yu-Jie Li, Lin-Jia Peng, Hui-Feng Gao, Lu-Ming Liu, Hao Chen
Summary: This study explores the role of M2 macrophage-derived exosomes in pancreatic cancer (PC). It is found that exosomal miR-193b-3p derived from M2 macrophages enhances the proliferation, migration, invasion, and glutamine uptake of PC cells by targeting TRIM62, resulting in the decrease of c-Myc ubiquitination.
Article
Biochemistry & Molecular Biology
Junfeng Guo, Xingyu Wang, Qingdong Guo, Shengtao Zhu, Peng Li, Shutian Zhang, Li Min
Summary: This study reveals the molecular mechanisms of M2 macrophage-derived extracellular vesicles (M2-EVs) in promoting colon cancer, with miR-186-5p identified as a key effector. It is found that M2-EVs transport miR-186-5p to inhibit DLC1 expression and activate the β-catenin pathway, leading to enhanced proliferation and motility of colon cancer cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Cell Biology
Shoukai Zong, Wei Dai, Xiangting Guo, Kai Wang
Summary: The study reveals that lncRNA SNHG1 plays a crucial role in M2 macrophage polarization, leading to the inhibition of tumor growth and angiogenesis.
Article
Oncology
Jianxu Jin, Guiping Yu
Summary: This study found that tumor cell-derived exosomes in hypoxic environments promote lung cancer progression by targeting IRF1 through miR-21.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Chong Hao, Zhimei Sheng, Wenhao Wang, Ruijun Feng, Yuanhang Zheng, Qinpei Xiao, Baogang Zhang
Summary: This study reveals the crucial role of tumor-associated macrophages (TAMs) and exosomes in the tumor microenvironment for breast cancer growth. Exosomal miR-148b-3p can induce M2 polarization of macrophages and promote the migration and invasion of breast cancer cells by targeting TSC2 and activating the mTORC1 signaling pathway.
Article
Medicine, Research & Experimental
Hui Teng, Sijia Chen, Kaijian Fan, Qishan Wang, Bingxin Xu, Di Chen, Futao Zhao, Tingyu Wang
Summary: This study investigated the effects and mechanisms of dexamethasone liposome (Dex-Lips) on osteoarthritis (OA) in miR-204/-211-deficient mice. Dex-Lips alleviated OA symptoms, reduced pain and inflammation, regulated PGE2, and repolarized synovial macrophages to M2 phenotypes.
MOLECULAR PHARMACEUTICS
(2023)