Article
Food Science & Technology
Jie Xu, Kun Liu, Wei Chang, Bor-Sen Chiou, Maoshen Chen, Fei Liu
Summary: Chitosan has great potential in food preservation, biomedicine, and environmental applications due to its excellent functional properties. This study found that the concentration of chitosan affects the mechanical and barrier properties of chitosan films, and neutralization treatment can improve the performance of chitosan films.
Article
Materials Science, Paper & Wood
Urska Jancic, Mojca Bozic, Silvo Hribernik, Tamilselvan Mohan, Rupert Kargl, Karin Stana Kleinschek, Selestina Gorgieva
Summary: This study investigated the use of Mg(OH)2 nanoparticles as a neutralisation agent for chitosan films, resulting in stable and high-performance films. The films were obtained by facile casting method of neat CS or CS-Mg(OH)2 dispersions without the use of cross-linkers and plasticizers.
Article
Chemistry, Multidisciplinary
Hsi-Hsin Lin, Yan Cheng, Jiajie Huo, Brent H. Shanks
Summary: The study investigated the amidation of bioderived platform molecules and its influencing factors, revealing a correlation between molecular structure and ammonolysis reactivity, leading to enhanced selectivity for unsaturated amides.
Article
Biochemistry & Molecular Biology
Yi-Qi Liu, Qiao-Wei Song, Chun-Ru Mo, Wen-Wen Yu, Chang-Ying Hu
Summary: Neutralization treatment improved the slow-release antioxidant food packaging function of CS/BLF/nano-metal oxides composite films. The neutralized films had good thermal stability and the neutralized CS/BLF film showed increased elongation at break, making it suitable for packaging applications. The neutralized films maintained their basic structure and had a lower degree of swelling after soaking in different pH solutions, and the release of BLF followed a logistic function. The neutralized CS/BLF/nano-ZnO film showed good ability to resist free radicals and had no toxicity to normal human gastric epithelial cells, making it a potential active food packaging material for oil-packed food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Food Science & Technology
Congde Qiao, Xianguang Ma, Xujie Wang, Libin Liu
Summary: The influence of acid type on the structure and properties of chitosan films was studied using FTIR, XRD, and DSC, revealing different interaction patterns such as ionic interactions and hydrogen bonding. The choice of acid significantly affected the crystallinity of chitosan and its glass transition temperature, with implications for specific applications. The tensile strength of the films was found to decrease with increasing acid volume, suggesting the importance of selecting the proper solvent for chitosan in different applications.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Polymer Science
Suyoung Lee, Dong Soo Hwang
Summary: By comparing the interaction energies of chitosan-catechol and chitosan-pyrogallol, this study reveals the impact of phenolic moieties on chitosan adhesives. The phenolic moieties can decrease the rigidity of the chitosan chain and increase solubility, thereby enhancing adhesion and cohesion.
MACROMOLECULAR RAPID COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Sofia-Maria Ioannidou, Jose Pablo Lopez-Gomez, Joachim Venus, Miguel Angel Valera, Vera Essmann, Irantzu Alegria-Dallo, Ioannis K. Kookos, Apostolis Koutinas, Dimitrios Ladakis
Summary: Process design, techno-economic assessment, and life cycle assessment methods were used to evaluate four biorefinery concepts utilizing the organic fraction of municipal solid waste (OFMSW) for the production of biosurfactants and lactic acid (LA), succinic acid (SA), hot melt adhesives (HMAs), or polyurethane urea dispersions (PUDs). LA and SA were produced through fermentation using sugar-rich OFMSW enzymatic hydrolysates, while biosurfactants were produced from OFMSW-derived lipids and proteins and bacterial biomass remaining at the end of fermentation. OFMSW-derived SA replaced fossil-based SA and adipic acid in PUDs production. The study employed process design for equipment sizing and costing, as well as the estimation of material and energy balances using experimental results obtained during the H2020 funded PERCAL project. HMAs and PUDs production could be profitable when biosurfactants are produced as co-products in OFMSW-based biorefineries, resulting in minimum selling prices (MSP) of $2.92 per kg (HMAs) and $1.95 per kg (PUDs) when considering biosurfactants market price of $4.1 per kg, OFMSW management fees of $0.035 per kg, and production capacities of SA and LA at economies of scale. If LA or SA are considered as final products together with biosurfactants, then the corresponding MSPs are $1.58 per kg (LA) and $2.14 per kg (SA). Five environmental indicators were estimated, considering either conventional electricity production mix (grid) or renewable electricity usage from photovoltaics. The proposed OFMSW-based biorefineries lead to 25-35% greenhouse gas emission savings per kg main product (or 0.95-2.06 kg CO2-eq per kg dry OFMSW) compared to conventional production of end-products and two OFMSW management practices based on either landfilling alone or combined composting (37.45%) and landfilling (62.55%). The results demonstrate that OFMSW-based biorefineries could lead to profitable and sustainable production of bio-based products and the utilization of OFMSW as feedstock.
Article
Nanoscience & Nanotechnology
Kenta Fukada, Takuro Tajima, Michiko Seyama
Summary: This study developed a capacitor using food materials, with gelatin and chitosan as the substrate for achieving sol-gel changes near body temperature. By finding the appropriate gel mixing ratio, slow sol-gel changes were achieved and thermal durability was improved.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Polymer Science
Elodie Melro, Filipe E. Antunes, Gabriela J. da Silva, Ines Cruz, Philippe E. Ramos, Fatima Carvalho, Luis Alves
Summary: The study focuses on the use of different acids to dissolve chitosan, with acetic acid showing the highest antimicrobial activity and solution viscosity, as well as better mechanical properties in the formed films. The selection of acid type not only facilitates chitosan dissolution but also plays a key role in the properties of the solutions and films.
Article
Biochemistry & Molecular Biology
Xiaoqi Liu, Yanyun Zhang, Yan Liu, Ting'an Zhang
Summary: This study synthesized a recyclable adsorbent from solid waste using a clean and environmentally friendly method to deal with Cr(VI) water pollution. The magnetic zeolite/chitosan composites prepared by the neutralization method showed higher adsorption capacity, with an adsorption process likely being monolayer coverage and chemical adsorption. The adsorption was determined to be spontaneous and endothermic at 30°C, indicating successful fabrication of an adsorbent with excellent recyclability and adsorbability through a green synthetic strategy.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Peng Fei, Zhigang Zhang, Youlin Wu, Liping Xiao, Yuanhong Zhuang, Nengshui Ding, Bingqing Huang
Summary: In this study, p-coumaric acid and caffeic acid were grafted onto chitosan to improve its properties and expand its application in the food industry. The modified chitosan exhibited enhanced water solubility, antioxidation, and antibacterial activities. Coating the modified chitosan on the pork surface effectively inhibited spoilage and prolonged the shelf life of pork.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biotechnology & Applied Microbiology
Lin Zhu, Gang Pan, Hui Xu, Lingwei Kong, Weijie Guo, Jianghua Yu, Robert J. G. Mortimer, Wenqing Shi
Summary: This study proposed and tested a method to increase chitosan charge neutralization using electrolysis, which resulted in higher microalgae harvesting efficiency at lower chitosan dosage. The electrolysis-induced deacetylation of chitosan may contribute to the increased charge neutralization ability, suggesting a novel strategy for enhancing flocculation in microalgae-based engineering.
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
(2021)
Article
Chemistry, Applied
Song Jiang, Congde Qiao, Runpeng Liu, Qinze Liu, Jing Xu, Jinshui Yao
Summary: Composite films of poly(vinyl alcohol) and citric acid cross-linked chitosan were prepared and their structure and properties were investigated. The crosslinking of chitosan with citric acid was confirmed by infrared spectra and X-ray photoelectron spectra. The 1:1 CS/PVA film exhibited excellent mechanical properties, good creep resistance, and hydrophobicity, making it a potential material for food packaging and preservation.
CARBOHYDRATE POLYMERS
(2023)
Article
Engineering, Environmental
Kaung Set Linn, Pornnapa Kasemsiri, Kaewta Jetsrisuparb, Wimonporn Iamamornphan, Prinya Chindaprasirt, Jesper T. N. Knijnenburg
Summary: In this study, pectin was extracted from Cissampelos pareira leaves using a simple and environmentally friendly method. The extracted pectin was used to prepare pectin/PVA films crosslinked with succinic acid, which showed improved mechanical properties and antioxidant activity. The films demonstrated high biodegradability, making them promising candidates for biodegradable food packaging with antioxidant properties.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2022)
Article
Polymer Science
Sheila Maiz-Fernandez, Leyre Perez-Alvarez, Unai Silvan, Jose Luis Vilas-Vilela, Senentxu Lanceros-Mendez
Summary: This study successfully developed an in situ, biodegradable, and self-healing hydrogel. The swelling, mechanical stability, rheological properties, and biodegradation kinetics of the hydrogel can be controlled by adjusting the molar ratio of S-CHI and A-HA. Furthermore, the hydrogel demonstrated rapid self-repairing ability and low cytotoxicity.
Article
Chemistry, Inorganic & Nuclear
Morena Nocchetti, Anna Donnadio, Eleonora Vischini, Tamara Posati, Cristiano Albonetti, Davide Campoccia, Carla Renata Arciola, Stefano Ravaioli, Valentina Mariani, Lucio Montanaro, Riccardo Vivani
Summary: New insoluble layered zirconium phosphate carboxyaminophosphonates (ZPs) were prepared and characterized. By intercalation of short amines, these layered compounds formed colloidal dispersions and Ag nanoparticles were grown in situ on their surface. The compounds showed potential antimicrobial activity against various bacteria.
INORGANIC CHEMISTRY
(2022)
Article
Materials Science, Multidisciplinary
Francesco Gabriele, Laura Bruno, Cinzia Casieri, Roberta Ranaldi, Lorenza Rugnini, Nicoletta Spreti
Summary: The study aims to minimize the impact of biocides on substrates, the environment, and operators by using alginate-oxidizing biocide hydrogels. The results showed that the proposed restoration protocol effectively removed biological patinas and restored the original chromaticity of the treated surfaces.
Article
Biotechnology & Applied Microbiology
Roberta Ranaldi, Lorenza Rugnini, Francesco Gabriele, Nicoletta Spreti, Cinzia Casieri, Gabriele Di Marco, Angelo Gismondi, Laura Bruno
Summary: The development of phototrophic biofilms deteriorates stone cultural heritage, and essential oils have emerged as successful natural biocides. Thyme essential oil suspended in alginate hydrogel shows significant inhibitory effects on photosynthetic efficiency, with the main plant compound identified as thymol.
INTERNATIONAL BIODETERIORATION & BIODEGRADATION
(2022)
Article
Biochemistry & Molecular Biology
Marianna Barbalinardo, Marta Giannelli, Ludovica Forcini, Barbara Luppi, Anna Donnadio, Maria Luisa Navacchia, Giampiero Ruani, Giovanna Sotgiu, Annalisa Aluigi, Roberto Zamboni, Tamara Posati
Summary: Skin disorders are common globally and oxidative stress is a major cause of skin cell dysfunction. In this study, researchers combined fibroin with antioxidant compounds extracted from pomegranate waste to fabricate bioactive and eco-sustainable films for potential skin repair. The films were visually transparent, flexible, stable and able to release bioactive compounds in a controlled manner. They were also biocompatible with main skin cells and demonstrated a high capacity to reduce oxidative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Matteo Capone, Laura Zanetti-Polzi, Ilenia Leonzi, Nicoletta Spreti, Isabella Daidone
Summary: This study uses computational methods to determine the protonation state of the active site in CALB at neutral or slightly basic pH. The research combines molecular dynamics simulation and the perturbed matrix method to calculate the pKa value of the active site.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Pier Luigi Gentili, Antonio Capaccioni, Raimondo Germani, Simona Fantacci
Summary: Photochromic compounds are utilized to develop neuron surrogates for neuromorphic engineering in wetware. The photochromic behaviors of (E)-3,4,6-trichloro-2-(p-diazenil)-phenol (t-DZH) and its conjugated phenoxide base (t-DZ) in various media have been experimentally investigated. The results suggest that t-DZH and t-DZ can serve as molecular probes and potential ingredients for implementing pacemaker neurons that communicate optically in wetware.
Article
Engineering, Biomedical
Matteo Puccetti, Anna Donnadio, Maurizio Ricci, Loredana Latterini, Giulia Quaglia, Donatella Pietrella, Alessandro Di Michele, Valeria Ambrogi
Summary: Recently, researchers proposed the use of silver-based nanoparticles in wound dressings due to their antimicrobial activity. However, these nanoparticles are cytotoxic for certain types of cells, limiting their application. In this study, a sustainable method was proposed to prepare alginate AgCl nanoparticles composite films with antimicrobial and antibiofilm activities and low cytotoxicity. The composite films showed promising antibacterial and antibiofilm effects against specific bacteria, while exhibiting low cytotoxicity towards human skin cells. This approach provides a potential solution for preventing infections in wounds without causing harm to tissue cells.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Sacha Fop, Riccardo Vivani, Silvia Masci, Mario Casciola, Anna Donnadio
Summary: A new crystalline metal acid triphosphate, ZrH5(PO4)(3) (ZP3), has been discovered with record-high proton conductivity of 0.5-3.1x10(-2) S cm(-1) in the range 25-110 degrees C in anhydrous conditions. ZP3 achieves superprotonic conductivity through extended defective frustrated hydrogen bond chains, where protons are dynamically disordered over two oxygen centers. The high proton conductivity and stability in anhydrous conditions make ZP3 an excellent candidate for innovative applications in fuel cells and other energy technologies.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Organic
Elisa Brambilla, Alessandra Gritti, Valentina Pirovano, Antonio Arcadi, Raimondo Germani, Matteo Tiecco, Giorgio Abbiati
Summary: We present an alternative and sustainable method for synthesizing 2,2'-disubstituted 3,3'-biindoles using 2,2'-diaminotolanes and (hetero)arylaldehydes. The key feature of this method is the use of an acidic Deep Eutectic Solvent (DES) that acts as both a solvent and a Bronsted Acid (BA) catalyst, eliminating the need for Volatile Organic Compounds (VOCs) as solvents and additional acid catalysts. We successfully synthesized twenty-five biindoles, including eighteen new compounds, in good to very good yields under mild conditions using microwave heating at 70 degrees C. The DES medium could be reused at least five times with minimal reduction in yields. Based on experimental evidence and literature findings, we propose a plausible mechanism.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Physical
Martina Fronduti, Tiziana Del Giacco, Elisa Rossi, Matteo Tiecco, Raimondo Germani
Summary: Deep eutectic solvents (DESs) have become increasingly relevant due to their environmentally friendly characteristics, catalytic properties, and complex structural features. This study analyzed the structural features of a DES mixture at different molar fractions to identify any singularities at the eutectic point. Ionic conductivity, viscosity, and surface tension measurements were analyzed, revealing unique characteristics at the eutectic point. Surface tension was found to be a valuable method for determining the eutectic point of low-melting point DES mixtures. The structural diversity of the eutectic was taken into account. (c) 2023 Elsevier B.V. All rights reserved.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Environmental Sciences
Francesco Gabriele, Roberta Ranaldi, Laura Bruno, Cinzia Casieri, Lorenza Rugnini, Nicoletta Spreti
Summary: A research field focused on developing innovative and sustainable methods to prevent the biodeterioration of stone monuments caused by microbial growth is discussed. It is important to consider the bioreceptivity of different substrates in addition to the efficacy of biocides. By studying five different lithotypes, researchers correlated the structural properties of stones with the photosynthetic yields of cyanobacterial biofilms, providing a method to estimate stone bioreceptivity.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Chemistry, Multidisciplinary
Anna Donnadio, Geo Paul, Marianna Barbalinardo, Valeria Ambrogi, Gabriele Pettinacci, Tamara Posati, Chiara Bisio, Riccardo Vivani, Morena Nocchetti
Summary: Different amounts of sodium-alendronate (ALN) were loaded into layered zirconium phosphates of alpha and gamma type by topotactic exchange reactions. To extend the exchange process to the interlayer regions, ALN solutions were in contact with exfoliated single sheets of the layered solids. The ALN loading degree was determined and the compounds were characterized. The effect of ZP derivatives on cell proliferation was assessed and showed no decrease after 7 days of incubation.
Article
Chemistry, Physical
Eduardo Picciolini, Genny Pastore, Tiziana Del Giacco, Gianluca Ciancaleoni, Matteo Tiecco, Raimondo Germani
Summary: Deep Eutectic Solvents (DESs) are a class of solvents that are becoming more and more important in research due to their environmentally friendly features, structural characteristics, and catalytic properties. They are formed by mixing a hydrogen bond donor and a hydrogen bond acceptor, and are finding applications as alternatives to common organic compounds.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Multidisciplinary
Alice Vetrano, Francesco Gabriele, Raimondo Germani, Nicoletta Spreti
Summary: The immobilization conditions of Candida rugosa lipase in calcium alginate beads play a significant role in enzyme properties and catalytic activity. The immobilized lipase shows better resistance to temperature inactivation and can be recycled effectively. The optimized bead formulation is used for enantioselective catalysis.
NEW JOURNAL OF CHEMISTRY
(2022)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)
