Article
Multidisciplinary Sciences
Hye-Rim Shin, Kon Chu, Woo-Jin Lee, Han Sang Lee, Eun Young Kim, Hyoshin Son, Jangsup Moon, Narae Kim, Ki-Young Jung, Keun-Hwa Jung, Soon-Tae Lee, Kyung-Il Park, Sang Kun Lee
Summary: This study screened epilepsy patients admitted for video-EEG monitoring and found a relationship between neuroinflammation and psychiatric symptoms such as anxiety and depression. Levels of IL-2 and IL-6 increased in cases of generalized tonic-clonic seizures, while CCL5 and CCL2 were associated with anxiety and depression in epilepsy patients.
SCIENTIFIC REPORTS
(2022)
Editorial Material
Clinical Neurology
Richard M. Camicioli, Carlo Colosimo
Summary: This study examined the association between different NPS profiles and the risk of cognitive decline in PD-MCI patients, which is of great importance for the diagnosis and management of PD-MCI patients.
Article
Environmental Sciences
Manuela Tondelli, Annalisa Chiari, Giulia Vinceti, Chiara Galli, Simone Salemme, Tommaso Filippini, Chiara Carbone, Claudia Minafra, Claudia De Luca, Riccardo Prandi, Simona Tondelli, Giovanna Zamboni
Summary: This study explores the relationship between greenness and neuropsychiatric symptoms in individuals with dementia. The findings suggest that green environments may have an impact on the mental well-being of people with dementia.
ENVIRONMENTAL RESEARCH
(2024)
Article
Clinical Neurology
Lucy L. Gibson, Lea T. Grinberg, Dominic Ffytche, Renata E. P. Leite, Roberta D. Rodriguez, Renata E. L. Ferretti-Rebustini, Carlos A. Pasqualucci, Ricardo Nitrini, Wilson Jacob-Filho, Dag Aarsland, Claudia K. Suemoto
Summary: In a post mortem study on LBD, hallucinations were found to be associated with higher LB Braak stages, while higher NFT Braak staging was associated with depression, agitation, and greater number of symptoms. Patients with dual AD+LBD pathology had the highest risk of hallucinations, agitation, apathy, and total symptoms.
ALZHEIMERS & DEMENTIA
(2023)
Article
Geriatrics & Gerontology
Willem S. Eikelboom, Amy den Teuling, Daphne E. Pol, Michiel Coesmans, Sanne Franzen, Lize C. Jiskoot, Judy van Hemmen, Ellen H. Singleton, Rik Ossenkoppele, Frank Jan de Jong, Esther van den Berg, Janne M. Papma
Summary: This study investigates the stability of neuropsychiatric symptoms (NPS) assessed biweekly using the Neuropsychiatric Inventory (NPI) in a memory clinic population during a 6 week period. The results showed that NPS scores were highly irregular and had large within-person variation, but were unrelated to changes in caregiver burden.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2022)
Review
Behavioral Sciences
Simona Karamazovova, Veronika Matuskova, Zahinoor Ismail, Martin Vyhnalek
Summary: In addition to motor coordination, the cerebellum also plays an important role in cognitive and affective processes. Spinocerebellar ataxias (SCA) and Friedreich ataxia (FRDA) are rare neurodegenerative diseases of the cerebellum that not only affect motor functions but also have cognitive and neuropsychiatric symptoms. This review discusses the prevalence, clinical features, and treatment approaches of neuropsychiatric impairments such as depression, anxiety, apathy, agitation, impulse dyscontrol, and psychosis in SCA and FRDA patients. Further research is needed to improve the detection and treatment options for these co-morbidities in ataxia patients due to their significant impact on quality of life.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Neurosciences
Kaicheng Li, Qingze Zeng, Xiao Luo, Shile Qi, Xiaopei Xu, Zening Fu, Luwei Hong, Xiaocao Liu, Zheyu Li, Yanv Fu, Yanxing Chen, Zhirong Liu, Vince D. Calhoun, Peiyu Huang, Minming Zhang
Summary: The study found that concomitant neuropsychiatric symptoms are associated with accelerated Alzheimer's disease progression. Using multimodal brain imaging, a pattern associated with these symptoms was identified and found to be correlated with the development of Alzheimer's disease. The pattern was also found to be associated with multiple cognitive domains and could predict cognitive decline.
HUMAN BRAIN MAPPING
(2023)
Review
Clinical Neurology
Christine Le, Elizabeth Finger
Summary: This review highlights the lack of disease-modifying and effective symptomatic treatments for frontotemporal dementias, particularly focusing on the behavioral and neuropsychiatric symptoms. The potential for cognitive neuroscience mechanisms to inform future approaches to clinical trials and more precise symptomatic treatments for FTDs is emphasized.
Article
Clinical Neurology
Behnam Iravani, Elaheh Abdollahi, Fatemeh Eslamdoust-Siahestalkhi, Robabeh Soleimani
Summary: This study assessed the relationship between neuropsychiatric symptoms in patients with Alzheimer's disease and caregiver burden. The results showed a significant correlation between NPS and CB, with apathy being the most common symptom in AD patients.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Grace J. Goodwin, Stacey Moeller, Amy Nguyen, Jeffrey L. Cummings, Samantha E. John
Summary: This study examined the network structure of neuropsychiatric symptoms in older adults with cognitive impairment. The results showed significant connectivity among these symptoms, and disinhibition and agitation/aggression were found to be the most central symptoms in the network. Targeting these symptoms may lead to overall improvement in neuropsychiatric symptoms.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Editorial Material
Clinical Neurology
Byron Creese, Katie Lannon
Summary: New research based on genome-wide association studies in Alzheimer's disease has identified molecular mechanisms that are also seen in some psychiatric disorders. The study used omics data and has the potential to reveal unknown disease mechanisms. However, insufficient information about neuropsychiatric symptoms in Alzheimer's disease patients limits the conclusions.
NATURE REVIEWS NEUROLOGY
(2022)
Article
Clinical Neurology
Giuseppe Scopelliti, Barbara Casolla, Gregoire Boulouis, Gregory Kuchcinski, Solene Moulin, Didier Leys, Hilde Henon, Charlotte Cordonnier, Marco Pasi
Summary: Neuropsychiatric symptoms were present in more than half of 6-month ICH survivors, with higher prevalence and severity in patients with post-ICH dementia. Apathy and hyperactivity symptoms may be associated with cognitive status and can inform on long-term dementia risk.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Hai-Juan Qin, Shuang Li, Yu-Bo Zhu, Yan-Bin Bao, Qi Tang, Wen-Bin Liu, Ming Zhong, YueTao Zhao, Yang Yang
Summary: The preparation of an OS-BSA conjugate for use as a multivalent NA inhibitor is reported, showing superior inhibitory effects compared to the monomeric OS azidohexyl ester. Further investigation revealed that the prepared OS-BSA has a dual role as a multivalent NA inhibitor and an adsorbent for virion particles, contributing to the inhibition of influenza viral replication. This study provides insight into the antiviral mechanism of multivalent NA inhibitors and lays the foundation for the development of novel antiviral agents.
CARBOHYDRATE RESEARCH
(2022)
Article
Neurosciences
Andrzej Sokolowski, Ashlin R. K. Roy, Sheng-Yang M. Goh, Emily G. Hardy, Samir Datta, Yann Cobigo, Jesse A. Brown, Salvatore Spina, Lea Grinberg, Joel Kramer, Katherine P. Rankin, William W. Seeley, Virginia E. Sturm, Howard J. Rosen, Bruce L. Miller, David C. Perry
Summary: Behavioral variant frontotemporal dementia is characterized by heterogeneous atrophy patterns in the frontal, insular, and anterior temporal lobes. This study aimed to assess the frequency of hemispheric and dorso-ventral asymmetry and examine their clinical correlates.
HUMAN BRAIN MAPPING
(2023)
Article
Neurosciences
Deidiane Elisa Ribeiro, Lyvia Lintzmaier Petiz, Talita Glaser, Agatha Oliveira-Giacomelli, Roberta Andrejew, Fernando de Azevedo Ribeiro Saab, Milena da Silva Milanis, Henrique Correia Campos, Vanessa Fernandes Arnaud Sampaio, Sophia La Banca, Beatriz Monteiro Longo, Claudiana Lameu, Yong Tang, Rodrigo Ribeiro Resende, Sergio T. Ferreira, Henning Ulrich
Summary: About 10 million new cases of dementia occur globally each year, with up to 70% attributed to Alzheimer's disease (AD). AD patients often experience non-cognitive symptoms known as behavioral and psychological symptoms of dementia (BPSDs), including sleep disorders and mood alterations such as depression and apathy. BPSDs have a significant impact on AD patients, caregivers, public health systems, and the economy. Understanding the role of purinergic signaling, particularly the A1, A2A, and P2X7 receptors, in AD may provide new therapeutic approaches for the disease and related conditions.
Article
Clinical Neurology
Shinsaku Yoshitomi, Shin-ichiro Hamano, Masaharu Hayashi, Hiroshi Sakuma, Shinichi Hirose, Atsushi Ishii, Ryoko Honda, Akio Ikeda, Katsumi Imai, Kazutaka Jin, Akiko Kada, Akiyoshi Kakita, Mitsuhiro Kato, Kensuke Kawai, Tamihiro Kawakami, Katsuhiro Kobayashi, Toyojiro Matsuishi, Takeshi Matsuo, Shin Nabatame, Nobuhiko Okamoto, Susumu Ito, Akihisa Okumura, Akiko Saito, Hideaki Shiraishi, Hiroshi Shirozu, Takashi Saito, Hidenori Sugano, Yukitoshi Takahashi, Hitoshi Yamamoto, Tetsuhiro Fukuyama, Ichiro Kuki, Yushi Inoue
Summary: The study reveals the challenging neurological, physical and developmental aspects, as well as intractable seizures, in patients with West syndrome. More than a half of the children showed developmental delay after onset, even though seizures were reduced during the course of the disease.
EPILEPTIC DISORDERS
(2021)
Article
Clinical Neurology
Yuka Murofushi, Itaru Hayakawa, Yuichi Abe, Tatsuyuki Ohto, Kei Murayama, Hisato Suzuki, Toshiki Takenouchi, Kenjiro Kosaki, Masaya Kubota
Summary: Mutations in KARS can lead to impaired protein synthesis, resulting in progressive leukodystrophies with mitochondrial dysfunction. Current therapy is limited to supportive care, but a ketogenic diet and vitamin supplementation may help alleviate symptoms and improve some functions in patients.
Article
Clinical Neurology
Yushi Inoue, Shin-ichiro Hamano, Masaharu Hayashi, Hiroshi Sakuma, Shinichi Hirose, Atsushi Ishii, Ryoko Honda, Akio Ikeda, Katsumi Imai, Kazutaka Jin, Akiko Kada, Akiyoshi Kakita, Mitsuhiro Kato, Kensuke Kawai, Tamihiro Kawakami, Katsuhiro Kobayashi, Toyojiro Matsuishi, Takeshi Matsuo, Shin Nabatame, Nobuhiko Okamoto, Susumu Ito, Akihisa Okumura, Akiko Saito, Hideaki Shiraishi, Hiroshi Shirozu, Takashi Saito, Hidenori Sugano, Yukitoshi Takahashi, Hitoshi Yamamoto, Tetsuhiro Fukuyama, Ichiro Kuki
Summary: This study examined the medical and psychosocial status of patients with epilepsy in Japan to assess the application of the Intractable/Rare Diseases Act. The majority of epilepsy patients met the severity criteria defined by the Act, but some groups had lower proportions due to successful surgical therapy. The study suggests that further research is needed to update the list of designated syndromes/diseases in the Act.
EPILEPTIC DISORDERS
(2022)
Article
Clinical Neurology
Michiko Kawai, Yuichi Abe, Masato Yumoto, Masaya Kubota
Summary: Landau-Kleffner syndrome is a rare neurological disorder characterized by acquired aphasia with distinctive EEG findings. In a pediatric case where LKS was diagnosed, imaging findings suggested involvement of the right hemisphere in language comprehension. Although little is known about the mechanisms of aphasia and its recovery, disparities between expressive and receptive aphasia recovery were observed.
Article
Clinical Neurology
Titaporn Thamcharoenvipas, Yukitoshi Takahashi, Nobusuke Kimura, Kazumi Matsuda, Naotaka Usui
Summary: The seizure onset patterns (SOPs) in surface EEG monitoring play a significant role in the presurgical evaluation of patients with focal cortical dysplasia (FCD), aiding in the localization of epileptic foci and pathologic subtypes of FCD.
PEDIATRIC NEUROLOGY
(2022)
Article
Multidisciplinary Sciences
Shota Myojin, Kyongsun Pak, Mayumi Sako, Tohru Kobayashi, Takuri Takahashi, Tomimasa Sunagawa, Norihiko Tsuboi, Kenji Ishikura, Masaya Kubota, Mitsuru Kubota, Takashi Igarashi, Ichiro Morioka, Isao Miyairi
Summary: This study aimed to evaluate the association between treatment for STEC infection and HUS development. The results showed that antibiotics, especially fosfomycin, may prevent the development of HUS in children, while the use of antidiarrheal agents should be avoided.
Article
Clinical Neurology
Mitsuhiro Kato, Akiko Kada, Hideaki Shiraishi, Jun Tohyama, Eiji Nakagawa, Yukitoshi Takahashi, Tomoyuki Akiyama, Akiyoshi Kakita, Noriko Miyake, Atsushi Fujita, Akiko M. Saito, Yushi Inoue
Summary: Sirolimus has a certain inhibitory effect on focal seizures in patients with FCD type II, however, the reduction level did not reach statistical significance.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2022)
Article
Clinical Neurology
Kentaro Tokumoto, Takuji Nishida, Norihiko Kawaguchi, Kimihiko Kaneko, Toshiyuki Takahashi, Yukitoshi Takahashi
Summary: Myelin oligodendrocyte glycoprotein (MOG) antibodies are associated with central nervous system demyelinating disorders. This study reviewed the electroclinical features of cerebral cortical encephalitis (CCE) associated with MOG antibodies. The analysis of 34 cases and a new case revealed distinct seizure types and EEG abnormalities in MOG-CCE.
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
(2022)
Article
Medical Laboratory Technology
Yoshiaki Yamamoto, Yushi Inoue, Naotaka Usui, Katsumi Imai, Yoshiyuki Kagawa, Yukitoshi Takahashi
Summary: This study assessed the drug interactions between rufinamide and concomitant antiepileptic drugs (AEDs), and identified the therapeutic window for rufinamide. The results showed that rufinamide exhibited linear pharmacokinetics and its concentrations were affected by the concomitant use of enzyme-inducing AEDs and valproate. Clinical response was observed in approximately 23.0% of patients, with higher rufinamide concentrations in patients with tonic/atonic seizures. Adverse events were reported in 35.8% of patients, and patients with concentrations greater than 20 mcg/mL had a higher incidence of adverse events.
THERAPEUTIC DRUG MONITORING
(2022)
Article
Multidisciplinary Sciences
Toshimitsu Suzuki, Tetsuya Tatsukawa, Genki Sudo, Caroline Delandre, Yun Jin Pai, Hiroyuki Miyamoto, Matthieu Raveau, Atsushi Shimohata, Iori Ohmori, Shin-ichiro Hamano, Kazuhiro Haginoya, Mitsugu Uematsu, Yukitoshi Takahashi, Masafumi Morimoto, Shinji Fujimoto, Hitoshi Osaka, Hirokazu Oguni, Makiko Osawa, Atsushi Ishii, Shinichi Hirose, Sunao Kaneko, Yushi Inoue, Adrian Walton Moore, Kazuhiro Yamakawa
Summary: This study found that variants in the CUX2 and CASP genes are associated with temporal lobe epilepsy, affecting dendrite branching and synaptic transmission in neurons.
SCIENTIFIC REPORTS
(2022)
Article
Pediatrics
Masaya Kubota, Nobuhiko Haga
Summary: COVID-19 outbreaks have had various effects on the physical and mental health of families and children with congenital insensitivity to pain with anhidrosis (CIPA). A questionnaire survey was conducted to identify the specific issues and needs of CIPA patients and their families during the pandemic. The survey found that families faced difficulties in predicting the future, household and work concerns, and fear of infection. Increased time together during the pandemic led to both stress and better understanding among families. Sleep disturbances and behavioral changes were observed in a significant number of CIPA patients. Each family had its own coping mechanisms, but the importance of peer support, connections with experts, and prompt responses for resolution were emphasized.
PEDIATRICS INTERNATIONAL
(2023)
Article
Clinical Neurology
Yoshiaki Yamamoto, Akiko Ohta, Naotaka Usui, Katsumi Imai, Yoshiyuki Kagawa, Yukitoshi Takahashi
Summary: The aim of this study is to identify pediatric patients who require therapeutic drug monitoring (TDM) of levetiracetam (LEV). The pharmacokinetics of LEV are significantly different between infants and preschool children, so TDM of LEV is clinically useful in these patients.
BRAIN & DEVELOPMENT
(2023)
Article
Clinical Neurology
Naoto Kuroda, Takafumi Kubota, Toru Horinouchi, Naoki Ikegaya, Yu Kitazawa, Satoshi Kodama, Izumi Kuramochi, Teppei Matsubara, Naoto Nagino, Shuichiro Neshige, Temma Soga, Yutaro Takayama, Daichi Sone
Summary: This multicenter retrospective cohort study investigated the impact of the COVID-19 pandemic on epilepsy care in Japan. Results showed that outpatient EEG studies and telemedicine for epilepsy were significantly affected by the pandemic. COVID-19 cases and a state of emergency were independently associated with epilepsy admission and EEG monitoring.
Article
Clinical Neurology
Yukitoshi Takahashi, Akiko Ota, Jun Tohyama, Tomoko Kirino, Yumi Fujiwara, Chizuru Ikeda, Shigeki Tanaka, Jyunya Takahashi, Toshihiko Shinoki, Hiroshi Shiraga, Takushi Inoue, Hiroshi Fujita, Motoki Bonno, Masayoshi Nagao, Hideo Kaneko
Summary: This study retrospectively examined the pharmacoresistance of focal epileptic spasms, generalized ES, and generalized ES combined with focal seizures. Different types of ES patients showed varying responses to ACTH treatment, suggesting the need to consider surgical options earlier in the course of treatment.
Article
Rheumatology
Haruka Tsuchiya, Yukiko Iwasaki, Hirofumi Shoda, Yukitoshi Takahashi, Keishi Fujio
Summary: Limbic encephalitis (LE) is characterized by acute or subacute impairment of short-term memory, seizures, and psychiatric symptoms. This report describes a 46-year-old Japanese female with SLE who was diagnosed with severe NPSLE presenting as LE-SLE and showed rapid response to treatment with methylprednisolone pulses and high-dose prednisolone. The patient had elevated anti-GluRs levels in serum and CSF on admission, which decreased to normal range at one-year follow up, indicating potential prognostic value.
MODERN RHEUMATOLOGY CASE REPORTS
(2021)