Article
Dermatology
Zhongshuai Wang, Huijuan Zhao, Wanying Zhai, Xiaofeng Zhang, Li Li, Chen Yuan, Yi Li, Yangqun Li, Yan Yan, Baoxi Wang
Summary: Mutations in the gamma-secretase complex have been well-described in familial hidradenitis suppurativa (HS). No gene mutations have been identified in sporadic HS, which comprises 60%-70% of all HS cases. Obesity and smoking are risk factors for HS and are closely related to DNA methylation, an essential epigenetic phenomenon. This study investigated the involvement of epigenetic modifications in sporadic HS and found downregulation of CXCL16 and CXCR6 in HS.
EXPERIMENTAL DERMATOLOGY
(2023)
Review
Cell Biology
Mahendra Pratap Kashyap, Jasim Khan, Rajesh Sinha, Lin Jin, Venkatram Atigadda, Jessy S. Deshane, Ayesha R. Ahmed, Ali Kilic, Chander Raman, M. Shahid Mukhtar, Craig A. Elmets, Mohammad Athar
Summary: Hidradenitis suppurativa (HS) is a highly inflamed and painful condition characterized by deep-seated lumps/abscesses, fistulae, and sinus tracts in the dermis. Dysregulated Notch signaling, bacterial infection, and alterations in keratinocytes and dermal fibroblasts play important roles in the pathogenesis of HS. However, the underlying mechanisms and effective treatments are still not fully understood. The presence of extracellular matrix degradation products and dysregulation in immune cells further complicate the disease progression. This review provides up-to-date information on the dysregulated keratinocyte and immune cells, the role of extracellular matrix and keratin in HS pathogenesis.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Francesco Borgia, Lucia Peterle, Paolo Custurone, Mario Vaccaro, Giovanni Pioggia, Sebastiano Gangemi
Summary: This article summarizes the current knowledge on the relationship between miRNAs and acne vulgaris (AV) and hidradenitis suppurativa (HS), and identifies common miRNAs that may explain the similar characteristics of these two diseases. These miRNAs are related to the pathological processes of both diseases and may serve as potential diagnostic and therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dermatology
Chia-Bao Chu, Chao-Chun Yang, Yuan-Yu Hsueh, Po-Chuan Chen, Yi-Kai Hong, Yu-Yun Kuo, Shaw-Jenq Tsai
Summary: This study identified IL-17A+ mast cells as a valuable pathological marker for diagnosing hidradenitis suppurativa (HS). Targeting IL-17A+ mast cells with therapeutic drugs may offer a promising and novel approach for the treatment of HS.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Review
Immunology
Elia Rosi, Prisca Guerra, Gianmarco Silvi, Giulia Nunziati, Ilaria Scandagli, Antonella Di Cesare, Francesca Prignano
Summary: Hidradenitis suppurativa (HS) is an inflammatory skin disease and the role of bacteria in HS patients has been the focus of research. The bacterial composition in HS patients is different from that in healthy controls. The question of whether changes in microbial populations are the cause or reflection of HS development remains unanswered. The aim of this article is to provide an overview of different hypotheses explaining the bacterial role in HS pathogenesis.
Review
Immunology
Shuo-Yan Gau, Ivan Arni C. Preclaro, James Cheng-Chung Wei, Chien-Ying Lee, Yu-Hsiang Kuan, Yu-Ping Hsiao, Sin-Ei Juang, Kevin Sheng-Kai Ma
Summary: This systematic review and meta-analysis found a significant association between hidradenitis suppurativa (HS) and psoriasis. HS patients had a higher risk of having psoriasis, and the risk was even higher in male patients and female patients with HS.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Kayla F. Goliwas, Mahendra P. Kashyap, Jasim Khan, Rajesh Sinha, Zhiping Weng, Allen S. W. Oak, Lin Jin, Venkatram Atigadda, Madison B. Lee, Craig A. Elmets, M. Shahid Mukhtar, Chander Raman, Jessy S. Deshane, Mohammad Athar
Summary: Hidradenitis suppurativa (HS) is a complex and debilitating inflammatory skin disease for which no effective treatment is available currently. In this study, we developed three ex vivo skin culture models that can effectively culture healthy and HS skin samples, supporting the growth of various cell populations. These culture systems provide a powerful tool to uncover the pathobiology of HS and screen drugs for their efficacy against the disease.
Review
Dermatology
Piotr K. Krajewski, Jacek C. Szepietowski, Antonio Martorell
Summary: This study finds that there is an increased number of immune cells and high levels of inflammatory factors in HS tunnels, contributing to increased inflammation and disease severity. Additionally, HS sinus tracts are often colonized by bacteria and tend to form biofilms. Furthermore, new drugs targeting IL-17 subunits show promise in reducing dermal tunnel drainage and resolving sinus tracts.
Article
Medicine, Research & Experimental
Daniel B. Yidana
Summary: HS is a chronic, recurrent skin disease with complex pathophysiology possibly related to immune system dysregulation, and IL-17 may be a common factor linking HS with other immune-mediated diseases. Further exploration into the role of fungi and aryl hydrocarbon receptor in HS pathogenesis is needed.
MEDICAL HYPOTHESES
(2021)
Article
Multidisciplinary Sciences
Paola Maura Tricarico, Chiara Moltrasio, Anton Gradisek, Angelo Marzano, Vincent Flacher, Wacym Boufenghour, Esther von Stebut, Matthias Schmuth, Wolfram Jaschke, Matjaz Gams, Michele Boniotto, Sergio Crovella
Summary: The European consortium BATMAN has developed an integrated pipeline to investigate the molecular pathways involved in Hidradenitis suppurativa (HS) and develop personalized treatments. Their objectives include identifying genetic variants associated with HS susceptibility, designing in vitro cell models to study HS mechanisms, and creating holistic health records through remote patient monitoring.
SCIENTIFIC REPORTS
(2022)
Review
Dermatology
Ana Preda-Naumescu, Hana N. Ahmed, Tiffany T. Mayo, Nabiha Yusuf
Summary: Hidradenitis suppurativa is a chronic inflammatory skin condition with a range of symptoms, from painful nodules to abscesses, associated with various mechanisms and comorbidities. It significantly impairs patients' quality of life and requires early recognition and treatment.
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2021)
Review
Biology
Stefano Caccavale, Vittorio Tancredi, Maria Pia Boccellino, Graziella Babino, Elisabetta Fulgione, Giuseppe Argenziano
Summary: The skin, mental health, and the central nervous system are closely connected. Chronic skin-inflammatory diseases such as Hidradenitis suppurativa (HS) can influence the activity of the CNS and also cause psychological burden. HS is associated with psychiatric disorders including depression, anxiety, substance abuse, psychotic and bipolar disorders, as well as an increased risk of suicide.
Article
Biochemistry & Molecular Biology
Dillon Mintoff, Isabella Borg, Nikolai P. Pace
Summary: This study investigated the role of serum IgG, M, and A levels as biomarkers of disease severity in Hidradenitis suppurativa. The results suggest that serum IgG level can be used as a biomarker for disease severity in a clinical setting.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Gautham Vellaichamy, Anya T. Amin, Peter Dimitrion, Zaakir Hamzavi, Li Zhou, Indra Adrianto, Qing-Sheng Mi
Summary: Hidradenitis suppurativa (HS) is a chronic skin disease characterized by inflammation around hair follicles, commonly affecting folded areas. The underlying pathogenesis and molecular mechanisms of HS are not well understood. Genetic studies have identified variants within the gamma-secretase complex associated with HS, but definitive genotype-phenotype correlations have not been established. The lack of knowledge about the intersection of genetics, immunology, and environmental risk factors is a major obstacle in improving treatment for HS patients.
FRONTIERS IN GENETICS
(2022)
Review
Medicine, General & Internal
Natsuko Saito-Sasaki, Yu Sawada
Summary: It is known that persistent skin inflammation caused by hidradenitis suppurativa (HS) can impact the functioning of multiple organs due to the circulation of inflammatory cells and cytokines throughout the body. Recent research has revealed a significant connection between HS and systemic inflammatory disorders. This article provides comprehensive molecular mechanisms and details associated with systemic inflammatory illnesses caused by HS.