Article
Cell Biology
Lushun Ma, Rui Li, Zhiwei Yao, Bo Wang, Yong Liu, Chunxiang Liu, Heng Wang, Shuxian Chen, Daqing Sun
Summary: This study identified two natural small molecules as potential inhibitors of TNIK through computer-assisted virtual screening and molecular dynamics simulation. These compounds exhibited high affinity and excellent pharmacological properties, providing valuable insights for the development of new colorectal cancer targeting drugs.
Article
Cardiac & Cardiovascular Systems
Bram W. van Os, Pascal J. H. Kusters, Myrthe den Toom, Linda Beckers, Claudia M. van Tiel, Winnie G. Vos, Elize de Jong, Arnd Kieser, Cindy van Roomen, Christoph J. Binder, Myrthe E. Reiche, Menno P. de Winther, Laura A. Bosmans, Esther Lutgens
Summary: This study investigates the role of B cell-specific TNIK deficiency in atherosclerosis. The results show that the lack of B cell TNIK does not affect atherosclerosis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Oncology
Jiali Li, Lili Lan, Yuru Xu, Shenghui Liu, Meng Liu, Guobin Hu, Ganxun Wu, Yan Zhao, Jian Shi, Jingtian Wang, Yixin Sun, Zhanlong Wang, Ruili Zhao
Summary: The aim of this study was to evaluate the expression of TNIK and p-TNIK in PTC and compare them with benign thyroid tumors and normal tissues. The results showed that both TNIK and p-TNIK were significantly upregulated in PTC tissues, and p-TNIK was associated with extrathyroidal extension. This suggests that TNIK and p-TNIK may play crucial roles in the carcinogenesis and progression of PTC.
Article
Pharmacology & Pharmacy
Hongchao Jiang, Yaxue Zhao, Huirong Tang, Shixin Duan, Mengkai Li, Xinyi Yang, Jingting Liu, Xinyi Lou, Yuanyuan Cai, Wenjuan Zhao, Lei Sun, Feng Qian
Summary: DSF inhibits pulmonary fibrosis by targeting TGF-beta/SMAD signaling pathway, making it a promising therapeutic candidate for idiopathic pulmonary fibrosis (IPF).
PHARMACOLOGICAL RESEARCH
(2021)
Article
Immunology
Marc Kaethner, Kerstin Epping, Peter Bernthaler, Kilian Rudolf, Irena Thomann, Nadine Leitschuh, Monika Bergmann, Markus Spiliotis, Uriel Koziol, Klaus Brehm
Summary: This study reveals the crucial role of the TGF beta/BMP signaling pathway in anterior pole formation and protoscolex development of Echinococcus. Both host-derived TGF beta/BMP ligands and parasite-derived TGF beta homolog EmACT promote protoscolex development, while inhibition of TGF beta/BMP receptors hinders protoscolex differentiation.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Xinyi Wang, Ting Liu, Yifei Huang, Yifeng Dai, Hui Lin
Summary: Fibrosis is a complex abnormal healing process that involves multiple signaling pathways, with the TGF-beta signaling pathway playing a central role. TGF-beta precisely regulates fibrogenesis by controlling gene transcription and translation, and SUMOylation has been identified as a key player in this process, providing potential therapeutic strategies for fibrosis.
Article
Plant Sciences
Shu-Fang Huang, Yu-Lun Wang, Jih-Jung Chen, Yaw-Bin Huang, Shun-Ban Tai, Chih-Ling Chung, Chun-Lin Chen
Summary: The study demonstrates that Garcimultiflorone K (GMK) extracted from Garcinia multiflora inhibits TGF-beta signaling in hepatocellular carcinoma cells, attenuating metastasis and the disease-promoting effects of epithelial-mesenchymal transition (EMT). GMK was found to suppress TGF-beta-induced cellular responses such as Smad protein phosphorylation, cell migration, and extracellular matrix production.
Review
Biochemistry & Molecular Biology
Fanyuan Yu, Changhao Yu, Feifei Li, Yanqin Zuo, Yitian Wang, Lin Yao, Chenzhou Wu, Chenglin Wang, Ling Ye
Summary: Wnt/β-catenin signaling plays a critical role in human cancers, associated with cancer progression, prognosis, and mortality. Despite the development of therapies targeting this pathway, there are challenges in translating them into clinical practice.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Review
Cell Biology
Keywan Mortezaee, Jamal Majidpoor
Summary: The low frequency of durable responses in patients treated with immune checkpoint inhibitors (ICIs) requires additional strategies to enhance immune responses against cancer. Transforming growth factor-beta (TGF-beta) is a cytokine often expressed in tumors and promotes an immunosuppressive tumor microenvironment (TME). TGF-beta also influences the efficacy of anti-PD-1/PD-L1 therapy. Combining TGF-beta inhibitors with anti-PD(L)1 has shown promising results, and clinical trials are currently underway to investigate the use of agents with bifunctional capacity and fusion proteins to reinvigorate immune responses against advanced stage cancers, particularly those with an immunologically cold ecosystem.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Oncology
Jie Sheng, Xin He, Wei Yu, Yingxi Chen, Yuxiang Long, Kejian Wang, Shujuan Zhu, Qian Liu
Summary: Glioma, the most prevalent intracranial tumor, is regulated by a positive feedback loop involving the p53/ST7-AS1/PTBP1 axis, which may serve as a promising therapeutic target for glioma treatment.
Article
Cell Biology
Ziyan Zhang, Xuemin Gao, Yang He, Yumeng Kang, Fuyu Jin, Yaqian Li, Tian Li, Zhongqiu Wei, Shifeng Li, Wenchen Cai, Na Mao, Shan Wang, Heliang Liu, Fang Yang, Hong Xu, Jie Yang
Summary: This study identified the role of miR-411-3p in bleomycin-induced skin fibrosis and skin fibroblast transformation, finding that overexpression of miR-411-3p can inhibit the TGF-beta/Smad signaling pathway by targeting Smurf2, thereby suppressing fibrosis.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Cell Biology
Hanane Akboua, Kaveh Eghbalzadeh, Ugur Keser, Thorsten Wahlers, Adnana Paunel-Gorgulu
Summary: The activation of TGF-beta in the infarcted heart can lead to adverse cardiac remodeling and heart failure by persistently activating cardiac fibroblasts. PAD4 plays a role in regulating non-canonical TGF-beta signaling, affecting the functional characteristics of CFs and myofibroblast transdifferentiation.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Immunology
Qiong Wang, Yubao Cui, Xufeng Wu, Junfang Wang
Summary: The study showed that riparin II has protective effects against asthma by reducing inflammatory cell and IgE levels, increasing interferon levels, and decreasing airway remodelling in the lung. Treatment with riparin II in combination with ephedrine further ameliorates the hyperresponsiveness of lung tissue in asthmatic rats.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Kiyo Sasaki, Nobuo Takeshita, Tomohiro Fukunaga, Masahiro Seiryu, Mayuri Sakamoto, Toshihito Oyanagi, Toshihiro Maeda, Teruko Takano-Yamamoto
Summary: This study examined the role of TGF-beta in the acceleration of orthodontic tooth movement by supplementary vibration. The results showed that supplementary vibration increased the production of TGF-beta 1 in osteocytes, which then induced osteoclastogenesis and accelerated tooth movement.
EUROPEAN JOURNAL OF ORTHODONTICS
(2022)
Article
Cardiac & Cardiovascular Systems
Yukihiro Yoshida, Masaya Yotsukura, Kazuo Nakagawa, Hirokazu Watanabe, Noriko Motoi, Shun-Ichi Watanabe
Summary: This study found that the locations and the number of stations of the positive lymph nodes were identified as prognostic factors in patients with pN1 NSCLC. The primary mode of recurrence was distant recurrence irrespective of postoperative adjuvant chemotherapy.
THORACIC AND CARDIOVASCULAR SURGEON
(2021)
Letter
Cell Biology
Masayuki Ota, Yukio Nakatani, Takahiro Nakajima, Kenzo Hiroshima, Noriko Motoi, Ichiro Yoshino, Jun-ichiro Ikeda
Letter
Oncology
Sayaka Arakawa, Tatsuya Yoshida, Masayuki Shirasawa, Daisuke Takayanagi, Shigehiro Yagishita, Noriko Motoi, Yuichiro Ohe
Article
Oncology
Toshiaki Takahashi, Hitomi Umeguchi, Akiko Tateishi, Tatsuya Yoshida, Noriko Motoi, Yuichiro Ohe
Summary: When CNS symptoms develop immediately after discontinuation of osimertinib, the possibility of a CNS disease flare should be considered even in the absence of radiological or cytological findings.
Article
Genetics & Heredity
Sho Ueda, Satoshi Yamashita, Shun-ichi Watanabe, Mika Wakabayashi, Noriko Motoi, Masayuki Noguchi, Shigeki Sekine, Yukio Sato, Toshikazu Ushijima
Summary: The study assessed the accuracy of measuring DNA in formalin-fixed and paraffin-embedded tissue samples using the Infinium MethylationEPIC BeadChip assay. Results showed that the correlation coefficient decreased with DNA degradation, even when meeting quality control standards. Exclusion of specific probes improved correlation, regardless of tissue type, suggesting potential for assay accuracy improvement.
Review
Cell Biology
Erik Thunnissen, Noriko Motoi, Yuko Minami, Daisuke Matsubara, Wim Timens, Yukio Nakatani, Yuichi Ishikawa, Ximena Baez-Navarro, Teodora Radonic, Hans Blaauwgeers, Alain C. Borczuk, Masayuki Noguchi
Summary: This review summarises the use of elastin staining in pulmonary pathology, focusing especially on the interpretation of elastin staining in pulmonary adenocarcinomas and the distinction between iatrogenic collapse and alveolar collapse.
Article
Oncology
Rintaro Noro, Kazufumi Honda, Kengo Nagashima, Noriko Motoi, Shinobu Kunugi, Jun Matsubayashi, Susumu Takeuchi, Hideaki Shiraishi, Tetsuya Okano, Ayumi Kashiro, Xue Meng, Yukihiro Yoshida, Shunichi Watanabe, Jitsuo Usuda, Tatsuya Inoue, Huang Wilber, Norihiko Ikeda, Masahiro Seike, Akihiko Gemma, Kaoru Kubota
Summary: This study aimed to provide predictive biomarkers for selecting postoperative adjuvant chemotherapy. The results showed that ACTN4 gene amplification was associated with better recurrence-free survival in the adjuvant chemotherapy group in patients aged 65 or older.
Article
Oncology
Kotaro Sugawara, Takashi Fukuda, Yutaka Kishimoto, Daiji Oka, Takako Yoshii, Hiroki Hara, Yukari Uemura, Yoshiyuki Kawashima, Hiroaki Kanda, Noriko Motoi
Summary: This study investigated the intratumoral heterogeneity (ITH) and the potential of tumor surface in representing the tumor microenvironment (TME) in esophageal squamous cell carcinoma (ESCC). The results showed significant differences in ITH among ESCC specimens, and the tumor surface had high capabilities in predicting the CD8 and PD-L1 status of the whole tumor.
Review
Cell Biology
Eiichi Morii, Yutaka Hatanaka, Noriko Motoi, Akihiko Kawahara, Shinji Hamakawa, Takeshi Kuwata, Tadasuke Nagatomo, Yoshinao Oda, Aikou Okamoto, Ryota Tanaka, Akira Iyoda, Maeda Ichiro, Yukiko Matsuo, Nobuyuki Nakamura, Tokiko Nakai, Mei Fukuhara, Kazuya Tokita, Tomohiko Yamaguchi, Masataka Takenaka, Ayako Kawabata, Kanako C. Hatanaka, Kaho Tsubame, Yukitoshi Satoh
Summary: With the advancement of cancer drug therapy, personalized medicine is becoming more common. Genomic testing is often performed using pathological tissue from malignant tumors, while cytological specimens fixed in alcohol are preferred for preserving nucleic acid quality and quantity. This article shares information on the proper handling of cytological specimens in genomic medicine based on guidelines published by the Japanese Society of Clinical Cytology. The guidelines provide practical advice on specimen handling, including fixation, preparation, and evaluation.
Article
Pathology
Masahiro Higashiyama, Noriko Motoi, Masaya Yotsukura, Yukihiro Yoshida, Kazuo Nakagawa, Shigehiro Yagishita, Masayuki Shirasawa, Tatsuya Yoshida, Kouya Shiraishi, Takashi Kohno, Yuichiro Ohe, Shun-ichi Watanabe
Summary: Ciliated muconodular papillary tumor/bronchiolar adenoma (CMPT/BA) is a recently introduced benign lung tumor. This study aimed to investigate the clinicopathological characteristics and genetic profiles of coexisting primary lung cancer and CMPT/BA (LCCM) cases. Eight LCCM cases were identified, showing differences in gene mutation profiles between CMPT/BA and lung cancer, suggesting independent clonal tumorigenesis.
PATHOLOGY INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Kiyohiro Ando, Ryo Kurashina, Noriko Motoi, Toshihiko Iizuka, Masaharu Inoue, Riko Maruyama, Kouki Mitani, Hisanori Takenobu, Masayuki Haruta, Ritsuko Onuki, Yoh Matsuoka, Takehiko Kamijo, Yukio Kageyama
Summary: Our study found a significant correlation between low hemoglobin levels and high platelet-to-lymphocyte ratio (PLR) and overall survival in UC patients who did not benefit from Pembrolizumab treatment. We also identified a possible link between PDGF-DD-induced STAT3 activation and these unfavorable prognostic indicators in UC. By inhibiting STAT3 and detecting PDGF-DD in the tumor microenvironment, we suggest a potential therapeutic strategy to overcome resistance to Pembrolizumab.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Oncology
Tomohiro Tanaka, Yasushi Goto, Masafumi Horie, Ken Masuda, Yuki Shinno, Yuji Matsumoto, Yusuke Okuma, Tatsuya Yoshida, Hidehito Horinouchi, Noriko Motoi, Yasushi Yatabe, Shunichi Watanabe, Noboru Yamamoto, Yuichiro Ohe
Summary: This study investigates somatic single-nucleotide variants or copy number variations in exceptional responders to pemetrexed treatment using whole-exome sequencing. The results suggest that exceptional responders may have a higher number of copy number variations. This study provides important insights into the mechanism of exceptional responses and contributes to genomic findings on thymomas and chemosensitivity.
Article
Oncology
Kazunori Aoki, Yukari Nishito, Noriko Motoi, Yasuhito Arai, Nobuyoshi Hiraoka, Tatsuhiro Shibata, Yukiko Sonobe, Yoko Kayukawa, Eri Hashimoto, Mina Takahashi, Etsuko Fujii, Takashi Nishizawa, Hironori Fukuda, Kana Ohashi, Kosuke Arai, Yukihiro Mizoguchi, Yukihiro Yoshida, Shun-ichi Watanabe, Makiko Yamashita, Shigehisa Kitano, Hiromi Sakamoto, Yuki Nagata, Risa Mitsumori, Kouichi Ozaki, Shumpei Niida, Yae Kanai, Akiyoshi Hirayama, Tomoyoshi Soga, Toru Maruyama, Keisuke Tsukada, Nami Yabuki, Mei Shimada, Takehisa Kitazawa, Osamu Natori, Noriaki Sawada, Atsuhiko Kato, Teruhiko Yoshida, Kazuki Yasuda, Hideaki Mizuno, Hiroyuki Tsunoda, Atsushi Ochiai
Summary: This study analyzed the TIL profiles of 281 NSCLC tissues and classified NSCLC into three subtypes based on TIL status, which were significantly correlated with patient prognosis. Integrated genomic and transcriptomic analyses revealed subtype-specific molecular pathways and genomic alterations that should play important roles in constructing immune tumor microenvironments. These classifications based on TIL status are useful for developing personalized immune therapies for NSCLC.
CANCER RESEARCH COMMUNICATIONS
(2023)
Article
Pathology
Mitsuyoshi Hirokawa, Masahiro Ito, Noriko Motoi, Tomohiro Chiba, Yoshiaki Imamura, Hironao Yasuoka, Rumi Hino, Miyoko Higuchi, Akira Miyauchi, Takashi Akamizu
Summary: This multi-institutional study investigated the frequency and diagnostic significance of non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) in Japan. The study found that NIFTP was more common in follicular thyroid adenoma (FTA) than in non-invasive encapsulated follicular variant of papillary thyroid carcinoma (PTC). Additionally, NIFTP with nuclear score 3 showed potential for metastasis and BRAFV600E mutation.
PATHOLOGY INTERNATIONAL
(2023)
