Article
Health Care Sciences & Services
Ziyi Lin, Lu Cheng, Xue Han, Hongqiong Wang, Yuhua Liao, Lan Guo, Jingman Shi, Beifang Fan, Kayla M. Teopiz, Muhammad Youshay Jawad, Huimin Zhang, Yan Chen, Ciyong Lu, Roger S. Mcintyre
Summary: Due to a lack of mental health services and significant stigma toward mental illness, many Chinese individuals with major depressive disorder (MDD) do not receive treatment. This study evaluated the efficacy of internet-based cognitive behavioral therapy (ICBT) in treating depressive symptoms in MDD patients. The results showed that ICBT led to significant improvements in depressive symptoms, anxiety symptoms, and psychological distress, as well as increased general self-efficacy. The ICBT program was well-accepted and satisfying for the participants.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Article
Health Care Sciences & Services
Paul Ritvo, Yuliya Knyahnytska, Meysam Pirbaglou, Wei Wang, George Tomlinson, Haoyu Zhao, Renee Linklater, Shari Bai, Megan Kirk, Joel Katz, Lillian Harber, Zafiris Daskalakis
Summary: The study demonstrated that online mindfulness-based cognitive behavioral therapy is an effective treatment for youth depression, showing significant improvements in depression, anxiety, and pain levels. The results suggest the potential feasibility and advantages of using online CBT-M in the treatment of depression in young adults.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2021)
Article
Psychology, Clinical
Astrid Langergaard, Kim Mathiasen, Jesper Sondergaard, Sabrina S. Sorensen, Sidsel L. Laursen, Alexander A. P. Xylander, Mia B. Lichtenstein, Lars H. Ehlers
Summary: This study aimed to compare the cost-effectiveness of blended cognitive-behavioral therapy (CBT) and standard CBT for adult patients with major depressive disorder (MDD). The results showed that blended CBT was cost-saving but resulted in a loss in quality-adjusted life-years (QALYs) compared to standard CBT. However, the small sample size calls for cautious interpretation of the results.
INTERNET INTERVENTIONS-THE APPLICATION OF INFORMATION TECHNOLOGY IN MENTAL AND BEHAVIOURAL HEALTH
(2022)
Article
Clinical Neurology
Stephan Heinzel, Melanie Schwefel, Alba Sanchez, Darlene Heinen, Lydia Fehm, Romy Henze, Christina Teran, Gunnar Kallies, Michael A. Rapp, Thomas Fydrich, Andreas Strohle, Andreas Heissel
Summary: The study found that high-intensity physical exercise did not universally enhance the outcome of CBT, but higher levels of physical fitness improvement seem to aid in symptom change during CBT. Therefore, future research and clinical practice might consider more individually tailored exercise programs.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychiatry
Mizuki Amano, Nariko Katayama, Satoshi Umeda, Yuri Terasawa, Hajime Tabuchi, Toshiaki Kikuchi, Takayuki Abe, Masaru Mimura, Atsuo Nakagawa
Summary: This study found that patients with major depressive disorder (MDD) who received cognitive behavioral therapy (CBT) showed reduced response time for positive and negative valence in the future thinking task. CBT had a positive impact on future thinking in MDD patients, but more large-scale trials are needed to confirm these findings.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Psychiatry
Nazanin Alavi, Elnaz Moghimi, Callum Stephenson, Gilmar Gutierrez, Jasleen Jagayat, Anchan Kumar, Yijia Shao, Shade Miller, Caitlin S. Yee, Anthi Stefatos, Maedeh Gholamzadehmir, Zara Abbaspour, Amirhossein Shirazi, Tessa Gizzarelli, Ferwa Khan, Charmy Patel, Archana Patel, Megan Yang, Mohsen Omrani
Summary: The increased prevalence of major depressive disorder (MDD) during the COVID-19 pandemic has led to a growth in online mental health care delivery. Online cognitive behavioral therapy (e-CBT) is a time-flexible and cost-effective method for improving MDD symptoms. This study compared the efficacy of therapist-supported e-CBT and in-person therapy in individuals diagnosed with MDD.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Clinical Neurology
Nariko Katayama, Atsuo Nakagawa, Satoshi Umeda, Yuri Terasawa, Takayuki Abe, Chika Kurata, Yohei Sasaki, Dai Mitsuda, Toshiaki Kikuchi, Hajime Tabuchi, Masaru Mimura
Summary: The study suggests that cognitive behavioral therapy may improve future thinking in depressed patients by modulating frontopolar cortex function differently from unstructured psychotherapy. Larger clinical trials are needed to confirm if BA10 activity can serve as a neuromarker for successful depression treatment with CBT.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Nutrition & Dietetics
Jihee Choi, Jong-Hoon Kim, Miey Park, Hae-Jeung Lee
Summary: This study aimed to assess the effects of flavonoid-rich orange juice on young people diagnosed with depression. The results showed that orange juice intake improved depressive symptoms and caused changes in blood markers.
Article
Psychiatry
Wei Peng, Yang Wang, Qinghong Hao, Jun Wang, Yalin Chen, Mimi Qiu, Yang Tu, Hui Li, Tianmin Zhu
Summary: The study demonstrated the efficacy of acupuncture and psychological intervention in treating IAD from an electrophysiological perspective. Additionally, the increase in CNV amplitude may be the underlying neurophysiological mechanism by which CI improves depression and cognitive function in IAD patients.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Psychiatry
Margot Paul, Kim Bullock, Jeremy Bailenson
Summary: This study explored the feasibility and clinical efficacy of using virtual reality (VR) as a method of delivering behavioral activation (BA) for individuals diagnosed with major depressive disorder (MDD). Results demonstrated that VR BA is safe, feasible, and may have potential clinical utility for treating MDD, with promising indications of efficacy.
JMIR MENTAL HEALTH
(2022)
Article
Health Care Sciences & Services
Yiwen Wu, Xin Li, Yuxin Zhou, Rui Gao, Kaifeng Wang, Huiling Ye, Na Lyu, Chun Wang, Ning Zhang, Zhen Wang, Qing Fan
Summary: This study compares the efficacy and cost-effectiveness of internet-based cognitive behavioral therapy (ICBT) combined with medication, face-to-face cognitive behavioral group therapy (CBGT) combined with medication, and conventional medical treatment for adults with obsessive-compulsive disorder (OCD). The results show that ICBT combined with medication is as effective as CBGT combined with medication for treating OCD and is more cost-effective.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Article
Psychology, Clinical
Britta Westerberg, Fredrik Hollandare, Susanne Bejerot
Summary: This study aimed to evaluate the feasibility and effects of an internet-based intervention for adults with ASD. The intervention showed satisfactory adherence and participant satisfaction, but no significant effects on quality of life, sense of coherence, or psychiatric symptoms were found. Autism traits were found to be associated with negative outcomes.
INTERNET INTERVENTIONS-THE APPLICATION OF INFORMATION TECHNOLOGY IN MENTAL AND BEHAVIOURAL HEALTH
(2023)
Article
Psychiatry
Sunniva Brurok Myklebost, Rolf Gjestad, Yavuz Inal, Asa Hammar, Tine Nordgreen
Summary: This study aimed to explore factors associated with treatment response to a guided internet-delivered intervention for former depressed adults with residual cognitive symptoms. The results suggest that individuals with shorter duration of previous depressions may have larger reductions in residual cognitive symptoms, and treatment credibility and expectancy also predict treatment response.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Health Care Sciences & Services
Ieva Biliunaite, Evaldas Kazlauskas, Robbert Sanderman, Inga Truskauskaite-Kuneviciene, Austeja Dumarkaite, Gerhard Andersson
Summary: The study evaluated the effects of therapist-guided 8-week-long ICBT intervention for informal caregivers and found that it effectively reduced caregiver burden, anxiety, depression, stress, and improved quality of life. Participants experienced little difficulty in using the program and were mostly satisfied with the intervention's platform and content.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2021)
Article
Psychiatry
Evgenia E. Psarraki, Flora Bacopoulou, Eustathios Panagoulias, Maria Michou, Panagiotis Pelekasis, Artemios Artemiadis, George P. Chrousos, Christina Darviri
Summary: A randomized clinical trial implemented a holistic stress management program, PSAI, for adults with MDD, showing that the intervention group had greater reductions in depressive symptoms, perceived stress, and negative affect, along with improvements in visual memory and healthy lifestyle compared to the control group.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Psychology, Clinical
Glenn Kiekens, Penelope Hasking, Ronny Bruffaerts, Jordi Alonso, Randy P. Auerbach, Jason Bantjes, Corina Benjet, Mark Boyes, Wai Tat Chiu, Laurence Claes, Pim Cuijpers, David D. Ebert, Arthur Mak, Philippe Mortier, Siobhan O'Neill, Nancy A. Sampson, Dan J. Stein, Gemma Vilagut, Matthew K. Nock, Ronald C. Kessler
Summary: Non-suicidal self-injury (NSSI) is common among college students and is a behavioral marker of various common mental disorders.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Clinical
Mathilde M. Husky, Ekaterina Sadikova, Sue Lee, Jordi Alonso, Randy P. Auerbach, Jason Bantjes, Ronny Bruffaerts, Pim Cuijpers, David D. Ebert, Raul Gutierrez Garcia, Penelope Hasking, Arthur Mak, Margaret McLafferty, Nancy A. Sampson, Dan J. Stein, Ronald C. Kessler
Summary: This study examines the relationship between childhood adversities and lifetime mental disorders, 12-month disorder persistence, and impairment among incoming college students. The findings suggest that childhood adversities are associated with the onset and impairment of mental disorders, but not with disorder persistence.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychiatry
Kira L. Alqueza, David Pagliaccio, Katherine Durham, Apoorva Srinivasan, Jeremy G. Stewart, Randy P. Auerbach
Summary: This study examined the correlates of suicidal thoughts and behaviors (STBs) among psychiatric inpatients. The results showed that suicidal ideation occurred during early adolescence, with more than half of the patients making a plan and one-third attempting suicide. The strongest correlates were depressive disorders, physical abuse, and non-suicidal self-injury. Knowing a peer with a history of suicide attempts also increased the likelihood of attempting suicide.
ARCHIVES OF SUICIDE RESEARCH
(2023)
Article
Psychology, Clinical
Nicholas A. Hubbard, Randy P. Auerbach, Viviana Siless, Nicole Lo, Isabelle R. Frosch, Danielle E. Clark, Robert Jones, Rebecca Kremens, Megan Pinaire, Flavia Vaz-DeSouza, Satrajit S. Ghosh, Aude Henin, Stefan G. Hofmann, Diego A. Pizzagalli, Isabelle M. Rosso, Anastasia Yendiki, Susan Whitfield-Gabrieli, John D. E. Gabrieli
Summary: Adolescents with anxiety or depression show cognitive biases towards negative emotional information processing. This study found that reduced changes in brain connectivity patterns between conditions where adolescents needed to ignore or attend to fearful faces were associated with a shared dimension of anxious and depressive symptoms. The findings suggest a failure to adapt communication patterns with sensory-representation areas in the presence of negative emotional information, which may explain the biases common to anxiety and depression in adolescents.
CLINICAL PSYCHOLOGICAL SCIENCE
(2023)
Article
Psychology, Clinical
Eirini Karyotaki, Anke M. Klein, Marketa Ciharova, Felix Bolinski, Lisa Krijnen, Lisa de Koning, Leonore de Wit, Claudia M. van der Heijde, David D. Ebert, Heleen Riper, Neeltje Batelaan, Peter Vonk, Randy P. Auerbach, Ronald C. Kessler, Ronny Bruffaerts, Sascha Struijs, Reinout W. Wiers, Pim Cuijpers
Summary: Common mental disorders such as depression and anxiety often emerge in college students during the transition to early adulthood. Offering internet-based interventions to college students with mental health problems could be a promising way to provide accessible treatment. However, this study found no evidence of the effectiveness of guided web-based transdiagnostic individually tailored Cognitive Behavioral Therapy (iCBT) compared to treatment as usual for college students with depression and/or anxiety symptoms.
BEHAVIOUR RESEARCH AND THERAPY
(2022)
Article
Psychology, Clinical
Shir Hanuka, Elizabeth A. Olson, Roee Admon, Christian A. Webb, William D. S. Killgore, Scott L. Rauch, Isabelle M. Rosso, Diego A. Pizzagalli
Summary: This study suggests that internet-based cognitive-behavioral therapy (iCBT) may reduce anhedonia severity in patients with major depressive disorder (MDD) and this therapeutic effect may be accompanied by enhanced reward circuit reactivity.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Developmental
Emma M. Millon, Kira L. Alqueza, Rahil A. Kamath, Rachel Marsh, David Pagliaccio, Hilary P. Blumberg, Jeremy G. Stewart, Randy P. Auerbach
Summary: Non-suicidal self-injury (NSSI) is a serious public health concern among adolescents, with high prevalence rates. Factors such as depressive disorder, sexual abuse, and comorbidity are associated with experiencing NSSI thoughts and behaviors, and longitudinal studies are needed to investigate interventions that can reduce the persistence of NSSI.
CHILD PSYCHIATRY & HUMAN DEVELOPMENT
(2022)
Article
Psychology, Developmental
Randy P. Auerbach, Ranqing Lan, Hanga Galfalvy, Kira L. Alqueza, Jeffrey F. Cohn, Ryann N. Crowley, Katherine Durham, Karla J. Joyce, Lauren E. Kahn, Rahil A. Kamath, Louis-Philippe Morency, Giovanna Porta, Apoorva Srinivasan, Jamie Zelazny, David A. Brent, Nicholas B. Allen
Summary: Suicide is a leading cause of death among adolescents, but there are no clinical tools currently available to detect proximal risk for suicide. This study demonstrates that intensive longitudinal assessment through the use of personal smartphones offers a feasible method to assess variability in adolescents' emotional experiences and suicide risk.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Jiahe Zhang, Jovicarole Raya, Francesca Morfini, Zoi Urban, David Pagliaccio, Anastasia Yendiki, Randy P. Auerbach, Clemens C. C. Bauer, Susan Whitfield-Gabrieli
Summary: Adolescents have alarmingly high rates of major depressive disorder (MDD), but current gold-standard treatments are only effective for about 50% of them. Therefore, there is a critical need for novel interventions that target neural mechanisms believed to potentiate depressive symptoms. This study developed a mindfulness-based fMRI neurofeedback (mbNF) for adolescents that aims to reduce default mode network (DMN) hyperconnectivity, which is implicated in the onset and maintenance of MDD. The results demonstrate that personalized mbNF can effectively and non-invasively modulate the intrinsic networks associated with the emergence and persistence of depressive symptoms during adolescence.
MOLECULAR PSYCHIATRY
(2023)
Review
Psychology, Biological
Michael W. Lewis, Daniel E. Bradford, Edward F. Pace-Schott, Scott L. Rauch, Isabelle M. Rosso
Summary: Persistent fear is a major symptom of PTSD, and deficient fear extinction retention is considered to be a mechanism of the illness and a target of therapy. However, the evidence for deficient fear extinction in PTSD using laboratory paradigms is inconclusive, possibly due to methodological variations across studies. This study reviewed the literature to identify these methodological differences and conducted a Multiverse Analysis to measure their impact on statistical findings. The findings revealed inconsistent results for fear extinction retention in PTSD, but consistently elevated skin conductance response to a danger cue was found. The study discusses the methodological parameters contributing to inconsistent findings and their implications for future research.
Article
Psychology, Clinical
Penelope A. Hasking, Kealagh Robinson, Peter Mcevoy, Glenn Melvin, Ronny Bruffaerts, Mark E. Boyes, Randy P. Auerbach, Delia Hendrie, Matthew K. Nock, David A. Preece, Clare Rees, Ronald C. Kessler
Summary: A predictive algorithm was developed to identify college students at risk of suicidal behavior, and telehealth was used to reduce subsequent risk. The algorithm effectively identified high-risk individuals and decreased their likelihood of engaging in suicidal behavior through universal screening and remote intervention.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Biological
Michael W. Lewis, Daniel E. Bradford, Eylul Akman, Kevin Frederiks, Scott L. Rauch, Isabelle M. Rosso
Summary: Unconditioned responding (UCR) to an aversive stimulus is associated with defensive responding during fear acquisition, but its relationships with extinction training, PTSD symptom severity, and fearful traits are unknown. This study found that UCR, particularly unconditioned startle, is positively associated with defensive responding and fearful traits, but not with PTSD symptom severity.
Article
Neurosciences
Grace O. Allison, Rahil A. Kamath, Vivian Carrillo, Kira L. Alqueza, David Pagliaccio, George M. Slavich, Stewart A. Shankman, Randy P. Auerbach
Summary: This study found that self-referential processing biases persist during remission in adults with depression and may contribute to the occurrence of stress and depressive symptoms over time.
BIOLOGICAL PSYCHIATRY: GLOBAL OPEN SCIENCE
(2023)
Article
Psychology, Clinical
Randy P. Auerbach, Apoorva Srinivasan, Jaclyn S. Kirshenbaum, J. John Mann, Stewart A. Shankman
Summary: Depression recurrence is a significant issue and clinical tools are needed to detect symptom reemergence. This study found that remitted depressed adults have reduced circadian routine and lower average daily distance traveled. Mobile sensing approaches hold promise for improving clinical care for depressive disorders.
JOURNAL OF PSYCHOPATHOLOGY AND CLINICAL SCIENCE
(2022)
Article
Psychology, Multidisciplinary
Jason Bantjes, Elsie Breet, Wylene Saal, Christine Lochner, Janine Roos, Lian Taljaard, Philippe Mortier, Randy P. Auerbach, Ronny Bruffaerts, Ronald C. Kessler, Dan J. Stein
Summary: This study used a cross-sectional web-based survey and discrete-time survival analysis to estimate the prevalence and predictors of suicidal ideation, plan, and attempt among South African university students. The results showed that the lifetime prevalence of ideation, plan, and attempt were 46.4%, 26.5%, and 8.6% respectively. Multiple primary mental disorders predicted subsequent onset of suicidality and transitions from ideation to plan and attempt. The findings highlight the importance of campus-based suicide prevention, the vulnerability of historically disadvantaged students, and the promotion of mental health in suicide prevention.