Article
Psychology, Clinical
Wicher A. Bokma, Paul Zhutovsky, Erik J. Giltay, Robert A. Schoevers, Brenda W. J. H. Penninx, Anton L. J. M. van Balkom, Neeltje M. Batelaan, Guido A. van Wingen
Summary: This study aimed to predict recovery from anxiety disorders within 2 years using a machine learning approach. The results showed moderate performance in predicting recovery from anxiety disorders, with anxiety features being the most indicative for improvement.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Psychology, Clinical
Andre Pittig, Juliane M. Boschet, Valentina M. Gluck, Kristina Schneider
Summary: The study found that patients with anxiety disorders are unable to inhibit avoidance behavior in the presence of competing positive outcomes, offering a new perspective on the mechanisms and treatment of anxiety disorders. Interestingly, some patients exhibited persistent avoidance behavior, while others showed little to no avoidance, with this elevated costly avoidance not being linked to higher conditioned fear levels.
DEPRESSION AND ANXIETY
(2021)
Review
Biochemistry & Molecular Biology
Sonja Elsaid, Dafna S. Rubin-Kahana, Stefan Kloiber, Sidney H. Kennedy, Sofia Chavez, Bernard Le Foll
Summary: This systematic review examines the molecular pathogenesis of Social Anxiety Disorder (SAD) by evaluating data from proton magnetic resonance spectroscopic (H-1 MRS) studies. The study finds regional abnormalities in the fear neurocircuitry of patients with SAD, suggesting impairments in neuronal and glial cell function. Further cross-sectional studies with larger sample sizes are needed to validate these findings.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Psychology, Clinical
Yongrae Cho, Younghee Choi, Sunyoung Kim
Summary: The study revealed that the dimensions of panic appraisal, particularly anticipated panic and panic coping efficacy, uniquely predicted agoraphobic symptoms among patients with panic disorder, beyond the influence of anxiety sensitivity.
JOURNAL OF CLINICAL PSYCHOLOGY
(2021)
Article
Endocrinology & Metabolism
Dirk Alexander Wittekind, Jurgen Kratzsch, Roland Mergl, Steffi Riedel-Heller, A. Veronica Witte, Arno Villringer, Michael Kluge
Summary: The hormone ghrelin is believed to play a role in regulating anxiety. This study found a positive association between ghrelin and mild anxiety, suggesting that ghrelin may be involved in the regulation of physiological anxiety in humans. This association is similar to findings in animals regarding the effects of ghrelin in acute and chronic stress.
PSYCHONEUROENDOCRINOLOGY
(2022)
Article
Clinical Neurology
Borwin Bandelow, Antonia M. Werner, Ina Kopp, Sebastian Rudolf, Joerg Wiltink, Manfred E. Beutel
Summary: The 2014 German Guidelines for Anxiety Disorders have been revised by a consensus group in 2019, with the addition of 92 new RCTs. The guideline recommends the use of CBT as the primary psychological treatment, and SSRIs and SNRIs as first-line drugs for anxiety disorders. Alternative strategies should be considered for patients non-responsive to standard treatments.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2022)
Article
Psychiatry
Irena Milosevic, Duncan H. Cameron, Melissa Milanovic, Randi E. McCabe, Karen Rowa
Summary: Telehealth, including videoconferencing, is increasingly used in mental health care delivery. This study compared the outcomes of group CBT for anxiety disorders delivered via videoconference versus face-to-face, finding that videoconference CBT may be a promising alternative, though further research is needed to establish equivalence between the delivery formats.
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE
(2022)
Article
Psychology, Clinical
Solbjorg M. M. Saether, Marit Knapstad, Nick Grey, Otto R. F. Smith
Summary: In this study, it was found that the primary care service Prompt Mental Health Care (PMHC) is as effective as treatment as usual (TAU) for depression and anxiety, and no significant moderators of treatment effect were identified.
BEHAVIOUR RESEARCH AND THERAPY
(2022)
Article
Clinical Neurology
Seoyoung Yoon, Yong-Ku Kim
Summary: Anxiety and mood disorders are common and challenging to treat, and oxytocin is believed to have therapeutic effects. However, the results of studies on the relationship between oxytocin and these disorders are inconsistent, possibly due to factors such as participant characteristics and research methodology.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Review
Biochemistry & Molecular Biology
Alice Caldiroli, Enrico Capuzzi, Letizia M. M. Affaticati, Teresa Surace, Carla L. L. Di Forti, Antonios Dakanalis, Massimo Clerici, Massimiliano Buoli
Summary: Social anxiety disorder (SAD) is a common psychiatric condition that requires prompt treatment to prevent psychiatric comorbidity and impairment in social and occupational functioning. This study systematically reviewed the literature on potential biomarkers for SAD. While some preliminary evidence suggests the role of certain genes and neuroimaging findings in SAD, the results overall remain inconsistent and need further investigation on larger samples to identify more specific biomarkers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Psychiatry
Pasquale Roberge, Patricia Marx, Jonathan Couture, Nathalie Carrier, Annie Benoit, Martin D. Provencher, Martin M. Antony, Peter J. Norton
Summary: The study aimed to validate the Panic Disorder Severity Scale - Self-Report (PDSS-SR) in a French-Canadian population and examine its psychometric properties. The French version of PDSS-SR demonstrated good psychometric properties and can be used to assess the severity of panic disorder and changes in severity over time in both research and clinical practice.
Review
Physiology
Susanne Fischer, Florence Haas, Jana Strahler
Summary: The study aimed to investigate alterations in thermosensory/thermoregulatory system in individuals with anxiety disorders. Results showed no changes in thermosensation in specific phobia, while individuals with social anxiety and panic disorder may exhibit altered vasodilation and sweating. Longitudinal research is needed to explore whether these changes represent vulnerability to anxiety/panic.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Medicine, General & Internal
Kristin L. Szuhany, Naomi M. Simon
Summary: Anxiety disorders have a high prevalence in the US and significantly impact the quality of life and functioning of individuals. Common symptoms include worry, fear, and panic attacks. Screening measures can assist in diagnosing anxiety disorders. Cognitive behavioral therapy and pharmacotherapy, such as SSRIs and SNRIs, are the first-line treatments for anxiety disorders.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Article
Psychology, Clinical
J. Rubel, J. Quest, L. Pruessner, C. Timm, S. Hartmann, S. Barnow, L. Rittmeyer, D. Rosenbaum, C. Lalk
Summary: This study aims to evaluate the efficacy of an online self-help program for panic disorder and its benefits for the German healthcare system.
INTERNET INTERVENTIONS-THE APPLICATION OF INFORMATION TECHNOLOGY IN MENTAL AND BEHAVIOURAL HEALTH
(2022)
Article
Psychology, Clinical
Nicole E. Lorenzo, Danielle R. Novick, Kaylee Seddio, Kathryn A. Degnan, Heather A. Henderson, Alisa N. Almas, Andrea Chronis-Tuscano, Nathan Fox
Summary: This study explores the interactive effect of parenting behaviors and child temperament on the developmental trajectory of social anxiety from age 9 to 15. Results suggest that highly inhibited children benefit from high supportive and low dismissive parenting, while children low in behavioral inhibition benefit more from high dismissive parenting.
DEPRESSION AND ANXIETY
(2022)
Article
Psychiatry
Jasmine Turna, Beth Patterson, Carolina Goldman Bergmann, Nina Lamberti, Maryam Rahat, Heather Dwyer, Ana Paula Francisco, Matteo Vismara, Bernardo Dell'Osso, Beth Sideris, Michael Van Ameringen
Summary: The study found that despite differences in mental health among healthcare practitioners in different countries, the overall impact of the pandemic on mental health appeared to be similar. Canadian healthcare practitioners reported the highest rates of anxiety and depression, while non-healthcare practitioners in other countries reported higher symptom severity than healthcare practitioners.
INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE
(2022)
Article
Psychiatry
M. Van Ameringen, B. Patterson, J. Turna, G. Lethbridge, C. Goldman Bergmann, N. Lamberti, M. Rahat, B. Sideris, A. P. Francisco, N. Fineberg, S. Pallanti, G. Grassi, M. Vismara, U. Albert, R. Gedanke Shavitt, E. Hollander, J. Feusner, C. Rodriguez, P. Morgado, B. Dell'Osso
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Review
Psychiatry
Smadar V. Tourjman, Gabriella Buck, Didier Jutras-Aswad, Atul Khullar, Shane McInerney, Gayatri Saraf, Jairo V. Pinto, Stephane Potvin, Marie-Josee Poulin, Benicio N. Frey, Sidney H. Kennedy, Raymond W. Lam, Glenda MacQueen, Roumen Milev, Sagar V. Parikh, Arun Ravindran, Roger S. McIntyre, Ayal Schaffer, Valerie H. Taylor, Michael van Ameringen, Lakshmi N. Yatham, Serge Beaulieu
Summary: This task force report examines the association between cannabis use and bipolar disorder, major depressive disorder, and comorbid cannabis use disorder. The results indicate that cannabis use is associated with worsened course and functioning of both mood disorders, particularly in bipolar disorder. However, the treatment of comorbid cannabis use disorder and major depressive disorder did not show significant results.
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE
(2023)
Review
Psychiatry
Naomi A. Fineberg, Jose M. Menchon, Natalie Hall, Bernardo Dell'Osso, Matthias Brand, Marc N. Potenza, Samuel R. Chamberlain, Giovanna Cirnigliaro, Christine Lochner, Joel Billieux, Zsolt Demetrovics, Hans Jurgen Rumpf, Astrid Muller, Jesus Castro-Calvo, Eric Hollander, Julius Burkauskas, Edna Grunblatt, Susanne Walitza, Ornella Corazza, Daniel L. King, Dan J. Stein, Jon E. Grant, Stefano Pallanti, Henrietta Bowden-Jones, Michael Van Ameringen, Konstantinos Ioannidis, Lior Carmi, Anna E. Goudriaan, Giovanni Martinotti, Celia M. D. Sales, Julia Jones, Biljiana Gjoneska, Orsolya Kiraly, Beatrice Benatti, Matteo Vismara, Luca Pellegrini, Dario Conti, Ilaria Cataldo, Gianluigi M. Riva, Murat Yucel, Maeva Flayelle, Thomas Hall, Morgan Griffiths, Joseph Zohar
Summary: This article reviews the scientific progress and knowledge gaps in the field of problematic usage of the internet (PUI) and highlights the importance of research goals, including better understanding of the course and evolution of PUI-related problems, reliable methods for early identification of at-risk individuals, efficacious preventative and therapeutic interventions, and ethical health and social policy changes that safeguard digital rights.
COMPREHENSIVE PSYCHIATRY
(2022)
Article
Psychiatry
Beatrice Benatti, Nicolaja Girone, Laura Celebre, Matteo Vismara, Eric Hollander, Naomi A. Fineberg, Dan J. Stein, Humberto Nicolini, Nuria Lanzagorta, Donatella Marazziti, Stefano Pallanti, Michael van Ameringen, Christine Lochner, Oguz Karamustafalioglu, Luchezar Hranov, Martin Figee, Lynne M. Drummond, Jon E. Grant, Damiaan Denys, Leonardo F. Fontenelle, Jose M. Menchon, Joseph Zohar, Carolyn Rodriguez, Bernardo Dell'Osso
Summary: This study found significant differences between genders in OCD, with females having a higher proportion of adult onset, older age at illness onset, lower education level, higher marriage rate, and higher rate of living with a partner compared to males. However, there were no significant gender differences in the severity of OCD symptoms or comorbid depressive symptoms. The researchers suggest that gender may influence the heterogeneity of OCD and may require different treatment strategies.
COMPREHENSIVE PSYCHIATRY
(2022)
Article
Psychiatry
Borwin Bandelow, Christer Allgulander, David S. Baldwin, Daniel Lucas da Conceicao Costa, Damiaan Denys, Nesrin Dilbaz, Katharina Domschke, Eric Hollander, Siegfried Kasper, Hans-Juergen Moeller, Elias Eriksson, Naomi A. Fineberg, Josef Haettenschwiler, Hisanobu Kaiya, Tatiana Karavaeva, Martin A. Katzman, Yong-Ku Kim, Takeshi Inoue, Leslie Lim, Vasilios Masdrakis, Jose M. Menchon, Euripedes C. Miguel, Antonio E. Nardi, Stefano Pallanti, Giampaolo Perna, Dan Rujescu, Vladan Starcevic, Dan J. Stein, Shih-Jen Tsai, Michael Van Ameringen, Anna Vasileva, Zhen Wang, Joseph Zohar
Summary: According to the guideline by the World Federation of Societies of Biological Psychiatry, OCD and PTSD can be effectively treated with medications and CBT. SSRIs and CBT are first-line treatments for OCD, while SSRIs and venlafaxine are first-line treatments for PTSD.
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2023)
Article
Psychiatry
Borwin Bandelow, Christer Allgulander, David S. Baldwin, Daniel Lucas da Conceicao Costa, Damiaan Denys, Nesrin Dilbaz, Katharina Domschke, Elias Eriksson, Naomi A. Fineberg, Josef Hattenschwiler, Eric Hollander, Hisanobu Kaiya, Tatiana Karavaeva, Siegfried Kasper, Martin Katzman, Yong-Ku Kim, Takeshi Inoue, Leslie Lim, Vasilios Masdrakis, Jose M. Menchon, Euripedes C. Miguel, Hans-Jurgen Moller, Antonio E. Nardi, Stefano Pallanti, Giampaolo Perna, Dan Rujescu, Vladan Starcevic, Dan J. Stein, Shih-Jen Tsai, Michael Van Ameringen, Anna Vasileva, Zhen Wang, Joseph Zohar
Summary: This study presents the third version of the guideline for the pharmacological treatment of anxiety, obsessive-compulsive, and posttraumatic stress disorders. It provides recommendations based on efficacy and acceptability of available treatments, evaluated through rigorous methods. The study highlights the importance of selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) as first-line medications, and cognitive behavioral therapy (CBT) as the first-line psychotherapy for anxiety disorders.
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2023)
Review
Psychiatry
Amy Pipe, Nisha Ravindran, Angela Paric, Beth Patterson, Michael Van Ameringen, Arun V. Ravindran
Summary: ADHD affects 2-7% of children globally, but treatment outcomes in low-and middle-income countries are rarely reported. Pharmacological treatments, especially methylphenidate, are more available than psychological interventions in these regions. More research is needed to improve mental health services and access to treatment for ADHD in LMICs.
ASIAN JOURNAL OF PSYCHIATRY
(2022)
Review
Psychiatry
Joshua D. Rosenblat, M. Ishrat Husain, Yena Lee, Roger S. McIntyre, Rodrigo B. Mansur, David Castle, Hilary Offman, Sagar Parikh, Benicio N. Frey, Ayal Schaffer, Kyle T. Greenwaym, Nicolas Garel, Serge Beaulieu, Sidney H. Kennedy, Raymond W. Lam, Roumen Milev, Arun Ravindran, Valerie Tourjman, Michael Van Ameringen, Lakshmi N. Yatham, Valerie Taylor
Summary: There is currently only low-level evidence to support the efficacy and safety of psychedelics for major depressive disorder.
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE
(2023)
Article
Psychiatry
Peter J. van Roessel, Giacomo Grassi, Elias N. Aboujaoude, Jose M. Menchon, Michael Van Ameringen, Carolyn Rodriguez
Summary: Serotonin reuptake inhibitor (SRI) medications are the first-line pharmacotherapeutic treatment for Obsessive-Compulsive Disorder (OCD), but a substantial proportion of patients do not respond well to these medications. This review discusses the clinical features associated with poor response to SRIs and presents alternative therapies for treatment-resistant OCD. Pharmacotherapies targeting various neurotransmitter systems and anti-inflammatory pathways have shown preliminary evidence of efficacy.
COMPREHENSIVE PSYCHIATRY
(2023)
Review
Psychiatry
Ana Paula Francisco, Grace Lethbridge, Beth Patterson, Carolina Goldman Bergmann, Michael Van Ameringen
Summary: Treatment options for adult ADHD include stimulants, non-stimulant medications, and cognitive-behavioral therapy. Cannabis has been reported by patients to improve ADHD symptoms, but there is limited scientific literature on its effects. This study reviewed existing research on the effects of cannabis on ADHD symptoms and found mixed results.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Review
Substance Abuse
Marie N. S. Gendy, Benicio N. Frey, Michael Van Ameringen, Nirushi Kuhathasan, James MacKillop
Summary: Considering the limited availability of candidate medications for sleep disturbances in individuals with alcohol use disorder (AUD), this review critically examines the potential of cannabidiol (CBD) as a treatment for AUD-induced sleep disturbance. CBD's modulation of the endocannabinoid system and its favorable safety profile have generated substantial interest for its therapeutic use. Preclinical and clinical studies suggest promise for CBD in restoring normal sleep-wake cycle and enhancing sleep quality in AUD patients. Well-designed randomized controlled trials are needed to further investigate CBD's potential in managing this challenging feature of AUD.
ALCOHOL AND ALCOHOLISM
(2023)
Article
Psychiatry
Molly L. Scarfe, Kyla Belisario, Jessica Gillard, Jane De Jesus, Benicio N. Frey, Michael Van Ameringen, Margaret C. McKinnon, Mahmood R. Gohari, Jason W. Busse, James MacKillop
Summary: This study examined the mental health changes during the COVID-19 pandemic through 10 waves of data collection. Depression and anxiety showed significant changes, initially increasing and then decreasing over time. The severity of depression and anxiety before the pandemic moderated these changes, with lower severity participants experiencing increases and higher severity participants showing no significant change or decreases. Approximately 10% to 11% exhibited minimal important differences (MID) increases in depression and anxiety, while approximately 4% to 6% exhibited MID decreases.
PSYCHIATRY RESEARCH
(2023)
Meeting Abstract
Neurosciences
Michael Van Ameringen, Barbara T. M. Q. dos Santos, Beth Patterson, Maryam Rahat, Juliette Mojgani, Grace Lethbridge, Fernando Sumiya, Carolina Goldman Bergmann
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Jasmine Turna, Iris Balodis, Michael Van Ameringen, Jason W. Busse, James MacKillop
Summary: This study provides a comprehensive description of attitudes towards cannabis among Canadian adults before legalization. The results show that most individuals hold positive attitudes towards medical cannabis and have a realistic perception of the risks associated with cannabis use. However, a notable proportion of individuals underestimate the risk of cannabis use disorder and overestimate the benefits for mental health.
CANNABIS AND CANNABINOID RESEARCH
(2022)