Review
Nutrition & Dietetics
Laurien Ulfman, Angela Tsuang, Aline B. Sprikkelman, Anne Goh, R. J. Joost van Neerven
Summary: The incidence of food allergies has increased worldwide in the past 20 years. Early introduction of allergenic foods has been shown to reduce the risk of allergies, but less is known about the introduction of cow's milk. Recent studies suggest that early introduction of cow's-milk-based formulas with intact milk proteins can reduce the risk of cow's milk allergy, while very early introduction followed by discontinuation may increase the risk.
Article
Food Science & Technology
Natalia Zofia Maryniak, Ana Isabel Sancho, Egon Bech Hansen, Katrine Lindholm Bggh
Summary: Cow's milk allergy is the most prevalent type of food allergy among infants. There is a growing demand for more options for infant feeding, especially for the prevention and management of cow's milk allergy. Milk from other mammalian sources and proteins from plant sources have gained increased interest due to their potentially lower allergenicity.
Article
Nutrition & Dietetics
Nicolette W. de Jong, Marloes E. van Splunter, Joyce A. M. Emons, Kasper A. Hettinga, Roy Gerth van Wijk, Harry J. Wichers, Huub F. J. Savelkoul, Aline B. Sprikkelman, R. J. Joost van Neerven, Liu Liu, Gerbrich van der Meulen, Irene Herpertz, Yvonne C. M. Duijvestijn, Mijke Breukels, Marianne I. Brouwer, Jaap Schilperoord, Olga van Doorn, Berber Vlieg-Boerstra, Jochum van den Berg, Linette Pellis, Severina Terlouw, Astrid I. Hendriks, Marco W. J. Schreurs, Frank E. van Boven, Nicolette J. T. Arends
Summary: The aim of this study was to evaluate the safety and tolerability of a new heated cow's milk protein product in cow's milk allergic children. The results showed that 72% of the children tolerated the product, while some experienced adverse events. Skin prick tests and specific IgE levels may predict the tolerability of the product.
Review
Pediatrics
Khaled Saad, Anas Elgenidy, Mostafa Atef, Mostafa K. Abdelsattar, Mahmoud Al-Ashwah, Emad M. Hammad, Faisal-Alkhateeb Ahmed, Amir Aboelgheet, Mohamed Shawky Elfarargy, Ahmad M. Ali, Amira H. El-Ashry, Hamad Ghaleb Dailah, Amira Elhoufey, Samaher F. Taha
Summary: This study assessed the ability of Cow's Milk-related Symptom Score (CoMiss) in screening cow's milk protein allergy (CMPA). The results showed that CoMiss may be a promising symptom score in CMPA awareness and a useful tool in monitoring the response to a cow's milk-free diet.
PEDIATRIC RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Kai Zhang, Lina Zhang, Ruoya Zhou, Jinjing Zhong, Kui Xie, Yanmei Hou, Peng Zhou
Summary: This study aimed to compare the sensitization of alpha(S1)-CN in cow and goat's milk in a mouse model. The results showed that cow's milk alpha(S1)-CN had higher allergenicity than goat's milk alpha(S1)-CN and the sensitization of cow's milk alpha(S1)-CN damaged the intestinal barrier of mice and resulted in an increase of IFN-gamma. Additionally, mice allergic to cow's milk alpha(S1)-CN were less sensitized to goat's milk alpha(S1)-CN.
Article
Food Science & Technology
Natalia Zofia Maryniak, Mette Halkjaer Stage, Anne-Sofie Ravn Ballegaard, Ana Isabel Sancho, Egon Bech Hansen, Katrine Lindholm Bogh
Summary: Currently, there are no specific recommendations for using any particular infant formula to prevent cow's milk allergy. There is increasing interest in alternative infant formulas made from milk proteins from animals other than cows, but their ability to prevent cow's milk allergy has not been studied.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Nutrition & Dietetics
Frank E. E. van Boven, Nicolette J. T. Arends, Aline B. B. Sprikkelman, Joyce A. M. Emons, Astrid I. I. Hendriks, Marloes van Splunter, Marco W. J. Schreurs, Severina Terlouw, Roy Gerth van Wijk, Harry J. J. Wichers, Huub F. J. Savelkoul, R. J. Joost van Neerven, Kasper A. Hettinga, Nicolette W. W. de Jong
Summary: Accelerating tolerance induction to cow's milk can reduce the burden of cow's milk allergy. This study aimed to investigate the tolerance induction of a novel heated cow milk protein in children with cow's milk allergy. Results showed that 73% of children in the treatment group had a negative food challenge test, compared to 57% in the control group.
Review
Nutrition & Dietetics
Katerina Bajerova, Silvia Salvatore, Christophe Dupont, Philippe Eigenmann, Mikael Kuitunen, Rosan Meyer, Carmen Ribes-Koninckx, Raanan Shamir, Hania Szajewska, Yvan Vandenplas
Summary: This review summarizes the current evidence on the Cow's Milk-related Symptom Score (CoMiSS), which is a clinical tool used to assess symptoms possibly related to cow's milk intake. It found that CoMiSS can be used to predict the response to a cow's milk-free diet in infants and diagnose cow's milk allergy in children.
Article
Immunology
Nicholas A. Smith, Danielle L. Germundson, Pan Gao, Junguk Hur, Angela M. Floden, Kumi Nagamoto-Combs
Summary: The study demonstrated that genetic background plays a role in influencing immediate physical reactions to allergens, anxiety-like behavior, immune response levels, and shifts in gut microbiota in mouse models of milk allergy.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Nutrition & Dietetics
Lucia Liotti, Annamaria Bianchi, Paolo Bottau, Silvia Caimmi, Giuseppe Crisafulli, Fabrizio Franceschini, Francesca Mori, Claudia Paglialunga, Francesca Saretta, Carlo Caffarelli
Summary: The COVID-19 pandemic is the most challenging global health crisis of our times, with vaccination playing a key role in controlling the current situation. While there is debate about the safety of COVID-19 vaccines for allergic patients, current data suggest that even patients with allergies to cow's milk or other foods should receive the vaccine in a setting with treatments for anaphylactic reactions and under medical supervision.
Review
Food Science & Technology
Carlos Franco, Cristina Fente, Cristina Sanchez, Alexandre Lamas, Alberto Cepeda, Rosaura Leis, Patricia Regal
Summary: The functionality of breast milk in terms of immunity is well-known, however, many breastfed infants exhibit sensitization to potential allergens and clinical reactivity before the introduction of complementary feeding. The potential induction of early oral tolerance through allergen exposure in breast milk remains controversial. This scoping review critically appraised the content of cow's milk antigens in human milk to better understand their impact on allergic disease development.
Article
Allergy
Yvonne M. d'Art, Lisa Forristal, Aideen M. Byrne, John Fitzsimons, Ronald van Ree, Audrey DunnGalvin, Jonathan O'Brien Hourihane
Summary: The study shows that introducing baked milk after the diagnosis of cow's milk allergy can safely and effectively improve infants' tolerance to milk. Maternal anxiety is also found to be associated with infants' progress on the milk ladder.
Article
Allergy
Karen M. Switkowski, Emily Oken, Sheryl L. Rifas-Shiman, Carlos A. Camargo, Diane R. Gold, Joanne E. Sordillo, Jenifer R. Lightdale
Summary: This study examined the timing of cow's milk protein introduction and its relationship with adverse reactions in children. The results showed that early and consistent exposure to cow's milk can protect children from adverse reactions.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)
Review
Nutrition & Dietetics
Caoimhe Cronin, Yukta Ramesh, Carlo De Pieri, Roberto Velasco, Juan Trujillo
Summary: IgE-mediated cow's milk protein allergy (CMPA) is a common food allergy in early childhood. The management methods of avoidance, the milk ladder, and oral immunotherapy (OIT) are all effective in promoting tolerance, but further research is needed to compare their safety and effectiveness.
Review
Nutrition & Dietetics
Dafni Moriki, Maria Pilar Francino, Despoina Koumpagioti, Barbara Boutopoulou, Jose Angel Rufian-Henares, Kostas N. Priftis, Konstantinos Douros
Summary: Cow's milk allergy is the most common food allergy in infancy and early childhood, with recent increases in allergy rates possibly linked to limited microbial exposure and changes in gut microbiome composition. The gut microbiome plays a crucial role in the host's lifelong health.
Article
Immunology
Danielle L. Germundson, Nicholas A. Smith, Lane P. Vendsel, Andrea V. Kelsch, Colin K. Combs, Kumi Nagamoto-Combs
JOURNAL OF NEUROINFLAMMATION
(2018)
Article
Neurosciences
Nicholas A. Smith, Danielle L. Germundson, Colin K. Combs, Lane P. Vendsel, Kumi Nagamoto-Combs
FRONTIERS IN CELLULAR NEUROSCIENCE
(2019)
Article
Immunology
Nicholas A. Smith, Danielle L. Germundson, Pan Gao, Junguk Hur, Angela M. Floden, Kumi Nagamoto-Combs
Summary: The study demonstrated that genetic background plays a role in influencing immediate physical reactions to allergens, anxiety-like behavior, immune response levels, and shifts in gut microbiota in mouse models of milk allergy.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Cell Biology
Danielle L. Germundson, Kumi Nagamoto-Combs
Summary: Through studies in a mouse model, we found that MC numbers increased in the brains of sensitized mice. Activation of beta-lactoglobulin resulted in changes in mobility and behavior, as well as neuroinflammatory responses in the brain.
Article
Allergy
Afrina Brishti, Danielle L. Germundson-Hermanson, Nicholas A. Smith, Angela E. Kearney, Yassmine Warda, Kumi Nagamoto-Combs
Summary: Mouse models of food allergy have been important in understanding the disease. This study used a mouse model of cow's milk allergy and found that continuous exposure to the allergen led to neuroinflammation and behavioral changes, despite a decrease in allergen-specific immunoglobulin levels.
FRONTIERS IN ALLERGY
(2022)
Article
Allergy
Danielle L. Germundson, Suba Nookala, Nicholas A. Smith, Yassmine Warda, Kumi Nagamoto-Combs
Summary: Food allergy symptoms vary greatly between individuals, potentially influenced by genetic determinants such as HLA-II allelic variance.
FRONTIERS IN ALLERGY
(2022)
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.