Article
Medicine, Research & Experimental
Yanfei Huo, Yungang Lai, Qiang Feng, Qingxiang Wang, Junhua Li
Summary: This study investigates the relationship between ITIH4 and inflammatory cytokines, stenosis degrees, and prognosis in coronary heart disease patients. The results show that serum ITIH4 levels are reduced in CHD patients and negatively correlated with inflammatory cytokines and stenosis degrees. High levels of ITIH4 are associated with a lower risk of major adverse cardiovascular events in CHD patients.
BIOMARKERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Doo-Hwan Kim, Young-Kug Kim, Tae-Yong Ha, Shin Hwang, Wooil Kim, Hyun-Jung Koo, Dong-Hyun Yang, Joon-Won Kang, Sung-Gyu Lee
Summary: The study evaluated the association between CTCA and long-term MACEs within 5 years after living donor liver transplantation (LDLT), finding that a combination of a coronary artery calcium score (CACS) of >400 and obstructive coronary artery disease (CAD) may be associated with long-term MACEs.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Emergency Medicine
Zhiyong Li, Hui Rong, Wenxun Wu, Ting Huang, Jun Xu
Summary: The application value of NT-proBNP combined with NLR in evaluating MACE in elderly CHF patients was explored. It was found that these two indicators have high sensitivity and specificity in evaluating MACE, and can be used as auxiliary predictive indices.
EMERGENCY MEDICINE INTERNATIONAL
(2022)
Article
Peripheral Vascular Disease
Qingrong Pan, Wenkai Zhang, Xiaoli Li, Zhe Chen, Yanna Yang, Guang Wang
Summary: The neutrophil to lymphocyte ratio (NLR) is associated with coronary artery disease (CAD) risk and severity, but the relationship differs between males and females. NLR is correlated with CAD severity in male patients and serves as an independent risk factor and predictor for CAD in males, but not in females.
Article
Neurosciences
Lu Song, Shunming Zhang, Huiping Li, Oskar Hansson, Emily Sonestedt, Yan Borne
Summary: Parkinson's disease (PD) and cardiovascular disease share many important risk factors, but there are also differences. This study aimed to compare the risk factors for PD, coronary events, and ischemic stroke, and found both similarities and differences in the risk factor profiles for these conditions.
NPJ PARKINSONS DISEASE
(2022)
Article
Cardiac & Cardiovascular Systems
Ninghao Huang, Zhenhuang Zhuang, Zimin Song, Wenxiu Wang, Yueying Li, Yimin Zhao, Wendi Xiao, Xue Dong, Jinzhu Jia, Zhonghua Liu, Caren E. Smith, Tao Huang
Summary: The study constructed a modified Healthy Aging Index (mHAI) to quantify the association between physiological aging and vascular events. The mHAI was found to be significantly correlated with major cardiovascular events, with systolic blood pressure being the most significant factor. A healthy lifestyle was shown to attenuate the associations between mHAI and vascular events.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Medicine, General & Internal
Yaochen Wang, Zhongxing Peng
Summary: This study found that PLR and CAMI-STEMI score were independent risk factors for MACE in STEMI patients after PCI.
Article
Oncology
Saeka Egami, Hitoshi Kawazoe, Hironobu Hashimoto, Ryuji Uozumi, Toko Arami, Naomi Sakiyama, Yuichiro Ohe, Hideo Nakada, Tohru Aomori, Shinnosuke Ikemura, Koichi Fukunaga, Masakazu Yamaguchi, Tomonori Nakamura
Summary: This study aimed to investigate the association between immune-related adverse events (irAEs) and peripheral blood cell counts in patients receiving pembrolizumab for advanced non-small cell lung cancer (NSCLC). The results showed that patients with higher pretreatment absolute lymphocyte count (ALC) and lymphocyte-to-monocyte ratio (LMR) had a reduced risk of developing any irAEs, while patients with higher pretreatment neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) had an increased risk. Routine evaluation of blood cell count data before pembrolizumab treatment initiation may help identify early-onset irAEs during the first 6 weeks of treatment.
Article
Oncology
Masafumi Haraguchi, Yasuhiko Nakao, Syouhei Narita, Kousuke Matsumoto, Masanori Fukushima, Ryu Sasaki, Takuya Honda, Satoshi Miuma, Hisamitsu Miyaaki, Kazuhiko Nakao
Summary: This study aimed to investigate the correlation between immune checkpoint inhibitors (ICIs) and changes in lymphocyte counts for predicting immune-related adverse events (irAEs). The percentage change in lymphocyte count was found to be associated with the incidence of severe irAEs. Close monitoring of the patient's condition is crucial when the lymphocyte count decreases during ICI treatment.
Article
Oncology
Saeka Egami, Hitoshi Kawazoe, Hironobu Hashimoto, Ryuji Uozumi, Toko Arami, Naomi Sakiyama, Yuichiro Ohe, Hideo Nakada, Tohru Aomori, Shinnosuke Ikemura, Koichi Fukunaga, Masakazu Yamaguchi, Tomonori Nakamura
Summary: This study found that an absolute lymphocyte count >820 at 2 weeks following nivolumab initiation predicts the early onset of immune-related adverse events during a 6-week study period in patients with advanced non-small cell lung cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Peripheral Vascular Disease
Merve Erkan, Ismet Zengin, Suleyman Bekircavusoglu, Dursun Topal, Turhan Bulut, Hakan Erkan
Summary: Sarcopenia is recognized as an indicator of subclinical atherosclerosis, but its effects on the clinical coronary atherosclerotic burden, lesion complexity, and major adverse cardiovascular events (MACE) in elderly patients with non-ST elevation myocardial infarction (NSTEMI) are still unclear. Therefore, this study aimed to evaluate these potential effects.
Article
Cardiac & Cardiovascular Systems
Yehong Liu, Ting Ye, Liang Chen, Tianhui Jin, Ying Sheng, Gangyong Wu, Gangjun Zong
Summary: The study investigated the association between SII and the severity of coronary artery disease (CAD), and found that SII is an independent risk factor for the occurrence and severity of CAD.
CORONARY ARTERY DISEASE
(2021)
Article
Immunology
Chen Wei, Wenjun Fan, Ying Zhang, Yixiang Liu, Zhenjiang Ding, Yueqiao Si, Jingyi Liu, Lixian Sun
Summary: The aim of this study was to develop and validate two nomograms incorporating the albumin/neutrophil-to-lymphocyte ratio score (ANS) for predicting the risk of coronary artery disease (CAD) or subclinical CAD. The nomograms were established based on independent predictors of CAD or subclinical CAD. The results showed that ANS was an independent predictor of CAD and subclinical CAD, and the nomograms had good performance in predicting CAD or subclinical CAD.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Oncology
Pei Yi Lee, Kellynn Qi Xuan Oen, Grace Rui Si Lim, Juanda Leo Hartono, Mark Muthiah, Daniel Q. Huang, Felicia Su Wei Teo, Andrew Yunkai Li, Anselm Mak, Nisha Suyien Chandran, Chris Lixian Tan, Peiling Yang, E. Shyong Tai, Kay Wei Ping Ng, Joy Vijayan, Yee Cheun Chan, Li Ling Tan, Martin Beng-Huat Lee, Horng Ruey Chua, Wei Zhen Hong, Eng Soo Yap, Dawn K. Lim, Yew Sen Yuen, Yiong Huak Chan, Folefac Aminkeng, Alvin Seng Cheong Wong, Yiqing Huang, Sen Hee Tay
Summary: In this case-control study, lower NLR (<3) was associated with increased occurrence of irAEs, while higher NLR values were correlated with worse clinical outcomes in cancer patients treated with immune checkpoint inhibitors.
Article
Medical Laboratory Technology
Fanqin Lv, Liang Liu, Qiang Feng, Xuefeng Yang
Summary: This study found significant differences in the relative expression of long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 and miR-125b in patients with coronary heart disease, with a negative correlation between the two. Additionally, lncRNA MALAT1 was positively correlated with the severity and incidence of major adverse cardiovascular events in CHD patients, while miR-125b showed an opposite trend.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Article
Cardiac & Cardiovascular Systems
Yi Yang, Jun Wang, A. Ji Gu Li Wai Si Ding, Yanan Xu, Haibing Jiang, Kezhong Ma, Tongjian Zhu
Summary: This study evaluated the potential predictive value of total bilirubin (TBIL) for long-term prognosis in patients with new-onset non-ST elevation myocardial infarction (NSTEMI). The results showed that higher levels of TBIL at admission may independently predict poor prognosis in NSTEMI patients. Additionally, TBIL was also associated with the severity of coronary lesions.
BMC CARDIOVASCULAR DISORDERS
(2022)
Article
Cell Biology
Fuding Guo, Yueyi Wang, Jun Wang, Zhihao Liu, Yanqiu Lai, Zhen Zhou, Zihan Liu, Yuyang Zhou, Xiao Xu, Zeyan Li, Meng Wang, Fu Yu, Ruijie Hu, Liping Zhou, Hong Jiang
Summary: This study demonstrates that choline protects the heart from DOX-induced cardiotoxicity by reducing oxidative stress, inflammation, and apoptosis. Choline also modulates the levels of cardiac neurotransmitters and heart rate variability, which contribute to its protective effects.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Cardiac & Cardiovascular Systems
Jun Wang, Chengzhe Liu, Fuding Guo, Zhen Zhou, Liping Zhou, Yueyi Wang, Huaqiang Chen, Huixin Zhou, Zhihao Liu, Shoupeng Duan, Ji Sun, Qiang Deng, Saiting Xu, Hong Jiang, Lilei Yu
Summary: This study evaluated the predictive ability of the relative increase and final coronary physiology measured by quantitative flow ratio (QFR) and deceleration capacity (DC) for adverse cardiovascular events in NSTE-ACS patients. The results showed that higher post-PCI QFR, higher relative QFR increase, and higher DC were all independent predictors of lower risk of MACCEs.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Shoupeng Duan, Jun Wang, Fu Yu, Lingpeng Song, Chengzhe Liu, Ji Sun, Qiang Deng, Yijun Wang, Zhen Zhou, Fuding Guo, Liping Zhou, Yueyi Wang, Wuping Tan, Hong Jiang, Lilei Yu
Summary: This study found that capturing cardiac autonomic nervous system-related modulations can enhance the predictive capability of existing prognostic models for prognosis after acute coronary syndrome (ACS).
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Zhen Zhou, Chengzhe Liu, Saiting Xu, Jun Wang, Fuding Guo, Shoupeng Duan, Qiang Deng, Ji Sun, Fu Yu, Yuyang Zhou, Meng Wang, Yueyi Wang, Liping Zhou, Hong Jiang, Lilei Yu
Summary: In this study, it was found that adiponectin can protect the heart by modulating the function and neural activity of the stellate ganglia, as well as reducing sympathetic nervous system activity. Adiponectin also improves heart rate variability, decreases cardiac sympathetic activity, serum noradrenaline and neuropeptide Y levels, and reduces the expression of nerve growth factors and growth associated proteins. These findings suggest that adiponectin may be a potential therapeutic strategy for the treatment of myocardial infarction.
BASIC RESEARCH IN CARDIOLOGY
(2022)
Article
Cell Biology
Yanan Xu, Zongwei Ye, Benfang Wang, Long Tang, Jun Sun, Xuedong Chen, Yi Yang, Jun Wang
Summary: This study constructed a risk nomogram using routine clinical variables to predict comorbid obstructive sleep apnea syndrome (OSAS) in patients with chronic coronary syndrome (CCS). The nomogram showed satisfactory discriminative ability and could be useful for identifying high-risk patients with OSAS in patients with CCS.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Cardiac & Cardiovascular Systems
Long Tang, Jingshui Zhang, Yanan Xu, Tingting Xu, Yi Yang, Jun Wang
Summary: This study found a close association between seasonal variations and blood pressure variability in patients with new-onset essential hypertension, providing insight into the underlying pathogenesis of new-onset essential hypertension.
BMC CARDIOVASCULAR DISORDERS
(2022)
Correction
Cell Biology
Yanan Xu, Zongwei Ye, Benfang Wang, Long Tang, Jun Sun, Xuedong Chen, Yi Yang, Jun Wang
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Physiology
Yi Yang, Jun Wang, Bing Wu, Yanan Xu, Long Tang, Haibing Jiang, Benfang Wang, Tongjian Zhu
Summary: This study evaluated the predictive value of new-onset permanent RBBB and LBBB in patients with new-onset STEMI who underwent PCI. The results showed that new-onset permanent RBBB and LBBB were independently associated with an increased risk of poor long-term prognosis.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Jun Wang, Xiaolin Wu, Ji Sun, Tianyou Xu, Tongjian Zhu, Fu Yu, Shoupeng Duan, Qiang Deng, Zhihao Liu, Fuding Guo, Xujun Li, Yijun Wang, Lingpeng Song, Hui Feng, Xiaoya Zhou, Hong Jiang
Summary: The study developed a model based on heart rate variability data to predict the risk of MACEs in ACS patients following emergency coronary angiography. The results showed that the model had high predictive accuracy for MACEs occurrence at 1 and 2 years, providing potential for personalized treatment strategies.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Fuding Guo, Jun Wang, Qiang Deng, Hui Feng, Mengjie Xie, Zhen Zhou, Liping Zhou, Yueyi Wang, Xujun Li, Saiting Xu, Shoupeng Duan, Ji Sun, Hong Jiang, Lilei Yu
Summary: The study aimed to evaluate the impact of PFA on the autonomic nervous system in patients with paroxysmal AF. The results showed that PFA did not cause nerve injury and there were no postablation cerebral microembolus events.
Article
Cardiac & Cardiovascular Systems
Zongwei Ye, Yanan Xu, Long Tang, Min Wu, Bing Wu, Tongjian Zhu, Jun Wang
Summary: This study aimed to develop a nomogram to predict the long-term prognosis of new-onset ST-elevation myocardial infarction (STEMI) patients following emergency percutaneous coronary intervention (PCI) by integrating the triglyceride glucose (TyG) index and clinical data. The nomogram included age, diabetes mellitus, current smoking, and TyG index as independent risk factors. The nomogram showed good discrimination and calibration in both the development and validation cohorts, as assessed by Harrell's C-index and decision curve analysis (DCA).
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Cell Biology
Long Tang, Min Wu, Yanan Xu, Tongjian Zhu, Cunming Fang, Kezhong Ma, Jun Wang
Summary: We developed a nomogram model based on inflammatory indices, clinical data, and imaging data to predict in-hospital major adverse cardiac and cerebrovascular events (MACCEs) following emergency percutaneous coronary intervention (PCI) in patients with new-onset ST-elevation myocardial infarction (STEMI). The model was constructed using data from 547 patients and demonstrated good predictive ability in both the training and independent verification cohorts.
INFLAMMATION RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Ji Sun, Qiang Deng, Jun Wang, Shoupeng Duan, Huaqiang Chen, Huixin Zhou, Zhen Zhou, Fu Yu, Fuding Guo, Chengzhe Liu, Saiting Xu, Lingpeng Song, Yijun Wang, Hui Feng, Lilei Yu
Summary: This study found that lower extremity arteriosclerosis obliterans (LEASO) is an independent predictor of major cardiovascular and cerebrovascular adverse events (MACCEs) in both male and female patients, and there is no significant difference in event-free survival between different sexes with LEASO.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)