☆ 4.8 Article

Detection of colorectal cancer-derived exosomes based on covalent organic frameworks

BIOSENSORS & BIOELECTRONICS (2020)

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BIOSENSORS & BIOELECTRONICS
卷 169, 期 -, 页码 -

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ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2020.112638

关键词

Covalent organic frameworks; Exosome; Colorectal cancer; Electrochemical

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Biophysics Biotechnology & Applied Microbiology Chemistry, Analytical Electrochemistry Nanoscience & Nanotechnology

资金

  1. National Natural Science Foundation of China [81772593]

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Covalent organic frameworks (COFs) have attracted more and more attention due to their diverse structures and multifunctionality. Their unique physicochemical properties make them exhibit great application potential in the field of biosensing. In this work, we have designed and fabricated a novel COFs-based nanoprobe named HRP-pSC(4)-AuNPs@COFs, where spherical COFs are functionalized with para-sulfocalix [4] arene hydrate (pSC(4))-modified gold nanoparticles (AuNPs) and horseradish peroxidase (HRP). Then, we have applied it for the electrochemical detection of colorectal cancer (CRC)-derived exosomes. In this design, pSC(4) as amicable linker can recognize and bind with various amino acid residues on the exosomes surface, while AuNPs with excellent conductivity can accelerate the migration of charge carriers and improve the response of biosensors. Noteworthy, the high porosity of COFs allows them to load a large amount of HRP, endowing COF with high catalytic activity. Meanwhile, the exoskeleton of COFs can maintain the functionality of HRP with significantly elevated stability. With such design, the proposed method shows excellent analytical performance for the detection of CRC-derived exosomes in the linear range from 5 x 10(2) to 10(7) particles/mu L with a detection limit down to 160 particles/mu L. Further, this method has also been used to analyze clinical serum sample, and can successfully distinguish CRC patients from healthy people, indicating the promising potential in clinical diagnosis.

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CRISPR-Cas12a powered hybrid nanoparticle for extracellular vesicle aggregation and in-situ microRNA detection

Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu

Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.

BIOSENSORS & BIOELECTRONICS (2024)

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Article Biophysics

Facile synthesis of dual-ligand europium-metal organic gels for ratiometric electrochemiluminescence detecting I27L gene

Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li

Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.

BIOSENSORS & BIOELECTRONICS (2024)

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Article Biophysics

The use of biological fluids in microfluidic paper-based analytical devices (μPADs): Recent advances, challenges and future perspectives

Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho

Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.

BIOSENSORS & BIOELECTRONICS (2024)

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Article Biophysics

Development of a peptide microarray-based metal-enhanced fluorescence assay for ultrasensitive detection of multiple matrix metalloproteinase activities by using a gold nanorod-polymer substrate

Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang

Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.

BIOSENSORS & BIOELECTRONICS (2024)

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Article Biophysics

Plasmonic digital PCR for discriminative detection of SARS-CoV-2 variants

Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon

Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.

BIOSENSORS & BIOELECTRONICS (2024)

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Article Biophysics

A wearable and flexible lactic-acid/O2 biofuel cell with an enhanced air-breathing biocathode

Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu

Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.

BIOSENSORS & BIOELECTRONICS (2024)

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Article Biophysics

Gas-responsive two-dimensional metal-organic framework composites for trace visualization of volatile organic compounds

Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang

Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.

BIOSENSORS & BIOELECTRONICS (2024)

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