Article
Biochemistry & Molecular Biology
Abdelaziz Ghanemi, Mayumi Yoshioka, Jonny St-Amand
Summary: SPARC is a protein expressed in various tissues, and its levels can increase in response to physiological and pathological changes such as injuries, exercise, regeneration, obesity, cancer, and inflammation. The interrelation between these changes and SPARC expression/secretion suggests it may serve as a biomarker with potential applications in mechanistic studies, animal model validation, disease prognosis, and drug evaluation.
Article
Biology
Abdelaziz Ghanemi, Mayumi Yoshioka, Jonny St-Amand
Summary: SPARC protein plays a crucial role in tissue regeneration by creating an environment suitable for tissue regeneration and enhancing tissue repair ability, with potential applications in various diseases and bioengineering.
Article
Genetics & Heredity
Abdelaziz Ghanemi, Mayumi Yoshioka, Jonny St-Amand
Summary: Exercise has numerous benefits for health and is widely prescribed for various pathological conditions. Stimulating SPARC gene expression through exercise can be used for personalized medicine, optimizing exercise therapy by prescribing patterns corresponding to optimal SPARC/Sparc expression. Measuring exercise-dependent expression of Sparc could also enhance the selection of exercise animal models in research.
Article
Medicine, Research & Experimental
Yang Fu, Liying Luo, Ying Fan, Min Tang
Summary: The study showed that downregulation of SPARC in HTMCs reduced F-actin and ZO-1 expression levels, promoted phagocytosis, and may affect aqueous humor outflow through the trabecular meshwork pathway.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Genetics & Heredity
Abdelaziz Ghanemi, Mayumi Yoshioka, Jonny St-Amand
Summary: SPARC is proposed as a potential therapy for antiageing, as it can mimic the effects of exercise without the need for physical activity.
Article
Biochemistry & Molecular Biology
Hye Jung Jang, Myung Geun Song, Cho Rong Park, Hyewon Youn, Yun-Sang Lee, Gi Jeong Cheon, Keon Wook Kang
Summary: Glioblastoma is a common and fatal primary glioma, but complete removal of brain tumor tissues is challenging for neurosurgeons. Fluorescence-guided surgery (FGS) and indocyanine green (ICG) are used to enhance visualization of tumor edges. The binding properties of ICG to human serum albumin (HSA) and the extracellular glycoprotein SPARC were studied. In vitro and in vivo studies showed that the uptake of ICG-HSA complex was higher in SPARC-expressing glioblastoma cells and tumors compared to free ICG. This suggests that ICG-HSA complex could be an efficient imaging agent for SPARC-expressing tumors, especially glioblastoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Sport Sciences
Toshiaki Miyamoto, Yurika Shimizu, Yuka Matsuo, Taiki Otaru, Yuto Kanzawa, Nao Miyamae, Eri Yamada, Tomoyuki Katsuno
Summary: This study examined the effects of exercise intensity and duration on circulating SPARC levels, finding that high-intensity exercise (W60) significantly increased serum SPARC levels, with changes in SPARC levels correlating with lactate concentrations, skeletal muscle mass, and knee extensor muscle strength.
EUROPEAN JOURNAL OF SPORT SCIENCE
(2022)
Review
Chemistry, Multidisciplinary
Yu Shen, Ting Pan, Liu Wang, Zhen Ren, Weina Zhang, Fengwei Huo
Summary: Metal-organic frameworks (MOFs) are widely studied in catalysis due to their flexible components, high surface area, and uniform active sites. However, the complex structures of MOFs pose challenges for researchers in selecting suitable catalysts. A programmable design strategy based on metal ions, organic ligands, modifiers, and post-treatment modules is proposed to design MOF catalysts for various reactions, enabling precise construction and regulation of their microenvironments for heterogeneous catalysis, electrocatalysis, and photocatalysis. This modular design concept offers a potent tool for exploring structure-activity relationships and accelerating the tailored design of multicomponent catalysts.
ADVANCED MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Hong Jiang, Xiangxiang Zhao, Wenqiang Zhang, Yan Liu, Haiyang Li, Yong Cui
Summary: Chiral imidodiphosphates (IDPs) have been used as strong Bronsted acid catalysts, but their dynamic transformation often leads to low enantioselectivity. In this study, the topologies of metal-organic frameworks (MOFs) were utilized to control IDP conformations and local chiral microenvironments for efficient enantioselective catalysis. Two different porous Dy-MOFs were obtained from an enantiopure 1,1’-biphenol IDP-based tetracarboxylate ligand, and all IDPs were rigidified to a single O,O-syn conformation with enhanced Bronsted acidity. The more compact 4-connected IDP-based MOF exhibited high enantioselectivity in the challenging O,O-acetalization reaction.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
J. Song, X. Shen, F. Liu, X. Zhao, Y. Wang, S. Wang, P. Wang, J. . Wang, F. Su, S. Li
Summary: In this study, a Ca2+-based metal-organic framework (UTSA-280) was developed to encapsulate amylases in situ, resulting in increased relative activity of the enzymes. It was found that the released amylase from UTSA-280 had more Ca2+ on its surface, leading to stronger activation of the enzyme. Furthermore, UTSA-280 provided protection for the enzymes against various factors, making it a promising material for enzyme preparation with activity-promoting and protective effects.
MATERIALS TODAY CHEMISTRY
(2023)
Article
Endocrinology & Metabolism
Liying Luo, Xi Sun, Min Tang, Jiahui Wu, Tianwei Qian, Shimei Chen, Zhiyuan Guan, Yanyun Jiang, Yang Fu, Zhi Zheng
Summary: This study found that SPARC promotes diabetic retinopathy via the regulation of integrin beta 1. The results suggest that SPARC plays an important role in the development and progression of DR and may be a potential therapeutic target for its treatment.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Binbin Guo, Rui Chen, Wei Guo, Yueyue Kang, Ling Wu
Summary: Thiol-functionalized UiO-66-anchored atomically dispersed metal ions, denoted as UiO-66(SM)(2) (M = Pd, Pt, or Au), were prepared for the selective oxidation of benzyl alcohol to benzaldehyde under visible light irradiation. The introduction of the thiol group shifted the light absorption edge of UiO-66 from UV to visible light, minimized the bandgap, and improved the selectivity of producing benzaldehyde from 26.8% to 99.9%. The conversion of benzyl alcohol was greatly boosted from 8.9% to 33.4% after atomically dispersed metal ions were anchored.
CHEMICAL COMMUNICATIONS
(2021)
Review
Chemistry, Inorganic & Nuclear
Xiao Feng, Yanwei Ren, Huanfeng Jiang
Summary: The article reviews the recent research progress of M(bpy)/M(phen)-functionalized metal-organic frameworks (MOFs) and covalent organic frameworks (COFs), focusing on the synthetic strategies of these porous materials and their catalytic performances in thermocatalysis, photocatalysis and electrocatalysis.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Chemistry, Physical
Xiaohong Liu, Shuaihua Zhang, Guilin Feng, Zhen-Guo Wu, Dong Wang, Munirah D. Albaqami, Benhe Zhong, Yanxiao Chen, Xiaodong Guo, Xingtao Xu, Yusuke Yamauchi
Summary: The directed core-shell motif hybridization of COFs on MOFs results in selectively functionalized carbonaceous precursors, TiO2@COF, with titanium dioxide nanoparticles in the inner core and nitrogen-rich carbon in the outer shell. This design provides abundant faradic active sites and nitrogen dopants, as well as favorable cycling stability and enhanced pseudocapacitive capacity. Additionally, the interconnected COF-derived fibers contribute to increasing electrical conductivity of the material, leading to a high salt adsorption capacity and favorable cycling stability for CDI electrodes.
CHEMISTRY OF MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Abdelaziz Ghanemi, Aicha Melouane, Mayumi Yoshioka, Jonny St-Amand
Summary: The study found that Sparc KO mice exhibit an ageing-like phenotype, while SPARC overexpression and exercise provide similar benefits in counteracting ageing, helping to combat the ageing phenotype induced by SPARC deficiency and reversing age-related changes.
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)