Network pharmacology for the identification of phytochemicals in traditional Chinese medicine for COVID-19 that may regulate interleukin-6

A Novel Coronavirus from Patients with Pneumonia in China, 2019

(2020) Na Zhu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Quercetin ameliorates diabetic encephalopathy through SIRT1/ER stress pathway in db/db mfice

(2020) Tian Hu et al.   Aging-US

COVID-19 and chronological aging: senolytics and other anti-aging drugs for the treatment or prevention of corona virus infection?

(2020) Camillo Sargiacomo et al.   Aging-US

COVID ‐19, pulmonary mast cells, cytokine storms, and beneficial actions of luteolin

(2020) Theoharis C. Theoharides   BIOFACTORS

Extracts of Thai Perilla frutescens nutlets attenuate tumour necrosis factor-α-activated generation of microparticles, ICAM-1 and IL-6 in human endothelial cells

(2020) Narisara Paradee et al.   BIOSCIENCE REPORTS

Extracts and Flavonoids of Passiflora Species as Promising Anti-inflammatory and Antioxidant Substances

(2020) Marcin Ożarowski et al.   CURRENT PHARMACEUTICAL DESIGN

Existing bitter medicines for fighting 2019‐nCoV‐associated infectious diseases

(2020) Xiangqi Li et al.   FASEB JOURNAL

Quercetin protects human oral keratinocytes from lipopolysaccharide-induced injury by downregulating microRNA-22

(2020) F Wang et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

COVID-19: consider cytokine storm syndromes and immunosuppression

(2020) Puja Mehta et al.   LANCET

COVID-19, Chloroquine Repurposing, and Cardiac Safety Concern: Chirality Might Help

(2020) Giovanni Lentini et al.   MOLECULES

Efficacy and safety of Lianhuaqingwen capsules, a repurposed Chinese herb, in patients with coronavirus disease 2019: A multicenter, prospective, randomized controlled trial

(2020) Ke Hu et al.   PHYTOMEDICINE

Effective treatment of severe COVID-19 patients with tocilizumab

(2020) Xiaoling Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quercetin Prevents Lipopolysaccharide-Induced Experimental Preterm Labor in Mice and Increases Offspring Survival Rate

(2020) Xinxiu Lin et al.   Reproductive Sciences

Treatment efficacy analysis of traditional Chinese medicine for novel coronavirus pneumonia (COVID-19): an empirical study from Wuhan, Hubei Province, China

(2020) Erdan Luo et al.   Chinese Medicine

The Role of Cytokines including Interleukin-6 in COVID-19 induced Pneumonia and Macrophage Activation Syndrome-Like Disease

(2020) Dennis McGonagle et al.   AUTOIMMUNITY REVIEWS

Early administration of Interleukin-6 inhibitors for patients with severe Covid-19 disease is associated with decreased intubation, reduced mortality, and increased discharge

(2020) Pranay Sinha et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Efficacy and Safety of Integrated Traditional Chinese and Western Medicine for Corona Virus Disease 2019 (COVID-19): a systematic review and meta-analysis

(2020) Ming Liu et al.   PHARMACOLOGICAL RESEARCH

Liu Shen capsule shows antiviral and anti-inflammatory abilities against novel coronavirus SARS-CoV-2 via suppression of NF-κB signaling pathway

(2020) Qinhai Ma et al.   PHARMACOLOGICAL RESEARCH

Therapeutic targets of oxidative/nitrosative stress and neuroinflammation in ischemic stroke: Applications for natural product efficacy with omics and systemic biology

(2020) Hansen Chen et al.   PHARMACOLOGICAL RESEARCH

Review on the potential action mechanisms of Chinese medicines in treating Coronavirus Disease 2019 (COVID-19)

(2020) Yu-Feng Huang et al.   PHARMACOLOGICAL RESEARCH

Chemical composition and pharmacological mechanism of Qingfei Paidu Decoction and Ma Xing Shi Gan Decoction against Coronavirus Disease 2019 (COVID-19): In silico and experimental study

(2020) Ruocong Yang et al.   PHARMACOLOGICAL RESEARCH

Lianhuaqingwen exerts anti-viral and anti-inflammatory activity against novel coronavirus (SARS-CoV-2)

(2020) Li Runfeng et al.   PHARMACOLOGICAL RESEARCH

URSOLIC ACID: A NOVEL ANTIVIRAL COMPOUND INHIBITING ROTAVIRUS INFECTION IN VITRO

(2019) M.J. Tohmé et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Ursolic Acid and Its Derivatives as Bioactive Agents

(2019) Sithenkosi Mlala et al.   MOLECULES

Anti-Irritant and Anti-Inflammatory Effects of DHA Encapsulated in Resveratrol-Based Solid Lipid Nanoparticles in Human Keratinocytes

(2019) Simona Serini et al.   Nutrients

Paeoniflorin Prevents Intestinal Barrier Disruption and Inhibits Lipopolysaccharide (LPS)-Induced Inflammation in Caco-2 Cell Monolayers

(2019) Xi-Xi Wu et al.   INFLAMMATION

Ursolic acid exhibits anti-inflammatory effects through blocking TLR4-MyD88 pathway mediated by autophagy

(2019) Jun Zhao et al.   CYTOKINE

NGL viewer: web-based molecular graphics for large complexes

(2018) Alexander S Rose et al.   BIOINFORMATICS

UniProt: the universal protein knowledgebase

(2018) The UniProt Consortium   NUCLEIC ACIDS RESEARCH

Antiviral Activities of Oleanolic Acid and Its Analogues

(2018) Vuyolwethu Khwaza et al.   MOLECULES

Sinomenine Regulates Inflammatory Response and Oxidative Stress via Nuclear Factor kappa B (NF-κB) and NF-E2-Related Factor 2 (Nrf2) Signaling Pathways in Ankle Fractures in Children

(2018) Jie Shen et al.   MEDICAL SCIENCE MONITOR

Wwox deletion leads to reduced GABA-ergic inhibitory interneuron numbers and activation of microglia and astrocytes in mouse hippocampus

(2018) Tabish Hussain et al.   NEUROBIOLOGY OF DISEASE

Wogonin protects human retinal pigment epithelium cells from LPS-induced barrier dysfunction and inflammatory responses by regulating the TLR4/NF-κB signaling pathway

(2017) Chen Chen et al.   Molecular Medicine Reports

Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology

(2017) Rudragouda Channappanavar et al.   Seminars in Immunopathology

Daidzein increases OPG/RANKL ratio and suppresses IL-6 in MG-63 osteoblast cells

(2016) Jing Sun et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Quercetin, not caffeine, is a major neuroprotective component in coffee

(2016) Moonhee Lee et al.   NEUROBIOLOGY OF AGING

The STRING database in 2017: quality-controlled protein–protein association networks, made broadly accessible

(2016) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Atractylenolide I protects mice from lipopolysaccharide-induced acute lung injury

(2015) Jun-liang Zhang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Antimicrobial Activity of Oleanolic and Ursolic Acids: An Update

(2015) Jéssica A. Jesus et al.   Evidence-based Complementary and Alternative Medicine

Ursolic Acid—A Pentacyclic Triterpenoid with a Wide Spectrum of Pharmacological Activities

(2015) Łukasz Woźniak et al.   MOLECULES

Children with autism spectrum disorders, who improved with a luteolin-containing dietary formulation, show reduced serum levels of TNF and IL-6

(2015) I Tsilioni et al.   Translational Psychiatry

TCMSP: a database of systems pharmacology for drug discovery from herbal medicines

(2014) Jinlong Ru et al.   Journal of Cheminformatics

Melanin, a promising radioprotector: Mechanisms of actions in a mice model

(2012) A. Kunwar et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Cytoscape 2.8: new features for data integration and network visualization

(2010) M. E. Smoot et al.   BIOINFORMATICS

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Anti-inflammatory and antiarthritic effects of piperine in human interleukin 1β-stimulated fibroblast-like synoviocytes and in rat arthritis models

(2009) Jun Soo Bang et al.   ARTHRITIS RESEARCH & THERAPY