Article
Environmental Sciences
Vellingiri Manon Mani, Sethumathavan Kalaivani, Shanmugam Sabarathinam, Manikandan Vasuki, Arockiam Jeyasundar Parimala Gnana Soundari, M. P. Ayyappa Das, Ashraf Elfasakhany, Arivalagan Pugazhendhi
Summary: The study focused on synthesizing Copper Oxide Nanoparticles (CuONPs) using an endophytic fungus isolated from a medicinal tree in India, and evaluated their antibacterial, antifungal, antioxidant, and anti-cancer activities. The CuONPs exhibited significant anti-cancer effects on colon cancer cell lines and angiogenesis inhibition in tumor cells in a concentration-dependent manner, highlighting their potential in cancer therapeutics.
ENVIRONMENTAL RESEARCH
(2021)
Article
Chemistry, Applied
Md Abu Taher, Wen-Nee Tan, Nelson Jeng-Yeou Chear, Chean-Ring Leong, Syarifah Ab Rashid, Woei-Yenn Tong
Summary: This study assessed the antimicrobial activity of endophytic Phyllosticta fallopiae against diabetic wound microorganisms and identified biologically important metabolites. The study found that the dichloromethane extract exhibited significant activity and inhibited biofilm formation. Analysis of the most active fraction revealed the presence of various classes of metabolites. Overall, endophytic P. fallopiae showed promising antimicrobial potential against diabetic wound microorganisms.
NATURAL PRODUCT RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
David Medina-Cruz, Ada Vernet-Crua, Ebrahim Mostafavi, Maria Ujue Gonzalez, Lidia Martinez, A-Andrew D. Jones, Matthew Kusper, Eduardo Sotelo, Ming Gao, Luke D. Geoffrion, Veer Shah, Gregory Guisbiers, Jorge L. Cholula-Diaz, Christelle Guillermier, Fouzia Khanom, Yves Huttel, Jose Miguel Garcia-Martin, Thomas J. Webster
Summary: Nanomedicine offers promising solutions to healthcare concerns like cancer and antibiotic resistance, with green nanotechnology presenting a solution to traditional drawbacks in nanomaterial synthesis. This study developed a method for synthesizing tellurium (Te) nanostructures using aloe vera extracts as reducing and capping agents, resulting in AV-TeNPs with potential biomedical applications in antibacterial and anticancer fields.
Review
Biochemistry & Molecular Biology
Md. Hridoy, Md. Zobayer Hossain Gorapi, Sadia Noor, Nargis Sultana Chowdhury, Md. Mustafizur Rahman, Isabella Muscari, Francesco Masia, Sabrina Adorisio, Domenico V. Delfino, Md. Abdul Mazid
Summary: Endophytic fungi are an important reservoir of diverse bioactive compounds, including anticancer agents and antibiotics. By increasing the yield of specific compounds, they have the potential to become a promising source of anticancer drugs.
Article
Plant Sciences
Xueli Tong, Min Li, Di Li, Chunqin Lao, Jingmian Chen, Weijie Xu, Junxi Du, Meijiao Zhang, Xiangcai Yang, Jiejing Li
Summary: Aloe vera barbadensis extract C (AVBEC) demonstrated safety in rats with no toxicity observed in acute and chronic toxicity studies. It also showed potential anti-tumor activity by inducing cancer cell apoptosis, suggesting a novel mechanism for Aloe gel extract in cancer therapy.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Integrative & Complementary Medicine
Abdel-Rahman A. Nassar, Hossam M. Atta, Mohamed Ali Abdel-Rahman, Wageih S. El Naghy, Amr Fouda
Summary: Copper oxide nanoparticles synthesized by endophytic fungi showed promising antibacterial, anticancer, and antioxidant activities, making them suitable for a variety of biomedical and therapeutic applications.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2023)
Article
Microbiology
Rafael Dorighello Cadamuro, Isabela Maria Agustini da Silveira Bastos, Ana Claudia Oliveira de Freitas, Marilene da Silva Rosa, Geovanna de Oliveira Costa, Izabella Thais da Silva, Diogo Robl, Patricia Hermes Stoco, Louis Pergaud Sandjo, Helen Treichel, Mario Steindel, Gislaine Fongaro
Summary: The aim of this study was to identify the chemical profile of endophytic fungi Neofusicoccum parvum and Buergenerula spartinae isolated from Avecinnia schaueriana and Laguncularia racemosa. Solid-state fermentation and extraction were performed to obtain crude extracts, which were then evaluated through cytotoxicity and bacteriostatic assays. The results suggest that these endophytic fungi species with distinct chemical profiles represent a promising area for further exploration of new biomolecules.
Article
Environmental Sciences
Fareeha Iqbal, Ambreen Ahmed
Summary: Plant secondary metabolites, including phenolics, flavonoids, and alkaloids, have been found in Aloe vera extracts, with highest concentrations in the methanol, dichloromethane, and aqueous fractions. These extracts showed significant antibacterial activity, indicating the potential of Aloe vera as a herbal remedy and antibacterial agent.
POLISH JOURNAL OF ENVIRONMENTAL STUDIES
(2021)
Article
Engineering, Chemical
Fuad Al-Rimawi, Hamada Imtara, Mahmoud Khalid, Zaidoun Salah, Mohammad Khalid Parvez, Asmaa Saleh, Omkulthom Al Kamaly, Christina Shawki Dahu
Summary: Verthimia iphionoides extract from Palestine was found to exhibit strong antioxidant, antibacterial, and anticancer activities in vitro. The extract contained high levels of polyphenolic compounds and flavonoids, which contributed to its bioactivities.
Review
Medicine, Research & Experimental
Hanna Svitina, Josias H. Hamman, Chrisna Gouws
Summary: Aloe has been used as traditional folk medicine since ancient times and has shown therapeutic effects in cancer treatment. Phytochemical compounds from various Aloe species affect cell signaling and can be used as therapeutic agents, especially in cancer treatment.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Pooja Singh, Kshitij R. B. Singh, Rahul Verma, Priyanka Prasad, Ranjana Verma, Subha Narayan Das, Jay Singh, Ravindra Pratap Singh
Summary: This work focuses on the biogenic synthesis of CuFeO2 nanocomposites and their utility as electrochemical sensors for the quantification of hydrazine for agricultural applications. The synthesized nanocomposites exhibited high sensitivity and low detection limits for hydrazine, and also demonstrated efficient antibacterial activity.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Biology
Aisha M. H. Al-Rajhi, Abdullah Mashraqi, Mohamed A. Al Abboud, Abdel-Rahman M. Shater, Soad K. Al Jaouni, Samy Selim, Tarek M. Abdelghany
Summary: Endophytic fungi provide a rich source of biologically active compounds. In this study, three fungal species were found to have the highest isolation frequency, density, and antimicrobial activity. The extract of Penicillium rubens showed the most effective antimicrobial and anticancer activities, and also exhibited inhibitory effects on various microorganisms and prostate cancer cells.
Article
Engineering, Chemical
Fateme Amani, Aidin Azadi, Atefe Rezaei, Mohammad Saeed Kharazmi, Seid Mahdi Jafari
Summary: The present study aimed to fabricate Aloe vera mucilage/gelatin complexes as a carrier for cinnamon essential oil and demonstrated their good encapsulation efficiency and release properties. The results showed that the complexes had a stable structure and higher thermal stability, and the encapsulated cinnamon essential oil exhibited enhanced antibacterial activity. These findings highlight the potential application of Aloe vera/gelatin complexes for the encapsulation of sensitive bioactive compounds.
JOURNAL OF FOOD ENGINEERING
(2022)
Article
Integrative & Complementary Medicine
Tsolanku Sidney Maliehe, Melusi Mbambo, Londeka Sibusisiwe Ngidi, Jabulani Siyabonga Emmanuel Shandu, Ofentse Jacob Pooe, Peter Masoko, Tlou Nelson Selepe
Summary: The endophytic actinobacterium OlKP 1632.1 isolated from Aloe ferox Mill showed noteworthy antibacterial activity, indicating its potential as a source of effective antibacterial compounds.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2022)
Article
Materials Science, Multidisciplinary
Bilal Ahmad, M. I. Khan, M. A. Naeem, Aiyeshah Alhodaib, Mahvish Fatima, Mongi Amami, Eman A. Al-Abbad, Abida Kausar, Norah Alwadai, Arif Nazir, Munawar Iqbal
Summary: A cost-effective and eco-friendly green synthesis method was used to prepare NiO nanoparticles using Aloe vera gel. The NPs annealed at 500 degrees C exhibited promising antibacterial activity, outperforming antifungal activity, indicating the potential of Aloe vera gel in preparing NiO NPs with significant antimicrobial activity for medical applications.
MATERIALS CHEMISTRY AND PHYSICS
(2022)
Article
Biotechnology & Applied Microbiology
Nouf M. Al-Enazi, Khawla Alsamhary, Mansour Kha, Fuad Ameen
Summary: The synthesis of pure and Ag and Ce dual-doped ZnO NPs was achieved through a green and facile method, and their cytotoxicity in breast cancer cells and normal cells was studied. The nanoparticles exhibited a hexagonal structure, spherical shape, and smooth surfaces, with Ag and Ce evenly distributed in ZnO. Cytotoxicity experiments showed that the dual-doped NPs had a significantly greater impact on breast cancer cells compared to pure NPs, while both types had no effect on normal cells. Additionally, the antimicrobial activity against harmful bacteria was investigated.
BIOPROCESS AND BIOSYSTEMS ENGINEERING
(2023)
Review
Cardiac & Cardiovascular Systems
Karam R. Motawea, Mostafa R. Mostafa, Merna Aboelenein, Mohamed Magdi, Hager Fathy, Sarya Swed, Mohamed M. Belal, Dina M. Awad, Rowan H. Elhalag, Nesreen E. Talat, Samah S. Rozan, Abdulqadir J. Nashwan, Naim Battikh, Bisher Sawaf, Mhd K. Albuni, Elias Battikh, Gihan M. Mohamed, Amr Farwati, Hani Aiash
Summary: The efficacy of anteriolateral versus anterior-posterior electrode positions in external cardioversion of atrial fibrillation (AF) was compared in a meta-analysis. A total of 11 trials with 1845 patients were included. The analysis showed that anteriolateral electrode position was associated with a significantly increased cardioversion rate of AF compared to anterior-posterior position, particularly in specific patient subgroups.
CLINICAL CARDIOLOGY
(2023)
Editorial Material
Endocrinology & Metabolism
Abdulqadir J. Nashwan
ENDOCRINE PRACTICE
(2023)
Letter
Psychiatry
Syeda Tayyaba Rehan, Sharmeen Fatima, Laiba Imran, Zayeema Khan, Sarya Swed, Abdulqadir J. Nashwan
Summary: Perinatal depression is a significant risk to both maternal and fetal health, and is associated with adverse outcomes. Recent research has indicated that a mother's adverse childhood experiences may predispose her to perinatal depression, with higher prevalence rates observed in Asian and lower-income countries. Our paper elucidates the relationship between perinatal depression and adverse childhood experiences, and suggests potential interventions Asian countries can implement to address the increasing rates of perinatal depression.
ASIAN JOURNAL OF PSYCHIATRY
(2023)
Article
Biotechnology & Applied Microbiology
Osama Abdel-Hafeez Mohamed Al-Bedak, Ahmed Mohamed Moharram, Nemmat Abdel-Gawad Hussein, Doaa Mohamed Taha, Steven L. Stephenson, Fuad Ameen
Summary: A distinctive isolate from diverse fruit juices was identified as Didymella keratinophila and showed a 100% identity to the type strain. It produced high keratinase and collagenase activities by fermenting native chicken feathers under certain conditions. This research provides a reliable way to utilize and manage chicken feathers for obtaining valuable collagenase and keratinase enzymes.
FERMENTATION-BASEL
(2023)
Review
Biotechnology & Applied Microbiology
Mohamad Zulfadhli Ahmad Sobri, Alya Redhwan, Fuad Ameen, Jun Wei Lim, Chin Seng Liew, Guo Ren Mong, Hanita Daud, Rajalingam Sokkalingam, Chii-Dong Ho, Anwar Usman, D. H. Nagaraju, Pasupuleti Visweswara Rao
Summary: Biohydrogen production from microalgae is being intensively researched as a potential alternative energy source. Traditional modelling and optimization methods are inaccurate and costly, so machine learning algorithms have been employed to predict nonlinear interactions and handle multivariate data. This review focuses on the recent applications of machine learning techniques, such as random forests, artificial neural networks, support vector machines, and regression algorithms, in microalgal biohydrogen production. Despite the limitations of complex and nonlinear data sets, these techniques have shown great performance, although overfitting remains a challenge.
FERMENTATION-BASEL
(2023)
Article
Biochemical Research Methods
Turki Dawoud, Fuad Ameen
Summary: This study experimentally confirmed the potential of Pimpinella anisum extracts in eradicating oral pathogens and identified their antibacterial and antifungal activities. The findings are important for further exploration of the biological activity of P. anisum and the development of novel drugs for treating oral diseases.
BIOMEDICAL CHROMATOGRAPHY
(2023)
Article
Environmental Sciences
Karnan Singaravelu Dharshini, T. Yokesh, Mariappan Mariappan, Fuad Ameen, M. Amirul Islam, Anbazhagan Veerappan
Summary: In this study, silver nanoparticles (AgNPs) were synthesized using eco-friendly methods and their potential for detecting Hg2+ ions in environmental samples was investigated. The aqueous extract of Hemidesmus indicus root rapidly converted silver ions into AgNPs under sunlight. The synthesized AgNPs were found to detect Hg2+ ions and could be immobilized onto paper to create a portable device for sensing mercury in water.
Article
Environmental Sciences
Shaymaa Arif Shukur, Fikrat M. Hassan, Saad Sabah Fakhry, Fuad Ameen, Steven L. Stephenson
Summary: This study investigated the presence and characteristics of microplastics (MPs) in the Tigris River. The study found that the concentration of MPs was high in both the water and sediment, with fibers and fragments being the main morphology. The MPs were mainly composed of polyethylene (PE) and polypropylene (PP), and the colors were mostly transparent and white. Ecological risk assessment indicated a moderate to high risk level. These findings highlight the need for action to mitigate microplastic pollution in the Tigris River.
MARINE POLLUTION BULLETIN
(2023)
Editorial Material
Health Policy & Services
Abdulqadir J. Nashwan
Summary: This paper discusses the progress of Open Access initiatives in the Eastern Mediterranean Region (EMR) countries, focusing on healthcare and medicine. Examples such as the Egyptian Knowledge Bank (EKB), Qatar National Library (QNL), and the Open Educational Resources (OER) policy in the United Arab Emirates demonstrate efforts to democratize knowledge and bridge the gap between high-income and lower-middle-income countries. However, challenges like limited funding, infrastructure, and awareness still need to be addressed, requiring a unified regional strategy for effective implementation.
Meeting Abstract
Respiratory System
Wongi Woo, Vincent Kipkorir, Du-young Kang, Adina Marza, Alessandro Belletti, Shadi Hamouri, Abdulqadir Nashwan, Giuseppe Fiorentino, Muhammad Mohsin Khan, Ayat Alhakeem, Sarya Swed, Moezedin Javad Rafiee, Wooshik Kim, Duk Hwan Moon, Jae Il Shin, Sungsoo Lee
Article
Medicine, General & Internal
Usamah Al-Anbagi, Shybin Usman, Abdulrahman Saad, Abdulqadir J. Nashwan
Summary: This is a case report describing a 43-year-old male patient with alcohol-related pancreatitis and severe hypophosphatemia. The authors urge clinicians to consider serial monitoring of serum phosphate levels in patients admitted with acute pancreatitis, especially when alcohol is involved.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Clinical Neurology
Milad Shenno, Almonzer Al-Qiami, Ismail A. Ibrahim, Lojin Elhaw, Abdulqadir J. Nashwan
Summary: This report presents a rare case of a 19-year-old male with bilateral periventricular nodular heterotopia (PVNH) and an intra-axial pontine lesion. Unlike the common diffuse midline glioma, the patient's condition is more favorable, and the lesion is suspected to be a pilocytic astrocytoma. The final diagnosis was made based on clinical evaluation and various medical diagnostic tests, and management and follow-up were initiated.
INTERDISCIPLINARY NEUROSURGERY-ADVANCED TECHNIQUES AND CASE MANAGEMENT
(2024)
Article
Medicine, General & Internal
Ahmed Zaki, Nour Shaheen, Mohamed Hosny, Abdelraouf Ramadan, Abdulqadir J. Nashwan
Summary: This case report describes a 3-year-old female child with 2q37 deletion syndrome and patent foramen ovale, who showed improvement in hypotonia and gross motor delay after 1 year of physical therapy. The case highlights the importance of thorough examination and diagnostic testing in identifying underlying causes of developmental delays. The effectiveness of physical therapy in managing cases of 2q37 deletion syndrome and PFO is also emphasized.
CLINICAL CASE REPORTS
(2023)
Review
Public, Environmental & Occupational Health
Syeda Tayyaba Rehan, Mishal Shan, Syed Hasan Shuja, Zayeema Khan, Hassan Ul Hussain, Rohan Kumar Ochani, Asim Shaikh, Iqbal Ratnani, Abdulqadir J. Nashwan, Salim Surani
Summary: This systematic review aims to determine the prevalence of workplace violence against healthcare workers in Pakistan, as well as identify the associated risk factors and perpetrators. The findings show a prevalence of 25-100% of workplace violence against healthcare workers in Pakistani medical setups, highlighting the need for protective enforcement policies and further surveys.
GLOBAL HEALTH ACTION
(2023)