Identification of fenoldopam as a novel LSD1 inhibitor to abrogate the proliferation of renal cell carcinoma using drug repurposing strategy

Natural protoberberine alkaloids, identified as potent selective LSD1 inhibitors, induce AML cell differentiation

(2020) Zhong-Rui Li et al.   BIOORGANIC CHEMISTRY

Expression profile of H3K4 demethylases with their clinical and pathological correlation in patients with clear cell renal cell carcinoma

(2020) Aman Kumar et al.   GENE

New tranylcypromine derivatives containing sulfonamide motif as potent LSD1 inhibitors to target acute myeloid leukemia: Design, synthesis and biological evaluation

(2020) Liyun Liang et al.   BIOORGANIC CHEMISTRY

Capsaicin: A “hot” KDM1A/LSD1 inhibitor from peppers

(2020) Gang Jia et al.   BIOORGANIC CHEMISTRY

Synthesis and biological evaluation of some novel thiobenzimidazole derivatives as anti-renal cancer agents through inhibition of c-MET kinase

(2019) Hany S. Ibrahim et al.   BIOORGANIC CHEMISTRY

Discovery and synthesis of novel indole derivatives-containing 3-methylenedihydrofuran-2(3H)-one as irreversible LSD1 inhibitors

(2019) Hong-Min Liu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Effects of fenoldopam on kidney function parameters and its therapeutic efficacy in the management of acute kidney injury in dogs with heatstroke

(2018) Gilad Segev et al.   JOURNAL OF VETERINARY INTERNAL MEDICINE

Drug repurposing: progress, challenges and recommendations

(2018) Sudeep Pushpakom et al.   NATURE REVIEWS DRUG DISCOVERY

LSD1 inhibition suppresses the growth of clear cell renal cell carcinoma via upregulating P21 signaling

(2018) Liangsong Zhu et al.   Acta Pharmaceutica Sinica B

Identification of osimertinib (AZD9291) as a lysine specific demethylase 1 inhibitor

(2018) Zhong-Rui Li et al.   BIOORGANIC CHEMISTRY

LincRNAFEZF1-AS1 represses p21 expression to promote gastric cancer proliferation through LSD1-Mediated H3K4me2 demethylation

(2017) Yan-wen Liu et al.   Molecular Cancer

Baicalin, a natural LSD1 inhibitor

(2016) Yi-Chao Zheng et al.   BIOORGANIC CHEMISTRY

Impact on clinical practice of the implementation of guidelines for the toxicity management of targeted therapies in kidney cancer. The protect-2 study

(2016) Nuria Lainez et al.   BMC CANCER

Androgen and AR contribute to breast cancer development and metastasis: an insight of mechanisms

(2016) J Feng et al.   ONCOGENE

A Systematic Review of Histone Lysine-Specific Demethylase 1 and Its Inhibitors

(2015) Yi-Chao Zheng et al.   MEDICINAL RESEARCH REVIEWS

Landmarks in the diagnosis and treatment of renal cell carcinoma

(2014) Jaimin R. Bhatt et al.   Nature Reviews Urology

Triazole–Dithiocarbamate Based Selective Lysine Specific Demethylase 1 (LSD1) Inactivators Inhibit Gastric Cancer Cell Growth, Invasion, and Migration

(2013) Yi-Chao Zheng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay

(2013) D. M. Molina et al.   SCIENCE

Epidemiology and risk factors for kidney cancer

(2010) Wong-Ho Chow et al.   Nature Reviews Urology

Renal cell carcinoma

(2009) Brian I Rini et al.   LANCET

Epidemiologic and socioeconomic burden of metastatic renal cell carcinoma (mRCC): A literature review

(2008) Kiran Gupta et al.   CANCER TREATMENT REVIEWS