Review
Plant Sciences
Damien Caubriere, Anna Moseler, Nicolas Rouhier, Jeremy Couturier
Summary: This review focuses on the biochemical, structural, and physiological roles of cysteine desulfurases in sulfur-dependent biosynthetic pathways in photosynthetic organisms, with particular emphasis on Arabidopsis isoforms. Cysteine desulfurases are highly conserved enzymes that catalyze the extraction of sulfur from cysteine, leading to the formation of persulfide groups on catalytic cysteine residues. The sulfur is then transferred to various targets, including iron-sulfur clusters and molybdenum cofactors. While there is extensive knowledge about cysteine desulfurases in some pathways, such as iron-sulfur cluster synthesis, our understanding of their involvement in other pathways, especially in photosynthetic organisms, is limited. This review summarizes the current knowledge of cysteine desulfurases and highlights gaps in understanding, emphasizing the need for future research in this area.
JOURNAL OF EXPERIMENTAL BOTANY
(2023)
Article
Biology
Xi Jiang, Lucia Paya-Tormo, Diana Coroian, Ines Garcia-Rubio, Rocio Castellanos-Rueda, Alvaro Eseverri, Gema Lopez-Torrejon, Stefan Buren, Luis Manuel Rubio
Summary: By constructing a knowledge-based library and screening, researchers identified superior NifH variants for expression in plant mitochondria and yeast, which could potentially facilitate efficient nitrogen fixation engineering in eukaryotes.
COMMUNICATIONS BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Ralf R. Mendel, Guenter Schwarz
Summary: This review summarizes the research history and importance of sulfite oxidase, a molybdenum-containing enzyme that plays a crucial role in redox regulation, signaling, and metabolism in both plants and animals.
Article
Chemistry, Analytical
Jianbin Chao, Jiamin Zhao, Yongbin Zhang, Fangjun Huo, Caixia Yin
Summary: Biothiols play important physiological and pathological roles in organisms, but their specific markers are challenging to identify due to their high reactivity and short half-life. By designing reaction sites and studying intramolecular rearrangement, different biothiols can be distinguished successfully.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Agriculture, Multidisciplinary
Hui Yang, Bo Zhang, Zi-Dan Wu, Li-Feng Chen, Jia-Yuan Pan, Xiao-Ling Xiu, Xue Cai, Zhi-Qiang Liu, Yu-Guo Zheng
Summary: This study proposed a combinatorial metabolic engineering strategy to develop an efficient Escherichia coli cell factory for L-cysteine production. The researchers investigated the crucial regulatory modes and employed multi-copy gene expression to achieve a two-stage fermentation for improved balance between production and growth. They further optimized carbon flux distribution by modifying the C1 unit metabolism and the glycolytic pathway, and demonstrated the superior performance of thiosulfate utilization pathways in enhancing L-cysteine production. The work also highlighted the vital role of synergistic enhancement of sulfur-carbon metabolism in L-cysteine overproduction. In a 5 L bioreactor, the engineered strain accumulated 12.6 g/L of L-cysteine.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Agriculture, Multidisciplinary
Hui Yang, Bo Zhang, Zi-Dan Wu, Li-Feng Chen, Jia-Yuan Pan, Xiao-Ling Xiu, Xue Cai, Zhi-Qiang Liu, Yu-Guo Zheng
Summary: This study presents a combinatorial metabolic engineering strategy for the development of an efficient Escherichia coli cell factory dedicated to L-cysteine production. By optimizing crucial regulatory modes, improving the balance between production and growth, optimizing carbon flux distribution, and modifying sulfur assimilation pathways, the study successfully achieved high L-cysteine titer.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Biochemical Research Methods
Wenshu He, Stefan Buren, Can Baysal, Xi Jiang, Teresa Capell, Paul Christou, Luis M. Rubio
Summary: This study shows that expression and purification of NifB protein from archaea in transgenic rice plants can successfully produce soluble proteins in plants. This is an important breakthrough for achieving independent biological nitrogen fixation in cereals.
ACS SYNTHETIC BIOLOGY
(2022)
Article
Biochemical Research Methods
Wenshu He, Stefan Buren, Can Baysal, Xi Jiang, Teresa Capell, Paul Christou, Luis M. Rubio
Summary: The engineering of nitrogen fixation in plants requires the assembly of an active prokaryotic nitrogenase complex. However, the production of NifB protein in plants is challenging due to its insolubility and sensitivity to oxygen. In this study, transgenic rice plants expressing NifB from Archaea were generated, and the NifB proteins accumulated as soluble proteins in planta. The purified proteins were also functional in the in vitro synthesis assay. This study represents a significant step towards the biosynthesis of a functional NifDK complex for biological nitrogen fixation in cereals.
ACS SYNTHETIC BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Malin Eh, Alexander Tobias Kaczmarek, Guenter Schwarz, Daniel Bender
Summary: Sulfite oxidase (SOX) is an enzyme that contains both molybdenum and heme, and is responsible for oxidizing sulfite to sulfate. It has been found that one functional subunit in SOX is sufficient for catalysis, and electrons can be transferred between different subunits.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Sven-A Freibert, Michal T. Boniecki, Claudia Stuempfig, Vinzent Schulz, Nils Krapoth, Dennis R. Winge, Ulrich Muehlenhoff, Oliver Stehling, Miroslaw Cygler, Roland Lill
Summary: The conserved N-terminal Tyr35 of ISCU2 plays a crucial mechanistic role in de novo mitochondrial [2Fe-2S] cluster synthesis, with ionic forces replacing Tyr-Tyr interactions during dimerization-induced [2Fe-2S] cluster formation. Hydrophobic interaction of two conserved N-terminal tyrosines induces ISCU2 dimerization and concomitant [2Fe-2S] cluster synthesis.
NATURE COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Naoki Shigi
Summary: Sulfur-containing biomolecules play crucial roles in cells, including enzyme cofactors, RNA composition, and regulation of gene translation efficiency. Modulating sulfur modification allows cells to adapt to different environments. Mutations in related genes can lead to diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Genetics & Heredity
Anna-Theresa Mellis, Juliane Roeper, Albert L. Misko, Joshua Kohl, Guenter Schwarz
Summary: Molybdenum cofactor deficiency (MoCD) is a metabolic genetic disorder characterized by the loss of sulfite oxidase (SO) function, leading to the accumulation of sulfurous compounds. Mitochondria are severely affected in MoCD, showing altered function and morphology which contribute to the disease phenotype.
FRONTIERS IN GENETICS
(2021)
Article
Biochemistry & Molecular Biology
Yi Tong Vincent Aw, Azadeh Seidi, Jenni A. Hayward, Jiwon Lee, F. Victor Makota, Melanie Rug, Giel G. van Dooren
Summary: Fe-S clusters are essential for the survival of eukaryotes, with independent biosynthesis pathways occurring in different compartments of the cell. Little is known about cytosolic Fe-S cluster biosynthesis in apicomplexan parasites, but it has been found that NBP35 in Toxoplasma gondii localizes to the outer mitochondrial membrane and is critical for parasite proliferation.
MOLECULAR MICROBIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Leon P. Jenner, Mickael Cherrier, Patricia Amara, Luis M. Rubio, Yvain Nicolet
Summary: The nitrogenase MoFe protein contains two different FeS centers, the P-cluster and the iron-molybdenum cofactor (FeMo-co). NifB is an important enzyme in FeMo-co assembly. Recent crystal structures of NifB proteins show the plasticity of the protein and suggest how ligand reorganization would accommodate cluster loading and fusion in the time-course of NifB-co synthesis.
Article
Chemistry, Multidisciplinary
Haoran Pang, Lindsey M. Walker, Alexey Silakov, Pan Zhang, Weitao Yang, Sean J. Elliott, Kenichi Yokoyama
Summary: The diversity of reactions catalyzed by radical S-adenosyl-L-methionine (SAM) enzymes is achieved in part through various mechanisms to quench radical intermediates. Among the SPASM-twitch family, MoaA serves as a representative member with unique cyclization of GTP involving an auxiliary 4Fe-4S cluster. The radical quenching step in MoaA involves a proton-coupled electron transfer mechanism, providing detailed insights into radical SAM enzyme catalysis.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Review
Pharmacology & Pharmacy
Joshua B. Kohl, Anna-Theresa Mellis, Guenter Schwarz
BRITISH JOURNAL OF PHARMACOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Alexander T. Kaczmarek, Marc J. F. Strampraad, Peter-Leon Hagedoorn, Guenter Schwarz
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
(2019)
Correction
Cell Biology
Jasmina Zivanovic, Emilia Kouroussis, Joshua B. Kohl, Bikash Adhikari, Biljana Bursac, Sonia Schott-Roux, Dunja Petrovic, Jan Lj. Miljkovic, Daniel Thomas-Lopez, Youngeun Jung, Marko Miler, Sarah Mitchell, Verica Milosevic, Jose Eduardo Gomes, Moran Benhar, Bruno Gonzalez-Zorn, Ivana Ivanovic-Burmazovic, Roberta Torregrossa, James R. Mitchell, Matthew Whiteman, Guenter Schwarz, Solomon H. Snyder, Bindu D. Paul, Kate S. Carroll, Milos R. Filipovic
Article
Chemistry, Physical
Morten M. C. H. van Schie, Alexander T. Kaczmarek, Florian Tieves, Patricia Gomez de Santos, Caroline E. Paul, Isabel W. C. E. Arends, Miguel Alcalde, Guenter Schwarz, Frank Hollmann
Article
Biochemistry & Molecular Biology
Simon J. Mayr, Juliane Roeper, Guenter Schwarz
JOURNAL OF BIOLOGICAL CHEMISTRY
(2020)
Article
Endocrinology & Metabolism
Daniel Bender, Alexander T. Kaczmarek, Sabina Kuester, Alberto B. Burlina, Guenter Schwarz
JOURNAL OF INHERITED METABOLIC DISEASE
(2020)
Article
Biochemistry & Molecular Biology
Anna-Theresa Mellis, Albert L. Misko, Sita Arjune, Ye Liang, Katalin Erdelyi, Tamas Ditroi, Alexander T. Kaczmarek, Peter Nagy, Guenter Schwarz
Summary: Molybdenum cofactor deficiency and isolated sulfite oxidase deficiency are rare genetic disorders caused by impairment of the mitochondrial enzyme sulfite oxidase. Investigation of the contributions of cytosolic and mitochondrial glutamate oxaloacetate transaminase (GOT) in cellular extracts revealed that the cytosolic isoform GOT1 is primarily responsible for sulfite production. Loss of sulfite oxidase activity leads to accumulation of sulfite, H2S, and persulfidated cysteine and glutathione, suggesting an increase in SQR protein levels. Surprisingly, under conditions of sulfite toxicity, none of the known H2S-producing pathways were found to be upregulated, indicating an alternative route of sulfite-induced shift from oxidative to H2S dependent cysteine catabolism.
Article
Genetics & Heredity
Anna-Theresa Mellis, Juliane Roeper, Albert L. Misko, Joshua Kohl, Guenter Schwarz
Summary: Molybdenum cofactor deficiency (MoCD) is a metabolic genetic disorder characterized by the loss of sulfite oxidase (SO) function, leading to the accumulation of sulfurous compounds. Mitochondria are severely affected in MoCD, showing altered function and morphology which contribute to the disease phenotype.
FRONTIERS IN GENETICS
(2021)
Article
Endocrinology & Metabolism
Alexander Tobias Kaczmarek, Nike Bahlmann, Besarta Thaqi, Patrick May, Guenter Schwarz
Summary: Isolated sulfite oxidase deficiency (ISOD) is a rare hereditary metabolic disease caused by the absence of functional sulfite oxidase (SO) due to mutations of the SUOX gene. Research using exome/genome data from the gnomAD database and published variants has identified 15 novel ISOD-causing SO variants and established a database for future diagnosis of ISOD patients. The study also calculated the first comprehensive incidence rate for ISOD and provided a pathogenicity score for 303 naturally occurring SO missense variants.
MOLECULAR GENETICS AND METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Malin Eh, Alexander Tobias Kaczmarek, Guenter Schwarz, Daniel Bender
Summary: Sulfite oxidase (SOX) is an enzyme that contains both molybdenum and heme, and is responsible for oxidizing sulfite to sulfate. It has been found that one functional subunit in SOX is sufficient for catalysis, and electrons can be transferred between different subunits.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Endocrinology & Metabolism
Alexander Tobias Kaczmarek, Daniel Bender, Titus Gehling, Joshua Benedict Kohl, Hulya-Sevcan Daimagueler, Jose Angel Santamaria-Araujo, Max Christoph Liebau, Anne Koy, Sebahattin Cirak, Guenter Schwarz
Summary: Isolated sulfite oxidase deficiency (ISOD) is a rare metabolic disorder caused by mutations in the SUOX gene, leading to a loss of sulfite oxidase (SO) function and accumulation of harmful metabolites, resulting in severe neurodegenerative diseases. The correct insertion of heme cofactor and molybdenum cofactor into SO is crucial for its function, with deficiencies in this process contributing to the development of ISOD.
JOURNAL OF INHERITED METABOLIC DISEASE
(2022)
Article
Pharmacology & Pharmacy
Julika Pristup, Elke Schaeffeler, Sita Arjune, Ute Hofmann, Jose Angel Santamaria-Araujo, Patrick Leuthold, Nele Friedrich, Matthias Nauck, Simon Mayr, Mathias Haag, Thomas Muerdter, Franz-Josef Marner, Mary Relling, William E. Evans, Guenter Schwarz, Matthias Schwab
Summary: This study identified a methyltransferase involved in urothione synthesis and revealed a novel link between molybdenum cofactor catabolism and drug metabolism. The study demonstrated that TPMT genotype and phenotype are associated with urothione excretion levels and validated these findings in a population-based study.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
G. F. Senguel, R. Mishra, E. Candiello, P. Schu
Summary: AP2 forms AP2 CCV with clathrin and other coat proteins, and synapses contain different types of CCV. The stability and composition of CCV are regulated by various factors, including Hsc70 and phosphorylation patterns. The knockout of the AP1/O1B complex disrupts synaptic vesicle recycling and endosomal protein sorting, leading to upregulation of endocytosis. Stable CCV, termed stCCV, have distinct characteristics and specialized functions in synaptic plasticity. The phosphorylation of Hsc70 and the levels of kinases play a crucial role in regulating the stability and disassembly of clathrin in CCV.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Martin Fluck, Colline Sanchez, Vincent Jacquemond, Christine Berthier, Marie-Noelle Giraud, Daniel Jacko, Kathe Bersiner, Sebastian Gehlert, Guus Baan, Richard T. Jaspers
Summary: Enhancing CaMKII signaling improves fatigue resistance and contractile characteristics of skeletal muscle by enhancing calcium release.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Letter
Biochemistry & Molecular Biology
Federica Coppola, Sara Monaci, Alessandro Falsini, Carlo Aldinucci, Irene Filippi, Daniela Rossi, Fabio Carraro, Antonella Naldini
Summary: The adaptor protein p62 plays a crucial role in maintaining the survival of dendritic cells (DCs) under hypoxic conditions by preserving Erk1/2 phosphorylation and reducing AMPK activation, thus extending their lifespan to ensure their functions in hypoxic microenvironments.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Jenifer Pendiuk Goncalves, Jorvani Cruz Villarreal, Sierra A. Walker, Xuan Ning Sharon Tan, Chad Borges, Joy Wolfram
Summary: This study used a mass spectrometry-based approach to assess the differences in glycan features between extracellular vesicles (EVs) and originating cells. The results showed that EVs selectively enriched specific glycan features, particularly those associated with binding to the extracellular matrix. The study also found differences in EV glycan sorting between different metastatic cell lines and mouse models, indicating a potential role of glycan diversity in the metastatic process.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
De-ao Gong, Peng Zhou, Wen-yi Chang, Jia-yao Yang, Yan-lai Zhang, Ai-long Huang, Ni Tang, Kai Wang
Summary: Liver cancer, ranked sixth globally, is a major contributor to cancer-related mortality. Metastasis is the main cause of treatment failure and deaths in liver cancer. The SPOP-CREB5-MET axis plays a significant role in liver cancer metastasis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Ning Huang, Jun Tang, Xiaoyao Yi, Maoxin Zhang, Bin Li, Yuan Cheng, Jin Chen
Summary: This study reveals that glioma-derived S100A9 can induce microglial M2 polarization, inhibit CD8+ T lymphocytes, and promote immunosuppression. The mechanism is related to the interaction with alpha v133 integrin and subsequent activation of AKT1 in microglia. The expression of S100A9 is positively associated with CD206 expression and negatively correlated with CD8+ T lymphocyte accumulation in the TME, suggesting a potential role of S100A9 in regulating the tumor microenvironment and immune evasion in glioma.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Yomna S. Abd El-Aziz, Matthew J. McKay, Mark P. Molloy, Betty McDowell, Elizabeth Moon, Loretta Sioson, Amy Sheen, Angela Chou, Anthony J. Gill, Patric J. Jansson, Sumit Sahni
Summary: This study identified a novel combination of autophagy inhibitors that can effectively inhibit the proliferation of oral squamous cell carcinoma (OSCC) cells, including both chemosensitive and chemoresistant cells. This research is important for the development of new therapies for advanced OSCC tumors.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Luojia Liu, Xiaoqiang Liu, Ying Chen, Meng Kong, Jinghong Zhang, Min Jiang, Hongling Zhou, Jinrui Yang, Xu Chen, Ze Zhang, Chao Wu, Xupin Jiang, Jiaping Zhang
Summary: Our study revealed that the Paxillin/HDAC6 signaling pathway regulates microtubule acetylation in electric field-guided keratinocyte migration.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Julia Weikum, Jeroen F. van Dyck, Saranya Subramani, David P. Klebl, Merete Storflor, Stephen P. Muench, Soren Abel, Frank Sobott, J. Preben Morth
Summary: The study reveals the complex interaction between bacterial magnesium transporter A (MgtA) and cardiolipin 18:1 and cardiolipin 16:0, highlighting the importance of lipid environment in protein activity and stability. Further understanding of Mg2+ homeostasis in bacteria will provide insights into bacterial infections.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Sumit Kinger, Yuvraj Anandrao Jagtap, Ankur Rakesh Dubey, Prashant Kumar, Akash Choudhary, Rohan Dhiman, Vijay Kumar Prajapati, Deepak Chitkara, Krishna Mohan Poluri, Amit Mishra
Summary: Efficient protein synthesis and quality control mechanisms are crucial for maintaining proteostasis and preventing neurodegeneration. This study demonstrates that treating cells with Lanosterol can enhance the proteolytic activity of Proteasome and promote the removal of misfolded proteins, suggesting a potential therapeutic approach for abnormal protein accumulation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Karolina Stepien, Adrianna Skoneczna, Monika Kula-Maximenko, Lukasz Jurczyk, Mateusz Molon
Summary: The replication of DNA requires a complex machinery called the replisome, which is highly conserved across species. One crucial component of the replisome is the CMG helicase complex, which unwinds DNA and coordinates the assembly and function of other replisome components. In this study, the impact of the absence of one copy of the CMG complex genes on the physiology and aging of yeast cells was investigated. The findings showed disruptions in the cell cycle, extended doubling times, and alterations in the biochemical profile of these cells. Importantly, it was found that heterozygous cells for CMG helicase genes exhibited increased reproductive potential and delayed aging. The study also highlighted potential therapeutic targets for cancer treatment using yeast.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Nishadh Rathod, Guadalupe Guerrero-Serna, Howard S. Young, L. Michel Espinoza-Fonseca
Summary: This study reveals that replacing Lys27 with Asn enhances the inhibitory potency of MLN without affecting SERCA's affinity for Ca2+. The findings suggest that the SERCA site modulating Ca2+ affinity also functions as a catalytic activity switch.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Can Jiang, Chunyang Zhang, Min Dai, Fuyan Wang, Sa Xu, Dan Han, Yanyan Wang, Yajie Cao, Yanyan Liang, Ziyu Zhang, Lina Yan, Yujun Shen, Kewu He, Yuxian Shen, Jun Liu
Summary: The phosphorylation of p65 and the expression of SUMO1 are increased in cancer tissues of HCC patients, and there is a positive correlation between SUMO1 and phosphorylated p65. SUMOylation of p65 by SUMO1 promotes p65 nuclear import and enhances NF-xB activity. Both SUMOylation and phosphorylation of p65 increase the viability and invasion of hepatoma cells, and decrease cell apoptosis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Ming-Fo Hsu, Yoshihiro Ito, Jai Prakash Singh, Shu-Fang Hsu, Alan Wells, Kuang-Yu Jen, Tzu-Ching Meng, Fawaz G. Haj
Summary: This study identified alpha-actinin4 as a novel substrate of PTP1B in podocytes and demonstrated their interaction in regulating podocyte function. Targeting PTP1B and alpha-actinin4 could be a potential therapeutic approach for podocyte injury.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Paulo F. V. Bizerra, Eduardo H. Gilglioni, Hang Lam Li, Simei Go, Ronald P. J. Oude Elferink, Arthur J. Verhoeven, Jung -Chin Chang
Summary: This study investigates the role of cyclic AMP (cAMP) in glycogen metabolism and reveals that cAMP regulates glycogenolysis in opposite directions depending on its site of synthesis within cells and downstream effectors. The canonical tmAC-cAMP-PKA signaling promotes glycogenolysis, while the non-canonical sAC-cAMP-Epac1 signaling suppresses glycogenolysis. This highlights the importance of cAMP microdomain organization for distinct metabolic regulation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)