期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
卷 1866, 期 12, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.bbadis.2020.165935
关键词
Obesity; T2DM; Insulin resistance; Liver; Respiratory supercomplexes
资金
- Consejo Nacional de Ciencia y Tecnologia, Mexico [283363]
- Programa de Apoyo a Proyectos de Investigacion e Innovacion Tecnologica (PAPIIT), Direccion General de Asuntos del Personal Academico (DGAPA) de la UNAM [IN202219]
Deregulation of nutrient, hormonal, or neuronal signaling produces metabolic alterations that result in increased mitochondrial reactive oxygen species (ROS) production. The associations of the mitochondrial respiratory chain components into supercomplexes could have pathophysiological relevance in metabolic diseases, as supramolecular arrangements, by sustaining a high electron transport rate, might prevent ROS generation. In this review, the relationship between mitochondrial dysfunction and supercomplex arrangement of the mitochondrial respiratory chain components in obesity, insulin resistance, hepatic steatosis and diabetes mellitus is summarized and discussed.
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