Article
Multidisciplinary Sciences
Gilles Barthe, Roberta De Viti, Peter Druschel, Deepak Garg, Manuel Gomez-Rodriguez, Pierfrancesco Ingo, Heiner Kremer, Matthew Lentz, Lars Lorch, Aastha Mehta, Bernhard Schoelkopf
Summary: This paper introduces a new privacy-preserving and inclusive system for epidemic risk assessment and notification. By capturing encounters between user devices and beacons placed in potential infection cluster locations, the system aims to enhance the accuracy of contact tracing and mitigate the spread of epidemics.
SCIENTIFIC REPORTS
(2022)
Review
Chemistry, Multidisciplinary
Taylor M. Oeschger, Duncan S. McCloskey, Rose M. Buchmann, Aakash M. Choubal, Juan M. Boza, Saurabh Mehta, David Erickson
Summary: This article discusses various new technologies developed in the past decade that may help in earlier detection of infectious diseases, from predictive technologies to population screening tools. Using artificial intelligence to analyze factors such as climate variation and zoonotic spillover can help identify high-risk infection areas earlier, guiding public health officials to respond promptly.
ACCOUNTS OF CHEMICAL RESEARCH
(2021)
Article
Geosciences, Multidisciplinary
Prakash Singh Thapa, Basanta Raj Adhikari, Rajib Shaw, Diwakar Bhattarai, Seiji Yanai
Summary: The Nepal Himalayas is prone to landslides, which are caused by seismic activity, monsoon rainfall, and improper land-use practices. Mitigating and preventing landslides is challenging for countries like Nepal, but low-cost techniques like bioengineering combined with affordable early warning systems have been effective. A case study in Lalitpur district analyzed landslide geomorphology, triggering factors, and evaluated the effectiveness of a landslide early warning system (LEWS). The LEWS measures rainfall, soil moisture, and displacement activity to generate alarms for nearby residents, reducing landslide risk at the community level.
Review
Environmental Sciences
Deepak Panchal, Om Prakash, Prakash Bobde, Sukdeb Pal
Summary: Transmission of the novel coronavirus (SARS-CoV-2) in humans can occur through respiratory droplets or contact with contaminated surfaces. The presence of the virus in feces and sewage systems raises public health concern, with monitoring through sewage potentially providing epidemiological data on COVID-19 trends. Tracking the virus in sewage could serve as an early warning system for public health authorities to take necessary actions.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Multidisciplinary Sciences
Nicolo Gozzi, Michele Tizzoni, Matteo Chinazzi, Leo Ferres, Alessandro Vespignani, Nicola Perra
Summary: This study explored the spatiotemporal spread of SARS-CoV-2 in Santiago de Chile using anonymized mobile phone data, finding that more developed and wealthier areas experienced a lower burden of the pandemic after government interventions. The impact of NPIs on individuals' mobility was found to correlate with the Human Development Index of comunas in the city.
NATURE COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Catherine Chen, Aisah Amelia, George W. Ashdown, Ivo Mueller, Anna K. Coussens, Emily M. Eriksson
Summary: The clinical presentation of COVID-19 varies significantly between individuals, from asymptomatic, mild/moderate to severe disease. Understanding the immune mechanisms behind severe disease can help predict life-threatening complications, with autoantibodies playing a crucial role in inflammation, pathogen defense, and coagulation processes. Studies show a higher prevalence of autoantibodies targeting immunomodulatory proteins in severe COVID-19 patients compared to those with mild or asymptomatic infections.
MOLECULAR MEDICINE
(2021)
Article
Engineering, Geological
Gaetano Pecoraro, Michele Calvello
Summary: The study proposed a methodology that integrates meteorological monitoring and pore water pressure measurements, which was tested in 30 hydrological basins in Norway. By analyzing data on weather-induced landslides, meteorological monitoring, and pore water pressure measurements, an effective territorial warning model was developed, providing accurate identification and warning of landslide events.
Review
Engineering, Environmental
Manish Kumar, Guangming Jiang, Alok Kumar Thakur, Shreya Chatterjee, Tanushree Bhattacharya, Sanjeeb Mohapatra, Tushara Chaminda, Vinay Kumar Tyagi, Meththika Vithanage, Prosun Bhattacharya, Long D. Nghiem, Dibyendu Sarkar, Christian Sonne, Jurgen Mahlknecht
Summary: This paper evaluates the global data on temporal tracking of COVID-19 through wastewater surveillance, focusing on the robustness, advantages, and sensitivity of the wastewater-based epidemiological (WBE) approach. The study highlights the variations in lead time reported globally and the factors impacting the comparability of WBE results, such as gene copies detected, lag time, and per capita RNA concentrations. It also emphasizes the influence of sanitation facilities and climatic conditions on the degradation rate of the virus and the applicability of WBE in WASH countries.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Multidisciplinary Sciences
Denis Nash, Saba Qasmieh, McKaylee Robertson, Madhura Rane, Rebecca Zimba, Sarah G. Kulkarni, Amanda Berry, William You, Chloe Mirzayi, Drew Westmoreland, Angela Parcesepe, Levi Waldron, Shivani Kochhar, Andrew R. Maroko, Christian Grov
Summary: This study investigated the role of children in the home and household crowding as risk factors for severe COVID-19 disease. The results showed that among participants living in multi-unit dwellings, the odds of hospitalization due to COVID-19 were 10.5 times higher for those with children in the home compared to those without, while among participants living in single-unit dwellings, the odds were 2.2 times higher. Additionally, among participants living in multi-unit dwellings, having more than 4 persons in the household increased the odds of COVID-19 hospitalization by 2.5 times compared to having only 1 person.
Article
Multidisciplinary Sciences
Jacob Kazenelson, Tori Jefferson, Ryan G. G. Rhodes, Lawrence B. B. Cahoon, Arthur R. R. Frampton
Summary: Using quantitative PCR, our group detected SARS-CoV-2 RNA in wastewater samples collected from the University of North Carolina Wilmington campus. The virus signal was detected in the wastewater prior to the reporting of individual cases on campus, indicating the potential for wastewater monitoring as a surveillance program for early detection of outbreaks. These findings support the use of wastewater testing for SARS-CoV-2 and its integration with other metrics to inform public health response.
Article
Environmental Sciences
Eszter Roka, Bernadett Khayer, Zoltan Kis, Luca Bella Kovacs, Eszter Schuler, Nora Magyar, Tibor Malnasi, Orsolya Oravecz, Bernadett Palyi, Tamas Pandics, Marta Vargha
Summary: Wastewater based epidemiology is a potential early warning tool for the detection of COVID-19 outbreak. The sewage surveillance in Hungary showed effectiveness in predicting the second wave of the outbreak, even with relatively low frequency sampling.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Health Care Sciences & Services
Dae-Young Kim, Surendra Krushna Shinde, Saifullah Lone, Ramasubba Reddy Palem, Gajanan Sampatrao Ghodake
Summary: COVID-19, a newly emerged respiratory disease caused by SARS-CoV-2, has led to a global pandemic with significant impacts on health and economies. Despite a lower case fatality ratio compared to other coronaviruses, it has a higher transmissibility rate, resulting in a constant rise in global infections. Efforts are being made to enhance risk mitigation strategies and containment interventions to suppress future pandemic crises and improve global coordination in responding to such outbreaks.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Engineering, Environmental
Kyle Bibby, Aaron Bivins, Zhenyu Wu, Devin North
Summary: Wastewater-based epidemiology (WBE) is a valuable tool for tracking and containing COVID-19 spread, with potential for early warning, but delays in analysis and reporting should be considered for a full assessment of its potential. Analysis suggests a potential lead time of four days for WBE in community-level wastewater surveillance, increasing in settings with limited clinical testing capacity.
Article
Multidisciplinary Sciences
Leonidas Salichos, Jonathan Warrell, Hannah Cevasco, Alvin Chung, Mark Gerstein
Summary: This study models the spatiotemporal flow of COVID-19 transmission based on genetic sequences and finds that the initial outbreak can mostly be traced to a few lineages, indicating a continuous viral flow. The study also suggests that localized strategies relying on herd immunity can negatively impact neighboring regions, and more efficient mitigation can be achieved with unified cross-border interventions.
SCIENTIFIC REPORTS
(2023)
Article
Pharmacology & Pharmacy
Jose Manuel Ramos-Rincon, Hector Pinargote-Celorio, Jara Llenas-Garcia, Oscar Moreno-Perez, Inmaculada Gonzalez-Cuello, Pilar Gonzalez-de-la-Aleja, Belen Martinez-Lopez, Sergio Reus, Maria Garcia-Lopez, Juan Carlos Rodriguez, Vicente Boix, Esperanza Merino
Summary: This study evaluated the effectiveness and safety of remdesivir therapy in immunocompromised COVID-19 outpatients at high risk for disease progression. The results showed that treatment with remdesivir reduced the risk of hospitalization or death in high-risk COVID-19 outpatients, regardless of immunocompetence status.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Engineering, Chemical
Chiara Vianello, Andrea Bassani, Paolo Mocellin, Flavio Manenti, Carlo Pirola, Bruno Fabiano, Simone Colombo, Giuseppe Maschio
Summary: Sustainable development is crucial for environmental policy and requires technological innovation. Combining Life Cycle Assessment and Risk Assessment can highlight the health and environmental impacts of processes.
JOURNAL OF LOSS PREVENTION IN THE PROCESS INDUSTRIES
(2022)
Article
Chemistry, Physical
Mattia Carboni, Gianmaria Pio, Paolo Mocellin, Francesco Pilo, Chiara Vianello, Paola Russo, Giuseppe Maschio, Ernesto Salzano
Summary: This study presents an experimental and numerical characterization of the jet flame produced after the accidental release of pure hydrogen from a high-pressure tank. The results, expressed in terms of temperature history and flame length, show excellent agreement between the computational fluid dynamic and experimental data.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2022)
Review
Energy & Fuels
Andrea Pietro Reverberi, Valery Pavlovic Meshalkin, Oleg B. B. Butusov, Tamara B. B. Chistyakova, Maurizio Ferretti, Anna Maria Cardinale, Bruno Fabiano
Summary: A critical survey of biocidal energetics based on their chemical structure is proposed, with a focus on optimizing compound performance for the inertization of biological weapons. The study discusses and compares the physicochemical aspects related to synthesis technique, thermodynamic variables, and antimicrobial activity. The role of iodine as an eco-friendly chemical species is emphasized. Evaluation protocols for biocidal agents are examined, and suggestions for future research are provided.
Article
Computer Science, Interdisciplinary Applications
Andrea Galeazzi, Kristiano Prifti, Carlo Cortellini, Alessandro Di Pretoro, Francesco Gallo, Flavio Manenti
Summary: Advancements in the process industry require more complex simulations and computationally intensive operations. This study developed a surrogate model for an industrial amine scrubbing digital twin, based on a process simulation created in Aspen HYSYS and validated against real process data. The surrogate model relied on an accurate Design of Experiments procedure, using the Latin-Hypercube method and nested domains. Multiple machine learning models were trained and the most accurate one was selected. The resulting surrogate model showed satisfactory performance given the available data.
COMPUTERS & CHEMICAL ENGINEERING
(2023)
Article
Engineering, Chemical
Kristiano Prifti, Andrea Galeazzi, Flavio Manenti
Summary: Plastic waste treatment is crucial for circular economic models and the energy transition, and this work aims to address the lack of chemical valorization methods for low quality plastic waste with high impurity content. The proposed solution involves converting plastic waste to methanol through gasification, with thermodynamic characterization and kinetic modeling used to simulate the process. Different proportions of polystyrene in a polypropylene/polyethylene mixture are tested to evaluate the process behavior for feedstock with low hydrogen content. The performance of the process is assessed for each type of feedstock, and the operational expenditures, net present value, and internal rate of return are calculated for different plant capacities.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2023)
Article
Engineering, Chemical
Kristiano Prifti, Andrea Galeazzi, Flavio Manenti
Summary: Chemical recycling of plastic waste is a topic of high interest due to the inefficiency of waste management and the increasing production of polymers each year. Gasification, as a potential treatment, offers the synthesis of chemicals with advantages such as autothermal conditions and robustness to contaminants. This paper proposes a concept for gasification recycling, validated by experimental campaigns in a demo-scale plant, to estimate methanol synthesis yield. The economic performance of the plant at different scales is evaluated through net present value, internal rate of return, and payback time analysis.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2023)
Article
Engineering, Environmental
Tomaso Vairo, Davide Cademartori, Davide Clematis, Maria Paola Carpanese, Bruno Fabiano
Summary: With increasing concerns about shipping emissions and the need to reduce the environmental impact, fuel cells are expected to play a vital role in ship propulsion. Specifically, Solid Oxide Fuel Cells (SOFCs) are seen as offering high electrical efficiency and the ability to combine heat and power production. This study focuses on the safety implications of using fuel cells in maritime applications and develops a machine-learning model to detect critical events and enhance predictive capabilities for SOFC systems. This approach, although requiring further validation, represents a significant step towards accurately predicting accident conditions.
PROCESS SAFETY AND ENVIRONMENTAL PROTECTION
(2023)
Article
Engineering, Environmental
Tomaso Vairo, Margherita Pettinato, Andrea P. Reverberi, Maria Francesca Milazzo, Bruno Fabiano
Summary: Machine learning tools have gained increased importance in enhancing system resilience due to energy transition, climate change, and digitalization. However, challenges remain in defining system requirements and ensuring the reliability of the learning process. This study proposes a systematic framework based on system engineering to improve the reliability of learning process using the Hidden Markov Model (HMM) coupled with the Baum-Welch algorithm. The framework was applied to a real case of LNG bunkering, demonstrating its ability to learn from incomplete data, improve learning quality, make predictions, and enhance system resilience. The novelty of this work lies in ensuring the learning process and contributing to the development of an explainable, robust, and interpretable data-driven approach.
PROCESS SAFETY AND ENVIRONMENTAL PROTECTION
(2023)
Article
Green & Sustainable Science & Technology
Daniel Cristiu, Federico d'Amore, Paolo Mocellin, Fabrizio Bezzo
Summary: This study develops a multi-objective mixed integer linear programming model framework to optimize the design of carbon capture and sequestration infrastructure in Italy. The results show that the optimal solution considering seismic risk increases the total cost, and offshore sequestration alone also leads to cost increase.
INTERNATIONAL JOURNAL OF GREENHOUSE GAS CONTROL
(2023)
Article
Engineering, Chemical
Paolo Mocellin, Gianmaria Pio, Mattia Carboni, Francesco Pilo, Chiara Vianello, Ernesto Salzano
Summary: The use of cryogenic liquefaction for the transportation and storage of natural gas has been promoted due to the need for sustainable energy sources and the current energetic crisis. Understanding the combustion at low temperatures and the interactions between water and cryogenic liquid are crucial for a robust and safe infrastructure. This study presents an experimental campaign on mitigation strategies for the accidental release of LNG, focusing on the effects of water on cryogenic pool fire. The findings provide insights for the development of safe emergency response procedures for cryogenic fuels.
JOURNAL OF LOSS PREVENTION IN THE PROCESS INDUSTRIES
(2023)
Article
Engineering, Industrial
Paolo Mocellin, Lisa Pilenghi
Summary: In the European Union, many chemical plants that are over 50 years old have caused more than half of the major accidents due to technical integrity loss and aging equipment. Therefore, it is crucial to include aging issues in risk evaluation and prioritization. Current literature and initiatives have focused on providing structured tools to evaluate system performance based on safety, economics, and aging. However, these strategies and practices tend to overlook a global perspective, leading to controversial solutions. This study aims to fill the knowledge gap by developing a semi-quantitative methodology that prioritizes risk based on unbiased and aggregated safety, economic, and aging indicators. The methodology utilizes matrices to systematically embed these indicators, resulting in the ranking of process equipment and providing practical recommendations for inspections. A case study in a major accident establishment producing agrochemicals demonstrates the implementation of the proposed methodology, which has helped prioritize risk reduction actions, improve resource allocation, and adjust equipment maintenance plans while meeting legislative requirements.
RELIABILITY ENGINEERING & SYSTEM SAFETY
(2023)
Article
Ecology
Paolo Mocellin, Gianmaria Pio, Mattia Carboni, Francesco Pilo, Chiara Vianello, Ernesto Salzano
Summary: The need for sustainable energy sources has led to the increased use of LNG as a low-carbon fuel. However, there are concerns about its safe use and transportation. This study conducted experiments to characterize the release of medium-scale LNG and found that the commonly assumed equality between evaporation rate and burning rate for LNG pools is inaccurate. The flame morphology analysis showed a maximum ratio between flame height and diameter of 2.5 and temperatures up to 1100 K near the flame.
Article
Thermodynamics
Diego Maporti, Federico Galli, Paolo Mocellin, Gianluca Pauletto
Summary: This work reports the design of a flexible combined process in which electrified cracking and oxidative dehydrogenation processes are coupled. It identifies an economic viable alternative to the conventional fuel-fired cracking for the production of ethylene, reducing energy consumptions and carbon dioxide emissions.
ENERGY CONVERSION AND MANAGEMENT
(2023)
Article
Engineering, Industrial
Giordano Lilli, Matteo Sanavia, Roberto Oboe, Chiara Vianello, Mattia Manzolaro, Pasquale Luca De Ruvo, Alberto Andrighetto
Summary: This paper presents the Probabilistic Risk Assessment (PRA) developed for crucial components of the SPES nuclear facility, aiming to improve operational safety and reliability. HAZOP and LOPA methods were used to evaluate the risk and consequences of failure scenarios, leading to proposed safety measures and design improvements.
RELIABILITY ENGINEERING & SYSTEM SAFETY
(2024)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)