Pathogenesis of COVID-19 and the quality control of nucleic acid detection

The new coronavirus pneumonia (COVID-19) epidemic spread rapidly throughout the world. Considering the strong infectivity and clustering of COVID-19, early detection of infectious cases is of great significance to control the epidemic. Nucleic acid testing (NAT) plays an important role in rapid laboratory diagnosis, treatment assessment, epidemic prevention and control of COVID-19. However, since COVID19 is caused by a new emerging virus and NAT for COVID-19 has not been clinically applied before, false negative results inconsistent with clinical diagnosis have appeared in clinical practice. Therefore, it is urgent to improve the sensitivity of NAT for COVID-19. This study aimed to summarize the current situation and prospect of NAT based on the latest findings on COVID-19 infection. Also, the quality control of sample collection was discussed. Hopefully, this study could help to improve the effectiveness of NAT for COVID-19. (c) 2021 Elsevier Inc. All rights reserved.

Automated summary

This study aims to summarize the current situation and prospect of nucleic acid testing (NAT) for COVID-19, as well as the urgency to improve its sensitivity. The article discusses the quality control of sample collection and hopes that this study will help improve the effectiveness of COVID-19 nucleic acid testing.