期刊
AQUACULTURE RESEARCH
卷 52, 期 6, 页码 2361-2376出版社
WILEY
DOI: 10.1111/are.15089
关键词
aquaculture organisms; aquatic diseases; pathogenic bacteria; toxins; virulence molecules
类别
资金
- Aquaculture and Marine Biotechnology Program, Department of Biotechnology (DBT), Ministry of Science and Technology, Government of India, New Delhi [BT/PR13183/AAQ/3/723/2015]
- Universiti Putra Malaysia Research Grant, Malaysia [LRGS/1/2019/UPM/1]
Bacterial virulence factors, especially toxins, play a crucial role in influencing host cells and facilitating microbial infection. These factors, such as adhesins and capsular polysaccharides, interact with host immune molecules and play a significant role in the pathogenesis of bacterial infections in fish.
Bacterial virulence factors play a major role in infection, which provides devastating effect on the aquaculture industry. Bacterial toxins are the major virulence factors that influence the roles of host cells and take control of living organisms' vital processes to facilitate microbial infection. Various other bacterial virulent components such as adhesins, capsular polysaccharides, lipopolysaccharides, bacterial flagellum, pili and microbial siderophore provide a diverse effect in the microbial pathogenesis and express a variety of pathogenic molecules including aebABCEG, HutA, cpsD and pPHDD1. Bacterial protein secretion system secretes enzymes and toxins from bacterial cytoplasm to the host membrane targeting the immune cells and promoting biofilm formation. However, as they enter, the host body expresses various immune molecules that interact to utilize the pathogen recognition receptors. Toxins are powerful molecules formed by a broad range of bacterial pathogens attacking host cells and playing key roles in the dialogue between host and pathogen. They are important virulence factors that are often enough to decide the outcome of the infection. Hence, a detailed view on the virulence molecules majorly exotoxins from various bacterial pathogenic strains that are necessary to understand the pathogenesis. This review focuses on bacterial toxins and various other virulence factors, which influence the pathogenesis in fish.
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