Article
Ophthalmology
Noriko Inada, Jun Shoji, Gaku Harata, Kenji Miyazawa, Fang He, Akiko Tomioka, Akira Hirota, Yukiko Tonozuka, Satoru Yamagami
Summary: The diversity of ocular surface microbiota is decreased in patients with refractory allergic conjunctival diseases (ACDs), especially in severe cases. The dysbiosis of microbiota is more pronounced in severe ACD patients compared to mild ACD patients and healthy controls.
Article
Immunology
Xueyan Zhang, Xianyang Hu, Tengfei Tian, Wenhui Pang
Summary: With the rising incidence of allergic diseases, the role of ICOS in the development of these diseases has been extensively studied. ICOS affects the functional activity of immune cells involved in allergic reactions and plays a crucial role in coordinating the immune system response.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Mahmoud Mostafa, Adel Al Fatease, Raid G. Alany, Hamdy Abdelkader
Summary: Chronic ocular diseases have a significant impact on vision and the potential to cause blindness. Developing sophisticated, long-acting drug delivery systems is crucial for treating these conditions. This review explores non-invasive drug delivery nanocarriers that can control chronic eye disorders, although most are still in preclinical or clinical stages.
Review
Ophthalmology
Sean Ming Sheng Ng, Rebecca Low, Clara Pak, SerSei Lai, Bernett Lee, Peter McCluskey, Richard Symes, Alessandro Invernizzi, Edmund Tsui, Ranju Kharel Sitaula, Muna Kharel, Anadi Khatri, Anna Nur Utami, Rina La Distia Nora, Ikhwanuliman Putera, Alok Sen, Manisha Agarwal, Padmamalini H. Mahendradas, Jyotirmay Biswas, Carlos Pavesio, Luca Cimino, Lucia Sobrin, John Kempen, Vishali Gupta, Rupesh Agrawal
Summary: In the current literature, there is a lack of clinical registry cohorts related to ocular inflammation, especially those involving multinational data. Existing registries are limited in scope and may not provide robust data for prognostication or epidemiological conclusions in the field of uveitis. To address this, the Ocular Autoimmune Systemic Inflammatory Infectious Study (OASIS) Clinical Registry has been developed. OASIS collects comprehensive clinical data from patients with ocular inflammatory conditions worldwide, aiming to create a well-organized dataset for analysis and various applications such as epidemiological analysis and treatment guidelines development.
Article
Multidisciplinary Sciences
Woohyun Park, Van Phuc Nguyen, Yale Jeon, Bongjoong Kim, Yanxiu Li, Jonghun Yi, Hyungjun Kim, Jung Woo Leem, Young L. Kim, Dong Rip Kim, Yannis M. Paulus, Chi Hwan Lee
Summary: This article introduces a unique platform for ocular drug delivery, which integrates silicon nanoneedles with tear-soluble contact lenses. The platform enables painless and long-term sustained delivery of ocular drugs, and has shown effectiveness in treating chronic ocular diseases.
Article
Ophthalmology
Animesh Sahu, Savleen Kaur, Jaspreet Sukhija, Priyanka Srivastava, Anupriya Kaur
Summary: This study presents the experience of a developing ocular genetic service, conducted at a tertiary care hospital in North-West India from Jan 2020 to Dec 2021. The study included children with congenital or late-onset ocular disorders and individuals of any age referred for genetic counseling. Genetic testing was outsourced and accepted by 55.5% of families, with the opportunity for prenatal diagnosis being the most useful application.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2023)
Review
Immunology
Peng Liu, Chenglin Kang, Jin Zhang, Yue Liu, Jiangqi Liu, Tianyong Hu, Xianhai Zeng, Shuqi Qiu
Summary: Allergic diseases are common and important diseases affecting many patients worldwide. Dendritic cells (DC) play a crucial role in these diseases by presenting allergens, secreting cytokines, and participating in immune regulation. However, current research on DC is limited and further exploration is needed to understand their role in different allergic diseases.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Microbiology
Maimaiti Tuniyazi, Shuang Li, Xiaoyu Hu, Yunhe Fu, Naisheng Zhang
Summary: Allergic diseases are becoming a major healthcare issue in developed nations due to distinct living environments and lifestyle factors. Modulating the human microbiota has been shown to improve allergic symptoms, suggesting a potential therapeutic or preventive strategy. This paper reviews recent findings on the role of human microbiota in the development of allergic diseases and discusses the implications for modulating microbial composition.
Review
Pharmacology & Pharmacy
Xiaojun Wang, Fuxiao Luan, Hua Yue, Cui Song, Shuang Wang, Jing Feng, Xiao Zhang, Wei Yang, Yuxin Li, Wei Wei, Yong Tao
Summary: Due to the complexity of ocular diseases and the natural ocular barriers, drug therapy for these diseases has limitations. With the development of biotechnology, smart materials have been widely tested to treat ocular diseases. This review analyzes recent developments in smart materials and discusses future directions for clinical translation.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Environmental Sciences
Min-Hua Lin, She-Yu Chiu, Wen-Chao Ho, Kai-Hsien Chi, Tsung-Yun Liu, I-Jen Wang
Summary: The study revealed a positive association between TCS exposure and IgE levels, suggesting a potentially higher risk of pediatric atopic disorders among preschoolers.
JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
(2022)
Review
Cell Biology
Nicoletta Marchesi, Foroogh Fahmideh, Federica Boschi, Alessia Pascale, Annalisa Barbieri
Summary: The possible interconnection between the eye and central nervous system has been discussed for many years, with the eye considered an extension of the brain. The visual process involves the retina and optic nerve transferring visual stimuli to the brain. Ocular pathologies, including glaucoma and age-related macular degeneration, may lead to irreversible blindness, highlighting the importance of understanding the relationship between eye and brain for potential new therapies.
Review
Immunology
Yongfang Wang, Huiying Wang
Summary: HDAC1 plays a critical role in allergic response by regulating cytokine levels and key protein expression. Research on HDAC1 helps to understand the pathogenesis of allergic diseases and provides potential directions for developing new therapeutic targets for these conditions.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Wei Xue, Jing Jing Li, Yanli Zou, Bin Zou, Lai Wei
Summary: Recent research has identified significant associations between the gut microbiota and eye diseases, with the potential impact of microbial communities on ocular disorders being recognized. The review discusses microbiota analysis methods, the role of commensal microbes in ophthalmic diseases, the hypothesis of the gut-eye axis, and the therapeutic potential of targeting commensal microbiota to alleviate ocular inflammation.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Lei Wan, Yu-An Hsu, Chang-Ching Wei, Fu-Tong Liu
Summary: Allergic inflammatory diseases are a global public health concern. Galectins, a group of beta-galactoside-binding proteins, have been identified as important factors in modulating inflammatory reactions, but there may be potential issues in understanding their exact biological functions.
MOLECULAR ASPECTS OF MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Wenran Li, Mengqi Liu, Ming Chu
Summary: The IL-33/ST2 axis plays a crucial role in the pathogenesis of allergic diseases and shows promise in allergy treatment. Targeting regulation of IL-33 and ST2 or molecules involved in the signal transduction can block IL-33/ST2 activity.
BIOCHEMICAL PHARMACOLOGY
(2023)
