Article
Chemistry, Multidisciplinary
Daishun Ling
Summary: Self-assembly in nature creates complex structures and is important in drug delivery design. Understanding the behavior of dynamic nanoassembly-based drug delivery systems in biological media and cells is crucial for controlling drug release. Tailor-made drug delivery systems offer potential for precise diagnosis and treatment of diseases, with current challenges and future perspectives outlined.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Chemistry, Multidisciplinary
Yuanhui Xiang, Sijie Xian, Rachel C. Ollier, Sihan Yu, Bo Su, Irawan Pramudya, Matthew J. Webber
Summary: This study demonstrates the use of a new diboronate motif for preparing dynamic-covalent hydrogels with enhanced glucose binding and specificity, leading to improved glucose responsiveness and insulin release. Compared to traditional phenylboronic acid approaches, diboronate hydrogels show greater practicality.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Chemistry, Multidisciplinary
Selina Hollstein, Lamiaa M. A. Ali, Maeva Coste, Julian Vogel, Nadir Bettache, Sebastien Ulrich, Max von Delius
Summary: The increased importance of RNA-based therapeutics requires the development of next-generation stimuli-responsive systems for binding, transporting, and releasing RNA oligomers. In this study, we present triazolium-based amphiphiles capable of binding siRNA and enzyme-responsive release of the nucleic acid payload. These amphiphiles self-assemble into nanocarriers that can disintegrate in the presence of esterase. The molecular design includes a self-immolative linker anchored to the triazolium moiety, which acts as a positively-charged polar head group. Esterase triggers a cascade degradation of the linker, resulting in the release of the negatively-charged siRNA. This molecular design and approach are promising for various applications beyond this proof-of-principle study, thanks to efficient CuAAC click chemistry and mild esterase cleavage.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Engineering, Biomedical
Qiuhui Qian, Dali Wang, Leilei Shi, Zhihao Zhang, Jiwen Qian, Jian Shen, Chunyang Yu, Xinyuan Zhu
Summary: Local drug delivery systems, particularly hydrogels, have shown great potential in preventing postoperative tumor recurrence. However, their clinical translation has been hindered by the need for chemical modification or additional carrier molecules. A newly developed pure molecular anticancer drug hydrogel has demonstrated effectiveness in reducing tumor recurrence rates and could serve as a powerful tool in preventing postoperative local tumor recurrence.
Review
Chemistry, Multidisciplinary
Rouba D. Al Bostami, Waad H. Abuwatfa, Ghaleb A. Husseini
Summary: Cancer therapies have made significant advancements in the past decade, but there are still barriers to their success. Nanomedicines that deliver multiple drugs and genes simultaneously have shown improved effectiveness and synergistic effects. However, the development of co-delivery systems faces limitations and challenges and requires a better understanding of the therapeutic agent ratio and heterogeneity of cancer cells.
Article
Chemistry, Multidisciplinary
Bin Liu, Meagan A. Beatty, Charalampos G. Pappas, Kai Liu, Jim Ottele, Sijbren Otto
Summary: The study reports a system in which two cross-reactive dithiol building blocks self-sort into co-existing replicator fibers and foldamers, with the self-sorting behavior prevalent across different building block ratios.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Chong-Bin Tian, Qing-Fu Sun
Summary: Discrete organopalladium coordination cages have great potential in various applications such as molecular recognition and sensing, drug delivery, and enzymatic catalysis. Heteroleptic cages with complex architectures and anisotropic cavities have received increasing attention recently. This concept article discusses a powerful self-assembly strategy for constructing a family of organopalladium cages from a given library of ligands, including both homoleptic and heteroleptic structures. The heteroleptic cages often exhibit fine-tuned structures and emergent properties, distinct from their homoleptic counterparts. The concepts and examples provided in this article offer rational guidance for the design of new coordination cages with advanced functions.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Biotechnology & Applied Microbiology
Pengxuan Zhao, Yeteng Zhong, Pengcheng Pan, Shasha Zhang, Yu Tian, Jun Zhang, Guohui Yi, Zhendong Zhao, Tiantian Wu
Summary: Chronic myelogenous leukemia (CML) is a myeloproliferative disorder caused by BCR-ABL chimeric tyrosine kinase. In this study, a DNA nanoflower was prepared for the delivery of Vincristine (VCR) and P-glycoprotein small interfering RNA (P-gp siRNA) to overcome multidrug resistance (MDR) in CML. The nanoflower exhibited high VCR loading efficiency (80%) and successfully delivered VCR and P-gp siRNA into MDR CML cells, inducing potent cytotoxicity both in vitro and in vivo. Overall, this nanoflower shows promise as a tool for resistant CML therapy.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Marcin Sobczak, Karolina Kedra
Summary: With the development of polymeric biomaterials, drug delivery systems (DDSs) have become crucial in cancer therapy. Polyurethanes (PUs) are widely used in medicine and biomaterial engineering, and can be synthesized for anti-cancer DDSs by selecting suitable building blocks.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nanoscience & Nanotechnology
Emily M. Miller, Timothy M. Samec, Angela A. Alexander-Bryant
Summary: Ovarian cancer, characterized by lack of early symptoms and accurate diagnosis, poses the most lethal threat to women. Treatment complexity increases upon recurrence due to drug resistance development. Research in targeted nanoparticle delivery systems aims to improve specificity and efficacy in therapies for drug-resistant ovarian cancer.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
A. H. Lotfallah, J. J. Andreu, R. M. Hathout, D. H. Kassem, S. S. Ibrahim, B. Altava, E. Garcia-Verdugo, S. V. Luis
Summary: Nanovesicles based on tripodal amphiphilic pseudopeptides were developed as carriers for p-coumaric acid (p-CA) delivery. The nanovesicles obtained through thin film hydration and ethanol injection methods showed positive Z-potential values. The ethanol injection method resulted in smaller particle sizes and better polydispersity index. In vitro release experiments demonstrated interesting results under different external stimuli. The loaded pseudopeptide nanovesicles exhibited enhanced cytotoxicity against brain cancer cells, and the observed biological activity was associated with an enhanced permeability and retention effect.
MATERIALS TODAY CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Boris Bartolec, Armin Kiani, Meagan A. A. Beatty, Meniz Altay, Guillermo Monreal Santiago, Sijbren Otto
Summary: The complex interplay between systems and their environment is crucial in self-assembly and evolution. Polymorphism, induced by environmental pressures, leads to various structural organizations. By combining covalent and non-covalent bond formation, three distinct polymorphs can be generated from the same molecular network, depending on the solvent environment.
Article
Engineering, Biomedical
Wenjing Xu, Chunping Ye, Xin Qing, Shengli Liu, Xinyi Lv, Wenjun Wang, Xiaochen Dong, Yewei Zhang
Summary: Multi-target Tyrosine Kinase Inhibitors (MTKIs) have gained significant attention in tumor therapy due to their ability to inhibit tumor cell proliferation. However, their toxicity and drug resistance have limited their clinical application. In recent years, nano pharmaceutical technology has been used to deliver MTKIs through various types of nanocarriers, overcoming drug resistance and improving therapeutic efficiency.
MATERIALS TODAY BIO
(2022)
Article
Chemistry, Inorganic & Nuclear
Jan Holub, Antonio Santoro, Mihail-Adrian Stadler, Jean-Marie Lehn
Summary: The sequential assembly of terminally functionalized bishydrazone ligands followed by coordination with Zn(ii) metal cations yields multi-functionalized grid-type complexes. The introduction of aldehyde functional groups results in octavalent grids, offering potential for diverse dynamic covalent decorations. Further connection with a difunctional covalent linker leads to folded molecular grids with double hairpins geometry, allowing for multifunctional dynamic covalent chemistry.
INORGANIC CHEMISTRY FRONTIERS
(2021)
Article
Chemistry, Physical
Jia Liu, Daan Fu, Kang Wang, Ye Yuan, Yan Deng, Lin Shi, Mingyi Li, Cheng Zhou, Xiaohuan Lu, Qiying Lv, Guobin Wang, Lin Wang, Zheng Wang
Summary: Regorafenib nanodrug, fabricated with indocyanine green, overcomes the limitations of regorafenib's low bioavailability and improves its therapeutic efficacy in advanced CRC. The nanodrug significantly enhances regorafenib's tumor inhibiting efficacy and extends survival in preclinical CRC models, showing potential for clinical translation.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Review
Pharmacology & Pharmacy
Deepa Nakmode, Valamla Bhavana, Pradip Thakor, Jitender Madan, Pankaj Kumar Singh, Shashi Bala Singh, Jessica M. Rosenholm, Kuldeep K. Bansal, Neelesh Kumar Mehra
Summary: Poor aqueous solubility of drugs remains a major challenge in pharmaceutical product development. Utilizing lipids in formulation design offers an opportunity to enhance the solubility and bioavailability of drugs. This review comprehensively summarizes the classification, absorption mechanisms, and lipid-based product development of lipid excipients, as well as discusses the preparation methodologies, applications, phase behavior, and regulatory perspective of solid and semi-solid lipid formulations.
Review
Pharmacology & Pharmacy
Mijanur Rahman, Aliaa Ali, Erica Sjoholm, Sebastian Soindinsalo, Carl-Eric Wilen, Kuldeep Kumar Bansal, Jessica M. Rosenholm
Summary: This review article discusses the synthesis methods and post-synthesis modifications of allyl-terminated polymers, as well as their biomedical applications.
Review
Pharmacology & Pharmacy
Maram Suresh Gupta, Devegowda Vishakante Gowda, Tegginamath Pramod Kumar, Jessica M. Rosenholm
Summary: This review provides an overview of patented technologies for fabricating orodispersible films (ODFs) in the past two decades. The solvent casting method (SCM) is identified as the most popular method, while electrospinning is considered a recent and upcoming method for ODF fabrication.
Article
Chemistry, Analytical
Berrin Kucukturkmen, Wali Inam, Fadak Howaili, Mariam Gouda, Neeraj Prabhakar, Hongbo Zhang, Jessica M. Rosenholm
Summary: Microfluidics has been used to coat mesoporous silica nanoparticles (MSNs) with polymeric layers for achieving high protein loading and retention. This study demonstrates the potential of microfluidic technologies in the design of protein delivery systems, allowing for multicomponent systems and preservation of protein stability.
Article
Materials Science, Multidisciplinary
Lirong Zhang, Xiaodong Ma, Wenhui Zhou, Qiwei Wu, Jiaqi Yan, Xiaoyu Xu, Bhawana Ghimire, Jessica M. Rosenholm, Jing Feng, Dongqing Wang, Hongbo Zhang
Summary: This study successfully constructed a nanoplatform for triple-negative breast cancer treatment by combining photothermal therapy, prodrug design, and tumor cell camouflage formulation, achieving effective therapeutic effects against TNBC. The nanoparticles demonstrated excellent drug release performance and enhanced targeting ability to tumor cells.
MATERIALS TODAY ADVANCES
(2022)
Article
Chemistry, Multidisciplinary
Jingjing Yu, Dawei Qi, Ermei Makila, Lippo Lassila, Anastassios C. Papageorgiou, Markus Peurla, Jessica M. Rosenholm, Zhao Zhao, Pekka Vallittu, Sirpa Jalkanen, Chunman Jia, Jianwei Li
Summary: This study reports on the formation of plastics using liquid-liquid phase separation (LLPS) as a promising approach to explore eco-friendly supramolecular plastics. These plastics have the advantages of stability, sustainability, and recyclability.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Materials Science, Biomaterials
Kuldeep Kumar Bansal, Aliaa A. Ali, Mijanur Rahman, Erica Sjoholm, Carl-Eric Wilen, Jessica M. Rosenholm
Summary: Achieving high solubilization capacity with the aid of polymeric micelles is challenging. In this study, novel PJL-based PMs were developed and found to have significantly higher solubility compared to Soluplus and poly(lactide) copolymer. The presence of appropriate functional groups on the polymer chain was demonstrated to facilitate the solubilization potential of PM.
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2023)
Article
Multidisciplinary Sciences
Jia Shen, Chang Liu, Pengpeng Yan, Meifang Wang, Luying Guo, Shuaihui Liu, Jianghua Chen, Jessica M. Rosenholm, Hongfeng Huang, Rending Wang, Hongbo Zhang
Summary: This study investigates the potential of delivering Tacrolimus to helper T cells using functionalized mesoporous nanoparticles to block Tfh cell differentiation. The results demonstrate that this approach can alleviate humoral rejection injury in transplants without causing severe side effects.
Article
Nanoscience & Nanotechnology
XiaoHui Zhao, JinPing Cheng, Shushu Gui, Meng Jiang, Dawei Qi, Jianghua Huang, Liren Fu, Shijie Liu, Yujia Ma, Juntian Shi, Zairui Wang, Weike Zeng, Xiumei Li, Kejia Liu, Yamei Tang
Summary: Radiation-induced brain injury (RIBI) is a severe complication of radiotherapy for head and neck tumors with no effective prevention or treatment. This study developed a nanoparticle platform for targeted delivery of the free radical scavenger, AMF, to the brain. The results showed that the nanoparticles effectively crossed the blood-brain barrier and significantly reduced brain necrosis and neuronal damage in a mouse model of brain injury.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Organic
Jinjing Wang, Xiongbo Liu, Shikai Yang, Ao Yu, Jinshan Li, Hongtao Liu, Jianwei Li, Chunman Jia
Summary: A solvent-free ball-milling method has been developed to synthesize diverse disulfide and thiosulfonate derivatives from easily available and odorless sodium sulfinates. This convenient mechanochemical protocol allows the rapid and selective construction of disulfides and thiosulfonates.
Article
Chemistry, Multidisciplinary
Kang Yang, Dan Wei, Chunman Jia, Jianwei Li
Summary: In recent years, the sol-gel method has been widely used to develop efficient and stable organic semiconductor composite photocatalysts. However, high-temperature calcination requirements of this method degrade the encapsulated organic semiconductor molecules and decrease photocatalytic hydrogen production efficiency. In this study, using 1,4-naphthalene dicarboxylic acid (NA) as the organic semiconductor, high-temperature calcination was avoided in the sol-gel process, resulting in an organic-inorganic hybrid material with stable and effective photocatalytic properties. The uncalcined material exhibited higher hydrogen production rate and larger specific surface area compared to the calcined material.
Article
Nanoscience & Nanotechnology
Xiaoxia Wu, Dinghu Zhang, Ting Pan, Jianwei Li, Yujiao Xie, Chenguang Zhang, Chunshu Pan, Zhewei Zhang, Jie Lin, Aiguo Wu, Guoliang Shao
Summary: This study utilized in situ dynamic covalent chemistry to control the co-self-assembly of an anticancer drug and ultrasmall iron oxide nanoparticles. The dynamic covalent self-assembly strategy allowed for concentration regulation of the different components, resulting in a stable codelivery nanosystem with intelligent drug release. Furthermore, the codelivery system conjugated with a targeting molecule exhibited significant biocompatibility and enhanced dual-modal MRI abilities.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biochemical Research Methods
Yonglei Lyu, Xiaoxia Wu, Jinghui Yang, Xin Wang, Jianwei Li
Summary: This study provides a protocol for preparing a delivery system using a combination therapy against multiple drug resistance. By co-delivering doxorubicin and siRNA using dynamic covalent macrocycles, enhanced anti-cancer efficacy is achieved in vitro.
Article
Chemistry, Multidisciplinary
Dan Wei, Kang Yang, Chunman Jia, Jianwei Li
Summary: Sensitizing titanium dioxide (TiO2) with dye molecules reduces the band gap and enhances sunlight absorption, leading to cost-effective and environmentally friendly photocatalysts for hydrogen production. The use of a 1,8-naphthalimide derivative-sensitized TiO2 achieves ultra-efficient photocatalytic hydrogen production (10.615 mmol g(-1) h(-1)) and maintains activity after 30 hours of cycling. This research provides valuable insights for designing optimized organic dye-sensitized photocatalysts, advancing clean and sustainable energy solutions.
CHEMICAL COMMUNICATIONS
(2023)
Article
Materials Science, Biomaterials
Xiaoxia Wu, Jinghui Yang, Jie Xing, Yonglei Lyu, Ruifen Zou, Xin Wang, Junlie Yao, Dinghu Zhang, Dawei Qi, Guoliang Shao, Aiguo Wu, Jianwei Li
Summary: Researchers have developed a nano delivery system that combines photodynamic therapy (PDT) and chemotherapy (CHT), showing promise in safe and effective cancer treatment. The system utilizes engineered interfacial interactions between Ag2S quantum dots to deliver anti-cancer drugs and photosensitizers. Smart drug release under acidic microenvironments and high-efficiency drug delivery to tumor sites were achieved, demonstrating significant treatment efficacy in in vitro and in vivo studies.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
