Holistic characterization of single-hepatocyte transcriptome responses to high-fat diet

Multi-omics characterization of a diet-induced obese model of non-alcoholic steatohepatitis

(2020) Helene M. Ægidius et al.   Scientific Reports

Single-cell genomics and spatial transcriptomics: discovery of novel cell states and cellular interactions in liver physiology and disease biology

(2020) Antonio Saviano et al.   JOURNAL OF HEPATOLOGY

Single Cell RNA Sequencing Identifies Subsets of Hepatic Stellate Cells and Myofibroblastsin Liver Fibrosis

(2019) Oliver Krenkel et al.   Cells

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

Landscape of Intercellular Crosstalk in Healthy and NASH Liver Revealed by Single-Cell Secretome Gene Analysis

(2019) Xuelian Xiong et al.   MOLECULAR CELL

Resolving the fibrotic niche of human liver cirrhosis at single-cell level

(2019) P. Ramachandran et al.   NATURE

Single-Cell Transcriptomics Uncovers Zonation of Function in the Mesenchyme during Liver Fibrosis

(2019) Ross Dobie et al.   Cell Reports

ShinyGO: a graphical gene-set enrichment tool for animals and plants

(2019) Steven Xijin Ge et al.   BIOINFORMATICS

Recovering Gene Interactions from Single-Cell Data Using Data Diffusion

(2018) David van Dijk et al.   CELL

Lipotoxicity induces hepatic protein inclusions through TANK binding kinase 1-mediated p62/sequestosome 1 phosphorylation

(2018) Chun-Seok Cho et al.   HEPATOLOGY

SAVER: gene expression recovery for single-cell RNA sequencing

(2018) Mo Huang et al.   NATURE METHODS

Dimensionality reduction for visualizing single-cell data using UMAP

(2018) Etienne Becht et al.   NATURE BIOTECHNOLOGY

Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations

(2018) Sonya A. MacParland et al.   Nature Communications

Lipid zonation and phospholipid remodeling in nonalcoholic fatty liver disease

(2017) Zoe Hall et al.   HEPATOLOGY

Single-cell spatial reconstruction reveals global division of labour in the mammalian liver

(2017) Keren Bahar Halpern et al.   NATURE

Seq-Well: portable, low-cost RNA sequencing of single cells at high throughput

(2017) Todd M Gierahn et al.   NATURE METHODS

Ablation of cytochrome P450 omega-hydroxylase 4A14 gene attenuates hepatic steatosis and fibrosis

(2017) Xiaoyan Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hepatic Dysfunction Caused by Consumption of a High-Fat Diet

(2017) Anthony R. Soltis et al.   Cell Reports

High fat diet-induced changes of mouse hepatic transcription and enhancer activity can be reversed by subsequent weight loss

(2017) Majken Siersbæk et al.   Scientific Reports

Liver-specific loss of Perilipin 2 alleviates diet-induced hepatic steatosis, inflammation, and fibrosis

(2016) Charles P. Najt et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Hepatocyte-Specific Disruption of CD36 Attenuates Fatty Liver and Improves Insulin Sensitivity in HFD-Fed Mice

(2016) Camella G. Wilson et al.   ENDOCRINOLOGY

Perilipin-2 Deletion Impairs Hepatic Lipid Accumulation by Interfering with Sterol Regulatory Element-binding Protein (SREBP) Activation and Altering the Hepatic Lipidome

(2016) Andrew E. Libby et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Orchestrating Wnt signalling for metabolic liver zonation

(2016) Walter Birchmeier   NATURE CELL BIOLOGY

Zonation of hepatic fatty acid metabolism — The diversity of its regulation and the benefit of modeling

(2015) J. Schleicher et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Hybrid Periportal Hepatocytes Regenerate the Injured Liver without Giving Rise to Cancer

(2015) Joan Font-Burgada et al.   CELL

Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets

(2015) Evan Z. Macosko et al.   CELL

Probing hepatocyte heterogeneity

(2015) Ben Z Stanger   CELL RESEARCH

Self-renewing diploid Axin2+ cells fuel homeostatic renewal of the liver

(2015) Bruce Wang et al.   NATURE

Histopathology of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis

(2014) Yoshihisa Takahashi   WORLD JOURNAL OF GASTROENTEROLOGY

Integrated physiology and systems biology of PPARα

(2014) Sander Kersten   Molecular Metabolism

Prevalence of Nonalcoholic Fatty Liver Disease in the United States: The Third National Health and Nutrition Examination Survey, 1988–1994

(2013) Mariana Lazo et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Zonation of glucose and fatty acid metabolism in the liver: Mechanism and metabolic consequences

(2013) Brenda S. Hijmans et al.   BIOCHIMIE

A map of the PPARα transcription regulatory network for primary human hepatocytes

(2013) Patrick D. McMullen et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Targeted Disruption of G0/G1 Switch Gene 2 Enhances Adipose Lipolysis, Alters Hepatic Energy Balance, and Alleviates High-Fat Diet-Induced Liver Steatosis

(2013) X. Zhang et al.   DIABETES

NAFLD, NASH and liver cancer

(2013) Gregory A. Michelotti et al.   Nature Reviews Gastroenterology & Hepatology

Zonation of Nitrogen and Glucose Metabolism Gene Expression upon Acute Liver Damage in Mouse

(2013) Shahrouz Ghafoory et al.   PLoS One

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

(2012) Guangchuang Yu et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Transcription dynamics in a physiological process: β-Catenin signaling directs liver metabolic zonation

(2009) Cyril Torre et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Relationship of steatosis grade and zonal location to histological features of steatohepatitis in adult patients with non-alcoholic fatty liver disease

(2008) Naga Chalasani et al.   JOURNAL OF HEPATOLOGY