Article
Respiratory System
Robert Maidstone, Simon G. Anderson, David W. Ray, Martin K. Rutter, Hannah J. Durrington, John F. Blaikley
Summary: The study found that irregular or permanent shift work, day shift work, night shift work, etc. are associated with an increased risk of COVID-19 infection. Moreover, this association remained even after adjusting for factors like sleep duration, chronotype, premorbid disease, body mass index, alcohol, and smoking.
Article
Public, Environmental & Occupational Health
Mohamed Ghaith Al-Kuwari, Mariam Ali AbdulMalik, Asma Ali Al-Nuaimi, Jazeel Abdulmajeed, Hamad Eid Al-Romaihi, Sandy Semaan, Mujeeb Kandy
Summary: The study shows that COVID-19 infections are prevalent among healthcare workers in Qatar, particularly among outsourced non-clinical positions. Factors influencing infection rates may include environmental factors and compliance with preventative measures.
FRONTIERS IN PUBLIC HEALTH
(2021)
Review
Biochemistry & Molecular Biology
Pawel Franczuk, Michal Tkaczyszyn, Maria Kulak, Esabel Domenico, Piotr Ponikowski, Ewa Anita Jankowska
Summary: Viral respiratory infections (VRI) are common and can worsen existing cardiovascular diseases and lead to new complications, especially in COVID-19.
Article
Medicine, General & Internal
Kristen Grove, Dale W. Edgar, HuiJun Chih, Meg Harrold, Varsha Natarajan, Sheeraz Mohd, Elizabeth Hurn, Vinicius Cavalheri
Summary: This study compares the characteristics, in-hospital data, and rehabilitation needs between COVID-19 positive and negative patients during hospitalization. The results show significant differences in acute hospital length of stay, mechanical ventilation requirement, and discharge to inpatient rehabilitation between COVID-19 positive and negative patients. Despite having fewer pre-existing pulmonary diseases, COVID-19 positive patients require more care and rehabilitation.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Hannah Burke, Anna Freeman, Ahilanandan Dushianthan, Michael Celinski, James Batchelor, Hang Phan, Florina Borca, Christopher Kipps, Gareth J. Thomas, Saul N. Faust, Natasha Sheard, Sarah Williams, Paul Fitzpatrick, Donal Landers, Tom Wilkinson
Summary: This study aims to observe patients tested or treated for SARS-CoV-2 in order to identify those at risk of severe disease early on, allowing for intervention with experimental targeted treatments to reduce demand for critical care services. Data is collected electronically from hospital clinical record systems as well as manually by the clinical research team, with anonymised samples linked to clinical data for further analysis. Publications and presentations of the study results are planned.
Article
Public, Environmental & Occupational Health
Hamid Reza Saberi, Hadiseh Rabiei, Asma Zare, Milad Derakhshan Jazari, Mahdi Malakoutikhah
Summary: This study used scientometric methods to identify hot topics and research areas in the field of occupational diseases. The results showed that occupational exposures, epidemiology, mental health, and respiratory diseases were the most important keywords in this field.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Cardiac & Cardiovascular Systems
Thomas S. Metkus, Lori J. Sokoll, Andreas S. Barth, Matthew J. Czarny, Allison G. Hays, Charles J. Lowenstein, Erin D. Michos, Eric P. Nolley, Wendy S. Post, Jon R. Resar, David R. Thiemann, Jeffrey C. Trost, Rani K. Hasan
Summary: The study found that over 50% of intubated patients with severe COVID-19 had myocardial injury, which was associated with a higher mortality rate. Myocardial injury in COVID-19 was closely related to baseline comorbidities, age, and multisystem organ dysfunction. Compared with ARDS patients without COVID-19, COVID-19 patients were older and had poorer cardiac function, but had a lower incidence of myocardial injury.
Article
Multidisciplinary Sciences
Carole H. Sudre, Karla A. Lee, Mary Ni Lochlainn, Thomas Varsavsky, Benjamin Murray, Mark S. Graham, Cristina Menni, Marc Modat, Ruth C. E. Bowyer, Long H. Nguyen, David A. Drew, Amit D. Joshi, Wenjie Ma, Chuan-Guo Guo, Chun-Han Lo, Sajaysurya Ganesh, Abubakar Buwe, Joan Capdevila Pujol, Julien Lavigne du Cadet, Alessia Visconti, Maxim B. Freidin, Julia S. El-Sayed Moustafa, Mario Falchi, Richard Davies, Maria F. Gomez, Tove Fall, M. Jorge Cardoso, Jonathan Wolf, Paul W. Franks, Andrew T. Chan, Tim D. Spector, Claire J. Steves, Sebastien Ourselin
Summary: Documenting symptom time series in the early days of COVID-19 infection can help predict the need for respiratory support with high accuracy, allowing for the monitoring of at-risk patients and predicting medical resource requirements days in advance.
Review
Microbiology
Sima S. Toussi, Jennifer L. Hammond, Brian S. Gerstenberger, Annaliesa S. Anderson
Summary: This article reviews therapeutics for COVID-19 and their development, including prospects for anticoronavirals. Vaccines and monoclonal antibody treatments were available within a year, but there was still a need for therapeutics for certain patient groups. Investigational therapies showed mixed results, with some reducing viral load or preventing death. Nirmatrelvir-ritonavir and molnupiravir received Emergency Use Authorization in the United States. Immunomodulatory drugs targeting host-driven symptoms are also used. The article highlights the development of COVID-19 therapies and the challenges in developing anticoronavirals.
NATURE MICROBIOLOGY
(2023)
Article
Immunology
Edward M. Conway, Nigel Mackman, Ronald Q. Warren, Alisa S. Wolberg, Laurent O. Mosnier, Robert A. Campbell, Lisa E. Gralinski, Matthew T. Rondina, Frank L. van de Veerdonk, Karin M. Hoffmeister, John H. Griffin, Diane Nugent, Kyung Moon, James H. Morrissey
Summary: In this article, the authors discuss the emerging understanding of COVID-19-associated coagulopathy and the need to comprehend its cellular and molecular mechanisms. They categorize the current understanding into three main pathological mechanisms and address key questions and research gaps in order to improve diagnosis and treatment. The suitability of animal models for studying this condition is also considered.
NATURE REVIEWS IMMUNOLOGY
(2022)
Article
Environmental Sciences
Albert Nienhaus
Summary: The report provides an update on COVID-19 cases among health and social welfare workers in Germany. The majority of claims are from nursing homes (39.5%) and hospitals (37.6%), with the highest claim rate for hospitals. By May 3rd, 2021, 77 workers had died and 375 were hospitalized.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Review
Biochemistry & Molecular Biology
Alessandro Sette, Shane Crotty
Summary: The adaptive immune system, consisting of B cells, CD4(+) T cells, and CD8(+) T cells, plays varying roles in different viral infections and vaccines. Studies are showing that CD4(+) T cells, CD8(+) T cells, and neutralizing antibodies all play a part in controlling SARS-CoV-2 in COVID-19 cases, emphasizing the importance of understanding adaptive immunity in combating the disease.
Article
Critical Care Medicine
Luigi Camporota, Barnaby Sanderson, Davide Chiumello, Nicolas Terzi, Laurent Argaud, Thomas Rimmele, Romain Metuor, Aude Verstraete, Martin Cour, Julien Bohe, Vincent Piriou, Pascal Beuret, Claude Guerin
Summary: This study aimed to compare the response to prone position in patients with coronavirus disease 2019 acute respiratory distress syndrome and acute respiratory distress syndrome, and explore factors associated with survival. The results showed that prone position achieved similar oxygenation response in both patient groups and was associated with improved survival.
CRITICAL CARE MEDICINE
(2022)
Article
Health Care Sciences & Services
Robert Jarrin, Meredith A. Barrett, Leanne Kaye, Sibel Sayiner, Amanda von Leer, Jennifer Johns, Larissa D'Andrea, Carlos Nunez, Andrey Ostrovsky
Summary: The use of remote monitoring and virtual visits has accelerated during the COVID-19 pandemic to support socially-distanced patient care. Ambiguity in coding has hindered adoption and patient access, particularly for remote physiologic monitoring. Further clarification and broadening of coverage are needed to ensure equitable access to remote monitoring.
NPJ DIGITAL MEDICINE
(2021)
Review
Public, Environmental & Occupational Health
Amanda M. Wilson, Darrah K. Sleeth, Camie Schaefer, Rachael M. Jones
Summary: This article evaluates the roles of aerosol transmission and indirect contact transmission in viral respiratory infectious diseases, using COVID-19 as an example. Aerosol transmission is likely dominant for COVID-19. However, there are still key knowledge gaps regarding transmission processes and control strategies.
ANNUAL REVIEW OF PUBLIC HEALTH
(2022)
Article
Public, Environmental & Occupational Health
Emily M. Kraus, Kenneth A. Scott, Rachel Zucker, Dawn Heisey-Grove, Raymond J. King, Thomas W. Carton, Matthew F. Daley, Sara J. Deakyne Davies, Jason P. Block, Matthew Haemer, Alyson B. Goodman, Nedra Garrett, Arthur J. Davidson
Summary: Integrating longitudinal data from community-based organizations with electronic health record information can improve childhood obesity research. Through the implementation of a governance framework and specific policies, CODI successfully established a clinical-community governance strategy, enabling efficient data exchange and collaboration.
JOURNAL OF PUBLIC HEALTH MANAGEMENT AND PRACTICE
(2022)
Article
Public, Environmental & Occupational Health
Raymond J. King, Dawn M. Heisey-Grove, Nedra Garrett, Kenneth A. Scott, Matthew F. Daley, Matthew A. Haemer, Pradeep Podila, Jason P. Block, Tom Carton, Andrew J. Gregorowicz, K. Peter Mork, Renee M. Porter, Daniel L. Chudnov, Jim Jellison, Emily M. Kraus, Megan R. Harrison, Marissa Scalia Sucosky, Sarah Armstrong, Alyson B. Goodman
Summary: This study describes a participatory framework that enhances and implements innovative changes to support data linkage across sectors and systems. The framework engages stakeholders from public health and clinical fields to collaboratively develop an infrastructure that enhances data capacity. The study demonstrates the feasibility of rapid innovation and highlights the importance of early and iterative stakeholder engagement.
JOURNAL OF PUBLIC HEALTH MANAGEMENT AND PRACTICE
(2022)
Article
Respiratory System
Kristina Gaietto, Yueh-Ying Han, Erick Forno, Leonard B. Bacharier, Wanda Phipatanakul, Theresa W. Guilbert, Michael D. Cabana, Kristie Ross, Joshua Blatter, Edna Acosta-Perez, Gregory E. Miller, Rafael E. de la Hoz, Franziska J. Rosser, Sandy Durrani, Glorisa Canino, Stephen R. Wisniewski, Juan C. Celedon
Summary: This study found that violence-related distress may worsen lung function and quality of life in youth with asthma (even those treated with low-dose inhaled corticosteroids), further supporting policies to reduce exposure to violence among children in the USA and Puerto Rico.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Health Policy & Services
Kenneth A. Scott, Sara Deakyne Davies, Rachel Zucker, Toan Ong, Emily McCormick Kraus, Michael G. Kahn, Jessica Bondy, Matt F. Daley, Kate Horle, Emily Bacon, Lisa Schilling, Tessa Crume, Romana Hasnain-Wynia, Seth Foldy, Gregory Budney, Arthur J. Davidson
Summary: The study implements a two-step deduplication process within a distributed data network (DDN) to estimate chronic disease prevalence, using health information exchange (HIE)-assigned network identifiers. The findings suggest that cross-system duplication has limited impact on prevalence estimates, and factors such as data reconciliation strategy and demographic attributes may influence the degree of deduplication bias. This process demonstrates how learning health systems can address public health challenges and improve regional health outcomes.
LEARNING HEALTH SYSTEMS
(2022)
Article
Oncology
Keith Sigel, Rafael E. de la Hoz, Steven B. Markowitz, Chung Yin Kong, Kimberly Stone, Andrew C. Todd, Juan P. Wisnivesky
Summary: This study investigates the impact of toxic inhalable particles exposure on lung cancer risk among World Trade Center (WTC) rescue and recovery workers. The results suggest that there is no significant elevation in lung cancer incidence among WTC RRWV compared to an unexposed cohort. Age, smoking intensity, and mineral dust work are found to be associated with lung cancer risk.
Article
Environmental Sciences
Rafael E. E. de la Hoz, Michael R. R. Shohet
Summary: Chronic rhinosinusitis (CRS) is the most common adverse physical health effect among World Trade Center Health Program (WTCHP) members, and there is evidence supporting its association with dust, gases, and toxicant exposures. We selected the International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICARS-RS-2021) as a comprehensive evidence-based guide for the diagnosis and treatment of CRS in the WTCHP.
ARCHIVES OF ENVIRONMENTAL & OCCUPATIONAL HEALTH
(2023)
Article
Environmental Sciences
James E. Cone, Rafael E. de la Hoz
Summary: Exposure to the World Trade Center may have the potential to cause or worsen chronic obstructive pulmonary disease (COPD). The WTC Health Program follows the 2021 diagnostic and treatment guidelines of the Global Initiative for Chronic Obstructive Lung Disease (GOLD) to provide comprehensive clinical services for COPD.
ARCHIVES OF ENVIRONMENTAL & OCCUPATIONAL HEALTH
(2023)
Article
Environmental Sciences
Rafael E. E. de la Hoz, Kerri A. A. Johannson
Summary: Interstitial lung diseases (ILDs) are a diverse set of related conditions with multiple etiologies. Concerns exist about the potential association of ILD with WTC-related exposures, but no significant difference has been observed in the disease range compared to the general population. Evidence-based guidelines for diagnosis and management of ILDs have emerged and will continue to evolve as knowledge and therapeutic options increase. This article summarizes pertinent issues of ILD diagnosis and management applicable to the WTC Health Program covered population.
ARCHIVES OF ENVIRONMENTAL & OCCUPATIONAL HEALTH
(2023)
Review
Critical Care Medicine
Majdi R. M. Alghader, Damaskini Valvi, Rafael E. de la Hoz
Summary: COVID-19 poses a significant occupational risk to healthcare workers and effective measures need to be implemented to protect them. Risk factors for SARS-CoV-2 transmission among healthcare workers include job category, work environment, noncompliance with personal protective equipment, lack of awareness and training, unvaccinated status, and community and household exposures. Identifying and understanding these risk factors is crucial for policy makers to mitigate occupational and community transmission in current and future epidemics.
SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Review
Respiratory System
Johanna Feary, Irmeli Lindstrom, Christopher C. Huntley, Hille Suojalehto, Rafael E. de la Hoz
Summary: Exposure to toxic inhalants in the workplace can cause various types of lung diseases, but patients may not connect their disease to their job without proper awareness and questioning. Occupational lung diseases can have negative impacts on both clinical and socioeconomic outcomes, especially for individuals in lower paid work. Early identification and appropriate management are crucial for improving outcomes and providing necessary advice for ongoing exposure, clinical management, and legal compensation.
Article
Respiratory System
Rafael E. de la Hoz, Moshe Shapiro, Anna Nolan, Akshay Sood, Roberto G. Lucchini, James E. Cone, Juan C. Celedon
Summary: This study examined the association between World Trade Center occupational exposure and chronic obstructive pulmonary disease (COPD) or asthma COPD overlap (ACO). The results showed that early arrival at the disaster site was associated with COPD and ACO in workers.
Letter
Clinical Neurology
Rafael E. de la Hoz
SLEEP MEDICINE REVIEWS
(2023)
Meeting Abstract
Public, Environmental & Occupational Health
Max Lum, Rafael de la Hoz, Susanne Schunder-Tatzber
SAFETY AND HEALTH AT WORK
(2022)
Meeting Abstract
Public, Environmental & Occupational Health
Rafael de la Hoz
SAFETY AND HEALTH AT WORK
(2022)
Meeting Abstract
Public, Environmental & Occupational Health
Rafael E. de la Hoz
SAFETY AND HEALTH AT WORK
(2022)
