Human Brain Surrogates Research: The Onrushing Ethical Dilemma

Opportunities and limitations of genetically modified nonhuman primate models for neuroscience research

(2020) Guoping Feng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transgenic rhesus monkeys carrying the human MCPH1 gene copies show human-like neoteny of brain development

(2019) Lei Shi et al.   National Science Review

Cerebral organoids at the air–liquid interface generate diverse nerve tracts with functional output

(2019) Stefano L. Giandomenico et al.   NATURE NEUROSCIENCE

Restoration of brain circulation and cellular functions hours post-mortem

(2019) Zvonimir Vrselja et al.   NATURE

Part-revived pig brains raise slew of ethical quandaries

(2019) Nita A. Farahany et al.   NATURE

Pig experiment challenges assumptions around brain damage in people

(2019) Stuart Youngner et al.   NATURE

Cerebral organoids: ethical issues and consciousness assessment

(2018) Andrea Lavazza et al.   JOURNAL OF MEDICAL ETHICS

The ethics of experimenting with human brain tissue

(2018) Nita A. Farahany et al.   NATURE

An in vivo model of functional and vascularized human brain organoids

(2018) Abed AlFatah Mansour et al.   NATURE BIOTECHNOLOGY

Personhood and the Three Branches of Government

(2018) I. Glenn Cohen et al.   NEW ENGLAND JOURNAL OF MEDICINE

How to put an octopus to sleep—and make cephalopod research more humane

(2018) Danna Staaf   SCIENCE

A robust ex vivo experimental platform for molecular-genetic dissection of adult human neocortical cell types and circuits

(2018) Jonathan T. Ting et al.   Scientific Reports

Building Models of Brain Disorders with Three-Dimensional Organoids

(2018) Neal D. Amin et al.   NEURON

Human Cerebrospinal fluid promotes long-term neuronal viability and network function in human neocortical organotypic brain slice cultures

(2017) Niklas Schwarz et al.   Scientific Reports

Autism-like behaviours and germline transmission in transgenic monkeys overexpressing MeCP2

(2016) Zhen Liu et al.   NATURE

The promises and challenges of human brain organoids as models of neuropsychiatric disease

(2016) Giorgia Quadrato et al.   NATURE MEDICINE

Generation of cerebral organoids from human pluripotent stem cells

(2014) Madeline A Lancaster et al.   Nature Protocols

Forebrain Engraftment by Human Glial Progenitor Cells Enhances Synaptic Plasticity and Learning in Adult Mice

(2013) Xiaoning Han et al.   Cell Stem Cell

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE