期刊
DALTON TRANSACTIONS
卷 45, 期 19, 页码 8061-8072出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5dt04507j
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资金
- National Natural Science Foundation of China [21361003, 21101035]
- Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry
- Talent's Small Highland project of Guangxi Medicinal Industry [1201]
- New Century Ten, Hundred, Thousand Talents Project in Guangxi
- Foundation of Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources [IRT 1225]
An artificial metalloenzyme (BSA-CoL) based on the incorporation of a cobalt(II) Schiff base complex {CoL, H2L = 2,2'-[(1,2-ethanediyl)bis(nitrilopropylidyne)]bisphenol} with bovine serum albumin (BSA) has been synthesized and characterized. Attention is focused on the catalytic activity of this artificial metalloenzyme for enantioselective oxidation of a variety of sulfides with H2O2. The influences of parameters such as pH, temperature, and the concentration of catalyst and oxidant on thioanisole as a model are investigated. Under optimum conditions, BSA-CoL as a hybrid biocatalyst is efficient for the enantioselective oxidation of a series of sulfides, producing the corresponding sulfoxides with excellent conversion (up to 100%), chemoselectivity (up to 100%) and good enantiomeric purity (up to 87% ee) in certain cases.
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