Article
Biochemistry & Molecular Biology
Hannah A. Nonoguchi, Michael Jin, Rajitha Narreddy, Timothy Wee Shang Kouo, Mahasweta Nayak, Wulfran Trenet, Chitra D. Mandyam
Summary: Female and male GFAP-TK transgenic rats were made ethanol dependent using a chronic intermittent ethanol vapor (CIE) and ethanol drinking (ED) procedure. Valcyte was fed to some rats to ablate dividing progenitor cells. CIE increased ED in females and males, with higher consumption in females. Valcyte reduced progenitor cells in the dentate gyrus and had various effects on behavior. Progenitor cells may play a role in strengthening ethanol memories triggered by ethanol cues.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Melissa C. Knouse, Anna G. McGrath, Andre U. Deutschmann, Matthew T. Rich, Lia J. Zallar, Anjali M. Rajadhyaksha, Lisa A. Briand
Summary: This article investigates the sex differences in glutamatergic transmission within the medial prefrontal cortex, finding higher levels of glutamatergic transmission in females. This provides important evidence for the development of sex-specific pharmacotherapies for psychiatric diseases.
BIOLOGY OF SEX DIFFERENCES
(2022)
Article
Neurosciences
Jamshid Faraji, Hamid Lotfi, Alireza Moharrerie, S. Yaghoob Jafari, Nasrin Soltanpour, Rosa Tamannaiee, Kameran Marjani, Shabnam Roudaki, Farhad Naseri, Reza Moeeini, Gerlinde A. S. Metz
Summary: The early environment plays a critical role in brain development, and the type of stimulation (physical or social) can have different effects. In this study, male and female rats were subjected to physical and social environmental enrichment, and it was found that physical stimulation improved motor and cognitive functions, as well as the expression of BDNF in the hippocampus and medial prefrontal cortex (mPFC). However, the combination of physical and social enrichment had better effects on females, with increased functional and structural changes, as well as elevated levels of oxytocin and BDNF expression in the mPFC.
Article
Biochemistry & Molecular Biology
Andrea Cardenas, Alexander Papadogiannis, Eugene Dimitrov
Summary: Our study revealed that injection of CFA induced inflammatory pain leading to decreased thermal thresholds in both male and female mice. However, only male mice showed anxiety-like behavior and cognitive deficits, while females were unaffected. Additionally, our findings suggest that dysregulation of the top-down control of locus ceruleus's activity by the medial prefrontal cortex may contribute to sex differences in cognitive effects associated with inflammatory pain.
Article
Multidisciplinary Sciences
Malosree Maitra, Haruka Mitsuhashi, Reza Rahimian, Anjali Chawla, Jennie Yang, Laura M. Fiori, Maria Antonietta Davoli, Kelly Perlman, Zahia Aouabed, Deborah C. Mash, Matthew Suderman, Naguib Mechawar, Gustavo Turecki, Corina Nagy
Summary: Major depressive disorder (MDD) is a common psychiatric illness with diverse brain cell types involved in its development. There are significant sexual differences in MDD clinical presentation and molecular basis. In this study, single-nucleus RNA-sequencing data was used to analyze brain cells from male and female donors, revealing similar gene expression patterns but differentially expressed genes (DEGs) in specific cell types between sexes. This research provides insights into the cell type specificity of sex differences in depression.
NATURE COMMUNICATIONS
(2023)
Article
Neurosciences
Annalise N. Binette, Jianfeng Liu, Hugo Bayer, Kennedi L. Crayton, Laila Melissari, Samantha O. Sweck, Stephen Maren
Summary: Stress has a significant impact on fear extinction and affects the activity of PV interneurons in the mPFC. PV interneurons regulate extinction learning under stress in a sex-dependent manner, and this effect is mediated by amygdaloprefrontal projections.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Psychology, Developmental
Karim Ibrahim, Carla Kalvin, Fangyong Li, George He, Kevin A. Pelphrey, Gregory McCarthy, Denis G. Sukhodolsky
Summary: This study found sex-specific differences in gray matter volume and cortical thickness in prefrontal regions in boys with disruptive behavior disorders (DBD), but not girls. Dimensional analyses revealed associations between sex, callous-unemotional traits, and disruptive behavior.
DEVELOPMENTAL COGNITIVE NEUROSCIENCE
(2021)
Article
Neurosciences
Alessandro Piva, Lucia Caffino, Francesca Mottarlini, Nicholas Pintori, Fernando Castillo Diaz, Fabio Fumagalli, Cristiano Chiamulera
Summary: The study found distinct effects of ketamine and MK-801 in the rat brain, with ketamine inducing a pattern of enhanced excitability while MK-801 causing sparse changes. The two substances showed different effects on glutamate synapses in different brain areas, with ketamine leading to fine tuning of glutamatergic synapses compared to MK-801.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Immunology
Jinxiang Jiang, Binliang Tang, Lei Wang, Qingwei Huo, Shuyi Tan, Afzal Misrani, Yuanyuan Han, Huidong Li, Haidong Hu, Jichen Wang, Tinghui Cheng, Sidra Tabassum, Ming Chen, Wenyuan Xie, Cheng Long, Li Yang
Summary: Neuroinflammation induced by LPS leads to increased inhibitory postsynaptic currents in glutamatergic neurons, associated with excessive microglial activation. Minocycline can block microglial activation, improve abnormal GABA signaling protein expression, and prevent LPS-induced behavioral abnormalities.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Oncology
Xiaoxuan Zhang, Xin Li, Wei Wang, Yuxin Zhang, Zhihao Gong, Yuan Peng, Jingxiang Wu, Xingji You
Summary: This study found that the STING pathway may activate M1 microglia in the mPFC, promoting cancer-induced bone pain. The use of the STING inhibitor C-176 effectively alleviated cancer-induced bone pain and pain-related anxiety. In addition, C-176 reversed LPS-induced M1 polarization. The findings provide a new direction for the treatment of cancer-induced bone pain.
Article
Neurosciences
Sonja Chu, Cendri Hutcherson, Rutsuko Ito, Andy C. H. Lee
Summary: The prefrontal cortex (PFC) and medial temporal lobe (MTL) contribute differently to resolving conflict information and uncertainty during approach-avoidance decisions. The PFC may adjust response caution and evidence strength towards each choice, involving the anterior cingulate cortex and dorsolateral prefrontal cortex, while the MTL contributes to evidence generation, particularly through the hippocampus. These findings suggest unique contributions of MTL and PFC regions in arbitrating approach-avoidance conflict.
Article
Clinical Neurology
Xuejun Jiang, Feng Wu, Yifan Zhang, Huizi Li, Jiahui Kang, Lingtao Kong, Fei Wang, Yanqing Tang
Summary: This study investigated the association between brain function and gender in bipolar disorder using amplitude of low-frequency fluctuations (ALFF). The results indicated gender differences in dysfunction of the cortico-limbic neural system in BD. Male and female patients with BD showed different patterns of ALFF in various brain regions.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Neurosciences
Wei Liu, Yingjie Shi, James N. Cousins, Nils Kohn, Guillen Fernandez
Summary: Research indicates that successfully remembered events are associated with distinct activation patterns in the hippocampus and medial prefrontal cortex, while similar connectivity patterns between events are linked to memory formation and retention of order. Different activation patterns represent neural segmentation of events, while similar connectivity patterns encode context information to integrate events into a narrative.
Article
Neurosciences
Vishwa Goudar, Barbara Peysakhovich, David J. Freedman, Elizabeth A. Buffalo, Xiao-Jing Wang
Summary: Learning-to-learn refers to the progressive acceleration of solving a series of problems with shared structure. This study demonstrates that in recurrent neural networks, learning-to-learn emerges through the reuse and refinement of a neural state subspace underlying schema formation. It is a core process of knowledge acquisition, attracting attention in both neuroscience and artificial intelligence. The study trained a recurrent neural network model on arbitrary sensorimotor mappings dependent on the prefrontal cortex, showing an exponential time course of accelerated learning. The emergence and reuse of a schema within a low-dimensional population activity subspace facilitate learning by restricting connection weight changes.
NATURE NEUROSCIENCE
(2023)
Article
Anatomy & Morphology
Tatiana D. Viena, Gabriela E. Rasch, Timothy A. Allen
Summary: The paraventricular nucleus (PVT) of the midline thalamus is a crucial integration site for cortico-thalamo-cortical pathways and plays a critical role in various behaviors. This study characterized the projection populations of PVT neurons that send collaterals to the medial prefrontal cortex (mPFC) and/or ventral hippocampus (vHC) in rats. The study also examined the distribution of calcium binding proteins calretinin (CR) and calbindin (CB) in relation to these projection populations. The results revealed separate populations of PVT cells that project to mPFC, vHC, and both regions, with dual projecting cells lacking expression of CR and CB. The study suggests the presence of a functional mPFC-PVT-vHC system that may support interactions between the mPFC and vHC in PVT-dependent behaviors.
BRAIN STRUCTURE & FUNCTION
(2022)
Article
Biochemical Research Methods
Prathamesh M. Kulkarni, Emily Barton, Michalis Savelonas, Raghav Padmanabhan, Yanbin Lu, Kristen Trett, William Shain, J. Leigh Leasure, Badrinath Roysam
JOURNAL OF NEUROSCIENCE METHODS
(2015)
Review
Psychiatry
J. Leigh Leasure, Clayton Neighbors, Craig E. Henderson, Chelsie M. Young
FRONTIERS IN PSYCHIATRY
(2015)
Article
Behavioral Sciences
Mark E. Maynard, Chasity Chung, Ashley Comer, Katharine Nelson, Jamie Tran, Nadja Werries, Emily A. Barton, Michael Spinetta, J. Leigh Leasure
BEHAVIOURAL BRAIN RESEARCH
(2016)
Article
Neurosciences
Shaefali P. Rodgers, Janice A. Zawaski, Iman Sahnoune, J. Leigh Leasure, M. Waleed Gaber
Article
Psychology, Biological
Rebecca K. West, Mark E. Maynard, J. Leigh Leasure
PHYSIOLOGY & BEHAVIOR
(2018)
Article
Substance Abuse
J. Leigh Leasure, Clayton Neighbors
Article
Neurosciences
Darby F. Hawley, J. Leigh Leasure
Article
Multidisciplinary Sciences
Mark E. Maynard, J. Leigh Leasure
Review
Neurosciences
Shaefali P. Rodgers, Melissa Trevino, Janice A. Zawaski, M. Waleed Gaber, J. Leigh Leasure
Article
Substance Abuse
Craig E. Henderson, Laian Z. Najjar, Chelsie M. Young, J. Leigh Leasure, Clayton Neighbors, Melissa L. Gasser, Kristen P. Lindgren
Summary: This study found a positive association between physical activity and alcohol use, indicating that the link between the two may become lasting during the college years.
PSYCHOLOGY OF ADDICTIVE BEHAVIORS
(2023)
Article
Neurosciences
Shiyu Xu, Satyabrata Pany, Kevin Benny, Khadeeja Tarique, Ola al-Hatem, Kathleen Gajewski, J. Leigh Leasure, Joydip Das, Gregg Roman
Article
Anatomy & Morphology
Mark E. Maynard, Emily A. Barton, Caleb R. Robinson, Jessica I. Wooden, J. Leigh Leasure
BRAIN STRUCTURE & FUNCTION
(2018)
Article
Geriatrics & Gerontology
Lisa Boss, Duck-Hee Kang, Nancy Bergstrom, J. Leigh Leasure
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2015)
Article
Physiology
Dorothy A. Kozlowski, J. Leigh Leasure, Timothy Schallert
COMPREHENSIVE PHYSIOLOGY
(2013)