Article
Surgery
Barbara Helena Barcaro Machado, Jufen Zhang, James Frame, Mohammad Najlah
Summary: This study investigated the use of laser-assisted drug delivery for scar improvement and found that using a cosmeceutical containing growth factors along with Vitamin C resulted in better outcomes compared to using Vitamin C alone.
AESTHETIC PLASTIC SURGERY
(2021)
Article
Biophysics
Nomin-Erdene Oyunbaatar, Pooja P. Kanade, Dong-Weon Lee
Summary: The study utilized a unique cantilever-based device with stress-assisted micro-wrinkle patterns on the surface to enhance cardiomyocyte growth and contractile properties, as well as improve cell-to-cell electrical conductivity. The polymer cantilevers with metallic wrinkle patterns were shown to increase adhesion and contraction-related protein expression levels significantly while confirming improvements in electrical conductivity and force-sensing properties. Additionally, the proposed cantilever device was proven to be versatile for screening drug-induced cardiotoxicity during drug development.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Engineering, Biomedical
Han Zhang, Kai Liu, Yimou Gong, Wenjun Zhu, Jiafei Zhu, Feng Pan, Yu Chao, Zhishen Xiao, Yanbin Liu, Xianwen Wang, Zhuang Liu, Yang Yang, Qian Chen
Summary: This study presents the use of a novel Vitamin C nanofiber hydrogel as a platform for enhanced cancer immunotherapy. The hydrogel not only serves as a reservoir for Vitamin C but also exhibits anti-tumor effects. The encapsulated stimulator of interferon genes (STING) agonist synergistically activates the immune system to inhibit the progression of tumors.
Article
Chemistry, Multidisciplinary
Woan-Ruoh Lee, Wei-Ling Chou, Zih-Chan Lin, Chien-Yu Lin, Calvin T. Sung, Jaiyouy Fang
Summary: This study developed a siRNA delivery system based on nanoparticles and combined it with ablative laser technology for treating psoriasis. The results showed that the system effectively enhanced siRNA absorption, reduced the expression of IL-6, and alleviated psoriasiform dermatitis in mice.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Materials Science, Multidisciplinary
Amr Attia Abuelwafa, Rucheng Zhu, Riteshkumar Vishwakarma, Sahar Elnobi, Sudip Adhikari, Tetsuo Soga, Masayoshi Umeno
Summary: In this study, laser irradiation was used to control the doping process of directly grown graphene, leading to the collection of gold particles on graphene network wrinkles which significantly enhance the electrical properties of graphene. This approach shows promise in designing transparent conductive electrodes for optoelectronic devices.
MATERIALS CHEMISTRY AND PHYSICS
(2021)
Review
Chemistry, Multidisciplinary
Andreea Crintea, Alina Gabriela Dutu, Alina Sovrea, Anne-Marie Constantin, Gabriel Samasca, Aurelian Lucian Masalar, Brigitta Ifju, Eugen Linga, Lidia Neamti, Rares Andrei Tranca, Zsolt Fekete, Ciprian Nicolae Silaghi, Alexandra Marioara Craciun
Summary: Mounting evidence suggests that nanocarriers have great potential for the transportation of vitamin D and K in the treatment of various diseases. Nanotechnology-based dietary supplements and drugs can enhance the bioavailability of vitamins and overcome issues associated with traditional vitamin administration.
Review
Polymer Science
Dong-Jin Lim, Hong-Jun Kim
Summary: This review provides an overview of advanced fabrication techniques for microneedles and discusses various drug coating and drug elution strategies. It also explores the potential of microneedle technologies in improving the clinical efficacy of treating skin diseases.
Article
Dermatology
Woraphong Manuskiatti, Arisa Kaewkes, Chadakan Yan, Janice Natasha Ng, Joshua Zev Glahn, Rungsima Wanitphakdeedecha
Summary: The study demonstrated that fractional laser monotherapy is effective for hypertrophic scars, and the application of topical corticosteroid does not provide a long-term synergistic effect to fractional laser monotherapy.
ACTA DERMATO-VENEREOLOGICA
(2021)
Article
Audiology & Speech-Language Pathology
Manon Jaffredo, Oceane Duchamp, Nicolas Touya, Yohan Bouleau, Didier Dulon, Raphael Devillard, Damien Bonnard
Summary: This study introduces a promising approach for inner ear drug delivery using laser-assisted bioprinting, which allows atraumatic, direct and controlled administration of drugs on the mouse round window membrane.
Article
Multidisciplinary Sciences
Haoran Guo, Xiangyu Zhang, Hui Li, Chuhan Fu, Ling Jiang, Yibo Hu, Jinhua Huang, Jing Chen, Qinghai Zeng
Summary: Fractional CO2 laser is commonly used in the treatment of various skin diseases. This study investigated the changes in skin function and regulatory mechanisms after fractional CO2 laser treatment. The results showed that the laser transformed the lesions into normal skin, regulated the skin barrier, rearranged collagen, enhanced local microvascular circulation, activated the immune system, and aided drug transport.
Article
Pharmacology & Pharmacy
Antonio Jose Guillot, Pablo Merino-Gutierrez, Andrea Bocchino, Conor O'Mahony, Rosa Maria Giner, Maria Carmen Recio, Teresa Maria Garrigues, Ana Melero
Summary: Vitamin B12 deficiency is a common condition that can be treated by oral or transdermal supplementation. This study aimed to enhance transdermal delivery of cyanocobalamin using ultraflexible lipid vesicles. The results showed that ultraflexible vesicles had better transdermal fluxes compared to a drug solution. The pre-treatment of the skin with a solid microneedle array also increased the potential systemic circulation of the drug.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2022)
Article
Emergency Medicine
Yan Yang, Lutong Liu, Xiaojin Wu, Xue Wang, Qiang Lu, Zhen Zhang
Summary: This study investigated the permeability of silk nanofiber hydrogels loaded with hydrophilic and hydrophobic model molecules into hypertrophic scar tissues mediated by CO2 fractional laser irradiation. The results showed that SNFs promoted the penetration of hydrophilic drug R6G but not the hydrophobic drug R110. Combining laser irradiation with SNF drug delivery improved the efficiency of hydrophilic drug delivery.
Article
Chemistry, Multidisciplinary
Elahe Memari, Fiona Hui, Hossein Yusefi, Brandon Helfield
Summary: This study aimed to investigate the effect of fluid flow rate and repeated short-pulse ultrasound on microbubble-mediated endothelial cell permeability. The results demonstrate that fast-flowing microbubbles significantly increased cell membrane permeability, and multiple short pulses of ultrasound also elevated endothelial cell permeability.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Pharmacology & Pharmacy
Kristoffer Hendel, Anders C. N. Hansen, Liora Bik, Charlotte Bagger, Martijn B. A. van Doorn, Christian Janfelt, Uffe H. Olesen, Merete Haedersdal, Catharina M. Lerche
Summary: Bleomycin is being repositioned in dermato-oncology for intralesional and intra-tumoural use. In this study, ablative fractional lasers (AFLs) and intradermal needle injections (NIs) were compared for topical drug delivery of BLM in an in vivo pig model. Both methods resulted in distinct cutaneous biodistribution patterns and pharmacokinetic profiles, with similar tolerability for skin reactions and potential for individualized approaches in a clinical setting.
Article
Nutrition & Dietetics
Anitra C. Carr, Jens Lykkesfeldt
Summary: In this study, the relationship between vitamin C status and demographic and lifestyle factors was investigated using NHANES 2017-2018 datasets. It was found that gender, smoking, and body weight have significant impacts on vitamin C requirements. Males and smokers require higher vitamin C intakes to achieve adequate serum concentrations. Overall, the general population should consume around 110 mg/day of vitamin C, smokers require approximately 165 mg/day, and heavier individuals (100+ kg) require about 155 mg/day to reach comparable vitamin C concentrations.
Article
Biochemistry & Molecular Biology
Mohammad Najlah, Mohit Jain, Ka-Wai Wan, Waqar Ahmed, Mohamed Albed Alhnan, David A. Phoenix, Kevin M. G. Taylor, Abdelbary Elhissi
JOURNAL OF LIPOSOME RESEARCH
(2018)
Article
Computer Science, Artificial Intelligence
Marzia Hoque Tania, Khin T. Lwin, Antesar M. Shabut, Mohammad Najlah, Jeannette Chin, M. A. Hossain
EXPERT SYSTEMS WITH APPLICATIONS
(2020)
Article
Pharmacology & Pharmacy
Mohammad Najlah, Ammar Said Suliman, Ibrahim Tolaymat, Sathishkumar Kurusamy, Vinodh Kannappan, Abdelbary M. A. Elhissi, Weiguang Wang
Article
Nutrition & Dietetics
Rudolph Schutte, Maria Papageorgiou, Mohammad Najlah, Hugo W. Huisman, Cristian Ricci, Jufen Zhang, Nicky Milner, Aletta E. Schutte
CLINICAL NUTRITION
(2020)
Article
Pharmacology & Pharmacy
Ammar Said Suliman, Rose Tom, Kirsty Palmer, Ibrahim Tolaymat, Husam M. Younes, Basel Arafat, Abdelbary M. A. Elhissi, Mohammad Najlah
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
(2020)
Article
Pharmacology & Pharmacy
Nada Khudair, Abdelali Agouni, Mohamed A. Elrayess, Mohammad Najlah, Husam M. Younes, Abdelbary Elhissi
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2020)
Article
Pharmacology & Pharmacy
Ammar Said Suliman, Mouhamad Khoder, Ibrahim Tolaymat, Matt Webster, Raid G. Alany, Weiguang Wang, Abdelbary Elhissi, Mohammad Najlah
Summary: In this study, inclusion complexes of DDC-Cu with cyclodextrins were prepared to enhance the solubility of DDC-Cu, showing a significant improvement in solubility and promising anticancer activity against chemoresistant triple negative breast cancer cells.
Article
Surgery
Barbara Helena Barcaro Machado, Jufen Zhang, James Frame, Mohammad Najlah
Summary: This study investigated the use of laser-assisted drug delivery for scar improvement and found that using a cosmeceutical containing growth factors along with Vitamin C resulted in better outcomes compared to using Vitamin C alone.
AESTHETIC PLASTIC SURGERY
(2021)
Review
Biochemistry & Molecular Biology
Layan Dahabra, Grace Broadberry, Adam Le Gresley, Mohammad Najlah, Mouhamad Khoder
Summary: Sunscreen protects the skin from solar ultraviolet radiation with UV filters and antioxidants, which can degrade when exposed to sunlight and oxygen. Cyclodextrins inclusion complexes have the potential to enhance the solubility of antioxidants and UV filters in sunscreens, improving their efficiency in preventing skin cancer.
Article
Biochemistry & Molecular Biology
Ana Maria Pereira, Ayse Kaya, Dan Alves, Niusha Ansari-Fard, Ibrahim Tolaymat, Basel Arafat, Mohammad Najlah
Summary: This study aimed to improve the solubility of Disulfiram (DS) by forming inclusion complexes with cyclodextrins (CDs). The results showed that the CD inclusion complexes significantly increased the aqueous solubility of DS and exhibited suitable aerosolization properties. The CD inclusion complexes have great potential for enhancing the solubility of DS.
Article
Pharmacology & Pharmacy
Afaf Abouzid, Abdelrhman Y. Moustafa, Natalie Allcock, Mohammad Najlah, Abdelbary Elhissi, Chi Wi Stanley, Waqar Ahmed, Peter Seville, StJohn Crean, Robert T. Forbes, Mohamed A. Elsawy
Summary: Oral aphthous stomatitis, a common disorder, was traditionally treated with Amlexanox (AMX) paste, but was discontinued due to adverse reactions. In this study, AMX-loaded nanoliposomes were developed as a potential alternative for local delivery of AMX. The optimal formulation showed high drug entrapment efficiency (94%) and demonstrated significant anti-inflammatory activity.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Iftikhar Khan, Sakib Yousaf, Mohammad Najlah, Waqar Ahmed, Abdelbary Elhissi
Summary: This study aimed to develop and compare proliposome powder and proliposome tablet formulations for drug delivery from a Pari-LC Sprint nebulizer. The tablet formulations showed shorter sputtering times and higher drug output compared to powder formulations. Liposomes size was larger in the nebulizer reservoir, indicating aggregation/fusion, and all formulations exhibited more than 80% mass output.
JOURNAL OF PHARMACEUTICAL INVESTIGATION
(2021)