Tuning the reactivity of Sp1 zinc fingers with platinum complexes

cis-DDP presents reactivity towards the transcription factor Sp1-F3, as opposed to previous observations for Sp1-F2. Replacing the ammine ligands with the chelating ethylenediamine increases the reactivity giving a unique dinuclear {Pt(en)}(2)-bis(cysteine)-bridged product, confirmed by study of the binding sequence ACPECP.