Recent advances in design of antimicrobial peptides and polypeptides toward clinical translation
出版年份 2021 全文链接
标题
Recent advances in design of antimicrobial peptides and polypeptides toward clinical translation
作者
关键词
Antibiotic resistance, Antimicrobial peptides, Membrane-active antimicrobial mechanism, Clinical translation, Radially amphiphilic conformation, Infection-responsive peptides, Nano-antimicrobials, Small synthetic mimics of antimicrobial peptides, Combination therapy
出版物
ADVANCED DRUG DELIVERY REVIEWS
Volume -, Issue -, Pages -
出版商
Elsevier BV
发表日期
2021-01-03
DOI
10.1016/j.addr.2020.12.016
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Small Molecules with Membrane-Active Antibacterial Activity
- (2020) Mi Zhou et al. ACS Applied Materials & Interfaces
- Combined efficacy of an antimicrobial cationic peptide polymer with conventional antibiotics to combat multi-drug resistant pathogens
- (2020) Kishore Reddy Venkata Thappeta et al. ACS Infectious Diseases
- A broad-spectrum antibiotic adjuvant reverses multidrug-resistant Gram-negative pathogens
- (2020) Meirong Song et al. Nature Microbiology
- Combating bacterial resistance by combination of antibiotics with antimicrobial peptides
- (2019) Dean E. Sheard et al. PURE AND APPLIED CHEMISTRY
- Synergy between Synthetic Antimicrobial Polymer and Antibiotics: A Promising Platform To Combat Multidrug-Resistant Bacteria
- (2019) Rashin Namivandi-Zangeneh et al. ACS Infectious Diseases
- Low cationicity is important for systemic in vivo efficacy of database-derived peptides against drug-resistant Gram-positive pathogens
- (2019) Biswajit Mishra et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Machine learning-enabled discovery and design of membrane-active peptides
- (2018) Ernest Y. Lee et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Prevalence of antibiotic resistance in Helicobacter pylori : a systematic review and meta-analysis in World Health Organization regions
- (2018) Alessia Savoldi et al. GASTROENTEROLOGY
- Rational Design of Dimeric Lysine N-Alkylamides as Potent and Broad-Spectrum Antibacterial Agents
- (2018) Youhong Niu et al. JOURNAL OF MEDICINAL CHEMISTRY
- MSP-4, an Antimicrobial Peptide, Induces Apoptosis via Activation of Extrinsic Fas/FasL- and Intrinsic Mitochondria-Mediated Pathways in One Osteosarcoma Cell Line
- (2018) Hsiao-Mei Kuo et al. Marine Drugs
- Antimicrobial polymeric nanoparticles
- (2018) Shu J. Lam et al. PROGRESS IN POLYMER SCIENCE
- Secondary structures in synthetic polypeptides from N-carboxyanhydrides: design, modulation, association, and material applications
- (2018) Ziyuan Song et al. CHEMICAL SOCIETY REVIEWS
- A Dual-Function Antibiotic-Transporter Conjugate Exhibits Superior Activity in Sterilizing MRSA Biofilms and Killing Persister Cells
- (2018) Alexandra Antonoplis et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Lithium hexamethyldisilazide initiated superfast ring opening polymerization of alpha-amino acid N-carboxyanhydrides
- (2018) Yueming Wu et al. Nature Communications
- Antibiotic Resistance Mechanisms in Bacteria: Relationships Between Resistance Determinants of Antibiotic Producers, Environmental Bacteria, and Clinical Pathogens
- (2018) Elizabeth Peterson et al. Frontiers in Microbiology
- Membrane-Active Hydantoin Derivatives as Antibiotic Agents
- (2017) Ma Su et al. JOURNAL OF MEDICINAL CHEMISTRY
- Amino Acid Block Copolymers with Broad Antimicrobial Activity and Barrier Properties
- (2017) Michael P. Bevilacqua et al. MACROMOLECULAR BIOSCIENCE
- Cytotoxic protein from the mushroomCoprinus comatuspossesses a unique mode for glycan binding and specificity
- (2017) Peilan Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Selective killing ofHelicobacter pyloriwith pH-responsive helix–coil conformation transitionable antimicrobial polypeptides
- (2017) Menghua Xiong et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Membrane Active Antimicrobial Peptides: Translating Mechanistic Insights to Design
- (2017) Jianguo Li et al. Frontiers in Neuroscience
- Rational Design of Single-Chain Polymeric Nanoparticles That Kill Planktonic and Biofilm Bacteria
- (2017) Thuy-Khanh Nguyen et al. ACS Infectious Diseases
- Hydrophilic Phage-Mimicking Membrane Active Antimicrobials Reveal Nanostructure-Dependent Activity and Selectivity
- (2017) Yunjiang Jiang et al. ACS Infectious Diseases
- Mechanisms of envelope permeability and antibiotic influx and efflux in Gram-negative bacteria
- (2017) Muriel Masi et al. Nature Microbiology
- Primary Outcomes From a Phase 3, Randomized, Double-Blind, Active-Controlled Trial of Surotomycin in Subjects With Clostridium difficile Infection
- (2017) Vicente Boix et al. Open Forum Infectious Diseases
- Host Cell Interactions Are a Significant Barrier to the Clinical Utility of Peptide Antibiotics
- (2016) Charles G. Starr et al. ACS Chemical Biology
- Antimicrobial Peptides Under Clinical Trials
- (2016) Katarzyna E. Greber et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Structure, toxicity and antibiotic activity of gramicidin S and derivatives
- (2016) J. Swierstra et al. EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
- Small Antimicrobial Agents Based on Acylated Reduced Amide Scaffold
- (2016) Peng Teng et al. JOURNAL OF MEDICINAL CHEMISTRY
- Mapping membrane activity in undiscovered peptide sequence space using machine learning
- (2016) Ernest Y. Lee et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Combating multidrug-resistant Gram-negative bacteria with structurally nanoengineered antimicrobial peptide polymers
- (2016) Shu J. Lam et al. Nature Microbiology
- Colistin and Fusidic Acid, a Novel Potent Synergistic Combination for Treatment of Multidrug-Resistant Acinetobacter baumannii Infections
- (2015) Lynette M. Phee et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Multifunctional Biocompatible and Biodegradable Folic Acid Conjugated Poly(ε-caprolactone)–Polypeptide Copolymer Vesicles with Excellent Antibacterial Activities
- (2015) Mingzhi Wang et al. BIOCONJUGATE CHEMISTRY
- Membrane-Active Small Molecules: Designs Inspired by Antimicrobial Peptides
- (2015) Chandradhish Ghosh et al. ChemMedChem
- New antibiotics and antimicrobial combination therapy for the treatment of gram-negative bacterial infections
- (2015) Matteo Bassetti et al. Current Opinion in Critical Care
- Membrane Active Small Molecules Show Selective Broad Spectrum Antibacterial Activity with No Detectable Resistance and Eradicate Biofilms
- (2015) Jiaul Hoque et al. JOURNAL OF MEDICINAL CHEMISTRY
- Nylon-3 Polymers Active against Drug-Resistant Candida albicans Biofilms
- (2015) Runhui Liu et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- APD3: the antimicrobial peptide database as a tool for research and education
- (2015) Guangshun Wang et al. NUCLEIC ACIDS RESEARCH
- Helical antimicrobial polypeptides with radial amphiphilicity
- (2015) Menghua Xiong et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Antibacterial Mechanisms of Polymyxin and Bacterial Resistance
- (2015) Zhiliang Yu et al. Biomed Research International
- Levofloxacin and Indolicidin for Combination Antimicrobial Therapy
- (2015) Khairunnisa Ghaffar et al. Current Drug Delivery
- Solution Structure and Model Membrane Interactions of P-113, a Clinically Active Antimicrobial Peptide Derived from Human Saliva
- (2015) Bak-Sau Yip et al. JOURNAL OF THE CHINESE CHEMICAL SOCIETY
- Engineering Persister-Specific Antibiotics with Synergistic Antimicrobial Functions
- (2014) Nathan W. Schmidt et al. ACS Nano
- Antibacterial polymeric nanostructures for biomedical applications
- (2014) Jing Chen et al. CHEMICAL COMMUNICATIONS
- Tuning the Biological Activity Profile of Antibacterial Polymers via Subunit Substitution Pattern
- (2014) Runhui Liu et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Synthetic Polymers Active against Clostridium difficile Vegetative Cell Growth and Spore Outgrowth
- (2014) Runhui Liu et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Structure–Activity Relationships among Antifungal Nylon-3 Polymers: Identification of Materials Active against Drug-Resistant Strains of Candida albicans
- (2014) Runhui Liu et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Host defense peptides: front-line immunomodulators
- (2014) Sarah C. Mansour et al. TRENDS IN IMMUNOLOGY
- Synthetic cationic antimicrobial peptides bind with their hydrophobic parts to drug site II of human serum albumin
- (2014) Annfrid Sivertsen et al. BMC STRUCTURAL BIOLOGY
- Covalent modification of a ten-residue cationic antimicrobial peptide with levofloxacin
- (2014) Carlos A. Rodriguez et al. Frontiers in Chemistry
- Synergistic Co-Delivery of Membrane-Disrupting Polymers with Commercial Antibiotics against Highly Opportunistic Bacteria
- (2013) Victor Wee Lin Ng et al. ADVANCED MATERIALS
- Staphylococcus aureusbiofilm susceptibility to small and potent β2,2-amino acid derivatives
- (2013) Dominik Ausbacher et al. BIOFOULING
- Molecular Design, Structures, and Activity of Antimicrobial Peptide-Mimetic Polymers
- (2013) Haruko Takahashi et al. MACROMOLECULAR BIOSCIENCE
- A Critical Evaluation of Random Copolymer Mimesis of Homogeneous Antimicrobial Peptides
- (2013) Kan Hu et al. MACROMOLECULES
- Acid-Activated Antimicrobial Random Copolymers: A Mechanism-Guided Design of Antimicrobial Peptide Mimics
- (2013) Yunjiang Jiang et al. MACROMOLECULES
- Supramolecular high-aspect ratio assemblies with strong antifungal activity
- (2013) Kazuki Fukushima et al. Nature Communications
- Broad-Spectrum Antimicrobial Supramolecular Assemblies with Distinctive Size and Shape
- (2012) Kazuki Fukushima et al. ACS Nano
- The Target of Daptomycin Is Absent from Escherichia coli and Other Gram-Negative Pathogens
- (2012) Christopher P. Randall et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature
- (2012) Paul G. Arnison et al. NATURAL PRODUCT REPORTS
- Modulating immunity as a therapy for bacterial infections
- (2012) Robert E. W. Hancock et al. NATURE REVIEWS MICROBIOLOGY
- The antimicrobial activity of the appetite peptide hormone ghrelin
- (2012) Christine Min et al. PEPTIDES
- Enhanced Membrane Pore Formation through High-Affinity Targeted Antimicrobial Peptides
- (2012) Christopher J. Arnusch et al. PLoS One
- Role of lipids in the interaction of antimicrobial peptides with membranes
- (2012) Vitor Teixeira et al. PROGRESS IN LIPID RESEARCH
- Lipidated Peptidomimetics with Improved Antimicrobial Activity
- (2012) Yaogang Hu et al. ACS Medicinal Chemistry Letters
- Effects of Side Group Functionality and Molecular Weight on the Activity of Synthetic Antimicrobial Polypeptides
- (2011) Amanda C. Engler et al. BIOMACROMOLECULES
- Highly dynamic biodegradable micelles capable of lysing Gram-positive and Gram-negative bacterial membrane
- (2011) Yuan Qiao et al. BIOMATERIALS
- Synthesis and antibacterial activity of amphiphilic lysine-ligated neomycin B conjugates
- (2011) Smritilekha Bera et al. CARBOHYDRATE RESEARCH
- The role of gut microbiota (commensal bacteria) and the mucosal barrier in the pathogenesis of inflammatory and autoimmune diseases and cancer: contribution of germ-free and gnotobiotic animal models of human diseases
- (2011) Helena Tlaskalová-Hogenová et al. Cellular & Molecular Immunology
- Predictors of mortality in patients with bloodstream infections caused by KPC-producing Klebsiella pneumoniae and impact of appropriate antimicrobial treatment
- (2011) O. Zarkotou et al. CLINICAL MICROBIOLOGY AND INFECTION
- Food Animals and Antimicrobials: Impacts on Human Health
- (2011) B. M. Marshall et al. CLINICAL MICROBIOLOGY REVIEWS
- Synthesis of Cationic Antimicrobial β2,2-Amino Acid Derivatives with Potential for Oral Administration
- (2011) Terkel Hansen et al. JOURNAL OF MEDICINAL CHEMISTRY
- A Synthetic Antimicrobial Peptidomimetic (LTX 109): Stereochemical Impact on Membrane Disruption
- (2011) Johan Isaksson et al. JOURNAL OF MEDICINAL CHEMISTRY
- Criterion for Amino Acid Composition of Defensins and Antimicrobial Peptides Based on Geometry of Membrane Destabilization
- (2011) Nathan W. Schmidt et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Biodegradable nanostructures with selective lysis of microbial membranes
- (2011) Fredrik Nederberg et al. Nature Chemistry
- Designing antimicrobial peptides: form follows function
- (2011) Christopher D. Fjell et al. NATURE REVIEWS DRUG DISCOVERY
- Ionic polypeptides with unusual helical stability
- (2011) Hua Lu et al. Nature Communications
- An Antimicrobial Peptide That Targets DNA Repair Intermediates In Vitro Inhibits Salmonella Growth within Murine Macrophages
- (2010) L. Y. Su et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Structural contributions to the intracellular targeting strategies of antimicrobial peptides
- (2010) Yun Lan et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Antimicrobial β-Peptides and α-Peptoids
- (2010) Troels Godballe et al. Chemical Biology & Drug Design
- In vitro activity of XF-73, a novel antibacterial agent, against antibiotic-sensitive and -resistant Gram-positive and Gram-negative bacterial species
- (2010) David J. Farrell et al. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
- Plectasin, a Fungal Defensin, Targets the Bacterial Cell Wall Precursor Lipid II
- (2010) T. Schneider et al. SCIENCE
- Binaphthyl-Based Dicationic Peptoids with Therapeutic Potential
- (2009) John B. Bremner et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Chemical Structure of Cationic Groups in Amphiphilic Polymethacrylates Modulates the Antimicrobial and Hemolytic Activities
- (2009) Edmund F. Palermo et al. BIOMACROMOLECULES
- Structural Determinants of Antimicrobial Activity and Biocompatibility in Membrane-Disrupting Methacrylamide Random Copolymers
- (2009) Edmund F. Palermo et al. BIOMACROMOLECULES
- High Potency and Broad-Spectrum Antimicrobial Peptides Synthesized via Ring-Opening Polymerization of α-Aminoacid-N-carboxyanhydrides
- (2009) Chuncai Zhou et al. BIOMACROMOLECULES
- “Doubly Selective” Antimicrobial Polymers: How Do They Differentiate between Bacteria?
- (2009) Karen Lienkamp et al. CHEMISTRY-A EUROPEAN JOURNAL
- XF-73, a novel antistaphylococcal membrane-active agent with rapid bactericidal activity
- (2009) N. Ooi et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Injury Is a Major Inducer of Epidermal Innate Immune Responses during Wound Healing
- (2009) K. Markus Roupé et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Antimicrobial Activity of Small β-Peptidomimetics Based on the Pharmacophore Model of Short Cationic Antimicrobial Peptides
- (2009) Terkel Hansen et al. JOURNAL OF MEDICINAL CHEMISTRY
- Structure−Activity Relationships of Polymyxin Antibiotics
- (2009) Tony Velkov et al. JOURNAL OF MEDICINAL CHEMISTRY
- Structure−activity Relationships among Random Nylon-3 Copolymers That Mimic Antibacterial Host-Defense Peptides
- (2009) Brendan P. Mowery et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Self-assembled cationic peptide nanoparticles as an efficient antimicrobial agent
- (2009) Lihong Liu et al. Nature Nanotechnology
- De novo design and in vivo activity of conformationally restrained antimicrobial arylamide foldamers
- (2009) S. Choi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Ceragenins: Cholic Acid-Based Mimics of Antimicrobial Peptides
- (2008) Xin-Zhong Lai et al. ACCOUNTS OF CHEMICAL RESEARCH
- Evaluation of Strategies for Improving Proteolytic Resistance of Antimicrobial Peptides by Using Variants of EFK17, an Internal Segment of LL-37
- (2008) A. A. Stromstedt et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Structure, membrane orientation, mechanism, and function of pexiganan — A highly potent antimicrobial peptide designed from magainin
- (2008) Lindsey M. Gottler et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Control of cell selectivity of antimicrobial peptides
- (2008) Katsumi Matsuzaki BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Investigating the Effect of Increasing Charge Density on the Hemolytic Activity of Synthetic Antimicrobial Polymers
- (2008) Zoha M. AL-Badri et al. BIOMACROMOLECULES
- The Role of Hydrophobicity in the Antimicrobial and Hemolytic Activities of Polymethacrylate Derivatives
- (2008) Kenichi Kuroda et al. CHEMISTRY-A EUROPEAN JOURNAL
- Dual Mechanism of Bacterial Lethality for a Cationic Sequence-Random Copolymer that Mimics Host-Defense Antimicrobial Peptides
- (2008) Raquel F. Epand et al. JOURNAL OF MOLECULAR BIOLOGY
- Influence of Lipid Composition on Membrane Activity of Antimicrobial Phenylene Ethynylene Oligomers
- (2008) Abhigyan Som et al. JOURNAL OF PHYSICAL CHEMISTRY B
- Antimicrobial Polymers Prepared by ROMP with Unprecedented Selectivity: A Molecular Construction Kit Approach
- (2008) Karen Lienkamp et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Mechanism of a prototypical synthetic membrane-active antimicrobial: Efficient hole-punching via interaction with negative intrinsic curvature lipids
- (2008) L. Yang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Peptoids that mimic the structure, function, and mechanism of helical antimicrobial peptides
- (2008) N. P. Chongsiriwatana et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Ghrelin treatment suppresses neutrophil-dominant inflammation in airways of patients with chronic respiratory infection
- (2008) Tsuyoshi Kodama et al. PULMONARY PHARMACOLOGY & THERAPEUTICS
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started