Article
Endocrinology & Metabolism
Abrar M. Al-Mutairi, Mohammad A. Alshabeeb, Salah Abohelaika, Fadhel A. Alomar, Keshore R. Bidasee
Summary: This study investigated the impact of telemedicine on glycemic control in patients with type 2 diabetes during the COVID-19 lockdown in Saudi Arabia. The results showed that 63.1% of patients maintained good glycemic control and some patients showed improvement through telemedicine. Male patients had better glycemic control compared to female patients.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Luca D'Onofrio, Silvia Pieralice, Ernesto Maddaloni, Carmen Mignogna, Sara Sterpetti, Lucia Coraggio, Cecilia Luordi, Gloria Guarisco, Gaetano Leto, Frida Leonetti, Silvia Manfrini, Raffaella Buzzetti
Summary: The study found that the COVID-19 lockdown did not significantly affect glycemic control in T2D patients, but those with poor psychological well-being may experience worsening glycemic control due to lockdown restrictions. These findings could help healthcare providers in managing diabetes after the end of the second wave of COVID-19.
DIABETES OBESITY & METABOLISM
(2021)
Article
Multidisciplinary Sciences
Feifei Bu, Jessica K. Bone, John J. Mitchell, Andrew Steptoe, Daisy Fancourt
Summary: Recent studies have shown reduced physical activity at early stages of the COVID-19 pandemic. However, there is substantial heterogeneity in longitudinal changes in physical activity, with a significant proportion showing persistent physical inactivity or decreasing physical activity. Various factors such as age, gender, education, and income were found to be associated with the class membership of physical activity trajectories. Efforts are needed to promote physical activity during the pandemic and beyond, given the well-established link between physical activity and health.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Savas Karatas, Tijen Yesim, Selvihan Beysel
Summary: The study aimed to evaluate the impact of prolonged COVID-19 lockdown on metabolic control in type 2 diabetes patients and healthy individuals, finding that both diabetic patients and healthy subjects experienced weight gain during the lockdown period.
PRIMARY CARE DIABETES
(2021)
Article
Endocrinology & Metabolism
William H. H. Dietz
Summary: This study compared the prevalence of pediatric obesity during the COVID-19 lockdown with the annual increases in obesity in NHANES. The changes in prevalence observed in two surveys during the lockdown were 28 to 63 times greater than the annual changes in obesity in NHANES. Increases in obesity were greater in Black and Hispanic youth than in White youth. The COVID-19 lockdown exacerbated the disparities in obesity among this age group.
Article
Endocrinology & Metabolism
Pierpaolo Falcetta, Michele Aragona, Annamaria Ciccarone, Alessandra Bertolotto, Fabrizio Campi, Alberto Coppelli, Angela Dardano, Rosa Giannarelli, Cristina Bianchi, Stefano Del Prato
Summary: The study aimed to evaluate the impact of home confinement during the COVID-19 lockdown on metabolic control in patients with T2DM in Italy. The results showed that home confinement did not negatively affect metabolic control, but older age and insulin therapy were associated with a higher risk of deterioration in glycaemic control.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2021)
Review
Endocrinology & Metabolism
Claudia Eberle, Stefanie Stichling
Summary: During the COVID-19 lockdown, glycemic control significantly improved in patients with type 1 diabetes, potentially due to positive changes in self-care and digital management. However, patients with type 2 diabetes experienced a short-term worsening in glycemic parameters. Further research is needed to understand the causes and effective management of type 2 diabetes during lockdown.
DIABETOLOGY & METABOLIC SYNDROME
(2021)
Article
Endocrinology & Metabolism
Zhongrong He, Yanyun Lv, Suijin Zheng, Yudong Pu, Qingmei Lin, He Zhou, Moran Dong, Jiaqi Wang, Jingjie Fan, Yufeng Ye, Hanwei Chen, Rui Qian, Juan Jin, Yumeng Chen, Guimin Chen, Guanhao He, Shouzhen Cheng, Jianxiong Hu, Jianpeng Xiao, Wenjun Ma, Xi Su, Tao Liu
Summary: This study aims to investigate the association between COVID-19 lockdown measures and gestational diabetes mellitus (GDM). The results showed a positive association between lockdown exposure and GDM risk, with the first four months of pregnancy being a sensitive exposure window.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Environmental Sciences
Valentin Benzing, Sanaz Nosrat, Alireza Aghababa, Vassilis Barkoukis, Dmitriy Bondarev, Yu-Kai Chang, Boris Cheval, Muhammet Cihat Ciftci, Hassan M. Elsangedy, Maria Luisa M. Guinto, Zhijian Huang, Martin Kopp, Hafrun Kristjansdottir, Garry Kuan, Luca Mallia, Dadi Rafnsson, Gledson Tavares Amorim Oliveira, Arto J. Pesola, Caterina Pesce, Noora J. Ronkainen, Sinika Timme, Ralf Brand
Summary: This study found that during the COVID-19 pandemic, many individuals switched from playing games to endurance activities like running, and that higher education, living in rural areas, and prior physical activity were associated with reduced risk for inactivity during lockdown. Overall, most participants were able to continue their preferred type of exercise or adapt to endurance activities, indicating a high level of resilience and adaptability during the pandemic.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Endocrinology & Metabolism
Eleftheria Papachristoforou, Stavros Liatis, Ourania Psoma, Aikaterini Kountouri, Vaia Lambadiari, Vasilis Tsimihodimos
Summary: The study aimed to analyze the impact of COVID-19 lockdown periods on metabolic control in type 2 diabetes patients at three academic diabetes centers in Greece. Results showed slight improvements in BMI, blood pressure, and lipid levels, with other parameters remaining stable.
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2023)
Article
Endocrinology & Metabolism
Benjamin Udoka Nwosu, Layana Al-Halbouni, Sadichchha Parajuli, Gabrielle Jasmin, Emily Zitek-Morrison, Bruce A. Barton
Summary: The study found that there was no significant change in glycemic control in children and adolescents with type 1 diabetes during the 2020 pandemic lockdown in the US.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Pediatrics
Elina Hakonen, Tero Varimo, Anna-Kaisa Tuomaala, Paivi J. Miettinen, Mari-Anne Pulkkinen
Summary: The glycemic control in children with type 1 diabetes did not worsen during the lockdown period in Finland, and those using insulin pumps even showed improvement in their control. This suggests that social distancing measures may have positively impacted insulin pump usage.
Article
Endocrinology & Metabolism
Jinrong Wu, Yang Wang, Xin Xiao, Xianwen Shang, Mingguang He, Lei Zhang
Summary: The study found a significant association between the spatial distribution of T2DM incidence and the geographical prevalence of obesity and physical inactivity rate in New South Wales, Australia. Regional variations in obesity prevalence and physical inactivity rate resembled the geographical variation in the incidence of T2DM.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, General & Internal
Mohammad S. Alyahya, Nadeen Saeed Okour, Yousef Khader, Nihaya Al-sheyab
Summary: This study aimed to assess the impact of the COVID-19 lockdown on glycaemic control among patients with type 2 diabetes mellitus. The results showed that glycemic control and lipid profile had significantly improved after the lockdown.
Review
Endocrinology & Metabolism
Salvatore Corrao, Karen Pinelli, Martina Vacca, Massimo Raspanti, Christiano Argano
Summary: This review discusses the prevalence, pathophysiological mechanisms, and outcomes of COVID-19 infection in people with diabetes, proposing a rationale for using drugs prescribed in patients with diabetes and providing pragmatic clinical recommendations for dealing with COVID-19 in this patient population.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Peripheral Vascular Disease
Edoardo Casiglia, Valerie Tikhonoff, Agostino Virdis, Guido Grassi, Fabio Angeli, Carlo M. Barbagallo, Michele Bombelli, Arrigo F. G. Cicero, Massimo Cirillo, Pietro Cirillo, Raffaella Dell'Oro, Lanfranco D'elia, Giovambattista Desideri, Claudio Ferri, Ferruccio Galletti, Loreto Gesualdo, Cristina Giannattasio, Guido Iaccarino, Luciano Lippa, Francesca Mallamaci, Stefano Masi, Alessandro Maloberti, Maria Masulli, Alberto Mazza, Alessandro Mengozzi, Maria Lorenza Muiesan, Pietro Nazzaro, Paolo Palatini, Gianfranco Parati, Roberto Pontremoli, Fosca Quarti-Trevano, Marcello Rattazzi, Gianpaolo Reboldi, Giulia Rivasi, Massimo Salvetti, Giuliano Tocci, Andrea Ungar, Paolo Verdecchia, Francesca Viazzi, Massimo Volpe, Claudio Borghi
Summary: In the URRAH study, we identified the cut-off value for the ratio of serum uric acid (SUA) to serum creatinine (sCr) that can predict cardiovascular events. We found that having SUA/sCr > 5.35 is an independent cardiovascular risk indicator for both men and women.
JOURNAL OF HYPERTENSION
(2023)
Article
Endocrinology & Metabolism
E. Biancalana, G. Petralli, F. Raggi, Mr Distaso, G. Piazza, C. Rossi, D. Trico, A. Solini
Summary: This study examined the role of patient phenotype prior to treatment in determining the kidney response to SGLT2 inhibitors and GLP1 receptor agonists in type 2 diabetes patients. The results showed that patients with a faster decline in eGFR were more likely to benefit from treatment with SGLT2 inhibitors.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Endocrinology & Metabolism
Florian A. Wenzl, Alessandro Mengozzi, Shafeeq A. Mohammed, Nicola Riccardo Pugliese, Alessia Mongelli, Era Gorica, Samuele Ambrosini, Peter Riederer, Peter Fischer, Margareta Hinterberger, Yustina Puspitasari, Thomas F. Luscher, Giovanni G. Camici, Christian M. Matter, Gian Paolo Fadini, Agostino Virdis, Stefano Masi, Frank Ruschitzka, Edna Grunblatt, Francesco Paneni, Sarah Costantino
Summary: This study investigated the association between circulating long noncoding RNAs (lncRNAs) and incident type 2 diabetes in older adults. The researchers found that four lncRNAs (ANRIL, MIAT, RNCR3, and PLUTO) were associated with the development of type 2 diabetes and were linked to hemoglobin A(1c) levels throughout the 7.5-year follow-up period.
Article
Endocrinology & Metabolism
Diego Moriconi, Luca Sacchetta, Martina Chiriaco, Lorenzo Nesti, Giovanna Forotti, Andrea Natali, Anna Solini, Domenico Trico
Summary: This study evaluated the prognostic value of glomerular hyperfiltration in predicting long-term kidney-related outcomes and mortality in patients with diabetes. The analysis of 21-year longitudinal data showed that glomerular hyperfiltration is associated with worse kidney function and increased risk of mortality from cardiovascular or renal causes. Active screening of these patients is recommended for better risk stratification and treatment of subclinical kidney disease.
Review
Biochemistry & Molecular Biology
Alessandro Mengozzi, Sarah Costantino, Alessia Mongelli, Shafeeq A. Mohammed, Era Gorica, Valentina Delfine, Stefano Masi, Agostino Virdis, Frank Ruschitzka, Francesco Paneni
Summary: Systemic arterial hypertension is a complex disease characterized by accelerated vascular aging and high cardiovascular morbidity and mortality. Recent evidence has shown the involvement of epigenetic signals in maladaptive vascular remodeling, sympathetic activation, and cardiometabolic alterations, all of which contribute to the development of hypertension. These epigenetic changes have long-lasting effects on gene regulation and are not easily reversible.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Edoardo Biancalana, Chiara Rossi, Francesco Raggi, Mariarosaria Distaso, Domenico Trico, Simona Baldi, Ele Ferrannini, Anna Solini
Summary: This study aimed to investigate the involvement of NHE3 in modulating the response to sodium glucose co-transporter-2 inhibitors in humans. The results showed that empagliflozin acutely increased urinary pH and induced a substrate shift toward lipid utilization and ketogenesis in healthy young male volunteers, without significant changes in renal NHE3 protein expression.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Alessandro Mengozzi, Nicola Riccardo Pugliese, Giovambattista Desideri, Stefano Masi, Fabio Angeli, Carlo Maria Barbagallo, Michele Bombelli, Federica Cappelli, Edoardo Casiglia, Rosario Cianci, Michele Ciccarelli, Arrigo F. G. Cicero, Massimo Cirillo, Pietro Cirillo, Raffaella Dell'Oro, Lanfranco D'Elia, Claudio Ferri, Ferruccio Galletti, Loreto Gesualdo, Cristina Giannattasio, Guido Grassi, Guido Iaccarino, Luciano Lippa, Francesca Mallamaci, Alessandro Maloberti, Maria Masulli, Alberto Mazza, Maria Lorenza Muiesan, Pietro Nazzaro, Paolo Palatini, Gianfranco Parati, Roberto Pontremoli, Fosca Quarti-Trevano, Marcello Rattazzi, Gianpaolo Reboldi, Giulia Rivasi, Elisa Russo, Massimo Salvetti, Valerie Tikhonoff, Giuliano Tocci, Andrea Ungar, Paolo Verdecchia, Francesca Viazzi, Massimo Volpe, Claudio Borghi, Agostino Virdis
Summary: High serum uric acid (SUA) levels have been found to predict all-cause mortality (ACM) and cardiovascular mortality (CVM) in cardiometabolic patients without established cardiovascular disease, regardless of triglyceride (TG) levels. The study included 8124 patients from the URic acid Right for heArt Health (URRAH) study cohort, and the findings were confirmed by exploratory and sensitivity analyses. This suggests that SUA plays a substantial role in predicting cardiovascular risk in both normotriglyceridemia and hypertriglyceridemia.
Article
Biochemistry & Molecular Biology
Daniela Mastroiacovo, Alessandro Mengozzi, Francesco Dentali, Fulvio Pomero, Agostino Virdis, Antonio Camerota, Mario Muselli, Stefano Necozione, Raffaella Bocale, Claudio Ferri, Giovambattista Desideri
Summary: This study found that vulnerable carotid atherosclerotic plaques are associated with a higher risk of cognitive impairment and dementia in elderly individuals. The echogenicity of carotid plaques was inversely correlated with cognitive performance, suggesting that assessing plaque echogenicity could help identify individuals at increased risk for cognitive dysfunction.
Article
Endocrinology & Metabolism
Cristina Bianchi, Olga Vaccaro, Mariarosaria Distaso, Laura Franzini, Francesco Raggi, Anna Solini
Summary: MG53 is not associated with cardiovascular risk profile or long-term mortality in Caucasian individuals with T2D.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Endocrinology & Metabolism
Giovanni Petralli, Antonio Salvati, Domenico Trico, Gabriele Ricco, Piero Colombatto, Maurizia Rossana Brunetto, Anna Solini
Summary: Insulin resistance is independently associated with non-invasive markers of MAFLD severity in overweight/obese individuals, and this relationship is largely mediated by hyperinsulinemia.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Review
Endocrinology & Metabolism
Anna Solini, Domenico Trico, Stefano Del Prato
Summary: Major cardiovascular outcome trials and real-life observations have shown that GLP-1 receptor agonists (GLP-1RAs) provide clinically relevant cardiovascular protection regardless of GLP-1 homology. GLP-1RAs offer cardioprotective benefits through various mechanisms, including improved insulin secretion and action, weight loss, reduced blood pressure, improved lipid profile, as well as direct effects on the heart and vasculature. The available evidence has led professional and medical societies to recommend GLP-1RAs for reducing cardiovascular risk in people with type 2 diabetes.
Review
Medicine, General & Internal
Johanna Paivarinta, Ioanna A. A. Anastasiou, Niina Koivuviita, Kanishka Sharma, Pirjo Nuutila, Ele Ferrannini, Anna Solini, Eleni Rebelos
Summary: Thanks to medical imaging technology, the study of renal anatomy and physiology has advanced. However, difficulties in studying the metabolism and vasculature of the human kidney have limited research in these areas. This review provides an overview of recent findings on renal perfusion, oxygenation, and substrate uptake. The use of PET and fMRI has allowed for the evaluation of renal perfusion and the effects of therapeutic agents on kidney hemodynamics. Despite limited studies, these imaging modalities offer promising prospects for understanding renal pathophysiology in various diseases.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Domenico Trico, Maria Chiara Masoni, Simona Baldi, Noemi Cimbalo, Luca Sacchetta, Maria Tiziana Scozzaro, Giulia Nesti, Alessandro Mengozzi, Lorenzo Nesti, Martina Chiriaco, Andrea Natali
Summary: The study found that early time-restricted carbohydrate consumption (eTRC) is a feasible and effective dietary strategy for individuals with type 2 diabetes, however, it does not provide additional metabolic benefits compared to conventional dieting. This research is significant for improving dietary management and overall health of diabetes patients.