Article
Materials Science, Multidisciplinary
Jun Shu, Lin Gao, Ying Li, Peiwen Wang, Xiaoyan Deng, Xingwu Yan, Konggang Qu, Lu Li
Summary: This study presents high-sensitivity pressure sensors achieved through efficient surface bonding of MXene materials with tissue paper. The sensors exhibit a broad working range, fast response and recovery time, excellent mechanical endurance, and low detection limit. Physiological signals were evaluated, revealing the potential of these sensors for commercial wearable electronics.
Review
Chemistry, Physical
Leonardo Mancini, Mario Romandini, Adriano Fratini, Lorenzo Maria Americo, Saurav Panda, Enrico Marchetti
Summary: Periodontal and peri-implant regeneration aims to restore damaged tissues around teeth and implants with a tailored approach based on the specific characteristics of each site. Current clinical practice relies on bone grafts, membranes for guided tissue regeneration, growth factors, and stem cells, combined with a patient-centered approach to achieve optimal results and reduce patient morbidity. Tissue engineering is constantly advancing, with a combination of biomaterials as the preferred choice in many cases for achieving reliable outcomes.
Article
Chemistry, Multidisciplinary
Weiang Yan, Alireza Rafieerad, Keshav Narayan Alagarsamy, Leena Regi Saleth, Rakesh C. Arora, Sanjiv Dhingra
Summary: This study reports the first application of Ti3C2Tx MXene nanosheets for preventing allograft vasculopathy. It was found that MXene nanosheets interacted with human ECs, downregulated genes involved in alloantigen presentation, and reduced the activation of allogeneic lymphocytes. In an in vivo rat model, MXene treatment reduced lymphocyte infiltration and preserved smooth muscle cell integrity in transplanted aortic allografts.
Article
Chemistry, Multidisciplinary
Yixuan Huang, Shuai He, Sheng Yu, Hannah M. Johnson, Yau Kei Chan, Zheng Jiao, Shouteng Wang, Zixiang Wu, Yi Deng
Summary: This study presents a decorated nanofibrous membrane that can generate local heat and elevate reactive oxygen species (ROS) levels for effective bacterial eradication through photothermal/photodynamic effects. The membrane loaded with aspirin exhibits good cytocompatibility, enhances cell growth, and suppresses the NF-& kappa;B pathway, showing excellent anti-inflammatory effects. In vivo investigations confirm that the nanofibrous membrane accelerates infectious cutaneous regeneration by killing bacteria, promoting collagen deposition, boosting angiogenesis, and dampening inflammatory reaction through the NF-& kappa;B pathway.
Review
Engineering, Biomedical
Yongjin Zhong, Si Huang, Zeru Feng, Yu Fu, Anchun Mo
Summary: This review summarizes the applications of MXene nanomaterials in tissue engineering and regeneration. The synthesis and surface modification engineering of MXene are briefly introduced, followed by a focus on its application and development in skin, bone, nerve, and heart tissue engineering. Research on MXene with potential future trends in tissue engineering and regeneration is also discussed.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2022)
Article
Chemistry, Multidisciplinary
Xiaoyan Qu, Yi Guo, Chenxi Xie, Sihua Li, Zhengqing Liu, Bo Lei
Summary: Bone defects caused by trauma often involve soft tissue damage, necessitating the development of multifunctional biomaterials for bone and soft tissue regeneration. This study demonstrates that photoactivated MXene nanosheet promotes both bone and soft tissue regeneration. The photoactivated MXene exhibits thermal effects and antibacterial activity, inhibits inflammation factors, induces pro-angiogenic factors, and enhances soft tissue wound repair. Additionally, it regulates osteogenic differentiation through the ERK signaling pathway, enhancing bone tissue repair. This work highlights the potential of bioactive MXene with photothermal activation for simultaneous bone and soft tissue regeneration.
Article
Materials Science, Multidisciplinary
Md. Reazuddin Repon, Daiva Mikucioniene, Rimvydas Milasius, Tamal Krishna Paul, Chowdhury Mashfik Ahmed, Syed Zubair Hussain, Aminoddin Haji
Summary: The maintenance of proper thermal equilibrium and energy saving have made wearable thermal devices extremely important. Modern thermo-regulated wearable technology, such as integrating MXene, can control personal heat while using less energy.
MATERIALS TODAY COMMUNICATIONS
(2023)
Review
Chemistry, Multidisciplinary
Junping Ma, Long Zhang, Bo Lei
Summary: This review summarizes the multifunctional properties of MXenes and discusses their applications in tissue regeneration and disease treatment. Research has shown that MXene-based biomaterials have favorable physicochemical properties and bioactive functions, making them promising for tissue regeneration and therapy. However, there are still challenges that need to be addressed for the practical use of MXene-based biomaterials.
Article
Engineering, Biomedical
Xue Mi, Zhenya Su, Yu Fu, Shiqi Li, Anchun Mo
Summary: Grafting bone-substitute biomaterials is crucial for reconstructing bone defects, but designing bioscaffolds for regeneration of critical-sized bone defects is challenging. Ti3C2 MXene is a promising candidate due to its biocompatibility, antibacterial properties, and osteogenesis promotion. Incorporating Ti3C2 MXene into composite scaffolds for bone regeneration shows great potential in clinical applications.
BIOMEDICAL MATERIALS
(2022)
Review
Chemistry, Multidisciplinary
Longfei Li, Xiaodi Zhang, Jun Zhou, Liqun Zhang, Jiajia Xue, Wei Tao
Summary: This review discusses the recent progress in applying various non-invasive thermal therapeutic modalities, such as photothermal therapy, magnetic thermotherapy, and ultrasound thermotherapy, for tissue engineering and regenerative medicine (TERM). The parameters and conditions required for well-controlled thermal therapy for tissue regeneration are also discussed. Challenges and concerns regarding the clinical application of thermal therapy are pointed out, and future development directions are provided to offer opportunities and a new pathway for TERM.
Review
Materials Science, Ceramics
Xipeng Chen, Yuanpei Cheng, Han Wu
Summary: Bone defects have long been of concern as they greatly impact the functioning of the motor system. The main treatment method for bone defect repair involves the implantation of biological materials and biological scaffolds in the defect site to promote healing. The emergence of two-dimensional materials, such as MXene, has provided new opportunities in the field of biological materials, offering unique physical and chemical properties that make it highly promising for bone defect biomaterial applications. This review explores the pathophysiological changes of bone defects, intervention factors for bone defect repair, preparation and modification methods, physical and chemical properties, biological characteristics, application status, and research progress of MXene in bone defect repair and bone tissue regeneration, providing valuable insights for its further application.
CERAMICS INTERNATIONAL
(2023)
Article
Biology
Alecsandru Ionescu, Aliona Dodi, Lucian Cristian Petcu, Mihnea Ioan Nicolescu
Summary: This study describes a minimally invasive technique for preserving the post-extraction tooth socket, leading to high implant survival and success rates at five-year follow-up.
Article
Nanoscience & Nanotechnology
Bo Yuan, Xin Zhou, Yingke Li, Yin Zhao, Mintao Xue, Qunfeng Guo, Gang Zheng, Xiongsheng Chen, Han Lin, Xiang Guo
Summary: This study demonstrates the excellent performance of a BPs@HA composite coating in eliminating bacterial biofilms and accelerating bone fracture healing. Through in vitro and in vivo studies on bacterial biofilms and bone fracture healing, the BPs@HA coating was shown to regulate the expression of core markers related to bone mesenchymal stem cell differentiation and bone formation through metabolism-related pathways.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Zhaopu Yang, Xinliang Fu, Daichuan Ma, Yulin Wang, Liming Peng, Jiacheng Shi, Jiyu Sun, Xueqi Gan, Yi Deng, Weizhong Yang
Summary: A nano platform with multiple antibacterial functions was designed and fabricated in this study, which effectively eliminates bacteria and promotes cell migration using phototherapy, showing a positive influence on wound healing.
Review
Chemistry, Multidisciplinary
Yue Wang, Haitao Cui, Timothy Esworthy, Deqing Mei, Yancheng Wang, Lijie Grace Zhang
Summary: The rapid development of 3D printing has had a significant impact on the field of biomedical engineering, particularly 4D printing. While there has been progress made in the development of 4D printing for tissue scaffolds and medical devices, there are limitations in printable smart materials and achievable responses with current stimulation sources. This review highlights recent progress in 4D printing, focusing on printing mechanisms, smart ink mechanisms, structural design, and printing technologies. It also summarizes recent studies on tissue/organ regeneration and medical device applications, and discusses current challenges and future perspectives of 4D printing.
ADVANCED MATERIALS
(2022)
Article
Engineering, Biomedical
Ruizhi Hu, Zhixin Chen, Chen Dai, Xiang Guo, Wei Feng, Zhuang Liu, Han Lin, Yu Chen, Rong Wu
Summary: The study presents a novel silicene-based silicene@Pt composite nanosheets that function as contrast agents for CT imaging and dual radio-sensitizing agents for radiotherapy through functionalization of Pt components, as well as realizing photonic tumor hyperthermia with strong photothermal-conversion performance. This approach broadens the biomedical applications of silicene and develops functionalization strategies for versatile biomedical applications.
Review
Chemistry, Multidisciplinary
Xiangyu Lu, Shanshan Gao, Han Lin, Jianlin Shi
Summary: This article reviews the latest advances in nanocatalytic tumor therapy, focusing on the remarkable achievements of single-atom catalysts (SACs) in several different treatment modalities, as well as the attention on catalytic nanoplatform construction and catalytic mechanism. Challenges still remain for the future design and engineering of SACs for tumor therapy.
Article
Chemistry, Multidisciplinary
Ruizhi Hu, Chen Dai, Chunmei Wang, Jie Lin, Hui Hu, Zhifang Li, Han Lin, Li Ding, Yu Chen, Bo Zhang
Summary: By developing 2D arsenic-phosphorus (AsP) nanosheets, toxic arsenic is confined into AsP crystals, improving the biosafety and biocompatibility of arsenic-based chemotherapeutic drugs. AsP nanosheets exhibit high light absorption and strong photothermal-conversion efficiency in the second near infrared biowindow (NIR-II), enabling contrast-enhanced photoacoustic imaging and local tumor hyperthermia, leading to a synergistic arsenic-mediated antineoplastic effect.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Review
Engineering, Biomedical
Wencheng Wu, Yinying Pu, Xiangyu Lu, Han Lin, Jianlin Shi
Summary: Nanocatalytic medicine is a promising strategy for cancer therapeutics that generates toxic agents within tumors through catalytic reactions. Transitional metal-based nanocatalytic medicines show significant catalytic activity and clinical potential, but face obstacles and challenges in design and clinical application.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Engineering, Biomedical
Xiang Guo, Mintao Xue, Fei Chen, Qunfeng Guo, Xin Zhou, Han Lin, Yu Chen
Summary: In this study, a HA/MONs@miR-34a composite coating was successfully engineered to deliver miR-34a into osteoclasts and inhibit their differentiation and resorptive activity by regulating downstream gene expression in the early stage of fracture healing. The composite coating also showed potential for bone regeneration in a rat tibial fracture model. RNA-seq and functional enrichment analysis revealed the molecular mechanism underlying the regulation of osteoclast physiological functions by miR-34a.
Article
Chemistry, Multidisciplinary
Wencheng Wu, Yinying Pu, Heliang Yao, Han Lin, Jianlin Shi
Summary: This study reports a novel microbiotic nanomedicine LOD/TPZ@Lips-LA, which combines lactate oxidase (LOD) and prodrug tirapazamine (TPZ) loaded liposomes anchored on lactobacillus (LA) surface for chemotherapy-synergized antitumor immunity. The nanomedicine induces tumor cell apoptosis through in situ ROS generation and TPZ activation based on LA metabolism, resulting in strong immunogenic cell death (ICD). By regulating biomarker expression, it promotes anti-tumorigenic M1 polarization of innate tumor-associated macrophages and infiltration of adaptive cytotoxic CD8+ T cells, synergistically enhancing the tumor inhibition effects.
Article
Nanoscience & Nanotechnology
Y. You, C. Yang, X. Zhang, H. Lin, J. Shi
Summary: Silicene, as a rising-star 2D material, has multifaceted properties and shows great potential in biomedical applications. Through synthetic strategies and rational design of multifunctional nanomedicine, the translation of silicene materials into innovative clinical tools can be promoted.
MATERIALS TODAY NANO
(2021)
Article
Chemistry, Multidisciplinary
Han Lin, Chuang Yang, Yao Luo, Min Ge, Hao Shen, Xianlong Zhang, Jianlin Shi
Summary: In this study, we developed a biomimetic nanomedicine called HMMP for in situ vaccination against bacterial infection, focusing on osteomyelitis. The HMMP showed a burst release of bacterial antigens, triggering both cellular and humoral adaptive immune responses. Furthermore, it generated robust systemic antibacterial immunity and long-lasting bacteria-specific immune memory responses.
Article
Engineering, Environmental
Yuanhe Sun, Yuanxin Zhao, Zhaofeng Liang, Han Lin, Zhiguo Ren, Zeying Yao, Yaru Yin, Ping Huai, Ke Yang, Jinyou Lin, Yaobo Huang, Wen Wen, Xiaolong Li, Renzhong Tai, Daming Zhu
Summary: This study demonstrates the potential of silicene as an anode material for potassium-ion batteries. Through synthesis and testing, it is shown that silicene possesses efficient potassium-ion insertion/extraction properties and cycle stability.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Yanling You, Ya-Xuan Zhu, Junjie Jiang, Min Wang, Zhixin Chen, Chenyao Wu, Jie Wang, Wujie Qiu, Deliang Xu, Han Lin, Jianlin Shi
Summary: In this study, hydrogen-terminated silicon nanosheets (H-silicene) were synthesized through a simple wet-chemical exfoliation method. These nanosheets can react with environmental water to rapidly and continuously generate H-2 gas, without the need for external energy input. The study also revealed the mechanism behind the enhanced H-2 generation efficacy of H-silicene nanosheets. The synthesized H-silicene was demonstrated as a flexible hydrogen gas generator, with potential applications in acute inflammatory treatments by scavenging reactive oxygen species through on-demand H-2 production.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Nanoscience & Nanotechnology
Bo Yuan, Xin Zhou, Yingke Li, Yin Zhao, Mintao Xue, Qunfeng Guo, Gang Zheng, Xiongsheng Chen, Han Lin, Xiang Guo
Summary: This study demonstrates the excellent performance of a BPs@HA composite coating in eliminating bacterial biofilms and accelerating bone fracture healing. Through in vitro and in vivo studies on bacterial biofilms and bone fracture healing, the BPs@HA coating was shown to regulate the expression of core markers related to bone mesenchymal stem cell differentiation and bone formation through metabolism-related pathways.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Multidisciplinary Sciences
Chuang Yang, Yao Luo, Hao Shen, Min Ge, Jin Tang, Qiaojie Wang, Han Lin, Jianlin Shi, Xianlong Zhang
Summary: By modulating antigen presentation and co-stimulatory molecule expression, the use of PVP-modified MPS nanosheets can trigger a strong immune response against bacterial biofilm infections, reducing residual and recurrent infections.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Yanling You, Ya-Xuan Zhu, Junjie Jiang, Zhixin Chen, Chenyao Wu, Zhimin Zhang, Han Lin, Jianlin Shi
Summary: In this study, a new two-dimensional iodine nanomaterial called iodinene was proposed for the treatment of infectious diseases in vivo. Iodinene demonstrated enhanced antibacterial efficacy against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa by in situ production of active HIO and I2 molecules via allotropic transformation. The in vivo results further confirmed the desirable antibacterial efficacy of iodinene in treating bacterial wound infection and pneumonia.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Ya-Xuan Zhu, Yanling You, Zhixin Chen, Deliang Xu, Wenwen Yue, Xinxin Ma, Junjie Jiang, Wencheng Wu, Han Lin, Jianlin Shi
Summary: In this study, a copolymer-modified two-dimensional H-silicene nanomaterial was developed to help probiotics adapt to different gastrointestinal microenvironments. The material can resist acidic destruction in the stomach and generate anti-inflammatory hydrogen gas in the intestine, thus alleviating colitis. This strategy holds great significance for the development of intelligent self-adaptive materials.