Article
Chemistry, Multidisciplinary
Kaili Yang, Weijun Xiu, Yuqing Li, Dou Wang, Qirui Wen, Lihui Yuwen, Xiao Li, Zhaowei Yin, Bin Liang, Lianhui Wang
Summary: In this study, a near-infrared responsive 2D nanozyme was developed for efficient treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections. The nanozyme exhibited effective antibacterial properties against MRSA through catalytic and photothermal effects. The results showed that the nanozyme had high bactericidal activity against MRSA under near-infrared light irradiation and promoted wound healing.
Article
Biochemistry & Molecular Biology
Jie Gao, Tianjiao Luan, Jiajia Lv, Mingyan Yang, Hongyu Li, Zeli Yuan
Summary: In this study, a multifunctional BODIPY derivative, FBD-M, was designed for synergistic chemo-phototherapy against hypoxic tumors. FBD-M exhibited near-infrared absorbance and emission, photosensitive activity, oxygen-carrying capability, high photothermal conversion efficiency, good photostability, lysosome targeting, low toxicity, and synergistic chemo-phototherapy against hypoxic tumors. It has been successfully applied for anticancer in vitro and in vivo, demonstrating its potential as an ideal multifunctional theranostic agent.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2023)
Article
Materials Science, Biomaterials
Xin Zhang, Ning Wang, Yetong Shen, Yang Zhang, Lu Han, Bo Hu
Summary: A novel drug loading system, Au@Si-N-N-Si@SiO2, was constructed through layer-by-layer assembly. The system utilized core gold nanorods with near-infrared light-responsive photothermal properties, as well as a middle layer that generates free radicals upon heating to trigger drug release. An outer layer of silica was used to prevent drug leakage. The system demonstrated excellent photothermal effect under near-infrared laser irradiation and showed improved antitumor efficiency through NIR-triggered drug release, free radical generation, and photothermal effect.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Chemistry, Multidisciplinary
Di Gao, Yupeng Shi, Jiahua Ni, Shuojia Chen, Ying Wang, Bin Zhao, Manli Song, Xiaoqing Guo, Xuechun Ren, Xingcai Zhang, Zhongmin Tian, Zhe Yang
Summary: The development of carrier-free nano-theranostic agents (AIBME@IR780-APM NPs) addresses the challenge of tumor hypoxia on PDT efficacy, utilizing alkyl radicals and heat effects to achieve synergistic cell death via MRI-guided photothermal therapy/thermodynamic therapy against cancer cells.
Article
Chemistry, Multidisciplinary
Sha Yang, Bin Sun, Fen Liu, Na Li, Minghui Wang, Peixian Wu, Gui-long Wu, Huilong Fang, Yuxuan He, Wei Zhou, Hao Xiao, Xiaofeng Tan, Li Tang, Shoujun Zhu, Qinglai Yang
Summary: Researchers have developed a phototheranostic system that targets the mitochondria of tumor cells, effectively interfering with their energy metabolism and changing the immunosuppressive microenvironment of the tumor. This system combines mitochondrial-targeting, NIR-II fluorescence imaging, and simultaneous photothermal therapy, photodynamic therapy, and immune therapy, providing an effective nanoplatform for imaging-guided tumor therapy.
Article
Materials Science, Multidisciplinary
Qing Chen, Su He, Fangjun Zhang, Fengzhi Cui, Jianhua Liu, Man Wang, Dongmei Wang, Zhigang Jin, Chunxia Li
Summary: The study synthesized a composite nanosystem Pt-Ce6 using porous Pt nanoparticles, which can continuously decompose H(2)O(2) into oxygen, alleviating tumor hypoxia and enhancing the effect of PDT. Additionally, Pt-Ce6 demonstrated good photothermal stability and high photothermal conversion efficiency in the NIR-II region, effectively suppressing tumor growth and recurrence under laser irradiation in U14 tumor-bearing mice.
SCIENCE CHINA-MATERIALS
(2021)
Article
Medicine, Research & Experimental
Chenyang Yin, ZeKun Wang, Chunxue Dai, Bangjia Yang, Weiyun Wang, Endong Yang, Feng Guo, Cundong Fan, Pu Zhang, Jikui Sun, Dongdong Sun
Summary: This study proposes a new strategy to enhance the effectiveness of photodynamic therapy (PDT) and photothermal therapy (PTT) for tumor treatment by utilizing a hybrid of photosynthetic bacteria/photosensitizer/photothermal agent to generate oxygen through photosynthesis. The combination of photosensitizer and photothermal agent with photosynthetic bacteria effectively enhances their accumulation in tumor tissues, and the oxygen produced through photosynthesis is converted to reactive oxygen species (ROS) to further enhance the therapeutic effect.
Article
Chemistry, Inorganic & Nuclear
Feng Ouyang, Li Zhao, Qi Shuai
Summary: In this study, a photothermal driven nanomotor was designed to address the issue of effective delivery of nanodrugs in tumour tissue altered by the dense extracellular matrix and internal fluid pressure. The nanomotor, named PZT, could simultaneously realize the functions of photothermal therapy, chemodynamic therapy, hypoxia-activation computed tomography, glutathione consumption, and photothermal driven. It offers advantages such as good stability, low cost, easy synthesis, excellent deep puncture ability, and strong anti-tumour effect.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Biophysics
Mi Wang, Lina Zhang, Han Hao, Xiaoxiao Hu, Zhichuan Xin, Yanyan Zhu, Yanting Shen, Jing Wang
Summary: Developing an effectively synergistic multi-mode drug delivery nanoplatform for cancer treatment is challenging but of great significance. The researchers constructed a core-shell nanoplatform coated with doxorubicin-loaded hyaluronic acid, which can function as a H2O2 self-supplying and near-infrared-enhanced reactive oxygen species producer for chemodynamic-photothermal-chemotherapy multi mode drug delivery.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Pharmacology & Pharmacy
Fenglin Li, Yi Lai, Jiayi Ye, Madiha Saeed, Yijing Dang, Zhifeng Zou, Fangmin Chen, Wen Zhang, Zhiai Xu
Summary: The study presents a dual-targeting nanotheranostic for precise photo-immunotherapy of glioblastoma (GBM). The nanotheranostic can deliver drugs to the tumor site and induce a photothermal effect, enhancing the therapeutic effect.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Engineering, Biomedical
Cheng Li, Zijin Luo, Lixia Yang, Jun Chen, Kai Cheng, Yanan Xue, Genyan Liu, Xiaogang Luo, Fengshou Wu
Summary: The development of organic nanoagents with high photothermal conversion efficiency has become a focus in photothermal cancer therapy. The designed porphyrin polymer P-PPor displayed intense absorbance in the NIR region and significant fluorescence in the NIR-II region. The P-PPor nanoparticles showed enhanced absorption in the NIR region and a remarkable photothermal effect, making them a potential agent for photothermal cancer therapy.
MATERIALS TODAY BIO
(2022)
Article
Nanoscience & Nanotechnology
Qi Cai, Chen Wang, Shili Gai, Piaoping Yang
Summary: In this study, a versatile nanosystem was constructed by encapsulating Au nanosheets in codoped gadolinium oxyfluoride (GdOF):Yb,Er spheres and decorating it with a chemotherapeutic drug, a photosensitizer, and a targeted agent. The nanosystem achieved targeted cancer treatment and real-time monitoring of curative efficacy through combining photothermal and photodynamic therapies. The nanosystem also enabled multimodal imaging.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Materials Science, Multidisciplinary
Indika Chandrasiri, Mahesh Loku Yaddehige, Bo Li, Yuzhe Sun, William E. Meador, Austin Dorris, Mohammad Farid Zia, Nathan Hammer, Alex Flynt, Jared H. Delcamp, Edward Davis, Alexander Lippert, Davita L. Watkins
Summary: This study compares the solution behavior and self-assembly pattern of two linear dendritic block copolymers (LDBCs) and finds that the introduction of phenyl substituents improves the stability and loading efficiency of LDBC nanoparticles, which shows great potential for use as nanocarriers in therapeutic nanomedicine.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Chemistry, Physical
Tianxiang Zhou, Jie Huang, Wenshi Zhao, Rui Guo, Sicheng Cui, Yuqing Li, Naveen Reddy Kadasala, Yuhong Jiang, Yang Liu, Qi Zhang
Summary: In this study, multifunctional Fe3O4 @Au nanocomposites were designed and synthesized as photothermal conversion agents (PCA) and photosensitizers (PS) for synergistic photothermal therapy (PTT) and photodynamic therapy (PDT) of cervical cancer (HeLa) cells using a single excitation light source. The nanocomposites exhibited high photothermal conversion efficiency and cytotoxic singlet oxygen generation. They also showed good biocompatibility and low cytotoxicity, making them ideal nanotherapeutic agents for HeLa cell treatment.
JOURNAL OF ALLOYS AND COMPOUNDS
(2023)
Article
Nanoscience & Nanotechnology
Xiao Li, Hang Xiao, Weijun Xiu, Kaili Yang, Yue Zhang, Lihui Yuwen, Dongliang Yang, Lixing Weng, Lianhui Wang
Summary: MPFPT nanosheets demonstrate enhanced therapeutic efficacy by targeting mitochondria, good photothermal performance, and acceleration of the Fenton reaction, making them promising nanoagents for oncotherapy.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Yi-Feng Wang, Qingrong Zhang, Falin Tian, Hongda Wang, Yufei Wang, Xiaowei Ma, Qianqian Huang, Mingjun Cai, Yinglu Ji, Xiaochun Wu, Yaling Gan, Yan Yan, Kenneth A. Dawson, Shutao Guo, Jinchao Zhang, Xinghua Shi, Yuping Shan, Xing-Jie Liang
Summary: This study investigated the internalization behaviors of rod-shaped nanostructures with different aspect ratios using atomic force microscopy, transmission electron microscopy, and molecular dynamic simulation. It revealed that gold nanorods are endocytosed in an intermittent rotation manner and the internalization force and time are positively correlated with the aspect ratios. The study also found that internalization speed is negatively correlated with internalization time.
Article
Engineering, Environmental
Junlang Li, Yongbo Lv, Dashuai Zhu, Xuan Mei, Ke Huang, Xianyun Wang, Zhenhua Li, Sichen Zhang, Shiqi Hu, Kristen D. Popowski, Ke Cheng, Juan Wang
Summary: A comparison between intramyocardial (IM) injection and intrapericardial cavity (IPC) injection of adult stem cells in hydrogel showed that IPC injection led to better retention and therapeutic benefits, resulting in significant improvement in cardiac function. Furthermore, IPC delivery demonstrated better cellular proliferation, less apoptosis, and improved vascular regeneration in the myocardium. Additionally, IPC injections led to higher rates of MSC-exosome absorption by heart cells, indicating more extensive paracrine activity and showing promise as a solution for the low retention issue of MSCs in the infarcted heart.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Physical
Linna Liang, Wendi Huo, Bei Wang, Lingzhi Cao, Haoran Huo, Yixin Liu, Yi Jin, Xinjian Yang
Summary: Tumor multidrug resistance is a major cause of chemotherapy failure, and reversing tumor multidrug resistance is crucial for increasing the sensitivity of tumor cells to chemodrugs. The self-assembled DNAzyme nanoflowers can efficiently reverse multidrug resistance, enhance drug loading capacity, and suppress P-glycoprotein expression.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Biotechnology & Applied Microbiology
Chi Zhang, Wei Zhang, Dashuai Zhu, Zhenhua Li, Zhenzhen Wang, Junlang Li, Xuan Mei, Wei Xu, Ke Cheng, Biao Zhong
Summary: This study proposes a method using cell-mimicking and targeted therapeutic nanoparticles to replace stem cells. The results show that in a rat model of osteoporosis, this treatment can accumulate in bone, inhibit osteoclast differentiation, and promote osteogenic proliferation. Additionally, this treatment reduces bone mass attenuation in rats with ovariectomy-induced bone loss.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Rui Wang, Yinan Zhao, Zhenlong Huang, Yaxin Zhou, Wei Wang, Yang Xuan, Yuhong Zhen, Benzhi Ju, Shutao Guo, Shubiao Zhang
Summary: We report the development of self-assembled podophyllotoxin-loaded lipid bilayer nanoparticles for regulating the immunosuppressive microenvironment of tumors. The nanoparticles exhibit both immunological effects and antitumor effects.
Article
Chemistry, Multidisciplinary
Xiaomeng Jia, Cuimiao Zhang, Lan Gao, Xinjian Yang, Ziman Yu, Xiaomeng Lou, Guang Jia
Summary: Hollow spherical Y2O3, YBO3, and YVO4 with excellent luminescent properties have been successfully synthesized using a facile template-directed strategy. The method involves the use of phenol-formaldehyde resin spheres as templates and a simple precipitation or hydrothermal route followed by annealing. The materials exhibited both down-conversion and up-conversion luminescence, making them promising for applications in lighting and displays. This synthesis strategy provides a new approach for the fabrication of inorganic compounds with perfect hollow structures and excellent properties.
Review
Chemistry, Physical
Yi-Feng Wang, Yaxin Zhou, JiaBei Sun, Xiaotong Wang, Yaru Jia, Kun Ge, Yan Yan, Kenneth A. Dawson, Shutao Guo, Jinchao Zhang, Xing-Jie Liang
Summary: Nanoparticles-based drug delivery systems have the potential to efficiently deliver drugs to target sites. However, challenges arise due to the complex interactions between nanoparticles and biological systems, as well as the formation of a protein corona on the nanoparticles' surface upon injection into the blood. Understanding the impact of the protein corona on nanoparticle delivery and developing strategies to exploit it can improve the transportation behavior of nanoparticles in vivo.
Article
Engineering, Environmental
Jingqing Mu, Yuyuan Du, Xingwei Li, Ran Yan, Haiping Zhong, Maoyu Cai, Na Yu, Jinchao Zhang, Xiaoyong Yuan, Xia Hua, Shutao Guo
Summary: Researchers have developed collagen-anchored hollow nanoreactors to improve the effectiveness of cancer starvation therapy. The nanoreactors enhance the intratumoral retention and biosafety of enzymes, while the catalytic cascade initiated by the enzymes leads to oxygen self-supply and glucose consumption, resulting in drug release.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Tao Liu, Hui Zou, Jingqing Mu, Xi Zhang, Guohua Liu, Na Yu, Bo Yuan, Xiaoyong Yuan, Xingjie Liang, Shutao Guo
Summary: Nanoparticulate formulations of small-molecule drugs can improve the performance of traditional chemo drugs, but the compatibility between drugs and nanocarriers is a challenge. Stimuli-responsive mPEG-PDLLA-drug conjugate-based nanomedicines can overcome this challenge and provide highly efficacious self-assembled nanomedicines. The hydrophobic content of a polymeric prodrug nanomedicine plays an important role in its performance.
CHINESE CHEMICAL LETTERS
(2023)
Article
Engineering, Biomedical
Maoyu Cai, Zunkai Xu, Xueyan Zhou, Liangpin Li, Xia Hua, Shutao Guo, Xiaoyong Yuan
Summary: The acid-sensitive stearoxyl-ketal-dexamethasone pro-drug microcrystals (SKD MCs) show promise as a new strategy for the treatment of noninfectious uveitis and potentially other ocular inflammatory diseases. SKD MCs effectively reduce inflammation, protect retinal function, and decrease retinal microglia activation.
APL BIOENGINEERING
(2022)
Article
Pharmacology & Pharmacy
Han Zhu, Xin Gao, Bei Wang, Biao Niu, Dandan Liu, Jinchao Zhang, Yi Jin, Xinjian Yang
Summary: In cancer therapy, blocking autophagy and reeducating tumor-associated macrophages can enhance the effectiveness of treatment by overcoming therapeutic resistance mechanisms.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Tiantian Guo, Haiping Zhong, Xingwei Li, Jingqing Mu, Tao Liu, Na Yu, Yang Zhao, Xing-Jie Liang, Shutao Guo
Summary: In this study, we synthesized four dextran-paclitaxel (PTX) conjugates with different drug contents and used them to construct self-assembled nanoparticles. We investigated how PTX content influenced the performance and antitumor efficacy of the nanoparticles. The results showed that nanoparticles with lower PTX content exhibited faster drug release, increased tumor accumulation, and enhanced antitumor efficacy.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Polymer Science
Yuyuan Du, Maoyu Cai, Jingqing Mu, Xingwei Li, Yapeng Song, Xiaoyong Yuan, Xia Hua, Shutao Guo
Summary: This study demonstrates the preservation of retinal ganglion cells (RGCs) through intravitreal injection of tannin (TA)-based nanoreactors loaded with catalase (CAT). The type I collagen-adhesive CAT@PTP nanoreactor adheres to the retina via collagen and effectively scavenges reactive oxygen species (ROS).
MACROMOLECULAR RAPID COMMUNICATIONS
(2023)
Review
Chemistry, Multidisciplinary
Xin Gao, Yixin Liu, Wendi Huo, Yuwei Song, Yu Chen, Jinchao Zhang, Xinjian Yang, Yi Jin, Xing-jie Liang
Summary: RNA-cleaving DNAzymes, known for their stability, catalytic activity, synthesis ease, functionalization ease, and modification ease, have been extensively studied in bioanalysis and biomedical applications. By incorporating these DNAzymes into amplification systems, sensing platforms can detect various targets with high sensitivity and selectivity. Additionally, these DNAzymes have therapeutic potential in gene therapy by cleaving mRNA to regulate protein expression. This review comprehensively summarizes the recent applications of RNA-cleaving DNAzymes, highlighting their uniqueness and superiority in biosensing and gene therapy. The challenges and prospects of utilizing RNA-cleaving DNAzymes as diagnostic and therapeutic agents are also discussed. This review provides valuable suggestions for researchers and promotes the development of DNAzymes for accurate analysis, early diagnosis, and effective therapy in medicine and beyond.
Article
Chemistry, Multidisciplinary
Haiping Zhong, Xingwei Li, Na Yu, Xi Zhang, Jingqing Mu, Tao Liu, Bo Yuan, Xiaoyong Yuan, Shutao Guo
Summary: The maintenance of robust ratiometric loading and release kinetics for effective optimization of combination effects of dual therapeutic agents remains challenging. Herein, we report a sequential drug release system based on nanoformulated mutual prodrugs, allowing acid-triggered release of anticancer drugs, paclitaxel and gemcitabine. The sequence of drug release substantially affected the combination effects in various cell lines, and time-staggered release profiles showed enhanced synergistic effects in A549 cells. In vivo assessment in A549 xenograft models confirmed that the best therapeutic effects were obtained with time-staggered release profiles. Our strategy provides a precise control of sequential drug release for optimizing drug combinations in vitro and in vivo.
