Multifunctional Composite Inverse Opal Film with Multiactives for Wound Healing

A film with an elaborate microstructure and multifunctions is urgently needed in wound healing. Here, we present a multiactive encapsulated inverse opal film with a monitorable delivery system for chronic wound healing. The inverse opal film is prepared by using poly(lactic-co-glycolic acid) to negatively replicate a colloidal crystal template, which presents a high specific surface area and interconnected nanopores. It could be imparted with a potent antibacterial effect and promote angiogenesis by loading the vascular endothelial growth factor into the nanopores and encapsulating by chitosan. In addition, it is demonstrated that the structure color change of the film could intuitively reflect the drug release progress from the nanopores, which made the film a real-time drug monitoring system. In the affected wound model, the properties of the multifunctional film in promoting wound healing are certified by the faster healing speed, more granulation tissue, less inflammation, and even a distribution of new blood vessels and collagen. These results indicate that the resultant multifunctional film has a practical application value in clinical wound care.

Automated summary

The multiactive encapsulated inverse opal film shows a potent antibacterial effect and promotes angiogenesis by loading vascular endothelial growth factor into nanopores and encapsulating by chitosan, making it crucial in chronic wound healing. The color change of the film structure can intuitively reflect the drug release progress, serving as a real-time drug monitoring system. In the affected wound model, the film's properties in promoting wound healing are confirmed by faster healing speed, more granulation tissue, less inflammation, and the distribution of new blood vessels and collagen, demonstrating its practical application value in clinical wound care.