MEKK3-MEK5-ERK5 signaling promotes mitochondrial degradation

Mitophagy regulates mitochondrial network signaling, oxidative stress, and apoptosis during myoblast differentiation

(2019) Brittany L. Baechler et al.   Autophagy

SQSTM1/p62 promotes mitochondrial ubiquitination independently of PINK1 and PRKN/parkin in mitophagy

(2019) Tatsuya Yamada et al.   Autophagy

Mitochondrial Genome (mtDNA) Mutations that Generate Reactive Oxygen Species

(2019) Hahn et al.   Antioxidants

BNIP3L/NIX-dependent mitophagy regulates cell differentiation via metabolic reprogramming

(2018) Lorena Esteban-Martínez et al.   Autophagy

Mitochondrial Stasis Reveals p62-Mediated Ubiquitination in Parkin-Independent Mitophagy and Mitigates Nonalcoholic Fatty Liver Disease

(2018) Tatsuya Yamada et al.   Cell Metabolism

Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic Demand

(2018) Thomas G. McWilliams et al.   Cell Metabolism

Mutant MAPK7-Induced Idiopathic Scoliosis is Linked to Impaired Osteogenesis

(2018) Taifeng Zhou et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance

(2018) Sarah Pickles et al.   CURRENT BIOLOGY

Mitochondrial DNA damage and reactive oxygen species in neurodegenerative disease

(2018) Nadee Nissanka et al.   FEBS LETTERS

BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis

(2018) Kate McArthur et al.   SCIENCE

Mitochondrial Complex I activity signals antioxidant response through ERK5

(2018) Abrar Ul Haq Khan et al.   Scientific Reports

CellProfiler 3.0: Next-generation image processing for biology

(2018) Claire McQuin et al.   PLOS BIOLOGY

Parkin and PINK1 mitigate STING-induced inflammation

(2018) Danielle A. Sliter et al.   NATURE

Mechanisms of mitophagy in cellular homeostasis, physiology and pathology

(2018) Konstantinos Palikaras et al.   NATURE CELL BIOLOGY

Loss of the selective autophagy receptor p62 impairs murine myeloid leukemia progression and mitophagy

(2018) The Duy Nguyen et al.   BLOOD

The Role of Mitochondria in Reactive Oxygen Species Generation and Its Implications for Neurodegenerative Diseases

(2018) Saima Kausar et al.   Cells

Statin regulated ERK5 stimulates tight junction formation and reduces permeability in human cardiac endothelial cells

(2017) Emma L. Wilkinson et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Expanding perspectives on the significance of mitophagy in cancer

(2017) Lauren E. Drake et al.   SEMINARS IN CANCER BIOLOGY

Metabolic stress-induced cardiomyopathy is caused by mitochondrial dysfunction due to attenuated Erk5 signaling

(2017) Wei Liu et al.   Nature Communications

Mitochondrial dysfunction activates lysosomal-dependent mitophagy selectively in cancer cells

(2017) Thomas G. Biel et al.   Oncotarget

From Erythroblasts to Mature Red Blood Cells: Organelle Clearance in Mammals

(2017) Martina Moras et al.   Frontiers in Physiology

Mitophagy in Parkinson’s Disease: Pathogenic and Therapeutic Implications

(2017) Fei Gao et al.   Frontiers in Neurology

The MEK5/ERK5 signalling pathway in cancer: a promising novel therapeutic target

(2016) André E.S. Simões et al.   DRUG DISCOVERY TODAY

Mitophagy is required for mitochondrial biogenesis and myogenic differentiation of C2C12 myoblasts

(2015) Jon Sin et al.   Autophagy

Erk5 contributes to maintaining the balance of cellular nucleotide levels and erythropoiesis

(2015) Maria Angulo-Ibáñez et al.   CELL CYCLE

TBK1 controls autophagosomal engulfment of polyubiquitinated mitochondria through p62/SQSTM1 phosphorylation

(2015) Gen Matsumoto et al.   HUMAN MOLECULAR GENETICS

Parkinson's disease

(2015) Lorraine V Kalia et al.   LANCET

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

(2015) Michael Lazarou et al.   NATURE

Mitochondrial DNA stress primes the antiviral innate immune response

(2015) A. Phillip West et al.   NATURE

The cerebral cavernous malformation proteins CCM2L and CCM2 prevent the activation of the MAP kinase MEKK3

(2015) Xavier Cullere et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of Extracellular Signal-regulated Kinase 5 in Adipocyte Signaling

(2014) Hong Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitophagy Is Required for Acute Cardioprotection by Simvastatin

(2013) Allen M. Andres et al.   ANTIOXIDANTS & REDOX SIGNALING

Using Functional Signature Ontology (FUSION) to Identify Mechanisms of Action for Natural Products

(2013) M. B. Potts et al.   Science Signaling

Mitophagy: mechanisms, pathophysiological roles, and analysis

(2012) Wen-Xing Ding et al.   BIOLOGICAL CHEMISTRY

ERK5: Structure, regulation and function

(2012) Gopika N. Nithianandarajah-Jones et al.   CELLULAR SIGNALLING

Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells

(2012) Lei Liu et al.   NATURE CELL BIOLOGY

Imaging Intracellular pH in Live Cells with a Genetically Encoded Red Fluorescent Protein Sensor

(2011) Mathew Tantama et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Identification and Analysis of Mouse Erythroid Progenitors using the CD71/TER119 Flow-cytometric Assay

(2011) Miroslav Koulnis et al.   Jove-Journal of Visualized Experiments

Pharmacological Inhibition of BMK1 Suppresses Tumor Growth through Promyelocytic Leukemia Protein

(2010) Qingkai Yang et al.   CANCER CELL

Regulation of mitochondrial biogenesis

(2010) François R. Jornayvaz et al.   Essays in Biochemistry

The regulation of autophagy - unanswered questions

(2010) Y. Chen et al.   JOURNAL OF CELL SCIENCE

Autophagy: cellular and molecular mechanisms

(2010) Danielle Glick et al.   JOURNAL OF PATHOLOGY

Ligand-induced EpoR internalization is mediated by JAK2 and p85 and is impaired by mutations responsible for primary familial and congenital polycythemia

(2009) R. Sulahian et al.   BLOOD

PB1 Domain Interaction of p62/Sequestosome 1 and MEKK3 Regulates NF-κB Activation

(2009) Kazuhiro Nakamura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamics and diversity in autophagy mechanisms: lessons from yeast

(2009) Hitoshi Nakatogawa et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial DNA: An Up-and-coming Actor in White Adipose Tissue Pathophysiology

(2009) Joan Villarroya et al.   Obesity

Identification of pharmacological inhibitors of the MEK5/ERK5 pathway

(2008) Revati J. Tatake et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY

Fluorescence imaging using a fluorescent protein with a large Stokes shift

(2008) Takako Kogure et al.   METHODS

Essential role for Nix in autophagic maturation of erythroid cells

(2008) Hector Sandoval et al.   NATURE