Article
Medicine, General & Internal
C. Sabrina Tan, Ai-ris Y. Collier, Jingyou Yu, Jinyan Liu, Abishek Chandrashekar, Katherine McMahan, Catherine Jacob-Dolan, Xuan He, Vicky Roy, Blake M. Hauser, Jennifer E. Munt, Michael L. Mallory, Melissa Mattocks, John M. Powers, Rita M. Meganck, Marjorie Rowe, Rachel Hemond, Esther A. Bondzie, Kate H. Jaegle, Ralph S. Baric, Aaron G. Schmidt, Galit Alter, Mathieu Le Gars, Jerald Sadoff, Dan H. Barouch
Summary: By using heterologous Ad26.COV2.S vaccine as a booster for individuals previously vaccinated with BNT162b2, durable humoral and cellular immune responses can be achieved. This suggests potential benefits of heterologous prime-boost vaccine regimens for SARS-CoV-2.
Article
Multidisciplinary Sciences
Immacolata Andolfo, Roberta Russo, Vito Alessandro Lasorsa, Sueva Cantalupo, Barbara Eleni Rosato, Ferdinando Bonfiglio, Giulia Frisso, Pasquale Abete, Gian Marco Cassese, Giuseppe Servillo, Gabriella Esposito, Ivan Gentile, Carmelo Piscopo, Romolo Villani, Giuseppe Fiorentino, Pellegrino Cerino, Carlo Buonerba, Biancamaria Pierri, Massimo Zollo, Achille Iolascon, Mario Capasso
Summary: The study conducted an in-depth genetic analysis of COVID-19, revealing five single nucleotide polymorphisms on chromosome 21 associated with severe cases. The minor alleles of these SNPs were found to be correlated with a reduced risk of developing severe COVID-19 and higher expression levels of MX1 in blood. These findings suggest that host genetic factors may influence the clinical presentations of COVID-19 and highlight MX1 as a potential therapeutic target.
Article
Multidisciplinary Sciences
Pei Sen, Teresa K. Yamana, Sasikiran Kandula, Marta Galanti, Jeffrey Shaman
Summary: The COVID-19 pandemic in the United States in 2020 was characterized by increasing ascertainment rates, high population susceptibility, and rising community infectious rates, with infection fatality rate decreasing towards the end of the year.
Review
Infectious Diseases
Dasha Majra, Jayme Benson, Jennifer Pitts, Justin Stebbing
Summary: Super spreader events (SSEs) can be categorized into 'societal' and 'isolated' events, with the former posing a greater threat and the latter being more easily quarantined.
JOURNAL OF INFECTION
(2021)
Article
Biochemistry & Molecular Biology
Ziyad Al-Aly, Benjamin Bowe, Yan Xie
Summary: This study analyzed the US Department of Veterans Affairs national healthcare databases to investigate the occurrence of Long COVID and death risk after breakthrough SARS-CoV-2 infection. The findings showed that vaccination significantly reduced the risk of death and post-acute sequelae but did not eliminate them completely. These results underscore the importance of further research on prevention and post-acute care for breakthrough infections.
Article
Multidisciplinary Sciences
Viviane Fongaro Botosso, Soraia Attie Calil Jorge, Renato Mancini Astray, Ana Marcia de Sa Guimaraes, Monica Beatriz Mathor, Patricia dos Santos de Carneiro, Edison Luiz Durigon, Dimas Covas, Danielle Bruna Leal de Oliveira, Ricardo das Neves Oliveira, Durvanei Augusto Maria, Silas Fernandes Eto, Neuza Maria Frazatti Gallina, Giselle Pidde, Carla Cristina Squaiella-Baptistao, Dilza Trevisan Silva, Isadora Maria Villas-Boas, Dayanne Carla Fernandes, Aline Vivian Vatti Auada, Alexandre Campos Banari, Antonio Francisco de Souza Filho, Camila Bianconi, Carla Lilian de Agostini Utescher, Denise Cristina Andre Oliveira, Douglas Oscar Ceolin Mariano, Flavia Ferreira Barbosa, Giuliana Rondon, Josana Kapronezai, Juliana Galvao da Silva, Mauricio Barbugiani Goldfeder, Priscila Comone, Regis Edgar Castilho Junior, Taiana Taina Silva Pereira, Fan Hui Wen, Denise Tambourgi, Ana Marisa Chudzinski-Tavassi
Summary: The new outbreak of COVID-19 has caused millions of deaths worldwide. Efforts are being made to find effective treatments, such as using immunoglobulin from immunized animals or plasma from convalescent patients. Clinical trials using anti-SARS-CoV-2 immunoglobulins from horses immunized with spike protein are underway. Researchers have developed an anti-SARS-CoV-2 equine F(ab ')(2) immunoglobulin that successfully neutralizes the virus, is safe in animal models, and reduces the severity of the disease in a hamster model of SARS-CoV-2 infection.
SCIENTIFIC REPORTS
(2022)
Review
Multidisciplinary Sciences
Miriam Merad, Catherine A. Blish, Federica Sallusto, Akiko Iwasaki
Summary: Considerable research effort has been focused on deciphering the immune response to SARS-CoV-2 infections and understanding the pathophysiology of COVID-19, including Long Covid syndrome. The hope is that knowledge gained from this research will be applied to studies of inflammatory processes in critical and chronic illnesses in the future.
Editorial Material
Multidisciplinary Sciences
Chris Woolston
Summary: The true impact of closed borders, cancelled travel plans and vaccine delays may take years to fully reveal.
Article
Medicine, General & Internal
Stephanie J. Schrag, Jennifer R. Verani, Brian E. Dixon, Jessica M. Page, Kristen A. Butterfield, Manjusha Gaglani, Gabriela Vazquez-Benitez, Ousseny Zerbo, Karthik Natarajan, Toan C. Ong, Victoria Lazariu, Suchitra Rao, Ryan Beaver, Sascha R. Ellington, Nicola P. Klein, Stephanie A. Irving, Shaun J. Grannis, Salome Kiduko, Michelle A. Barron, John Midturi, Monica Dickerson, Ned Lewis, Melissa S. Stockwell, Edward Stenehjem, William F. Fadel, Ruth Link-Gelles, Kempapura Murthy, Kristin Goddard, Nancy Grisel, Nimish R. Valvi, Bruce Fireman, Julie Arndorfer, Deepika Konatham, Sarah Ball, Mark G. Thompson, Allison L. Naleway
Summary: This study found that maternal mRNA COVID-19 vaccination, including booster doses, provided protection against medically attended COVID-19. Vaccine effectiveness estimates were higher for COVID-19-associated hospitalizations compared to emergency department/urgent care visits, and lower for the Omicron variant than the Delta variant. Protection decreased over time, especially during the Omicron predominance.
Review
Pharmacology & Pharmacy
Thales Kronenberger, Stefan A. Laufer, Thanigaimalai Pillaiyar
Summary: This article discusses the rationale for inhibitors targeting SARS-CoV-2 Mpro. Small molecules and peptidomimetic inhibitors are two types of inhibitors with different modes of action. Novel inhibitors discovered during the COVID-19 pandemic are highlighted, focusing on their binding modes and structures.
DRUG DISCOVERY TODAY
(2023)
Review
Biochemistry & Molecular Biology
Nikola Gligorijevic, Mirjana Radomirovic, Olgica Nedic, Marija Stojadinovic, Urmila Khulal, Dragana Stanic-Vucinic, Tanja Cirkovic Velickovic
Summary: The global outbreak of COVID-19 caused by SARS-CoV-2 has led to numerous clinical trials investigating the potential of polyphenols in prevention and treatment, providing a solid basis for developing polyphenol-based natural approaches for preventing and treating COVID-19.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Infectious Diseases
Carolina Q. Sacramento, Natalia Fintelman-Rodrigues, Jairo R. Temerozo, Aline de Paula Dias Da Silva, Suelen da Silva Gomes Dias, Carine dos Santos da Silva, Andre C. Ferreira, Mayara Mattos, Camila R. R. Pao, Caroline S. de Freitas, Vinicius Cardoso Soares, Lucas Villas Boas Hoelz, Tacio Vinicio Amorim Fernandes, Frederico Silva Castelo Branco, Monica Macedo Bastos, Nubia Boechat, Felipe B. Saraiva, Marcelo Alves Ferreira, Steffen Jockusch, Xuanting Wang, Chuanjuan Tao, Minchen Chien, Wei Xie, Dinshaw Patel, Aitor Garzia, Thomas Tuschl, James J. Russo, Rajith K. R. Rajoli, Carolina S. G. Pedrosa, Gabriela Vitoria, Leticia R. Q. Souza, Livia Goto-Silva, Marilia Zaluar Guimaraes, Stevens K. Rehen, Andrew Owen, Fernando A. Bozza, Dumith Chequer Bou-Habib, Jingyue Ju, Patricia T. Bozza, Thiago Moreno L. Souza
Summary: The study showed that the anti-HCV drugs sofosbuvir and daclatasvir have potential effects in inhibiting the SARS-CoV-2 virus, making them possible candidates for COVID-19 treatment. Sofosbuvir and daclatasvir not only can prevent virus replication, but also reduce neuronal apoptosis and release of inflammatory mediators.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Markus Hoffmann, Nadine Krueger, Sebastian Schulz, Anne Cossmann, Cheila Rocha, Amy Kempf, Inga Nehlmeier, Luise Graichen, Anna-Sophie Moldenhauer, Martin S. Winkler, Martin Lier, Alexandra Dopfer-Jablonka, Hans-Martin Jaeck, Georg M. N. Behrens, Stefan Poehlmann
Summary: The Omicron variant of SARS-CoV-2 is spreading rapidly and shows resistance to most therapeutic antibodies. It also evades neutralization by antibodies induced by infection or vaccination more efficiently than the Delta variant. This suggests that therapeutic antibodies may not be effective against the Omicron variant, and double vaccination with BNT162b2 may not provide adequate protection against severe disease caused by this variant.
Review
Microbiology
Jakob J. Malin, Isabelle Suarez, Vanessa Priesner, Gerd Fatkenheuer, Jan Rybniker
Summary: Remdesivir is the first approved treatment for COVID-19, showing therapeutic and prophylactic effects in animal models of various viruses. However, it failed in a clinical trial on ebolavirus disease but showed beneficial effects for patients with COVID-19 in a placebo-controlled trial.
CLINICAL MICROBIOLOGY REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Fang Sun, Chenglin Mu, Hang Fai Kwok, Jiyuan Xu, Yingliang Wu, Wanhong Liu, Jean-Marc Sabatier, Cedric Annweiler, Xugang Li, Zhijian Cao, Yingqiu Xie
Summary: The study identified the PI3K/AKT pathway as crucial in COVID-19, with inhibitors potentially blocking SARS-CoV-2 entry into cells and offering antiviral targets. This suggests that PI3K/AKT kinase inhibitor drugs could be a promising strategy for managing COVID-19, especially in cancer patients.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ayelen Toro, Maria Sol Ruiz, Sofia Lage-Vickers, Pablo Sanchis, Agustina Sabater, Gaston Pascual, Rocio Seniuk, Florencia Cascardo, Sabrina Ledesma-Bazan, Felipe Vilicich, Elba Vazquez, Geraldine Gueron
Summary: Heme oxygenase 1 (HO-1) plays a crucial role in maintaining cellular homeostasis and possesses cytoprotective, antioxidative, anti-inflammatory, and antiviral properties. This review highlights the protective role of HO-1 in inflammatory diseases and viral infections, suggesting its potential as a therapeutic target for ameliorating clinical manifestations during COVID-19.
Article
Biochemistry & Molecular Biology
Sofia Lage-Vickers, Pablo Sanchis, Juan Bizzotto, Ayelen Toro, Agustina Sabater, Rosario Lavignolle, Nicolas Anselmino, Estefania Labanca, Alejandra Paez, Nora Navone, Maria P. Valacco, Javier Cotignola, Elba Vazquez, Geraldine Gueron
Summary: Prostate cancer (PCa) cells with abnormal expression of proteins, including HMOX1 and YWHAZ, exhibit resistance to chemotherapy. Through a proteomics study, the researchers identified proteins that interact with HMOX1 and found correlations between HMOX1 and certain genes involved in PCa. High expression of HNRNPA2B1, HSPB1, NPM1, DDB1, HMGA1, ZC3HAV1, and HMOX1 was associated with improved relapse-free survival in PCa patients. Furthermore, the interaction between HO-1 and 14-3-3 zeta/delta was confirmed, suggesting these factors as potential therapeutic targets for PCa.
Article
Oncology
Pablo Sanchis, Nicolas Anselmino, Sofia Lage-Vickers, Agustina Sabater, Rosario Lavignolle, Estefania Labanca, Peter D. A. Shepherd, Juan Bizzotto, Ayelen Toro, Antonina Mitrofanova, Maria Pia Valacco, Nora Navone, Elba Vazquez, Javier Cotignola, Geraldine Gueron
Summary: This study investigates the metabolic changes in prostate cancer cells interacting with bone cells, identifying five lipid metabolism-related genes that play a critical role in the survival of metastatic patients. The study establishes a communication axis between tumor and bone cells and suggests a potential role of Protein Kinase A in early metabolic reprogramming of metastatic cells.
Article
Virology
Ayelen Toro, Sofia Lage-Vickers, Juan Bizzotto, Felipe Vilicich, Agustina Sabater, Gaston Pascual, Sabrina Ledesma-Bazan, Pablo Sanchis, Maria Sol Ruiz, Ana Paula Arevalo, Jorge L. Porfido, Mercedes Abbate, Rocio Seniuk, Estefania Labanca, Nicolas Anselmino, Nora M. Navone, Daniel F. Alonso, Elba Vazquez, Martina Crispo, Javier Cotignola, Geraldine Gueron
Summary: This study demonstrates the important role of IFN-gamma and ISGs in the response to SARS-CoV-2 infection, suggesting their potential as adjuvant immunotherapy for COVID-19 patients. The analysis showed increased expression of IFN-gamma-associated pathways and ISGs in COVID-19-positive patients, which correlated with viral load and STAT1/JAK2 expression.
Article
Medicine, General & Internal
Juan Manuel Castelli, Analia Rearte, Santiago Olszevicki, Carla Voto, Maria Del Valle Juarez, Martina Pesce, Agustina Natalia Iovane, Mercedes Paz, Maria Eugenia Chaparro, Maria Pia Buyayisqui, Maria Belen Markiewicz, Mariana Landoni, Carlos Maria Giovacchini, Carla Vizzotti
Summary: This study estimated the effectiveness of a two dose vaccine schedule against SARS-CoV-2 infection, COVID-19 related death, and short-term waning of immunity in children and adolescents during periods of delta and omicron variant predominance in Argentina. The results showed that vaccine effectiveness in preventing SARS-CoV-2 infection declined over time, especially during the omicron period. However, the vaccine remained effective in preventing death related to SARS-CoV-2 infection.
BMJ-BRITISH MEDICAL JOURNAL
(2022)
Meeting Abstract
Oncology
Pablo Sanchis, Nicolas Anselmino, Rosario Lavignolle, Agustina Sabater, Estefania Labanca, Juan Bizzotto, Sofia Lage-Vickers, Gaston Pascual, Rocio Seniuk, Ayelen Toro, Nora Navone, Javier Cotignla, Elba Vazquez, Geraldine Gueron
Article
Oncology
Estefania Labanca, Jun Yang, Peter D. A. Shepherd, Xinhai Wan, Michael W. Starbuck, Leah D. Guerra, Nicolas Anselmino, Juan A. Bizzotto, Jiabin Dong, Arul M. Chinnaiyan, Murali K. Ravoori, Vikas Kundra, Bradley M. Broom, Paul G. Corn, Patricia Troncoso, Geraldine Gueron, Christopher J. Logothethis, Nora M. Navone
Summary: This study found that FGFR1 expression plays an important role in bone metastasis of prostate cancer, and its activity enhanced bone metastasis and survival rate in mice, and the human samples also showed that FGFR1 were enriched in bone metastasis of castration-resistant prostate cancer. In addition, the study also found that the LAD1 protein co-expressed with FGFR1 plays an important role in the bone metastasis of prostate cancer.
EUROPEAN UROLOGY ONCOLOGY
(2022)
