Review
Hematology
Thomaz Alexandre Costa, Nicole Felix, Bruno Almeida Costa, Amanda Godoi, Alleh Nogueira, Adriana Rossi
Summary: Multiple myeloma patients undergoing anti-myeloma therapy have an increased risk of venous thromboembolism (VTE). Current guidelines recommend low-dose direct oral anticoagulants (DOACs) as an alternative to aspirin for thromboprophylaxis. A systematic review and meta-analysis comparing DOACs with aspirin showed that DOACs had a significantly lower incidence of VTE. Bleeding event rates did not differ significantly between the two groups. This suggests that DOACs may be a preferable option for thromboprophylaxis in multiple myeloma patients, but further research is needed to evaluate the optimal strategy.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Peripheral Vascular Disease
Jason Chung, Cal H. Robinson, Andrew Yu, Abdulaziz A. Bamhraz, Joycelyne E. Ewusie, Stephanie Sanger, Mark Mitsnefes, Rulan S. Parekh, Rupesh Raina, Lehana Thabane, Janis M. Dionne, Rahul Chanchlani
Summary: This systematic review found that children and adolescents with ambulatory hypertension have a higher risk of target organ damage, such as left ventricular hypertrophy, elevated left ventricular mass index, increased pulse wave velocity, and elevated carotid intima-media thickness. The findings highlight the importance of optimizing blood pressure control and screening for target organ damage in children with ambulatory hypertension.
Review
Medicine, General & Internal
Anastasios Kollias, Konstantinos G. Kyriakoulis, Ioannis P. Trontzas, Vassiliki Rapti, Ioannis G. Kyriakoulis, Christina A. Theochari, Evangelos Dimakakos, Garyphallia Poulakou, Konstantinos Syrigos
Summary: In hospitalized patients with COVID-19, intermediate thromboprophylaxis dose appears to be safer and provides additional survival benefit compared to standard prophylactic dose. However, the optimal choice of therapeutic dose remains controversial.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Orthopedics
Stephanie Marrannes, Klaas Victor, Nele Arnout, Tine De Backer, Jan Victor, Thomas Tampere
Summary: A systematic review comparing the effectiveness of aspirin prophylaxis following knee surgery with other standard prophylactic agents found no significant difference in VTE prevention between aspirin, LMWH, and warfarin, while factor Xa inhibitors were more effective but also associated with increased bleeding complications. Additional research with high-quality trials is needed due to limited evidence and substantial heterogeneity.
EFORT OPEN REVIEWS
(2021)
Review
Gastroenterology & Hepatology
Jakub Gazda, Sylvia Drazilova, Matej Gazda, Martin Janicko, Tomas Koky, Marian Macej, Marco Carbone, Peter Jarcuska
Summary: This study systematically reviewed and meta-analyzed various UDCA treatment response endpoints and their validations, finding that the GLOBE and UK-PBC Risk Scores serve as the most accurate predictive models. Additionally, the normalization of alkaline phosphatase and total bilirubin has been suggested as a new therapeutic target.
DIGESTIVE AND LIVER DISEASE
(2023)
Review
Medicine, General & Internal
Davide Ceccato, Angelo Di Vincenzo, Claudio Pagano, Raffaele Pesavento, Paolo Prandoni, Roberto Vettor
Summary: In obese hospitalized patients, weight-adjusted dose heparin is not associated with a lower risk of VTE or a higher risk of bleeding compared to fixed-dose heparins. However, it is associated with higher anti-Xa levels.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2021)
Review
Infectious Diseases
Rui Tang, Rui Luo, Shiwei Tang, Haoxin Song, Xiujuan Chen
Summary: Machine learning may be a potential technology for predicting antimicrobial resistance, but limitations in the retrospective methodology for model development, nonstandard data processing, and scarcity of validation in randomized controlled trials or real-world studies restrict the application of these models in clinical practice.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Review
Obstetrics & Gynecology
Sara Folkins, Ashley Miller, Christopher M. Nash
Summary: Pregnant patients with active malignancy have a higher risk of venous thromboembolism compared to pregnant patients without malignancy.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Review
Surgery
Izaskun Balciscueta, Ferran Barbera, Javier Lorenzo, Susana Martinez, Maria Sebastian, Zutoia Balciscueta
Summary: This study identified predictive factors of outpatient laparoscopic cholecystectomy failure through a systematic review and meta-analysis, including age, body mass index, American Society of Anesthesiologists score, history of complicated biliary pathology, gallbladder wall thickness, operative time, and surgery start time.
Review
Endocrinology & Metabolism
Aleena Shujaat Ali, Cecilia Pham, Grant Morahan, Elif Ilhan Ekinci
Summary: This systematic review summarizes the existing evidence of genetic risk scores (GRSs) for predicting diabetic kidney disease (DKD) in people with type 1 or type 2 diabetes. Most studies of high methodological quality reported a statistically significant association between GRS and at least one measure of DKD. GRSs can be used to identify people with diabetes at high risk of developing DKD.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Surgery
Roi Anteby, Benjamin G. Allar, Jordan M. Broekhuis, Priya B. Patel, Christina L. Marcaccio, Marianna V. Papageorge, Stefania Papatheodorou, April E. Mendoza
Summary: Based on the current observational evidence, initiating chemical thromboprophylaxis within 48 hours is associated with lower rates of venous thromboembolism (VTE) without an increased risk of failure in nonoperative management (NOM).
JOURNAL OF SURGICAL RESEARCH
(2023)
Review
Orthopedics
Chen Xi Kasia Chua, Joelle Hwee Inn Tan, Hamid Rahmatullah Bin Abd Razak
Summary: This systematic review and meta-analysis evaluated the efficacy of direct oral anticoagulants (DOACs) compared with enoxaparin in an Asian population after total knee arthroplasty (TKA). The results showed that DOACs significantly reduced the rate of overall venous thromboembolism (VTE) compared with enoxaparin. However, there were no significant differences in deep vein thrombosis, pulmonary embolism, and rates of bleeding complications between the two.
JOURNAL OF ARTHROPLASTY
(2022)
Review
Medicine, General & Internal
Zhiwei Yan, Yang Liu, Wei Li, Xiaopeng Zhao, Weichun Lin, Jing Zhang, Shuchun Yu, Jianyong Ma, Jingfeng Wang, Peng Yu, Weiguang Li, Xiao Liu
Summary: Higher levels of liver fibrosis scores are associated with increased risk of cardiovascular events, cardiovascular mortality, and all-cause mortality in patients with cardiovascular disease.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Review
Hematology
Meng-Fei Dai, Wen-Xiu Xin, Sisi Kong, Hai-Ying Ding, Luo Fang
Summary: This meta-analysis study confirms that extended thromboprophylaxis, particularly prophylactic use of anticoagulants for <35 days, can significantly reduce the risk of thrombosis and all-cause mortality without increasing the risk of major bleeding events in high-risk COVID-19 patients after discharge.
THROMBOSIS RESEARCH
(2023)
Review
Oncology
Hao Zhang, Hanqi Lei, Jun Pang
Summary: This study assessed the diagnostic performance of radiomics in adrenal tumors and conducted a quantitative analysis. The findings suggest that CT-based radiomics can effectively differentiate between malignant and benign adrenal tumors. However, there is heterogeneity among the included studies.
FRONTIERS IN ONCOLOGY
(2022)
Article
Obstetrics & Gynecology
Madeline F. Flanagan, Charlotte A. Vollgraff Heidweiller-Schreurs, Wentao Li, Wessel Ganzevoort, Marjon A. de Boer, Alicia Vazquez-Sarandeses, Ozhan M. Turan, Patrick M. Bossuyt, Ben W. J. Mol, Daniel L. Rolnik
Summary: The study aimed to investigate the prognostic value of different Doppler ultrasound measurements for adverse perinatal outcomes. The results showed that umbilical artery pulsatility index added prognostic value for adverse perinatal outcomes, while other Doppler ultrasound measurements did not further improve prognostic performance.
AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
(2023)
Article
Respiratory System
Inge A. H. van den Berk, Maadrika M. N. P. Kanglie, Tjitske S. R. van Engelen, Josje Altenburg, Jouke T. Annema, Ludo F. M. Beenen, Bart Boerrigter, Marije K. Bomers, Paul Bresser, Elvin Eryigit, Maarten Groenink, Suzanne M. R. Hochheimer, Frits Holleman, Jos A. J. Kooter, Ramon B. van Loon, Mitran Keijzers, Ivo van der Lee, Paul Luijendijk, Lilian J. Meijboom, Saskia Middeldorp, Laura J. Schijf, Robin Soetekouw, Ralf W. Sprengers, Alexander D. Montauban van Swijndregt, Wouter de Monye, Milan L. Ridderikhof, Michiel M. Winter, Shandra Bipat, Marcel G. W. Dijkgraaf, Patrick M. M. Bossuyt, Jan M. Prins, Jaap Stoker
Summary: Replacing chest X-ray with ultra-low-dose chest CT (ULDCT) in the diagnostic work-up of patients suspected of non-traumatic pulmonary disease at the emergency department has similar effects on short-term functional health, hospital admissions, and length of stay. However, more incidental findings were found in the ULDCT group.
Article
Gastroenterology & Hepatology
Arthur S. Aelvoet, Victorine H. Roos, Barbara A. J. Bastiaansen, Roel Hompes, Willem A. Bemelman, Cora M. Aalfs, Patrick M. M. Bossuyt, Evelien Dekker
Summary: This study compared the development of ileal adenomas in patients with familial adenomatous polyposis (FAP) who underwent ileal pouch-anal anastomosis (IPAA) or end ileostomy. The results showed that patients with IPAA had a higher incidence of ileal adenomas compared to those with end ileostomy.
GASTROINTESTINAL ENDOSCOPY
(2023)
Editorial Material
Critical Care Medicine
Julie Helms, Saskia Middeldorp, Alex C. Spyropoulos
INTENSIVE CARE MEDICINE
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Robert A. Frank, Haben Dawit, Patrick M. M. Bossuyt, Mariska Leeflang, Trevor A. Flood, Rodney H. Breau, Matthew D. F. McInnes, Nicola Schieda
Summary: This article provides a systematic review of the available evidence on the diagnostic accuracy of biparametric (bp)-MRI and multiparametric (mp)-MRI for solid renal masses in differentiating malignant from benign, aggressive from indolent, and clear cell renal cell carcinoma (ccRCC) from other histology. The review reveals deficits in the available evidence, with limited studies and high risk of bias, as well as heterogeneity in definitions, imaging techniques, diagnostic criteria, and outcome measures for solid masses.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Editorial Material
Obstetrics & Gynecology
Janneke van 't Hooft, Charlotte E. E. van Dijk, Cathrine Axfors, Zarko Alfirevic, Martijn A. A. Oudijk, Khalid S. S. Khan, Ben W. J. Mol, Patrick M. M. Bossuyt, John P. A. Ioannidis
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Review
Medical Laboratory Technology
Florent J. L. A. Vanstapel, Matthias Orth, Thomas Streichert, Ettore D. Capoluongo, Wytze P. Oosterhuis, Hikmet Can Cubukcu, Francisco A. Bernabeu-Andreu, Marc Thelen, Leo H. J. Jacobs, Solveig Linko, Harjit Pal Bhattoa, Patrick M. M. Bossuyt, Pika Mesko Brguljan, Guilaine Boursier, Christa M. Cobbaert, Michael Neumaier
Summary: The EU In-Vitro Diagnostic Device Regulation (IVDR) aims to ensure transparent validation of diagnostic devices, traceability of results, and post-market surveillance. Laboratory-developed tests (LDTs) may be used in the absence of suitable commercial devices. The implementation of IVDR may lead to the need for urgent replacement of commercial tests with LDTs, and the workload will depend on various factors.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Jr Tuman J. Milling, Saskia Middeldorp, Lizhen Xu, Bruce Koch, Andrew Demchuk, John W. Eikelboom, Peter Verhamme, Alexander T. Cohen, Jan Beyer-Westendorf, C. Michael Gibson, Jose Lopez-Sendon, Mark Crowther, Ashkan Shoamanesh, Michiel Coppens, Jeannot Schmidt, Pierre Albaladejo, Stuart J. Connolly
Summary: This study evaluated the safety and efficacy of andexanet alfa in patients with major bleeding caused by factor Xa inhibitors. The results showed that the drug reduced anti-FXa activity and achieved good or excellent hemostatic efficacy in 80% of the patients.
Article
Health Care Sciences & Services
Jenny Lee, Nick van Es, Toshihiko Takada, Frederikus A. Klok, Geert-Jan Geersing, Jeffrey Blume, Patrick M. Bossuyt, I. P. D. study team IPD study team
Summary: This study applied covariate-specific receiver operating characteristic (ROC) curve analysis to individual patient data on D-dimer testing for excluding pulmonary embolism. The results showed significant differences in D-dimer concentration and performance among age groups, while the distribution of results was similar for sex. Estimating conditional ROC curves can improve the ability to select thresholds with greater applicability.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2023)
Article
Health Care Sciences & Services
Janneke van t Hooft, Charlotte E. van Dijk, Cathrine Axfors, Zarko Alfirevic, Martijn A. Oudijk, Ben W. . J. Mol, Patrick M. Bossuyt, John P. A. Ioannidis
Summary: By evaluating randomized controlled trials on preterm birth prevention, it was found that only 10% of the trials met more than half of the usefulness criteria, but there was improvement over time. Future research planning should focus on using informative outcomes, patient-centeredness, pragmatism, and transparency.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2023)
Review
Oncology
R. A. L. Willems, N. Michiels, V. R. Lanting, S. Bouwense, B. L. J. van den Broek, M. Graus, F. A. Klok, B. Groot Koerkamp, B. de Laat, M. Roest, J. W. Wilmink, N. van Es, J. S. D. Mieog, H. ten Cate, J. de Vos-Geelen
Summary: In the past, patients with pancreatic ductal adenocarcinoma often underwent immediate surgery for tumor resection. Now, more and more patients receive chemotherapy (radiotherapy) before surgery. It is known that pancreatic cancer patients have a higher risk of developing thrombosis. However, the incidence of thrombosis in patients with pancreatic cancer during neoadjuvant chemotherapy is not well-studied. Few studies have investigated VTE incidence in this population, and it is unclear if these patients should use perioperative thromboprophylaxis. This narrative review summarizes the current evidence.
Review
Hematology
Dorien M. Salet, Siroon Bekkering, Saskia Middeldorp, Lucas L. van den Hoogen
Summary: Antiphospholipid syndrome (APS) is an autoimmune disease characterized by the presence of antiphospholipid antibodies (aPL) that cause thrombotic and obstetric complications. APS serves as a model for studying the mechanisms of thromboinflammation and the relationship between innate immune cells and thrombosis. Monocytes are activated by aPL to produce proinflammatory cytokines and tissue factor, while neutrophils generate neutrophil extracellular traps and interact with endothelial cells, leading to thrombosis. Platelets become procoagulant upon activation by aPL and increase interactions with leukocytes. Understanding these mechanisms provides potential therapeutic targets for APS and other thromboinflammatory diseases.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Meeting Abstract
Rheumatology
Renske G. Kamperman, Hannah A. W. Walter, Joost Raaphorst, Camiel Verhamme, Johannes H. T. M. Koelman, Wouter V. Potters, Robert Hemke, Frank F. Smithuis, Eleonora Aronica, Ester M. M. van Leeuwen, Paul A. Baars, Marianne de Visser, Ivo N. van Schaik, Patrick M. M. Bossuyt, Anneke J. van der Kooi
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)
Article
Health Care Sciences & Services
Matthew J. Thompson, Monica Zigman Suchsland, Victoria Hardy, Danielle C. Lavallee, Sally Lord, Emily Beth Devine, Jeffrey G. Jarvik, Steven Findlay, Thomas A. Trikalinos, Fiona M. Walter, Roger Chou, Beverly B. Green, Karen J. Wernli, Annette L. Fitzpatrick, Patrick M. Bossuyt
Summary: Imaging tests are commonly used in healthcare, but concerns about their overuse have overshadowed their benefits in clinical decision-making. This study demonstrates the importance of considering patient-centered outcomes (PCOs) when evaluating the value of imaging tests. The PROD framework categorizes PCOs into four main domains and highlights the interplay between them and the factors that can modify them.
BMJ QUALITY & SAFETY
(2023)
