Construction of Smart Manganese Dioxide‐Based All‐in‐One Nanoplatform for Cancer Diagnosis and Therapy

Smart Tumor Microenvironment-Responsive Nanotheranostic Agent for Effective Cancer Therapy

(2020) Shi-yan Guo et al.   ADVANCED FUNCTIONAL MATERIALS

Manganese Oxide Nanomaterials: Synthesis, Properties, and Theranostic Applications

(2020) Binbin Ding et al.   ADVANCED MATERIALS

Biomedical application of manganese dioxide nanomaterials

(2020) Yang Chen et al.   NANOTECHNOLOGY

Fusiform-Like Copper(II)-Based Metal–Organic Framework through Relief Hypoxia and GSH-Depletion Co-Enhanced Starvation and Chemodynamic Synergetic Cancer Therapy

(2020) Zhao Wang et al.   ACS Applied Materials & Interfaces

An 808 nm Light-Sensitized Upconversion Nanoplatform for Multimodal Imaging and Efficient Cancer Therapy

(2020) Arif Gulzar et al.   INORGANIC CHEMISTRY

Dual-response oxygen-generating MnO2 nanoparticles with polydopamine modification for combined photothermal-photodynamic therapy

(2020) Weiwei Zeng et al.   CHEMICAL ENGINEERING JOURNAL

Mesoporous Silica Nanoparticles for Co-Delivery of Drugs and Nucleic Acids in Oncology: A Review

(2020) Juan L. Paris et al.   Pharmaceutics

The impact of manganese on neurotransmitter systems

(2020) Ana Thalita Gonçalves Soares et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Wet/Sono‐Chemical Synthesis of Enzymatic Two‐Dimensional MnO 2 Nanosheets for Synergistic Catalysis‐Enhanced Phototheranostics

(2019) Wei Tang et al.   ADVANCED MATERIALS

Highly Efficient Vacancy-Driven Photothermal Therapy Mediated by Ultrathin MnO2 Nanosheets

(2019) Li Wang et al.   ACS Applied Materials & Interfaces

Direct Monitoring Cell Membrane Vesiculation with 2D AuNP@MnO2Nanosheet Supraparticles at Single-Particle Level

(2019) Yunyun Ling et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Toward Personalized Cancer Treatment: From Diagnostics to Therapy Monitoring in Miniaturized Electrohydrodynamic Systems

(2019) Kamil Reza Khondakar et al.   ACCOUNTS OF CHEMICAL RESEARCH

Tumor-Microenvironment-Induced All-in-One Nanoplatform for Multimodal Imaging-Guided Chemical and Photothermal Therapy of Cancer

(2019) Xiaodong Lin et al.   ACS Applied Materials & Interfaces

Hydrangea-structured tumor microenvironment responsive degradable nanoplatform for hypoxic tumor multimodal imaging and therapy

(2019) Qianyun Tang et al.   BIOMATERIALS

Facile Phototherapeutic Nanoplatform by Integrating a Multifunctional Polymer and MnO 2 for Enhancing Tumor Synergistic Therapy

(2019) Menglong Zhao et al.   Advanced Healthcare Materials

Smart Nanotherapeutic Targeting of Tumor Vasculature

(2019) Zifu Li et al.   ACCOUNTS OF CHEMICAL RESEARCH

Phase‐Change Materials Based Nanoparticles for Controlled Hypoxia Modulation and Enhanced Phototherapy

(2019) Shichao Zhang et al.   ADVANCED FUNCTIONAL MATERIALS

A GSH‐Gated DNA Nanodevice for Tumor‐Specific Signal Amplification of microRNA and MR Imaging–Guided Theranostics

(2019) Nan Yan et al.   Small

MnO2-DNAzyme-photosensitizer nanocomposite with AIE characteristic for cell imaging and photodynamic-gene therapy

(2019) Xudong Wang et al.   TALANTA

Magnetic Manganese Oxide Sweetgum-Ball Nanospheres with Large Mesopores Regulate Tumor Microenvironments for Enhanced Tumor Nanotheranostics

(2019) Yushuo Feng et al.   ACS Applied Materials & Interfaces

Cell Membrane-Coated Porphyrin Metal–Organic Frameworks for Cancer Cell Targeting and O2-Evolving Photodynamic Therapy

(2019) Di Zhang et al.   ACS Applied Materials & Interfaces

Manganese‐Based Functional Nanoplatforms: Nanosynthetic Construction, Physiochemical Property, and Theranostic Applicability

(2019) Xiaoqin Qian et al.   ADVANCED FUNCTIONAL MATERIALS

Recent Advances in Nanostrategies Capable of Overcoming Biological Barriers for Tumor Management

(2019) Da Huo et al.   ADVANCED MATERIALS

High performance one-for-all phototheranostics: NIR-II fluorescence imaging guided mitochondria-targeting phototherapy with a single-dose injection and 808 nm laser irradiation

(2019) Qi Wang et al.   BIOMATERIALS

Platelet membrane biomimetic bufalin-loaded hollow MnO2 nanoparticles for MRI-guided chemo-chemodynamic combined therapy of cancer

(2019) Haijun Wang et al.   CHEMICAL ENGINEERING JOURNAL

Mesoporous carbon‑manganese nanocomposite for multiple imaging guided oxygen-elevated synergetic therapy

(2019) Xian Li et al.   JOURNAL OF CONTROLLED RELEASE

Pd@Au Bimetallic Nanoplates Decorated Mesoporous MnO 2 for Synergistic Nucleus‐Targeted NIR‐II Photothermal and Hypoxia‐Relieved Photodynamic Therapy

(2019) Yiyi Zhang et al.   Advanced Healthcare Materials

MnO2 Motor: A Prospective Cancer-Starving Therapy Promoter

(2018) Yao-Hui Zhang et al.   ACS Applied Materials & Interfaces

Intelligent MnO2/Cu2–xS for Multimode Imaging Diagnostic and Advanced Single-Laser Irradiated Photothermal/Photodynamic Therapy

(2018) Yu Cao et al.   ACS Applied Materials & Interfaces

Upconversion Composite Nanoparticles for Tumor Hypoxia Modulation and Enhanced Near-Infrared-Triggered Photodynamic Therapy

(2018) Tongxu Gu et al.   ACS Applied Materials & Interfaces

Keratin-templated synthesis of metallic oxide nanoparticles as MRI contrast agents and drug carriers

(2018) Yan Li et al.   ACS Applied Materials & Interfaces

Tumor Microenvironment-Responsive Mesoporous MnO2 -Coated Upconversion Nanoplatform for Self-Enhanced Tumor Theranostics

(2018) Jiating Xu et al.   ADVANCED FUNCTIONAL MATERIALS

Oxygen-Generating MnO2 Nanodots-Anchored Versatile Nanoplatform for Combined Chemo-Photodynamic Therapy in Hypoxic Cancer

(2018) Wentao Zhang et al.   ADVANCED FUNCTIONAL MATERIALS

A Magnetofluorescent Carbon Dot Assembly as an Acidic H2 O2 -Driven Oxygenerator to Regulate Tumor Hypoxia for Simultaneous Bimodal Imaging and Enhanced Photodynamic Therapy

(2018) Qingyan Jia et al.   ADVANCED MATERIALS

Enhanced Photodynamic Therapy by Reduced Levels of Intracellular Glutathione Obtained By Employing a Nano-MOF with CuII as the Active Center

(2018) Wei Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Simultaneous Fenton-like Ion Delivery and Glutathione Depletion by MnO2 -Based Nanoagent to Enhance Chemodynamic Therapy

(2018) Li-Sen Lin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A multifunctional nanotheranostic for the intelligent MRI diagnosis and synergistic treatment of hypoxic tumor

(2018) Ruixue Song et al.   BIOMATERIALS

Oxygen-boosted immunogenic photodynamic therapy with gold nanocages@manganese dioxide to inhibit tumor growth and metastases

(2018) Ruijing Liang et al.   BIOMATERIALS

Tumor targeted, stealthy and degradable bismuth nanoparticles for enhanced X-ray radiation therapy of breast cancer

(2018) Junjie Deng et al.   BIOMATERIALS

Theranostic 2D ultrathin MnO 2 nanosheets with fast responsibility to endogenous tumor microenvironment and exogenous NIR irradiation

(2018) Zhuang Liu et al.   BIOMATERIALS

In situ formation of large pore silica–MnO2 nanocomposites with H+/H2O2 sensitivity for O2-elevated photodynamic therapy and potential MR imaging

(2018) Zhimei He et al.   CHEMICAL COMMUNICATIONS

Catalytic chemistry of glucose oxidase in cancer diagnosis and treatment

(2018) Lian-Hua Fu et al.   CHEMICAL SOCIETY REVIEWS

Manganese metabolism in humans

(2018) Pan Chen   Frontiers in Bioscience-Landmark

Facile Deposition of Manganese Dioxide to Albumin-Bound Paclitaxel Nanoparticles for Modulation of Hypoxic Tumor Microenvironment To Improve Chemoradiation Therapy

(2018) Lingtong Meng et al.   MOLECULAR PHARMACEUTICS

Nano-graphene oxide-manganese dioxide nanocomposites for overcoming tumor hypoxia and enhancing cancer radioisotope therapy

(2018) Yugui Tao et al.   Nanoscale

Turn-on fluorescent sensor for the detection of glucose using manganese dioxide−phenol formaldehyde resin nanocomposite

(2018) Zhong Feng Gao et al.   TALANTA

O2-generating MnO2 nanoparticles for enhanced photodynamic therapy of bladder cancer by ameliorating hypoxia

(2018) Tingsheng Lin et al.   Theranostics

Facile and Green Approach To Prepare Nanostructured Au@MnO2 and Its Applications for Catalysis and Fluorescence Sensing of Glutathione in Human Blood

(2018) Xu Zhou et al.   ACS Sustainable Chemistry & Engineering

In Situ Growth of CuS/SiO2-Based Multifunctional Nanotherapeutic Agents for Combined Photodynamic/Photothermal Cancer Therapy

(2018) Xiangmei Liu et al.   ACS Applied Materials & Interfaces

Biomimetic nanoflowers by self-assembly of nanozymes to induce intracellular oxidative damage against hypoxic tumors

(2018) Zhenzhen Wang et al.   Nature Communications

Switchable Photoacoustic Imaging of Glutathione Using MnO2 Nanotubes for Cancer Diagnosis

(2018) Chang Liu et al.   ACS Applied Materials & Interfaces

Construction of a biodegradable, versatile nanocarrier for optional combination cancer therapy

(2018) Jia Wen et al.   Acta Biomaterialia

Glutathione and H2O2 consumption promoted photodynamic and chemotherapy based on biodegradable MnO2–Pt@Au25 nanosheets

(2018) Huiting Bi et al.   CHEMICAL ENGINEERING JOURNAL

Precise nanomedicine for intelligent therapy of cancer

(2018) Huabing Chen et al.   Science China-Chemistry

Recent Advances in Cell Membrane-Camouflaged Nanoparticles for Cancer Phototherapy

(2018) Xu Zhen et al.   Small

A Core-Shell Nanoplatform for Synergistic Enhanced Sonodynamic Therapy of Hypoxic Tumor via Cascaded Strategy

(2018) Lei Wang et al.   Advanced Healthcare Materials

Oxygenic Hybrid Semiconducting Nanoparticles for Enhanced Photodynamic Therapy

(2017) Houjuan Zhu et al.   NANO LETTERS

A MnO2nanosheet-assisted GSH detection platform using an iridium(iii) complex as a switch-on luminescent probe

(2017) Zhen-Zhen Dong et al.   Nanoscale

Albumin-templated biomineralizing growth of composite nanoparticles as smart nano-theranostics for enhanced radiotherapy of tumors

(2017) Jiawen Chen et al.   Nanoscale

Oxidase-mimicking activity of ultrathin MnO2nanosheets in colorimetric assay of acetylcholinesterase activity

(2017) Xu Yan et al.   Nanoscale

Manganese Dioxide Coated WS2 @Fe3 O4 /sSiO2 Nanocomposites for pH-Responsive MR Imaging and Oxygen-Elevated Synergetic Therapy

(2017) Guangbao Yang et al.   Small

A label-free fluorescence turn-on assay for glutathione detection by using MnO 2 nanosheets assisted aggregation-induced emission-silica nanospheres

(2017) Xiaobin Zhang et al.   TALANTA

Hollow MnO2 as a tumor-microenvironment-responsive biodegradable nano-platform for combination therapy favoring antitumor immune responses

(2017) Guangbao Yang et al.   Nature Communications

Redox-Responsive Manganese Dioxide Nanoparticles for Enhanced MR Imaging and Radiotherapy of Lung Cancer

(2017) Mi Hyeon Cho et al.   Frontiers in Chemistry

Graphene Quantum Dot–MnO2 Nanosheet Based Optical Sensing Platform: A Sensitive Fluorescence “Turn Off–On” Nanosensor for Glutathione Detection and Intracellular Imaging

(2016) Xu Yan et al.   ACS Applied Materials & Interfaces

PEGylation as a strategy for improving nanoparticle-based drug and gene delivery

(2016) Jung Soo Suk et al.   ADVANCED DRUG DELIVERY REVIEWS

MnO2Gatekeeper: An Intelligent and O2-Evolving Shell for Preventing Premature Release of High Cargo Payload Core, Overcoming Tumor Hypoxia, and Acidic H2O2-Sensitive MRI

(2016) Zhifang Ma et al.   ADVANCED FUNCTIONAL MATERIALS

Modulation of Hypoxia in Solid Tumor Microenvironment with MnO2Nanoparticles to Enhance Photodynamic Therapy

(2016) Wenwen Zhu et al.   ADVANCED FUNCTIONAL MATERIALS

Intelligent Albumin-MnO2Nanoparticles as pH-/H2O2-Responsive Dissociable Nanocarriers to Modulate Tumor Hypoxia for Effective Combination Therapy

(2016) Qian Chen et al.   ADVANCED MATERIALS

A Bifunctional Photosensitizer for Enhanced Fractional Photodynamic Therapy: Singlet Oxygen Generation in the Presence and Absence of Light

(2016) Ilke Simsek Turan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Smart Photosensitizer-Manganese Dioxide Nanosystem for Enhanced Photodynamic Therapy by Reducing Glutathione Levels in Cancer Cells

(2016) Huanhuan Fan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Fluorescent glutathione probe based on MnO 2 -phenol formaldehyde resin nanocomposite

(2016) Xudong Wang et al.   BIOSENSORS & BIOELECTRONICS

Exploring the relationship between anti-PEG IgM behaviors and PEGylated nanoparticles and its significance for accelerated blood clearance

(2016) Kouichi Shiraishi et al.   JOURNAL OF CONTROLLED RELEASE

Core–shell Au@MnO2 nanoparticles for enhanced radiotherapy via improving the tumor oxygenation

(2016) Xuan Yi et al.   Nano Research

pH-Activatable MnO-Based Fluorescence and Magnetic Resonance Bimodal Nanoprobe for Cancer Imaging

(2016) Benedict You Wei Hsu et al.   Advanced Healthcare Materials

Analysis of nanoparticle delivery to tumours

(2016) Stefan Wilhelm et al.   Nature Reviews Materials

Bioresponsive materials

(2016) Yue Lu et al.   Nature Reviews Materials

Bioconjugated Manganese Dioxide Nanoparticles Enhance Chemotherapy Response by Priming Tumor-Associated Macrophages toward M1-like Phenotype and Attenuating Tumor Hypoxia

(2015) Manli Song et al.   ACS Nano

Design of Hybrid MnO2-Polymer-Lipid Nanoparticles with Tunable Oxygen Generation Rates and Tumor Accumulation for Cancer Treatment

(2015) Claudia R. Gordijo et al.   ADVANCED FUNCTIONAL MATERIALS

Intelligent MnO2Nanosheets Anchored with Upconversion Nanoprobes for Concurrent pH-/H2O2-Responsive UCL Imaging and Oxygen-Elevated Synergetic Therapy

(2015) Wenpei Fan et al.   ADVANCED MATERIALS

A Smart DNAzyme-MnO2Nanosystem for Efficient Gene Silencing

(2015) Huanhuan Fan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A rapid fluorescence “switch-on” assay for glutathione detection by using carbon dots–MnO2 nanocomposites

(2015) Qi-Yong Cai et al.   BIOSENSORS & BIOELECTRONICS

A FRET-based carbon dot–MnO2 nanosheet architecture for glutathione sensing in human whole blood samples

(2015) Yuhui Wang et al.   CHEMICAL COMMUNICATIONS

Advanced targeted therapies in cancer: Drug nanocarriers, the future of chemotherapy

(2015) Edgar Pérez-Herrero et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

The neurotoxicity of iron, copper and manganese in Parkinson's and Wilson's diseases

(2015) Petr Dusek et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Multifunctional nanosheets based on folic acid modified manganese oxide for tumor-targeting theranostic application

(2015) Yongwei Hao et al.   NANOTECHNOLOGY

One-Step Synthesis of Single-Layer MnO2Nanosheets with Multi-Role Sodium Dodecyl Sulfate for High-Performance Pseudocapacitors

(2015) Zhenning Liu et al.   Small

Hydrothermal synthesis of hierarchical core–shell manganese oxide nanocomposites as efficient dye adsorbents for wastewater treatment

(2015) Wei Wang et al.   RSC Advances

Multifunctional Albumin–MnO2 Nanoparticles Modulate Solid Tumor Microenvironment by Attenuating Hypoxia, Acidosis, Vascular Endothelial Growth Factor and Enhance Radiation Response

(2014) Preethy Prasad et al.   ACS Nano

Break-up of Two-Dimensional MnO2Nanosheets Promotes Ultrasensitive pH-Triggered Theranostics of Cancer

(2014) Yu Chen et al.   ADVANCED MATERIALS

Turn-On Fluorescence Sensor for Intracellular Imaging of Glutathione Using g-C3N4 Nanosheet–MnO2 Sandwich Nanocomposite

(2014) Xiao-Long Zhang et al.   ANALYTICAL CHEMISTRY

Activatable Fluorescence/MRI Bimodal Platform for Tumor Cell Imaging via MnO2 Nanosheet–Aptamer Nanoprobe

(2014) Zilong Zhao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells

(2014) Debangshu Samanta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

General synthesis of hollow MnO2, Mn3O4and MnO nanospheres as superior anode materials for lithium ion batteries

(2014) Jie Yue et al.   Journal of Materials Chemistry A

New insights into manganese toxicity and speciation

(2013) Bernhard Michalke et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

BSA-templated MnO2 nanoparticles as both peroxidase and oxidase mimics

(2012) Xing Liu et al.   ANALYST

Manganese oxide-based multifunctionalized mesoporous silica nanoparticles for pH-responsive MRI, ultrasonography and circumvention of MDR in cancer cells

(2012) Yu Chen et al.   BIOMATERIALS

Combinatorial drug therapy for cancer in the post-genomic era

(2012) Bissan Al-Lazikani et al.   NATURE BIOTECHNOLOGY

A New and Facile Method To Prepare Uniform Hollow MnO/Functionalized mSiO2 Core/Shell Nanocomposites

(2011) Yung-Kang Peng et al.   ACS Nano

The Shape Effect of Mesoporous Silica Nanoparticles on Biodistribution, Clearance, and Biocompatibility in Vivo

(2011) Xinglu Huang et al.   ACS Nano

Positive and Negative Lattice Shielding Effects Co-existing in Gd (III) Ion Doped Bifunctional Upconversion Nanoprobes

(2011) Feng Chen et al.   ADVANCED FUNCTIONAL MATERIALS

Urchin-Shaped Manganese Oxide Nanoparticles as pH-Responsive Activatable T1 Contrast Agents for Magnetic Resonance Imaging

(2011) Taekhoon Kim et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis and Capacitive Properties of Manganese Oxide Nanosheets Dispersed on Functionalized Graphene Sheets

(2011) Jintao Zhang et al.   Journal of Physical Chemistry C

Mesoporous Silica-Coated Hollow Manganese Oxide Nanoparticles as PositiveT1Contrast Agents for Labeling and MRI Tracking of Adipose-Derived Mesenchymal Stem Cells

(2011) Taeho Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Intracellular Glutathione Detection Using MnO2-Nanosheet-Modified Upconversion Nanoparticles

(2011) Renren Deng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results

(2011) Gooitzen M van Dam et al.   NATURE MEDICINE

Bypassing Multidrug Resistance in Cancer Cells with Biodegradable Polymer Capsules

(2010) Yan Yan et al.   ADVANCED MATERIALS

The characteristics of sub 10 nm manganese oxide T1 contrast agents of different nanostructured morphologies

(2010) Chih-Chia Huang et al.   BIOMATERIALS

Surface functionalized hollow manganese oxide nanoparticles for cancer targeted siRNA delivery and magnetic resonance imaging

(2010) Ki Hyun Bae et al.   BIOMATERIALS

Urchinlike MnO2 nanoparticles for the direct electrochemistry of hemoglobin with carbon ionic liquid electrode

(2010) Zhihong Zhu et al.   BIOSENSORS & BIOELECTRONICS

Challenges for Molecular Magnetic Resonance Imaging

(2010) Enzo Terreno et al.   CHEMICAL REVIEWS

To exploit the tumor microenvironment: Passive and active tumor targeting of nanocarriers for anti-cancer drug delivery

(2010) Fabienne Danhier et al.   JOURNAL OF CONTROLLED RELEASE

Morphology-Controlled Synthesis and Novel Microwave Absorption Properties of Hollow Urchinlike α-MnO2 Nanostructures

(2010) Min Zhou et al.   Journal of Physical Chemistry C

Manganese-Induced Dopaminergic Neurodegeneration: Insights into Mechanisms and Genetics Shared with Parkinson’s Disease

(2009) Alexandre Benedetto et al.   CHEMICAL REVIEWS

Low-Temperature Synthesis of Monodisperse 3D Manganese Oxide Nanoflowers and Their Pseudocapacitance Properties

(2009) Jipeng Ni et al.   Journal of Physical Chemistry C

Controlled Preparation of MnO2 Hierarchical Hollow Nanostructures and Their Application in Water Treatment

(2008) J. B. Fei et al.   ADVANCED MATERIALS

Hollow Manganese Oxide Nanoparticles as Multifunctional Agents for Magnetic Resonance Imaging and Drug Delivery

(2008) Jongmin Shin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Facile Synthesis of Monodisperse Manganese Oxide Nanostructures and Their Application in Water Treatment

(2008) Hongmin Chen et al.   Journal of Physical Chemistry C

Room-Temperature Synthesis of Manganese Oxide Monosheets

(2008) Kazuya Kai et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY