Article
Nanoscience & Nanotechnology
Shengren Xiong, Guosheng Xiong, Zhaohui Li, Qing Jiang, Jia Yin, Ting Yin, Hong Zheng
Summary: This study utilized gold nanomaterials to prepare a dual tumor-targeting nanoprobe, achieving successful photodynamic/photothermal combined anti-tumor therapy. By protecting photosensitive drugs from photodegradation and inducing treatment with mild laser irradiation, tumor growth in osteosarcoma was significantly inhibited.
Article
Biophysics
Yuqiong Xia, Cairu Li, Jianxia Cao, Zhaoxu Chen, Jun Wang, Yankun Wu, Xianghan Zhang
Summary: Mild temperature photothermal therapy is a promising approach for clinical tumor treatment, but the overexpression of heat shock proteins (HSPs) limits its therapeutic outcome. In this study, we investigated the correlation between HSP expression and photothermal temperature, and found that 47 degrees C was the optimal temperature for HSP management. By co-administrating an HSP70 inhibitor, we achieved enhanced tumor inhibition in temperature-controlled photothermal therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Chemistry, Analytical
Bingyan Yan, Min Li, Fang Luo, XiaoYa Jin, Bin Qiu, Zhenyu Lin
Summary: In this study, the aggregated and dispersed states of gold nanoparticles were utilized for photothermal detection of human papilloma virus (HPV). The presence of HPV16 triggered a strand-displacement amplification (SDA) reaction, preventing the aggregation of gold nanoparticles and enabling quantitative detection of HPV16.
Review
Immunology
Anirban Sengupta, Mohammad Azharuddin, Noha Al-Otaibi, Jorma Hinkula
Summary: The use of gold nanoparticles (GNPs) in vaccine development has gained popularity due to their excellent properties in biocompatibility, immune modulation, and antigen delivery. GNPs can effectively combat various pathogens by modulating immune responses of cells and antibodies. Despite their potential toxicity, it is worth further exploring and investing in GNPs for vaccine development.
Article
Pharmacology & Pharmacy
Yang Chen, Xun Feng
Summary: This review summarizes the application of gold nanoparticles as drug carriers for skin drug delivery. Factors influencing the penetration behaviors of gold nanoparticles, such as size, surface chemistry, and shape, are discussed. Drug loading, release, and penetration patterns are analyzed to implicate the design of gold nanoparticles for dermal or transdermal drug delivery. Physical methods, including microneedles and iontophoresis, are presented for enhancing the delivery efficacy of gold nanoparticles. The inherent activities of gold nanoparticles, especially their application in the treatment of skin disease, are also discussed.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Nanoscience & Nanotechnology
Jung-Dae Kim, Dong Uk Kim, Chan Bae Jeong, Ilkyu Han, Ji Yong Bae, Hwan Hur, Ki-Hwan Nam, Sangwon Hyun, I. Jong Kim, Kye-Sung Lee, Ki Soo Chang
Summary: The study introduces a wide-field photothermal reflectance spectroscopy technique for detecting individual nanoparticles and obtaining absorption spectra using a pump beam, a probe beam, and a CCD camera integrated into a commercial microscopic setup. This method enables the detection of numerous individual nanoparticles within a wide field of view, showcasing sufficient sensitivity for spectral imaging of single gold nanorods.
Article
Nanoscience & Nanotechnology
Xun Kang, Tao Sun, Liang Zhang, Chunyu Zhou, Zhongsheng Xu, Mengmeng Du, Shilin Xiao, Yun Liu, Mingfu Gong, Dong Zhang
Summary: Fe3O4-Aushell-PEG NPs, with uniform Janus-like morphology, demonstrated good biocompatibility, promising MRI effects, high transverse relaxivity, and potential photothermal therapy performance, making them a synergistic theranostic agent for breast cancer.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Engineering, Biomedical
Masayoshi Tanaka, Mirei Hayashi, Lucien Roach, Yuka Kiriki, Tetsuya Kadonosono, Takahiro Nomoto, Nobuhiro Nishiyama, Jonghoon Choi, Kevin Critchley, Stephen D. Evans, Mina Okochi
Summary: The study explored the synthesis of triangular gold nanoplates using peptides, demonstrating control over nanoplate size and properties by adjusting peptide concentration. These nanoplates showed promising potential as photothermal therapeutic agents and indicated the feasibility of synthesizing circular gold nanoplates using peptides.
ACTA BIOMATERIALIA
(2021)
Article
Engineering, Chemical
Yumin Oh, Jaehyuk Kim, Euijong Lee, Junggil Lee, Sanghyun Jeong
Summary: In this study, gold nanoparticles (GNPs) were embedded in MD membranes to improve MD performance through the photothermal effect. Two different techniques (electrospinning and electrospraying) were used to fabricate the photothermal layer and compared. The results showed that the GNPs embedded in the MD membranes improved the rejection efficiency and reduced membrane fouling.
Article
Chemistry, Physical
Shuqian Yu, Jie Zhang, Shenghua Liu, Ziyi Ma, Haotian Sun, Zhiwei Liu, Longgang Wang
Summary: In this study, gold nanoflowers with good photothermal conversion efficiency were successfully synthesized using polymyxin E as a template. The flower-shaped gold nanoparticles exhibited anisotropic properties and a large surface plasmon resonance peak, showing excellent antibacterial effects on HeLa cells and strong inhibition efficacy on tumor growth in vivo.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Chemistry, Analytical
Zahra Jafar-Nezhad Ivrigh, Arafeh Bigdeli, Somayeh Jafarinejad, Mohammad Reza Hormozi-Nezhad
Summary: In this study, a condition-based single component sensor array was proposed for the quantification and classification of antidepressants. By tuning the pH and ionic strength, the array achieved excellent sensitivity and selectivity in detecting the target analytes. The results of multivariate calibration and classification in human urine demonstrated the practicality of the array in complex biological fluids.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Multidisciplinary Sciences
Yeong-Cheol Heo, Dong-Kyoon Han, Min Tae Kim
Summary: The study investigated the therapeutic effect of local photothermal heating on suppression of stent-induced granulation tissue formation in mouse colon. Results showed that local PT heating significantly reduced the variables related to stent-induced granulation tissue and improved patency of the stented colon. Vascular endothelial growth factor (VEGF) positivity was lower in the group that underwent local heating, indicating a potential mechanism for the therapeutic effect.
Article
Chemistry, Physical
Mengzhu Zhang, Xiaohan Qin, Wei Xu, Yibing Wang, Yunmei Song, Sanjay Garg, Yuxia Luan
Summary: This study introduces a novel dual-modal phototherapeutic nanoplatform that achieves both PDT and PTT under single 660 nm laser irradiation by integrating core-shell structured CuS@Carbon with Ce6.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Chemistry, Applied
Jiawei Liu, Xingpeng Xu, Jing Wang, Ruoyu Sang, Zhen Zhang, Jiaqi Chen, Xiaomei Lu, Qi Wang, Quli Fan
Summary: This study developed water-soluble nanoparticles combining the functions of PDT and PTT, showing promising tumor treatment effects. The nanoparticles demonstrated significant anti-tumor effects in both in vitro and in vivo experiments, providing a potential approach for designing organic polymer nanoplatforms for combination cancer therapy with near-infrared absorption.
Article
Nanoscience & Nanotechnology
Zhenrui Xue, Minli You, Ping Peng, Haoyang Tong, Wanghong He, Ang Li, Ping Mao, Ting Xu, Feng Xu, Chunyan Yao
Summary: The study aimed to develop a simple and highly specific qPCR-based single-base mutation detection method, which successfully established the Taqman-MGB nanoPCR system by adding different concentrations of gold nanoparticles, improving the specificity of mutation detection with a performance of detecting mutations as low as 0.95%.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)